Sirtuins Link Inflammation and Metabolism

Surprising sirtuin crosstalk in the heart

(2016) Thaddeus T. Schug et al.   Aging-US

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT1 mediates a primed response to immune challenge after traumatic lung injury

(2015) Lane M. Smith et al.   Journal of Trauma and Acute Care Surgery

Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules inob/obmice

(2015) Xianfeng Wang et al.   Obesity

SIRT1 mediates a primed response to immune challenge after traumatic lung injury

(2015) Lane M. Smith et al.   Journal of Trauma and Acute Care Surgery

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

(2014) George A. Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

SIRT4 Suppresses Inflammatory Responses in Human Umbilical Vein Endothelial Cells

(2014) Yu Tao et al.   Cardiovascular Toxicology

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets

(2014) Vidula Vachharajani et al.   Expert Review of Clinical Immunology

Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure

(2014) Kian Peng Goh et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis

(2014) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

(2014) Vidula T. Vachharajani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sirtuin 1 (SIRT1) Activation Mediates Sildenafil Induced Delayed Cardioprotection against Ischemia-Reperfusion Injury in Mice

(2014) Mona Shalwala et al.   PLoS One

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

(2014) Takanobu Yamamoto et al.   PLoS One

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Resveratrol in metabolic health: an overview of the current evidence and perspectives

(2013) Morten Møller Poulsen et al.   Annals of the New York Academy of Sciences

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

How Metabolism Generates Signals during Innate Immunity and Inflammation

(2013) Anne F. McGettrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caloric Restriction

(2013) Connie W. Bales et al.   Journal of Cardiopulmonary Rehabilitation and Prevention

The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury

(2013) Hong Fan et al.   KIDNEY INTERNATIONAL

SIRT1 prevents atherosclerosis via liver-X-receptor and NF-κB signaling in a U937 cell model

(2013) HAI-TAO ZENG et al.   Molecular Medicine Reports

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Regulation of SIRT1 in Vascular Smooth Muscle Cells from Streptozotocin-Diabetic Rats

(2013) Alice Toniolo et al.   PLoS One

Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5

(2013) Bo Bai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells

(2012) Yu Jin Jung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes

(2012) Lucía Serrano-Marco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress

(2012) Chao Tong et al.   FASEB JOURNAL

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fueling the flame: bioenergy couples metabolism and inflammation

(2012) T. F. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sirtuin 1 in lipid metabolism and obesity

(2011) Thaddeus T. Schug et al.   ANNALS OF MEDICINE

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance

(2011) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited

(2010) Alexei Vazquez et al.   BMC Systems Biology

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

(2010) Sokrates Stein et al.   EUROPEAN HEART JOURNAL

Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation

(2010) Zhiyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene-Specific Epigenetic Regulation in Serious Infections with Systemic Inflammation

(2010) Charles E. McCall et al.   Journal of Innate Immunity

Alternate Day Calorie Restriction Improves Systemic Inflammation in a Mouse Model of Sepsis Induced by Cecal Ligation and Puncture

(2010) Akira Hasegawa et al.   JOURNAL OF SURGICAL RESEARCH

Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes

(2010) Sameer Sharma et al.   PHYTOTHERAPY RESEARCH

The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

(2009) Shin-ichiro Imai   CELL BIOCHEMISTRY AND BIOPHYSICS

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells

(2009) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner

(2008) Kenichiro Nishi et al.   ANTIOXIDANTS & REDOX SIGNALING

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance

(2008) Mohamed El Gazzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanisms of macrophage activation in obesity-induced insulin resistance

(2008) Justin I Odegaard et al.   Nature clinical practice. Endocrinology & metabolism

Obesity Exacerbates Sepsis-Induced Inflammation and Microvascular Dysfunction in Mouse Brain

(2007) VIDULA VACHHARAJANI et al.   MICROCIRCULATION