Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
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Title
Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 21, Pages 11847
Publisher
MDPI AG
Online
2021-11-02
DOI
10.3390/ijms222111847
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Note: Only part of the references are listed.- Some Molecular and Cellular Stress Mechanisms Associated with Neurodegenerative Diseases and Atherosclerosis
- (2021) Margarita A. Sazonova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin may slow disease progression in amyotrophic lateral sclerosis: Findings from the Pooled Resource Open‐Access ALS Clinic Trials database
- (2021) Elizabeth M. Bald et al. MUSCLE & NERVE
- Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
- (2021) Kun Leng et al. NATURE NEUROSCIENCE
- The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide
- (2021) Yew Mun Lee et al. Cell Death & Disease
- The Role of Natural Antioxidants in the Prevention of Dementia—Where Do We Stand and Future Perspectives
- (2021) Anamaria Jurcau Nutrients
- Influence of energy deficiency on the subcellular processes of Substantia Nigra Pars Compacta cell for understanding Parkinsonian neurodegeneration
- (2021) Vignayanandam Ravindernath Muddapu et al. Scientific Reports
- Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia
- (2021) Mehdi Eshraghi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer’s Disease Pathology
- (2021) Mariona Jové et al. Life-Basel
- Molecular and cellular pathways contributing to brain aging
- (2021) Aliabbas Zia et al. Behavioral and Brain Functions
- Advances in developing therapeutic strategies for Alzheimer's disease
- (2021) Thuy Trang Nguyen et al. BIOMEDICINE & PHARMACOTHERAPY
- The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS
- (2021) Elena Obrador et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glucose Metabolic Dysfunction in Neurodegenerative Diseases—New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming
- (2021) Rongrong Han et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Approval of Aducanumab for Alzheimer Disease—the FDA’s Perspective
- (2021) Billy Dunn et al. JAMA Internal Medicine
- Selective Neuron Vulnerability in Common and Rare Diseases—Mitochondria in the Focus
- (2021) Thomas Paß et al. Frontiers in Molecular Biosciences
- Oxidative stress in the pathogenesis of Alzheimer’s disease and cerebrovascular disease with therapeutic implications.
- (2020) Anamaria Jurcau et al. CNS & Neurological Disorders-Drug Targets
- Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- (2020) Haroon Khan et al. Biomolecules
- Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
- (2020) Maria Calvo-Rodriguez et al. Nature Communications
- The rise and rise of mitochondrial DNA mutations
- (2020) Conor Lawless et al. Open Biology
- Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD
- (2020) Ruxandra Dafinca et al. Stem Cell Reports
- Role of RNA Oxidation in Neurodegenerative Diseases
- (2020) Ziqian Liu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis
- (2020) Jean-Pierre Roussarie et al. NEURON
- Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System
- (2020) Md. Abdul Hannan et al. Frontiers in Molecular Neuroscience
- The Role of Oxidative Stress in Parkinson’s Disease
- (2020) Kuo-Hsuan Chang et al. Antioxidants
- Role of Toll Like Receptor 4 in Alzheimer’s Disease
- (2020) Maria Calvo-Rodriguez et al. Frontiers in Immunology
- Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology
- (2020) Noemi Esteras et al. Cells
- Mitophagy and the Brain
- (2020) Natalie S. Swerdlow et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease
- (2020) Fanny Eysert et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tau and DNA Damage in Neurodegeneration
- (2020) Luca Colnaghi et al. Brain Sciences
- Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis
- (2020) HaEun Cho et al. Pharmaceuticals
- Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity
- (2019) Vidhya Rangaraju et al. CELL
- LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
- (2019) Benjamin Scott Padman et al. Nature Communications
- Calcium signalling: a key regulator of neuronal migration
- (2019) Shin-ichiro Horigane et al. JOURNAL OF BIOCHEMISTRY
- Mitochondrial electron transport chain, ROS generation and uncoupling (Review)
- (2019) Ru‑Zhou Zhao et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
- (2019) Anju Singh et al. MOLECULES
- On the central role of mitochondria dysfunction and oxidative stress in Alzheimer’s disease
- (2019) Tobore Onojighofia Tobore NEUROLOGICAL SCIENCES
- Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse
- (2019) Keiko Ishida et al. NEUROSCIENCE RESEARCH
- Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
- (2019) P. Hemachandra Reddy et al. Cells
- The genetic architecture of Parkinson's disease
- (2019) Cornelis Blauwendraat et al. LANCET NEUROLOGY
- How do cells cope with RNA damage and its consequences?
- (2019) Liewei L. Yan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Roles for the Endoplasmic Reticulum in Regulation of Neuronal Calcium Homeostasis
- (2019) Nicholas E. Karagas et al. Cells
- What Do Microglia Really Do in Healthy Adult Brain?
- (2019) Marcus Augusto-Oliveira et al. Cells
- Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death
- (2019) Elena Britti et al. CELL CALCIUM
- ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
- (2019) Rita Mejzini et al. Frontiers in Neuroscience
- Novel mutation in optineurin causing aggressive ALS+/−frontotemporal dementia
- (2019) Shu‐Man Feng et al. Annals of Clinical and Translational Neurology
- Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART
- (2018) Sarah K. Kaufman et al. ACTA NEUROPATHOLOGICA
- Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson’s models
- (2018) Atossa Shaltouki et al. ACTA NEUROPATHOLOGICA
- Cerebral Metabolic Changes During Sleep
- (2018) Nadia Nielsen Aalling et al. Current Neurology and Neuroscience Reports
- Mitochondrial dynamics: overview of molecular mechanisms
- (2018) Lisa Tilokani et al. Essays in Biochemistry
- Anti-inflammatory Activity of 8-Hydroxydaidzein in LPS-Stimulated BV2 Microglial Cells via Activation of Nrf2-Antioxidant and Attenuation of Akt/NF-κB-Inflammatory Signaling Pathways, as Well As Inhibition of COX-2 Activity
- (2018) Pei-Shan Wu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis
- (2018) Tesfaye W Tefera et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?
- (2018) Kazutoshi Watanabe et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
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- (2018) Claudio Hetz et al. MOLECULAR CELL
- Autophagy and mitophagy in ALS
- (2018) Chantell S. Evans et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial alterations in Parkinson's disease human samples and cellular models
- (2018) Mara Zilocchi et al. NEUROCHEMISTRY INTERNATIONAL
- The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1
- (2018) Maria Perez Carrion et al. Frontiers in Molecular Neuroscience
- Sleep Disorders Associated With Alzheimer's Disease: A Perspective
- (2018) Anna Brzecka et al. Frontiers in Neuroscience
- 13 reasons why the brain is susceptible to oxidative stress
- (2018) James Nathan Cobley et al. Redox Biology
- A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease
- (2018) Lynne Shinto et al. JOURNAL OF ALZHEIMERS DISEASE
- Rasagiline for Amyotrophic Lateral Sclerosis: a Randomized Controlled Trial
- (2018) Jeffrey M Statland et al. MUSCLE & NERVE
- Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling
- (2018) Cheong-Meng Chong et al. Cell Death & Disease
- A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice
- (2018) Domenico Nuzzo et al. Nutrients
- Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets
- (2018) Thomas Briston et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Dopamine Autoxidation Is Controlled by Acidic pH
- (2018) Nejc Umek et al. Frontiers in Molecular Neuroscience
- Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target
- (2018) Mariona Jové et al. Redox Biology
- The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
- (2018) Saima Kausar et al. Cells
- On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis
- (2017) Estela Area-Gomez et al. FASEB JOURNAL
- Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders
- (2017) Fabio Di Domenico et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cholesterol and related sterols autoxidation
- (2017) Chiara Zerbinati et al. FREE RADICAL BIOLOGY AND MEDICINE
- Role of Glutamate and NMDA Receptors in Alzheimer’s Disease
- (2017) Rui Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- The constriction and scission machineries involved in mitochondrial fission
- (2017) Felix Kraus et al. JOURNAL OF CELL SCIENCE
- Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin
- (2017) Tadato Ban et al. NATURE CELL BIOLOGY
- ER-mitochondria tethering by PDZD8 regulates Ca2+dynamics in mammalian neurons
- (2017) Yusuke Hirabayashi et al. SCIENCE
- A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015
- (2017) Lama M. Chahine et al. SLEEP MEDICINE REVIEWS
- NAD + in Aging: Molecular Mechanisms and Translational Implications
- (2017) Evandro F. Fang et al. TRENDS IN MOLECULAR MEDICINE
- Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division
- (2017) Bongki Cho et al. Nature Communications
- αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease
- (2017) Victorio Martin Pozo Devoto et al. Scientific Reports
- Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression
- (2017) Jingzhu Zhang et al. Frontiers in Aging Neuroscience
- Phase IIb Study of Intranasal Glutathione in Parkinson’s Disease
- (2017) Laurie K. Mischley et al. Journal of Parkinsons Disease
- Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
- (2017) Prasad Tammineni et al. eLife
- Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)
- (2017) Richard J. Kryscio et al. JAMA Neurology
- Mitochondrial metabolic regulation by GRP78
- (2017) Manoj Prasad et al. Science Advances
- Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration
- (2017) David A. Patten et al. JOURNAL OF ALZHEIMERS DISEASE
- Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease
- (2017) Antonio Martin-Bastida et al. Scientific Reports
- Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins
- (2017) Vladimir V. Rogov et al. Scientific Reports
- Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD
- (2016) Alice Goode et al. Autophagy
- Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease
- (2016) Chung-Han Hsieh et al. Cell Stem Cell
- Quality control of chemically damaged RNA
- (2016) Carrie L. Simms et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Could Sirtuin Activities Modify ALS Onset and Progression?
- (2016) Bor Luen Tang CELLULAR AND MOLECULAR NEUROBIOLOGY
- Hydrogen peroxide (H 2 O 2 ) controls axon pathfinding during zebrafish development
- (2016) Carole Gauron et al. DEVELOPMENTAL BIOLOGY
- Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review
- (2016) Hena Khanam et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- OPA1 processing in cell death and disease – the long and short of it
- (2016) Thomas MacVicar et al. JOURNAL OF CELL SCIENCE
- Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients
- (2016) Pooja-Shree Mishra et al. Journal of Neuroinflammation
- Age-Related Changes in Axonal and Mitochondrial Ultrastructure and Function in White Matter
- (2016) K. E. Stahon et al. JOURNAL OF NEUROSCIENCE
- Multiple dynamin family members collaborate to drive mitochondrial division
- (2016) Jason E. Lee et al. NATURE
- Transfer of mitochondria from astrocytes to neurons after stroke
- (2016) Kazuhide Hayakawa et al. NATURE
- Understanding Dopaminergic Cell Death Pathways in Parkinson Disease
- (2016) Patrick P. Michel et al. NEURON
- Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- (2016) Lucio G. Costa et al. Oxidative Medicine and Cellular Longevity
- AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
- (2016) E. Q. Toyama et al. SCIENCE
- ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
- (2016) Samantha C. Lewis et al. SCIENCE
- Alterations in Mitochondrial Quality Control in Alzheimer’s Disease
- (2016) Qian Cai et al. Frontiers in Cellular Neuroscience
- Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2
- (2016) Riccardo Filadi et al. Cell Reports
- LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons
- (2016) Seok-Kyu Kwon et al. PLOS BIOLOGY
- Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease
- (2016) Simona Magi et al. Biomed Research International
- The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease
- (2016) Laura Narciso et al. NEURAL PLASTICITY
- Mitochondrial Complex 1 Activity Measured by Spectrophotometry Is Reduced across All Brain Regions in Ageing and More Specifically in Neurodegeneration
- (2016) Amelia Kate Pollard et al. PLoS One
- Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update
- (2015) Melissa A. Bradley-Whitman et al. ARCHIVES OF TOXICOLOGY
- Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria
- (2015) Yvette C Wong et al. Autophagy
- Ion Channel Formation by Tau Protein: Implications for Alzheimer’s Disease and Tauopathies
- (2015) Nirav Patel et al. BIOCHEMISTRY
- Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation
- (2015) Jessica L. Feldman et al. BIOCHEMISTRY
- Erratum: AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
- (2015) F Strappazzon et al. CELL DEATH AND DIFFERENTIATION
- Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding
- (2015) Michael J. Waterson et al. Cell Metabolism
- Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons
- (2015) Consiglia Pacelli et al. CURRENT BIOLOGY
- Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review
- (2015) M. Ramis et al. CURRENT MEDICINAL CHEMISTRY
- TDP-43 activates microglia through NF-κB and NLRP3 inflammasome
- (2015) Weihua Zhao et al. EXPERIMENTAL NEUROLOGY
- Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease
- (2015) Karl Kieburtz et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The human Nox4: gene, structure, physiological function and pathological significance
- (2015) Shuhui Guo et al. JOURNAL OF DRUG TARGETING
- Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
- (2015) LANCET NEUROLOGY
- Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis
- (2015) Aswin Pyakurel et al. MOLECULAR CELL
- The Chemistry of Neurodegeneration: Kinetic Data and Their Implications
- (2015) Matic Pavlin et al. MOLECULAR NEUROBIOLOGY
- DNA damage in neurodegenerative diseases
- (2015) Fabio Coppedè et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Searching for harmony in transition-metal signaling
- (2015) Christopher J Chang Nature Chemical Biology
- Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
- (2015) Wenzhang Wang et al. NATURE MEDICINE
- Creatine as a booster for human brain function. How might it work?
- (2015) Caroline D. Rae et al. NEUROCHEMISTRY INTERNATIONAL
- Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress
- (2015) Alicia M. Pickrell et al. NEURON
- Mechanisms of Long Non-coding RNAs in Mammalian Nervous System Development, Plasticity, Disease, and Evolution
- (2015) James A. Briggs et al. NEURON
- Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions
- (2015) Rohini Raman et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection
- (2015) E. H. Blackburn et al. SCIENCE
- NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1
- (2015) J Shi et al. Cell Death & Disease
- VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function
- (2015) Fu-Lei Tang et al. Cell Reports
- DNA Damage, DNA Repair, Aging, and Neurodegeneration
- (2015) Scott Maynard et al. Cold Spring Harbor Perspectives in Medicine
- Microglial cell dysregulation in brain aging and neurodegeneration
- (2015) Rommy von Bernhardi et al. Frontiers in Aging Neuroscience
- A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement
- (2015) Zachary Macchi et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Gene Expression Profiles of Entorhinal Cortex in Alzheimer’s Disease
- (2014) Bingqian Ding et al. American Journal of Alzheimers Disease and Other Dementias
- LAMP-2: A control step for phagosome and autophagosome maturation
- (2014) Paul Saftig et al. Autophagy
- Discovery and implications of transcellular mitophagy
- (2014) Chung-ha O. Davis et al. Autophagy
- Microglial dysfunction in brain aging and Alzheimer's disease
- (2014) Kira Irving Mosher et al. BIOCHEMICAL PHARMACOLOGY
- Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications
- (2014) Dale Edmondson CURRENT PHARMACEUTICAL DESIGN
- Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease
- (2014) Maurice W. Dysken et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions
- (2014) Noemí Fabelo et al. NEUROBIOLOGY OF AGING
- Targeted quantitative analysis of synaptic proteins in Alzheimer’s disease brain
- (2014) Rachel Yoon Kyung Chang et al. NEUROCHEMISTRY INTERNATIONAL
- Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
- (2014) Diane B. Re et al. NEURON
- Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
- (2014) Ashley E. Frakes et al. NEURON
- Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1
- (2014) Taku Amo et al. NEUROSCIENCE LETTERS
- Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
- (2014) Antonio Ayala et al. Oxidative Medicine and Cellular Longevity
- Transcellular degradation of axonal mitochondria
- (2014) Chung-ha O. Davis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
- (2014) Yvette C. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival
- (2014) Y-Y Park et al. Cell Death & Disease
- Systemic regulation of mammalian ageing and longevity by brain sirtuins
- (2014) Akiko Satoh et al. Nature Communications
- A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease
- (2014) et al. JAMA Neurology
- Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease
- (2013) David Devos et al. ANTIOXIDANTS & REDOX SIGNALING
- Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide
- (2013) Gerd P. Bienert et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease
- (2013) Ubaldo Armato et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons
- (2013) Johannes F.G. Neuhaus et al. BRAIN
- Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
- (2013) Akiko Satoh et al. Cell Metabolism
- Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
- (2013) Marc Liesa et al. Cell Metabolism
- Curcumin and Curcumin-like Molecules: From Spice to Drugs
- (2013) A. Marchiani et al. CURRENT MEDICINAL CHEMISTRY
- Mitochondrial Fusion and Fission Proteins Expression Dynamically Change in a Murine Model of Amyotrophic Lateral Sclerosis
- (2013) Wentao Liu et al. CURRENT NEUROVASCULAR RESEARCH
- Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein
- (2013) Chris Fröhlich et al. EMBO JOURNAL
- Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
- (2013) Yu-Chin Su et al. HUMAN MOLECULAR GENETICS
- Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
- (2013) Klodjan Stafa et al. HUMAN MOLECULAR GENETICS
- The Oxygen Paradox of Neurovascular Coupling
- (2013) Christoph Leithner et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Axons Giving Rise to the Palisade Endings of Feline Extraocular Muscles Display Motor Features
- (2013) L. Zimmermann et al. JOURNAL OF NEUROSCIENCE
- Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial
- (2013) Merit E Cudkowicz et al. LANCET NEUROLOGY
- Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
- (2013) Oliver C. Losón et al. MOLECULAR BIOLOGY OF THE CELL
- Roles for NF-κB and Gene Targets of NF-κB in Synaptic Plasticity, Memory, and Navigation
- (2013) Wanda M. Snow et al. MOLECULAR NEUROBIOLOGY
- Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment
- (2013) Omotayo O. Erejuwa et al. Oxidative Medicine and Cellular Longevity
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- (2013) L. Hedskog et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) Xiao-Yang Zhang et al. Neuroscience Bulletin
- Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?
- (2013) Karl Grenier et al. Frontiers in Neurology
- Stabilizers of Neuronal and Mitochondrial Calcium Cycling as a Strategy for Developing a Medicine for Alzheimer's Disease
- (2012) José-Carlos Fernández-Morales et al. ACS Chemical Neuroscience
- Changes in neuronal DNA content variation in the human brain during aging
- (2012) Hans-Georg Fischer et al. AGING CELL
- Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease
- (2012) Renato X. Santos et al. ANTIOXIDANTS & REDOX SIGNALING
- Antioxidants for Alzheimer Disease
- (2012) Douglas R. Galasko et al. ARCHIVES OF NEUROLOGY
- Cellular and molecular mechanisms of mitochondrial function
- (2012) Laura D. Osellame et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Small Molecule Signaling Agents: The Integrated Chemistry and Biochemistry of Nitrogen Oxides, Oxides of Carbon, Dioxygen, Hydrogen Sulfide, and Their Derived Species
- (2012) Jon M. Fukuto et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons
- (2012) Qian Cai et al. CURRENT BIOLOGY
- Mitochondrial quality control: a matter of life and death for neurons
- (2012) Elena I Rugarli et al. EMBO JOURNAL
- Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation
- (2012) Julia Romanov et al. EMBO JOURNAL
- Oxidative stress – assassin behind the ischemic stroke
- (2012) Hanumanthappa Pradeep et al. FOLIA NEUROPATHOLOGICA
- Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain
- (2012) Rukhsana Sultana et al. FREE RADICAL BIOLOGY AND MEDICINE
- An overview of the chemistry and biology of reactive aldehydes
- (2012) Kristofer S. Fritz et al. FREE RADICAL BIOLOGY AND MEDICINE
- Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- PINK1- and Parkin-mediated mitophagy at a glance
- (2012) Seok Min Jin et al. JOURNAL OF CELL SCIENCE
- Iron accumulation in Parkinson’s disease
- (2012) Hideki Mochizuki et al. JOURNAL OF NEURAL TRANSMISSION
- Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease
- (2012) Weilin Xie et al. JOURNAL OF NEUROCHEMISTRY
- Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases
- (2012) Muralidhar L. Hegde et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Living on the edge with too many mouths to feed: Why dopamine neurons die
- (2012) J. Paul Bolam et al. MOVEMENT DISORDERS
- Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
- (2012) Lei Liu et al. NATURE CELL BIOLOGY
- Mitochondria as sensors and regulators of calcium signalling
- (2012) Rosario Rizzuto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2012) R. Jeroen Pasterkamp NATURE REVIEWS NEUROSCIENCE
- Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy
- (2012) Chinatsu Otomo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Hypothalamic Control of Sleep in Aging
- (2012) Asya Rolls NEUROMOLECULAR MEDICINE
- Synaptic Energy Use and Supply
- (2012) Julia J. Harris et al. NEURON
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- (2012) R. J. Youle et al. SCIENCE
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- (2012) John M Ringman et al. Alzheimers Research & Therapy
- The Developing, Aging Neocortex: How Genetics and Epigenetics Influence Early Developmental Patterning and Age-Related Change
- (2012) Kelly Huffman Frontiers in Genetics
- Oxidative Stress and Antioxidant Defense
- (2012) Esra Birben et al. World Allergy Organization Journal
- ULK1, Mammalian Target of Rapamycin, and Mitochondria: Linking Nutrient Availability and Autophagy
- (2011) Mondira Kundu ANTIOXIDANTS & REDOX SIGNALING
- Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases
- (2011) Tohru Fukai et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2011) Marzia Perluigi et al. ANTIOXIDANTS & REDOX SIGNALING
- Redox Regulation of Mitochondrial Function
- (2011) Diane E. Handy et al. ANTIOXIDANTS & REDOX SIGNALING
- PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis
- (2011) Matthew E. Gegg et al. Autophagy
- GABARAPL1 (GEC1): Original or copycat?
- (2011) Jaclyn Nicole Le Grand et al. Autophagy
- Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum
- (2011) Dalibor Mijaljica et al. Autophagy
- Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
- (2011) Jisun Lee et al. BIOCHEMICAL JOURNAL
- Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
- (2011) Antero Salminen et al. CELLULAR SIGNALLING
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- (2011) Francisco J. Schopfer et al. CHEMICAL REVIEWS
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- (2011) Angelika L. Jacobs et al. CHROMOSOMA
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- (2011) Emilia Kansanen et al. FREE RADICAL BIOLOGY AND MEDICINE
- VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
- (2011) Kurt J. De Vos et al. HUMAN MOLECULAR GENETICS
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- (2011) Maria Manczak et al. HUMAN MOLECULAR GENETICS
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- (2011) Robin B. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Complex Inhibitory Effects of Nitric Oxide on Autophagy
- (2011) Sovan Sarkar et al. MOLECULAR CELL
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- (2011) Ligia C. Gomes et al. NATURE CELL BIOLOGY
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- (2011) Merit Cudkowicz et al. NATURE MEDICINE
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- (2011) Ralph A. Nixon et al. NEUROBIOLOGY OF DISEASE
- Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
- (2011) K.-i. Fujita et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER Tubules Mark Sites of Mitochondrial Division
- (2011) J. R. Friedman et al. SCIENCE
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- (2011) Eitan Okun et al. TRENDS IN NEUROSCIENCES
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- (2010) Amy K. Reeve et al. Annals of the New York Academy of Sciences
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- (2010) Anatoly A. Starkov Annals of the New York Academy of Sciences
- Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory
- (2010) Cynthia A. Massaad et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2010) Eisuke Itakura et al. Autophagy
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- (2010) Kelly A. Graham et al. CANCER BIOLOGY & THERAPY
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- (2010) Yasemin Sancak et al. CELL
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- (2010) Ryota Iwasawa et al. EMBO JOURNAL
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- (2010) Martin D. Brand EXPERIMENTAL GERONTOLOGY
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- (2010) Kelly Jean Thomas et al. HUMAN MOLECULAR GENETICS
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- (2010) Y.-F. Xu et al. JOURNAL OF NEUROSCIENCE
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- (2010) Barry J. Snow et al. MOVEMENT DISORDERS
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- (2010) Li Yu et al. NATURE
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- (2010) Jaime N. Guzman et al. NATURE
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- (2010) En Huang et al. NATURE CELL BIOLOGY
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- (2010) Brinda Ravikumar et al. NATURE CELL BIOLOGY
- Nox2 redox signaling maintains essential cell populations in the brain
- (2010) Bryan C Dickinson et al. Nature Chemical Biology
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- (2010) H. Mortiboys et al. NEUROLOGY
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- (2010) Noriyuki Shibata et al. NEUROPATHOLOGY
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- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
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- (2010) Marcelo R. Vargas et al. Neurotherapeutics
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- (2010) B. Schwaller Cold Spring Harbor Perspectives in Biology
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- (2010) M. Brini et al. Cold Spring Harbor Perspectives in Biology
- Dimebon disappointment
- (2010) Roy W Jones Alzheimers Research & Therapy
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- (2009) Lydia W.S. Finley et al. AGEING RESEARCH REVIEWS
- NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets
- (2009) Vladimir Kirkin et al. Autophagy
- Lrrk2 interaction with α-synuclein in diffuse Lewy body disease
- (2009) Hong Qing et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2009) Robert T. Youker et al. BIOCHEMICAL JOURNAL
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- (2009) Dale E. Edmondson et al. BIOCHEMISTRY
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- (2009) Isabel A. Abreu et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
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- (2009) Beatrice Terni et al. BRAIN PATHOLOGY
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- (2009) Tanea T. Reed et al. BRAIN RESEARCH
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- (2009) Damian Miles Bailey et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
- (2009) Martin Gamerdinger et al. EMBO JOURNAL
- Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum
- (2009) W. Matsuda et al. JOURNAL OF NEUROSCIENCE
- A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
- (2009) Vladimir Kirkin et al. MOLECULAR CELL
- Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease
- (2009) Robert A. Hauser et al. MOVEMENT DISORDERS
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex
- (2009) Yun Zhong et al. NATURE CELL BIOLOGY
- NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
- (2009) R. Palty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
- (2009) C. Vives-Bauza et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis
- (2009) Marzia Perluigi et al. Proteomics Clinical Applications
- S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
- (2009) Dong-Hyung Cho et al. SCIENCE
- Mitochondrial fusion and division: Regulation and role in cell viability
- (2009) Giovanni Benard et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK
- (2009) Seung J. Lee et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women
- (2008) C. E. Gleason et al. AGE AND AGEING
- Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells
- (2008) Muralidhar L Hegde et al. CELL RESEARCH
- Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
- (2008) Emily L. Que et al. CHEMICAL REVIEWS
- DAPK-1 Binding to a Linear Peptide Motif in MAP1B Stimulates Autophagy and Membrane Blebbing
- (2008) Ben Harrison et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
- (2008) Rachelle S Doody et al. LANCET
- Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals
- (2008) Eun Sun Cho et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
- (2008) Liyan Qiao et al. Molecular Brain
- Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities
- (2008) Marcel E. Dinger et al. PLoS Computational Biology
- Early α-synuclein lipoxidation in neocortex in Lewy body diseases
- (2006) Esther Dalfó et al. NEUROBIOLOGY OF AGING
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