Glucose Metabolic Dysfunction in Neurodegenerative Diseases—New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming

Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease

(2021) Sónia C. Correia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study

(2020) Hong Wang et al.   American Journal of Alzheimers Disease and Other Dementias

Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit

(2020) Shinichi Takahashi   NEUROPATHOLOGY

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism

(2020) Isha H. Jain et al.   CELL

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis

(2019) Tslil Ast et al.   CELL

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

(2019) Zoya O. Serebrovska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intermittent hypoxia improves cognition and reduces anxiety‐related behavior in APP/PS1 mice

(2019) Sheng‐Xi Meng et al.   Brain and Behavior

Neuroketotherapeutics: A modern review of a century-old therapy

(2018) Scott J. Koppel et al.   NEUROCHEMISTRY INTERNATIONAL

Metabolic Reprogramming in Amyotrophic Lateral Sclerosis

(2018) M. Szelechowski et al.   Scientific Reports

Integrative Characterization of the R6/2 Mouse Model of Huntington’s Disease Reveals Dysfunctional Astrocyte Metabolism

(2018) Niels H. Skotte et al.   Cell Reports

Enhanced Expression of the Voltage-Dependent Anion Channel 1 (VDAC1) in Alzheimer's Disease Transgenic Mice: An Insight into the Pathogenic Effects of Amyloid-β

(2018) Mar Cuadrado-Tejedor et al.   JOURNAL OF ALZHEIMERS DISEASE

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

(2018) Xiongwei Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

(2017) Michele Ferrari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress

(2016) De Huang et al.   CELL RESEARCH

Neuron-Microglia Interactions in Motor Neuron Degeneration. The Inflammatory Hypothesis in Amyotrophic Lateral Sclerosis Revisited

(2016) Manuel Rodríguez et al.   CURRENT MEDICINAL CHEMISTRY

Glucose Transporters in Brain: In Health and in Alzheimer’s Disease

(2016) Leszek Szablewski   JOURNAL OF ALZHEIMERS DISEASE

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain

(2016) Lisa Wagenführ et al.   STEM CELLS AND DEVELOPMENT

Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

(2016) Stephen C. Cunnane et al.   Frontiers in Molecular Neuroscience

Glycogen phosphorylation and Lafora disease

(2015) Peter J. Roach   MOLECULAR ASPECTS OF MEDICINE

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis

(2015) Gabriel N. Valbuena et al.   MOLECULAR NEUROBIOLOGY

Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions

(2015) Rohini Raman et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Future directions in Alzheimer's disease from risk factors to prevention

(2014) Bushra Imtiaz et al.   BIOCHEMICAL PHARMACOLOGY

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models

(2014) Adam L. Knight et al.   Cell Metabolism

Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells

(2014) Ismail Ismailoglu et al.   DEVELOPMENTAL BIOLOGY

Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease

(2014) A. Vittori et al.   HUMAN MOLECULAR GENETICS

Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia

(2014) Isabel Saez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis

(2014) M. Pagani et al.   NEUROLOGY

Value of18Fluorodeoxyglucose–Positron-Emission Tomography in Amyotrophic Lateral Sclerosis

(2014) Koen Van Laere et al.   JAMA Neurology

Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice

(2014) Hollis McClory et al.   Acta Neuropathologica Communications

Alzheimer’s as a metabolic disease

(2013) Lloyd A. Demetrius et al.   BIOGERONTOLOGY

Amyotrophic lateral sclerosis: cell vulnerability or system vulnerability?

(2013) Kevin Talbot   JOURNAL OF ANATOMY

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis

(2013) Scott P. Allen et al.   NEUROBIOLOGY OF AGING

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

(2013) Laura Dunn et al.   NEUROBIOLOGY OF AGING

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Age-Dependent Modulation of Synaptic Plasticity and Insulin Mimetic Effect of Lipoic Acid on a Mouse Model of Alzheimer’s Disease

(2013) Harsh Sancheti et al.   PLoS One

Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention

(2013) Fan Ding et al.   PLoS One

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

(2012) P Rodriguez-Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway

(2012) Gerardo Rodriguez-Araujo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metabolic Dysfunction in Alzheimers Disease and Related Neurodegenerative Disorders

(2012) Huan Cai et al.   Current Alzheimer Research

Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

(2012) Jordan T. Newington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis

(2011) N. Ticozzi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude

(2011) Cassandra Richardson et al.   CLINICAL NEUROPHYSIOLOGY

HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia

(2011) Simon C Warby et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Early and Progressive Impairment of Spinal Blood Flow—Glucose Metabolism Coupling in Motor Neuron Degeneration of ALS Model Mice

(2011) Kazunori Miyazaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

(2011) Ignacio Munoz-Sanjuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

(2011) A. Chio et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Parkinson’s disease: The non-motor issues

(2011) K. Ray Chaudhuri et al.   PARKINSONISM & RELATED DISORDERS

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

(2011) P. Tandon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current approaches to the treatment of Parkinson’s disease

(2011) Joseph Jankovic   Neuropsychiatric Disease and Treatment

Interruption of β-catenin suppresses the EGFR pathway by blocking multiple oncogenic targets in human glioma cells

(2010) Xiao Yue et al.   BRAIN RESEARCH

Cortical hypometabolism and hypoperfusion in Parkinson’s disease is extensive: probably even at early disease stages

(2010) Per Borghammer et al.   Brain Structure & Function

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Aspects of Carbohydrate Metabolism in Developing Brain

(2010) Najma Zaheer Baquer et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2010) S. Byrne et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

(2010) Y.-F. Xu et al.   JOURNAL OF NEUROSCIENCE

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Proliferation in the human ipsilateral subventricular zone after ischemic stroke

(2010) J. Marti-Fabregas et al.   NEUROLOGY

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice

(2010) X. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Death Pathways in Parkinson's Disease: Role of Mitochondria

(2009) Zhi Yao et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Incidence of amyotrophic lateral sclerosis in Europe

(2009) G. Logroscino et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Generating specificity and diversity in the transcriptional response to hypoxia

(2009) Urban Lendahl et al.   NATURE REVIEWS GENETICS

Proximal events in Wnt signal transduction

(2009) Stephane Angers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

High metabolic level in patients with familial amyotrophic lateral sclerosis

(2008) Benoit Funalot et al.   Amyotrophic Lateral Sclerosis

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant huntingtin and mitochondrial dysfunction

(2008) Ella Bossy-Wetzel et al.   TRENDS IN NEUROSCIENCES

Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004

(2007) O O'Toole et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues

(2007) G Logroscino et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY