The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function

(2020) Valeriy V. Pak et al.   Cell Metabolism

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

Oxidants, Antioxidants and Thiol Redox Switches in the Control of Regulated Cell Death Pathways

(2020) Moran Benhar   Antioxidants

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

(2019) Gaynor A. Smith et al.   NEURON

Mitochondrial Dysfunction Plays a Key Role in the Development of Neurodegenerative Diseases in Diabetes

(2019) Han Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

(2018) Ekaterina Pchitskaya et al.   CELL CALCIUM

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation

(2018) Jie Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration

(2018) Osamah Thaher et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial Antioxidants and the Maintenance of Cellular Hydrogen Peroxide Levels

(2018) Ryan J. Mailloux   Oxidative Medicine and Cellular Longevity

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

(2018) Edgar Djaha Yoboue et al.   Cell Death & Disease

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

(2018) Ulrike Topf et al.   Nature Communications

Chemical proteomics reveals new targets of cysteine sulfinic acid reductase

(2018) Salma Akter et al.   Nature Chemical Biology

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

(2018) Hao Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of mitochondrial ROS in the aging brain

(2017) Rhoda Stefanatos et al.   FEBS LETTERS

Sixty years old is the breakpoint of human frontal cortex aging

(2017) Rosanna Cabré et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein S-glutathionylation alters superoxide/hydrogen peroxide emission from pyruvate dehydrogenase complex

(2017) Marisa O’Brien et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

(2017) Bin Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain aging and neurodegeneration: from a mitochondrial point of view

(2017) Amandine Grimm et al.   JOURNAL OF NEUROCHEMISTRY

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan?

(2016) Alberto Sanz   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reactivity, Selectivity, and Stability in Sulfenic Acid Detection: A Comparative Study of Nucleophilic and Electrophilic Probes

(2016) Vinayak Gupta et al.   BIOCONJUGATE CHEMISTRY

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

(2016) Mohammed Akbar et al.   BRAIN RESEARCH

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Compartment-specific Control of Reactive Oxygen Species Scavenging by Antioxidant Pathway Enzymes

(2016) Swati Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying ROS levels using CM-H 2 DCFDA and HyPer

(2016) Monika Oparka et al.   METHODS

O 2 sensing, mitochondria and ROS signaling: The fog is lifting

(2016) Gregory B. Waypa et al.   MOLECULAR ASPECTS OF MEDICINE

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

(2016) David M. Booth et al.   MOLECULAR CELL

Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson’s Disease

(2016) M. Rodríguez-Arribas et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria

(2016) Ryan J. Mailloux et al.   Redox Biology

A Chemical Approach for the Detection of Protein Sulfinylation

(2015) Mauro Lo Conte et al.   ACS Chemical Biology

Biological and physiological role of reactive oxygen species - the good, the bad and the ugly

(2015) L. Zuo et al.   Acta Physiologica

Calcium and mitochondria in the regulation of cell death

(2015) Sten Orrenius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

A PDI-catalyzed thiol–disulfide switch regulates the production of hydrogen peroxide by human Ero1

(2015) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

The antioxidant machinery of the endoplasmic reticulum: Protection and signaling

(2015) Agnès Delaunay-Moisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

Biological chemistry and functionality of protein sulfenic acids and related thiol modifications

(2015) Nelmi O. Devarie-Baez et al.   FREE RADICAL RESEARCH

The human Nox4: gene, structure, physiological function and pathological significance

(2015) Shuhui Guo et al.   JOURNAL OF DRUG TARGETING

The Expanding Landscape of the Thiol Redox Proteome

(2015) Jing Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

Global, in situ, site-specific analysis of protein S-sulfenylation

(2015) Jing Yang et al.   Nature Protocols

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

(2015) Marleen Forkink et al.   Redox Biology

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Enhanced proteasome degradation extends Caenorhabditis elegans lifespan and alleviates aggregation-related pathologies

(2014) Niki Chondrogianni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Metabolic H2O2Generation

(2014) Helmut Sies   JOURNAL OF BIOLOGICAL CHEMISTRY

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding

(2014) Lihong Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Respiratory chain deficiency in aged spinal motor neurons

(2014) Karolina A. Rygiel et al.   NEUROBIOLOGY OF AGING

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

(2014) Revati Wani et al.   Frontiers in Pharmacology

Superoxide Generated at Mitochondrial Complex III Triggers Acute Responses to Hypoxia in the Pulmonary Circulation

(2013) Gregory B. Waypa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

(2013) Gustavo Barja   ANTIOXIDANTS & REDOX SIGNALING

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

(2013) Yoon Sun Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cysteine Oxidative Posttranslational Modifications

(2013) Heaseung S. Chung et al.   CIRCULATION RESEARCH

OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange

(2013) Jaime Santo-Domingo et al.   EMBO JOURNAL

Chemical approaches to detect and analyze protein sulfenic acids

(2013) Cristina M. Furdui et al.   MASS SPECTROMETRY REVIEWS

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Glutathione and modulation of cell apoptosis

(2012) Magdalena L. Circu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Ca2+ signals in autophagy

(2012) César Cárdenas et al.   CELL CALCIUM

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

(2012) T. Finkel   Science Signaling

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Sensing by Proteins: Oxidative Modifications on Cysteines and the Consequent Events

(2011) Ying Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria removal by autophagy

(2011) Ke Wang et al.   Autophagy

Redox Regulation of Mitochondrial ATP Synthase

(2011) Sheng-Bing Wang et al.   CIRCULATION RESEARCH

Protein sulfenic acid formation: From cellular damage to redox regulation

(2011) Goedele Roos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations

(2011) Damon Poburko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

(2011) Fanjun Meng et al.   Molecular Neurodegeneration

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

Hydrogen Peroxide Probes Directed to Different Cellular Compartments

(2011) Mikalai Malinouski et al.   PLoS One

The Lifespan-Regulator p66Shc in Mitochondria: Redox Enzyme or Redox Sensor?

(2010) Melanie Gertz et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduction of Cysteine Sulfinic Acid in Eukaryotic, Typical 2-Cys Peroxiredoxins by Sulfiredoxin

(2010) W. Todd Lowther et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase 4 is an oncoprotein localized to mitochondria

(2010) Kelly A. Graham et al.   CANCER BIOLOGY & THERAPY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Peroxisomes Are Oxidative Organelles

(2009) Vasily D. Antonenkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

(2009) M. Lebiedzinska et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiol-Based Redox Switches in Eukaryotic Proteins

(2008) Nicolas Brandes et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Ca2+ Signaling, Mitochondria and Cell Death

(2008) Paolo Pinton et al.   CURRENT MOLECULAR MEDICINE

Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis

(2008) Chunlai Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation

(2008) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fuel utilization by hypothalamic neurons: roles for ROS

(2008) Tamas L. Horvath et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY