The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer’s Disease Pathology

Is the NDUFV2 subunit of the hydrophilic complex I domain a key determinant of animal longevity?

(2021) Reinald Pamplona et al.   FEBS Journal

Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease

(2021) Kun Leng et al.   NATURE NEUROSCIENCE

Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease

(2021) Olayemi Joseph Olajide et al.   Biology Open

Oxidative stress and regulated cell death in Parkinson’s disease

(2021) P.A. Dionísio et al.   AGEING RESEARCH REVIEWS

Neuronal volume of the hippocampal regions in ageing

(2020) José Carlos Delgado‐González et al.   JOURNAL OF ANATOMY

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How

(2020) Cutler T. Lewandowski et al.   NEUROBIOLOGY OF DISEASE

The social nature of mitochondria: Implications for human health

(2020) Martin Picard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Brain regions vulnerable and resistant to aging without Alzheimer’s disease

(2020) Xinyang Feng et al.   PLoS One

ATP synthase and Alzheimer’s disease: putting a spin on the mitochondrial hypothesis

(2020) Brad Ebanks et al.   Aging-US

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking

(2020) Jorge Montesinos et al.   EMBO JOURNAL

The multi‐faceted role of mitochondria in the pathology of Parkinson’s disease

(2020) Dennison Trinh et al.   JOURNAL OF NEUROCHEMISTRY

Cryo-EM structure of the entire mammalian F-type ATP synthase

(2020) Gergely Pinke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease

(2020) Sue Kulason et al.   Frontiers in Neuroscience

Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease

(2020) D. Allan Butterfield et al.   Antioxidants

Mitonuclear Interactions in the Maintenance of Mitochondrial Integrity

(2020) Panagiotis Karakaidos et al.   Life-Basel

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response

(2020) Radha Desai et al.   Science Advances

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease

(2019) Stephen A. Semick et al.   ACTA NEUROPATHOLOGICA

On the central role of mitochondria dysfunction and oxidative stress in Alzheimer’s disease

(2019) Tobore Onojighofia Tobore   NEUROLOGICAL SCIENCES

Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide

(2019) Si-Yang Wang et al.   CELL CYCLE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits

(2018) Zachariah M. Reagh et al.   NEURON

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging

(2018) Mayelín Domínguez-González et al.   EXPERIMENTAL GERONTOLOGY

Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target

(2018) Mariona Jové et al.   Redox Biology

Sixty years old is the breakpoint of human frontal cortex aging

(2017) Rosanna Cabré et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders

(2017) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroRNA Expression in the Locus Coeruleus, Entorhinal Cortex, and Hippocampus at Early and Middle Stages of Braak Neurofibrillary Tangle Pathology

(2017) Franc Llorens et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Regional Gene Expression of Inflammation and Oxidative Stress Responses Does Not Predict Neurodegeneration in Aging

(2017) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Human anterolateral entorhinal cortex volumes are associated with cognitive decline in aging prior to clinical diagnosis

(2017) Rosanna K. Olsen et al.   NEUROBIOLOGY OF AGING

The impact of aging on subregions of the hippocampal complex in healthy adults

(2017) Florian Kurth et al.   NEUROIMAGE

The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging

(2017) Sarah E. Hancock et al.   GeroScience

Neuropathologic Alterations in Mild Cognitive Impairment: A Review

(2017) William R. Markesbery   JOURNAL OF ALZHEIMERS DISEASE

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease

(2016) Marta Blanch et al.   AMERICAN JOURNAL OF PATHOLOGY

Clinical implications from proteomic studies in neurodegenerative diseases: lessons from mitochondrial proteins

(2016) D. Allan Butterfield et al.   Expert Review of Proteomics

Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly

(2016) Mayelín Domínguez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Regional and Gender Study of Neuronal Density in Brain during Aging and in Alzheimer's Disease

(2016) Eva Martínez-Pinilla et al.   Frontiers in Aging Neuroscience

Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex

(2016) Rosanna Cabré et al.   Frontiers in Molecular Neuroscience

Cortical thickness in relation to clinical symptom onset in preclinical AD

(2016) Corinne Pettigrew et al.   NeuroImage-Clinical

Anxiety Symptoms in Amnestic Mild Cognitive Impairment Are Associated with Medial Temporal Atrophy and Predict Conversion to Alzheimer Disease

(2015) Linda Mah et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease

(2015) Anja Soldan et al.   HUMAN BRAIN MAPPING

Entorhinal Cortex Thickness across the Human Lifespan

(2015) Khader M. Hasan et al.   JOURNAL OF NEUROIMAGING

Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease

(2015) Chris Cadonic et al.   MOLECULAR NEUROBIOLOGY

Deregulation of purine metabolism in Alzheimer's disease

(2015) Belén Ansoleaga et al.   NEUROBIOLOGY OF AGING

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

(2014) Mariona Jové et al.   AGING CELL

Gene Expression Profiles of Entorhinal Cortex in Alzheimer’s Disease

(2014) Bingqian Ding et al.   American Journal of Alzheimers Disease and Other Dementias

An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach

(2014) Giovanna Cenini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Visual rating and volumetric measurement of medial temporal atrophy in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort: baseline diagnosis and the prediction of MCI outcome

(2014) Daniel Varon et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

(2014) Mariona Jové et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Targeting Synaptic Pathology with a Novel Affinity Mass Spectrometry Approach

(2014) Ann Brinkmalm et al.   MOLECULAR & CELLULAR PROTEOMICS

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions

(2014) Noemí Fabelo et al.   NEUROBIOLOGY OF AGING

Targeted quantitative analysis of synaptic proteins in Alzheimer’s disease brain

(2014) Rachel Yoon Kyung Chang et al.   NEUROCHEMISTRY INTERNATIONAL

Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer’s disease

(2014) C. Fernandez-Echevarria et al.   NEUROSCIENCE

Inferring changepoint times of medial temporal lobe morphometric change in preclinical Alzheimer's disease

(2014) Laurent Younes et al.   NeuroImage-Clinical

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment

(2013) Vanessa A. Guzman et al.   Alzheimers & Dementia

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human brain evolution: transcripts, metabolites and their regulators

(2013) Mehmet Somel et al.   NATURE REVIEWS NEUROSCIENCE

A longitudinal study of brain atrophy over two years in community-dwelling older individuals

(2013) Jiyang Jiang et al.   NEUROIMAGE

APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease

(2013) Markus Donix et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

The diffeomorphometry of temporal lobe structures in preclinical Alzheimer's disease

(2013) Michael I. Miller et al.   NeuroImage-Clinical

Accelerating Cortical Thinning: Unique to Dementia or Universal in Aging?

(2012) Anders M. Fjell et al.   CEREBRAL CORTEX

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Region-Specific Hierarchy between Atrophy, Hypometabolism, and  -Amyloid (A ) Load in Alzheimer's Disease Dementia

(2012) R. La Joie et al.   JOURNAL OF NEUROSCIENCE

Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study

(2012) Jennifer L Whitwell et al.   LANCET NEUROLOGY

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia

(2012) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

Human and rat brain lipofuscin proteome

(2012) Philipp Ottis et al.   PROTEOMICS

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

(2011) Reinald Pamplona et al.   BIOGERONTOLOGY

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Disentangling Alzheimer's disease

(2011) Charles Duyckaerts   LANCET NEUROLOGY

Individual subject classification for Alzheimer's disease based on incremental learning using a spatial frequency representation of cortical thickness data

(2011) Youngsang Cho et al.   NEUROIMAGE

Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults

(2011) B. C. Dickerson et al.   NEUROLOGY

Rapid metabolic evolution in human prefrontal cortex

(2011) X. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOR on the brain

(2010) Michael G. Garelick et al.   EXPERIMENTAL GERONTOLOGY

Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?

(2010) Herve Lemaitre et al.   NEUROBIOLOGY OF AGING

Selective neuronal vulnerability to oxidative stress in the brain

(2010) Wang   Frontiers in Aging Neuroscience

Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease

(2010) Alexis M. Stranahan et al.   NEURAL PLASTICITY

Cell Death and Learning Impairment in Mice Caused by in Vitro Modified Pro-NGF Can Be Related to Its Increased Oxidative Modifications in Alzheimer Disease

(2009) Anton Kichev et al.   AMERICAN JOURNAL OF PATHOLOGY

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates

(2009) Anna Martínez et al.   BRAIN PATHOLOGY

Mitochondrial ATP-Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology

(2009) Beatrice Terni et al.   BRAIN PATHOLOGY

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

(2009) Tanea T. Reed et al.   BRAIN RESEARCH

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

(2009) Joseph L. Price et al.   NEUROBIOLOGY OF AGING

The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?

(2009) L. T. Grinberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Does Alzheimer's disease begin in the brainstem?

(2009) G. Simic et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

(2009) Marzia Perluigi et al.   Proteomics Clinical Applications

Polyunsaturated fatty acid–cholesterol interactions: Domain formation in membranes

(2008) Stephen R. Wassall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

(2008) Bradford C. Dickerson et al.   CEREBRAL CORTEX

Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal

(2008) Liana G. Apostolova et al.   NEUROBIOLOGY OF AGING

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

Prevalence of dementia after age 90: Results from The 90+ Study

(2008) M. M. Corrada et al.   NEUROLOGY

What Does the Anatomical Organization of the Entorhinal Cortex Tell Us?

(2008) Cathrin B. Canto et al.   NEURAL PLASTICITY