The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease

Mutations in PNKP Cause Recessive Ataxia with Oculomotor Apraxia Type 4

(2015) Jose Bras et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability

(2015) M. Shimada et al.   EMBO JOURNAL

Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation

(2015) Anirban Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with OGG1 Is Required for Efficient Recruitment of XRCC1 to Base Excision Repair and Maintenance of Genetic Stability after Exposure to Oxidative Stress

(2015) Anna Campalans et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA damage in neurodegenerative diseases

(2015) Fabio Coppedè et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The current state of eukaryotic DNA base damage and repair

(2015) Nicholas C. Bauer et al.   NUCLEIC ACIDS RESEARCH

ATM prevents DSB formation by coordinating SSB repair and cell cycle progression

(2015) Svetlana V. Khoronenkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

(2015) Rui Gao et al.   PLoS Genetics

NADPH Oxidase and Neurodegeneration

(2015) Marina S. Hernandes et al.   Current Neuropharmacology

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

(2015) Peter Sykora et al.   NUCLEIC ACIDS RESEARCH

Causative novel PNKP mutations and concomitant PCDH15 mutations in a patient with microcephaly with early-onset seizures and developmental delay syndrome and hearing loss

(2014) Mitsuko Nakashima et al.   JOURNAL OF HUMAN GENETICS

Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease

(2014) Chandrika Canugovi et al.   NEUROBIOLOGY OF AGING

Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response

(2014) Alessio Cardinale et al.   NEUROCHEMICAL RESEARCH

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease

(2014) Aderbal R. T. Silva et al.   PLoS One

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

(2013) Silje Z. Krokeide et al.   DNA REPAIR

DNA glycosylases search for and remove oxidized DNA bases

(2013) Susan S. Wallace   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age

(2013) Amanda G. Mason et al.   HUMAN MOLECULAR GENETICS

Maintaining genome stability in the nervous system

(2013) Peter J McKinnon   NATURE NEUROSCIENCE

Modulation of DNA base excision repair during neuronal differentiation

(2013) Peter Sykora et al.   NEUROBIOLOGY OF AGING

Comet-FISH with strand-specific probes reveals transcription-coupled repair of 8-oxoGuanine in human cells

(2013) Jia Guo et al.   NUCLEIC ACIDS RESEARCH

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

(2013) Jennifer A. Calvo et al.   PLoS Genetics

Regulation of oxidative DNA damage repair: The adenine:8-oxo-guanine problem

(2012) Enni Markkanen et al.   CELL CYCLE

DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity

(2012) P Fortini et al.   CELL DEATH AND DIFFERENTIATION

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype

(2012) Mahesh Ramamoorthy et al.   FREE RADICAL BIOLOGY AND MEDICINE

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

(2012) Zijing Sheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

(2012) Muralidhar L. Hegde et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2012) David Sulzer et al.   MOVEMENT DISORDERS

Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP

(2012) Fernando Cardozo-Pelaez et al.   NEUROCHEMISTRY INTERNATIONAL

Progressive cerebellar atrophy and polyneuropathy: expanding the spectrum of PNKP mutations

(2012) Cathryn Poulton et al.   NEUROGENETICS

Hippocampal Adult Neurogenesis Is Maintained by Neil3-Dependent Repair of Oxidative DNA Lesions in Neural Progenitor Cells

(2012) Christine Elisabeth Regnell et al.   Cell Reports

ATM and the Molecular Pathogenesis of Ataxia Telangiectasia

(2011) Peter J. McKinnon   Annual Review of Pathology-Mechanisms of Disease

Glutamatergic neurotransmission in a mouse model of Niemann–Pick Type C Disease

(2011) Giovanna D'Arcangelo et al.   BRAIN RESEARCH

Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency

(2011) L Schneider et al.   CELL DEATH AND DIFFERENTIATION

DNA glycosylases: in DNA repair and beyond

(2011) Angelika L. Jacobs et al.   CHROMOSOMA

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

(2011) Hava Segal-Raz et al.   EMBO REPORTS

Sublethal Doses of β-Amyloid Peptide Abrogate DNA-dependent Protein Kinase Activity

(2011) Alessio Cardinale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond

(2011) Knut H. Lauritzen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity

(2011) Michael Fenech   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

(2011) Deniz Simsek et al.   NATURE

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe

(2011) Line Nilsen et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage

(2011) Angela E. Zolner et al.   NUCLEIC ACIDS RESEARCH

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

(2011) Y. Sejersted et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

(2011) D Nguyen et al.   Cell Death & Disease

Neurons Efficiently Repair Glutamate-induced Oxidative DNA Damage by a Process Involving CREB-mediated Up-regulation of Apurinic Endonuclease 1

(2010) Jenq-Lin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preferential Repair of Oxidized Base Damage in the Transcribed Genes of Mammalian Cells

(2010) Dibyendu Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant huntingtin impairs Ku70-mediated DNA repair

(2010) Yasushi Enokido et al.   JOURNAL OF CELL BIOLOGY

Evidence that OGG1 Glycosylase Protects Neurons against Oxidative DNA Damage and Cell Death under Ischemic Conditions

(2010) Dong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

(2010) En Huang et al.   NATURE CELL BIOLOGY

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

(2010) Jun Shen et al.   NATURE GENETICS

Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress

(2009) Xinkun Wang et al.   BMC NEUROSCIENCE

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression

(2009) L Carlessi et al.   CELL DEATH AND DIFFERENTIATION

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions

(2009) Yanlin Jiang et al.   DNA REPAIR

Tyrosyl-DNA phosphodiesterase and the repair of 3′-phosphoglycolate-terminated DNA double-strand breaks

(2009) Tong Zhou et al.   DNA REPAIR

DNA repair modulates the vulnerability of the developing brain to alkylating agents

(2009) G.E. Kisby et al.   DNA REPAIR

Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

(2009) Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA 3'-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress

(2009) C. Breslin et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms of dealing with DNA damage in terminally differentiated cells

(2009) P. Fortini et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1

(2009) Youngsoo Lee et al.   NATURE NEUROSCIENCE

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

(2009) Agathi-Vassiliki Goula et al.   PLoS Genetics

Eukaryotic DNA Ligases: Structural and Functional Insights

(2008) Tom Ellenberger et al.   Annual Review of Biochemistry

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

Implications of Apurinic/Apyrimidinic Endonuclease in Reactive Oxygen Signaling Response after Cisplatin Treatment of Dorsal Root Ganglion Neurons

(2008) Y. Jiang et al.   CANCER RESEARCH

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

(2008) Muralidhar L Hegde et al.   CELL RESEARCH

Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains

(2008) Veslemøy Rolseth et al.   DNA REPAIR

Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase

(2008) G. Kronenberg et al.   JOURNAL OF NEUROSCIENCE

Defective DNA Ligation during Short-Patch Single-Strand Break Repair in Ataxia Oculomotor Apraxia 1

(2008) J. J. Reynolds et al.   MOLECULAR AND CELLULAR BIOLOGY

XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells

(2008) Avanti Kulkarni et al.   NUCLEIC ACIDS RESEARCH