Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges
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Title
Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges
Authors
Keywords
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Journal
GREEN CHEMISTRY
Volume 24, Issue 3, Pages 975-1020
Publisher
Royal Society of Chemistry (RSC)
Online
2022-01-07
DOI
10.1039/d1gc04387k
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Note: Only part of the references are listed.- Liquid phase peptide synthesis via one‐pot nanostar sieving (PEPSTAR)
- (2021) Jet Yeo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling
- (2021) Yves Yeboue et al. ORGANIC LETTERS
- Asparaginyl Ligases: New Enzymes for the Protein Engineer’s Toolbox
- (2021) Fabian B H Rehm et al. CHEMBIOCHEM
- Trends in peptide drug discovery
- (2021) Markus Muttenthaler et al. NATURE REVIEWS DRUG DISCOVERY
- Propylphosphonic Anhydride (T3P®) as Coupling Reagent for Solid‐Phase Peptide Synthesis
- (2021) Othman Al Musaimi et al. ChemistrySelect
- Palladium Catalyst Recycling for Heck‐Cassar‐Sonogashira Cross‐Coupling Reactions in Green Solvent/Base Blend
- (2021) Tommaso Fantoni et al. ChemSusChem
- Process Intensification for the Purification of Peptidomimetics: The Case of Icatibant through Multicolumn Countercurrent Solvent Gradient Purification (MCSGP)
- (2021) Chiara De Luca et al. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
- Refractive Index: The Ultimate Tool for Real-Time Monitoring of Solid-Phase Peptide Synthesis. Greening the Process
- (2021) Beatriz G. de la Torre et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- The evolution of commercial drug delivery technologies
- (2021) Ava M. Vargason et al. Nature Biomedical Engineering
- Circular Aqueous Fmoc/t‐Bu Solid‐Phase Peptide Synthesis
- (2021) Jan Pawlas et al. ChemSusChem
- Downstream Processing of Therapeutic Peptides by Means of Preparative Liquid Chromatography
- (2021) Chiara De Luca et al. MOLECULES
- Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy
- (2021) Fanny Guzmán et al. MOLECULES
- Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release
- (2021) Srinivasa Rao Manne et al. ORGANIC LETTERS
- An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids
- (2021) Jian Li et al. ORGANIC LETTERS
- Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing
- (2021) Michael O. Frederick et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- The application of anisole in greener solid-phase peptide synthesis protocols – Compatibility with green bases in Fmoc removal and new green binary mixture for coupling
- (2021) Adam Přibylka et al. TETRAHEDRON
- Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives
- (2021) Walter Cabri et al. Frontiers in Molecular Biosciences
- Fmoc-Removal with Pyrrolidine Expands the Available Solvent Space in Green Solid-Phase Peptide Synthesis
- (2021) Peter H. G. Egelund et al. ACS Sustainable Chemistry & Engineering
- Green synthesis of bioactive oligopeptides promoted by recyclable nanocrystalline hydroxyapatite
- (2020) Michele Anselmi et al. Future Medicinal Chemistry
- Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 2
- (2020) Ivan Guryanov et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Rethinking chemistry for a circular economy
- (2020) Klaus Kümmerer et al. SCIENCE
- Sustainable Peptide Synthesis Enabled by a Transient Protecting Group
- (2020) Sascha Knauer et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification
- (2020) Martina Catani et al. Biotechnology Journal
- Synthesis of Tri(4-formylphenyl) Phosphonate Derivatives as Recyclable Triple-Equivalent Supports of Peptide Synthesis
- (2020) Haidi Li et al. JOURNAL OF ORGANIC CHEMISTRY
- Assessing the correlation of microscopy‐based and volumetry‐based measurements for resin swelling in a range of potential greener solvents for SPPS
- (2020) Jordan Kevin Magtaan et al. JOURNAL OF PEPTIDE SCIENCE
- Liquid-Phase Total Synthesis of Plecanatide Aided by Diphenylphosphinyloxyl Diphenyl Ketone (DDK) Derivatives
- (2020) Haidi Li et al. ORGANIC LETTERS
- Fast Heck–Cassar–Sonogashira (HCS) Reactions in Green Solvents
- (2020) L. Ferrazzano et al. ORGANIC LETTERS
- A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
- (2020) Junqiao Du et al. Nature Communications
- Side chain effect in the modulation of αvβ3/α5β1 integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems
- (2020) Lucia Ferrazzano et al. Scientific Reports
- Investigation of Parameters that Affect Resin Swelling in Green Solvents
- (2020) Chidi Amadi‐Kamalu et al. ChemistryOpen
- Biocatalysis: Enzymatic Synthesis for Industrial Applications
- (2020) Shuke Wu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Enhancing robustness of sortase A by loop engineering and backbone cyclization
- (2020) Zhi Zou et al. CHEMISTRY-A EUROPEAN JOURNAL
- N‐Butylpyrrolidinone (NBP) for Solid‐Phase Peptide Synthesis, Environmentally Friendlier and Synthetically Better than DMF
- (2020) Fernando Albericio et al. ChemSusChem
- Benzoisothiazolone (BIT): A Fast, Efficient and Recyclable Redox Reagent for Solid Phase Peptide Synthesis
- (2020) Hemalatha Bukya et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- From batch to continuous chromatographic purification of a therapeutic peptide through multicolumn countercurrent solvent gradient purification
- (2020) Chiara De Luca et al. JOURNAL OF CHROMATOGRAPHY A
- Environmentally Friendly SPPS II: Scope of Green Fmoc Removal Protocol Using NaOH and Its Application for Synthesis of Commercial Drug Triptorelin
- (2020) Adam Přibylka et al. JOURNAL OF ORGANIC CHEMISTRY
- Advantageous use of SFC for separation of crude therapeutic peptides and peptide libraries
- (2020) Manuel Ventura JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Minimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions
- (2020) Marion Erny et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Turning an Asparaginyl Endopeptidase into a Peptide Ligase
- (2020) Xinya Hemu et al. ACS Catalysis
- Translating bioactive peptides for COVID-19 therapy
- (2020) Khushwant S. Bhullar et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2020) Mannur Ismail Shaik et al. FOOD REVIEWS INTERNATIONAL
- The development of a sub/supercritical fluid chromatography based purification method for peptides
- (2020) Kamini Govender et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Peptides: Prospects for Use in the Treatment of COVID-19
- (2020) Vladimir Khavinson et al. MOLECULES
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- (2020) David J. C. Constable ACS Sustainable Chemistry & Engineering
- Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields
- (2020) Yuchen Huan et al. Frontiers in Microbiology
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- (2020) Valentin Plamenov Chernev et al. Processes
- Trypsiligase‐Catalyzed Labeling of Proteins on Living Cells
- (2020) Sandra Liebscher et al. CHEMBIOCHEM
- Evaluation of chromatographic parameters in supercritical fluid chromatography of amino acids as model polar analytes and extended to polypeptide separations
- (2020) Victor Spelling et al. JOURNAL OF CHROMATOGRAPHY A
- Chromatographic analysis of biomolecules with pressurized carbon dioxide mobile phases – A review
- (2020) Jérémy Molineau et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide
- (2020) Giuseppina Sabatino et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- The Role of Counter-Ions in Peptides—An Overview
- (2020) Karol Sikora et al. Pharmaceuticals
- Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production
- (2019) Albert Isidro-Llobet et al. JOURNAL OF ORGANIC CHEMISTRY
- Evaluation of global conformational changes in peptides and proteins following purification by supercritical fluid chromatography
- (2019) Nicole M. Schiavone et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP)
- (2019) Sebastian Vogg et al. Biotechnology Journal
- Resin Swelling in Mixed Solvents Analysed using Hansen Solubility Parameter Space
- (2019) Yanrui Ran et al. CHEMISTRY-A EUROPEAN JOURNAL
- A Comprehensive Review on Current Advances in Peptide Drug Development and Design
- (2019) Andy Chi-Lung Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Efficient Fmoc Group Removal Using Diluted 4-Methylpiperidine: An Alternative for a Less-Polluting SPPS-Fmoc/tBu Protocol
- (2019) Verónica Rodríguez et al. International Journal of Peptide Research and Therapeutics
- Troubleshooting When Using γ-Valerolactone (GVL) in Green Solid-Phase Peptide Synthesis
- (2019) Ashish Kumar et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Green Chemistry Articles of Interest to the Pharmaceutical Industry
- (2019) Marie-Gabrielle Braun et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- The Discovery and Development of Liraglutide and Semaglutide
- (2019) Lotte Bjerre Knudsen et al. Frontiers in Endocrinology
- A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein
- (2019) Karen S. Harris et al. Scientific Reports
- Green Solvent Mixtures for Solid-Phase Peptide Synthesis: A Dimethylformamide-Free Highly Efficient Synthesis of Pharmaceutical-Grade Peptides
- (2019) Lucia Ferrazzano et al. ACS Sustainable Chemistry & Engineering
- Rational Design of an Organocatalyst for Peptide Bond Formation
- (2019) Handoko et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Generation of Hydrogen Cyanide from the Reaction of Oxyma (Ethyl Cyano(hydroxyimino)acetate) and DIC (Diisopropylcarbodiimide)
- (2019) Adam D. McFarland et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Subtiligase-Catalyzed Peptide Ligation
- (2019) Amy M. Weeks et al. CHEMICAL REVIEWS
- Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis
- (2019) Ashish Kumar et al. MOLECULES
- Improved Tag-Assisted Liquid-Phase Peptide Synthesis: Application to the Synthesis of the Bradykinin Receptor Antagonist Icatibant Acetate
- (2019) Yohei Okada et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 1.
- (2019) Ivan Guryanov et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Recent trends in chiral supercritical fluid chromatography
- (2019) Caroline West TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain
- (2019) Stefan G. Koenig et al. ACS Sustainable Chemistry & Engineering
- Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization
- (2019) Timo Nuijens et al. Frontiers in Chemistry
- Modeling the nonlinear behavior of a bioactive peptide in reversed-phase gradient elution chromatography
- (2019) Chiara De Luca et al. JOURNAL OF CHROMATOGRAPHY A
- Immobilized Peptide Asparaginyl Ligases Enhance Stability and Facilitate Macrocyclization and Site-Specific Ligation
- (2019) Xinya Hemu et al. JOURNAL OF ORGANIC CHEMISTRY
- Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU
- (2019) Kate J. McKnelly et al. JOURNAL OF ORGANIC CHEMISTRY
- Therapeutic peptides: Historical perspectives, current development trends, and future directions
- (2018) Jolene L. Lau et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A Pot-economical Liquid-phase Peptide Nucleic Acid Synthesis Enabled by a Soluble Tag-assisted Method
- (2018) Keisuke Ogami et al. CHEMISTRY LETTERS
- Investigation of robustness for supercritical fluid chromatography separation of peptides: Isocratic vs gradient mode
- (2018) Martin Enmark et al. JOURNAL OF CHROMATOGRAPHY A
- Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1
- (2018) Marcel Schmidt et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- N-Butylpyrrolidinone as Alternative Solvent for Solid-Phase Peptide Synthesis
- (2018) John Lopez et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Choosing the Right Coupling Reagent for Peptides: A Twenty-Five-Year Journey
- (2018) Fernando Albericio et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?
- (2018) Joseph L. Howard et al. Chemical Science
- Microwave-Assisted Green Solid-Phase Peptide Synthesis Using γ-Valerolactone (GVL) as Solvent
- (2018) Ashish Kumar et al. ACS Sustainable Chemistry & Engineering
- Current trends in supercritical fluid chromatography
- (2018) Caroline West ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Recent Achievements and Future Challenges in Supercritical Fluid Chromatography for the Enantioselective Separation of Chiral Pharmaceuticals
- (2018) Simona Felletti et al. CHROMATOGRAPHIA
- Introduction of a process mass intensity metric for biologics
- (2018) Kristi Budzinski et al. New Biotechnology
- Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable
- (2018) Stefan G. Koenig et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing
- (2018) Jeffrey B. Sperry et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- A traceless catch-and-release method for rapid peptide purification
- (2018) Oliver Reimann et al. JOURNAL OF PEPTIDE SCIENCE
- The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography
- (2018) Omar Ismail et al. MOLECULES
- Greening the Solid-Phase Peptide Synthesis Process. 2-MeTHF for the Incorporation of the First Amino Acid and Precipitation of Peptides after Global Deprotection
- (2018) Othman Al Musaimi et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Hydrophobic Magnetic Nanoparticle Assisted One-Pot Liquid-Phase Peptide Synthesis
- (2017) Yohei Okada et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Mechanochemical Synthesis of Dipeptides Using Mg-Al Hydrotalcite as Activating Agent under Solvent-Free Reaction Conditions
- (2017) José M. Landeros et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Greener solvents for solid-phase synthesis
- (2017) Stefan Lawrenson et al. GREEN CHEMISTRY
- Mechanoenzymatic peptide and amide bond formation
- (2017) José G. Hernández et al. GREEN CHEMISTRY
- The greening of peptide synthesis
- (2017) Stefan B. Lawrenson et al. GREEN CHEMISTRY
- Tandem deprotection/coupling for peptide synthesis in water at room temperature
- (2017) Margery Cortes-Clerget et al. GREEN CHEMISTRY
- Identification of high performance solvents for the sustainable processing of graphene
- (2017) H. J. Salavagione et al. GREEN CHEMISTRY
- The E factor 25 years on: the rise of green chemistry and sustainability
- (2017) Roger A. Sheldon GREEN CHEMISTRY
- Equilibrium Theory Based Design Space for the Multicolumn Countercurrent Solvent Gradient Purification Process
- (2017) Fabian Steinebach et al. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
- Experimental design of a twin-column countercurrent gradient purification process
- (2017) Fabian Steinebach et al. JOURNAL OF CHROMATOGRAPHY A
- The Current State of Peptide Drug Discovery: Back to the Future?
- (2017) Antoine Henninot et al. JOURNAL OF MEDICINAL CHEMISTRY
- Altering Product Selectivity by Mechanochemistry
- (2017) José G. Hernández et al. JOURNAL OF ORGANIC CHEMISTRY
- Re-evaluating the stability of COMU in different solvents
- (2017) Ashish Kumar et al. JOURNAL OF PEPTIDE SCIENCE
- Engineering a Catalytically Efficient Recombinant Protein Ligase
- (2017) Renliang Yang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Novel Globular Polymeric Supports for Membrane-Enhanced Peptide Synthesis
- (2017) Vida Castro et al. MACROMOLECULES
- Green Solid-Phase Peptide Synthesis (GSPPS) 3. Green Solvents for Fmoc Removal in Peptide Chemistry
- (2017) Yahya E. Jad et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Green solid-phase peptide synthesis 4. γ-Valerolactone and N -formylmorpholine as green solvents for solid phase peptide synthesis
- (2017) Ashish Kumar et al. TETRAHEDRON LETTERS
- N-Acyl Benzotriazole Derivatives for the Synthesis of Dipeptides and Tripeptides and Peptide Biotinylation by Mechanochemistry
- (2017) Lori Gonnet et al. ACS Sustainable Chemistry & Engineering
- Photo-Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag-Assisted Liquid-Phase Peptide Synthesis
- (2017) Hiroki Wakamatsu et al. Asian Journal of Organic Chemistry
- Peptiligase, an Enzyme for Efficient Chemoenzymatic Peptide Synthesis and Cyclization in Water
- (2016) Ana Toplak et al. ADVANCED SYNTHESIS & CATALYSIS
- Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production
- (2016) Fabian Steinebach et al. Biotechnology Journal
- Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)
- (2016) Davin Tan et al. CHEMICAL COMMUNICATIONS
- GAP Peptide Synthesis through the Design of a GAP Protecting Group: An Fmoc/tBu Synthesis of Thymopentin Free from Polymers, Chromatography and Recrystallization
- (2016) Cole W. Seifert et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Peptide Mechanosynthesis by Direct Coupling of N -Protected α-Amino Acids with Amino Esters
- (2016) Vincent Porte et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Cyclization of Linear Tetrapeptides Containing N -Methylated Amino Acids by using 1-Propanephosphonic Acid Anhydride
- (2016) Shengping Zhang et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Updating and further expanding GSK's solvent sustainability guide
- (2016) Catherine M. Alder et al. GREEN CHEMISTRY
- CHEM21 selection guide of classical- and less classical-solvents
- (2016) Denis Prat et al. GREEN CHEMISTRY
- A fundamental study of the physicochemical properties of Rhodiasolv®Polarclean: A promising alternative to common and hazardous solvents
- (2016) Alena Randová et al. JOURNAL OF MOLECULAR LIQUIDS
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- (2016) Keith R. Solomon et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
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- (2016) Omar Luna et al. MOLECULES
- Toward a More Holistic Framework for Solvent Selection
- (2016) Louis J. Diorazio et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Oxyma-T, expanding the arsenal of coupling reagents
- (2016) Yahya E. Jad et al. TETRAHEDRON LETTERS
- Dimethyl trisulfide
- (2016) Gary A Rockwood et al. TOXICOLOGY AND INDUSTRIAL HEALTH
- Green Solid-Phase Peptide Synthesis 2. 2-Methyltetrahydrofuran and Ethyl Acetate for Solid-Phase Peptide Synthesis under Green Conditions
- (2016) Yahya E. Jad et al. ACS Sustainable Chemistry & Engineering
- Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production
- (2016) Fabian Steinebach et al. Biotechnology Journal
- Mechanochemistry: A Force of Synthesis
- (2016) Jean-Louis Do et al. ACS Central Science
- 2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis
- (2015) Yahya E. Jad et al. AMINO ACIDS
- Site-Specific N-Terminal Labeling of Peptides and Proteins using Butelase 1 and Thiodepsipeptide
- (2015) Giang K. T. Nguyen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Continuous downstream processing for high value biological products: A Review
- (2015) Andrew L. Zydney BIOTECHNOLOGY AND BIOENGINEERING
- Development of GSK's acid and base selection guides
- (2015) Richard K. Henderson et al. GREEN CHEMISTRY
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- (2015) F. Roschangar et al. GREEN CHEMISTRY
- A solvent selection guide based on chemometrics and multicriteria decision analysis
- (2015) Marek Tobiszewski et al. GREEN CHEMISTRY
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- (2015) Yao Shen et al. GREEN CHEMISTRY
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- (2015) Irina B. Valtcheva et al. JOURNAL OF MEMBRANE SCIENCE
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- (2015) Emiko Matsumoto et al. JOURNAL OF PEPTIDE SCIENCE
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- (2015) Yahya E. Jad et al. ORGANIC & BIOMOLECULAR CHEMISTRY
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- (2015) Christopher M. Gabriel et al. ORGANIC LETTERS
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- (2015) Alessandra Tolomelli et al. ACS Medicinal Chemistry Letters
- Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
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- (2015) Chuthamat Duangkamol et al. RSC Advances
- Piperazine and DBU: a safer alternative for rapid and efficient Fmoc deprotection in solid phase peptide synthesis
- (2015) Krittika Ralhan et al. RSC Advances
- Flow-Based Enzymatic Ligation by Sortase A
- (2014) Rocco L. Policarpo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- N-Terminal Protein Modification by Substrate-Activated Reverse Proteolysis
- (2014) Sandra Liebscher et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2014) James Sherwood et al. CHEMICAL COMMUNICATIONS
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- (2014) Denis Prat et al. GREEN CHEMISTRY
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- (2014) Giang K T Nguyen et al. Nature Chemical Biology
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- (2014) Yahya E. Jad et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Total Synthesis of Elastin Peptide Using High Pressure–Liquid Phase Synthesis Assisted by a Soluble Tag Strategy
- (2014) Yohei Okada et al. ORGANIC LETTERS
- Reprogramming the specificity of sortase enzymes
- (2014) Brent M. Dorr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides
- (2014) Jose M. Palomo RSC Advances
- The historical development of mechanochemistry
- (2013) Laszlo Takacs CHEMICAL SOCIETY REVIEWS
- Modulation of αvβ3- and α5β1-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics
- (2013) Alessandra Tolomelli et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2013) Prabhakar Cherkupally et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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- (2013) Muneo Saito JOURNAL OF BIOSCIENCE AND BIOENGINEERING
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- (2013) David Gétaz et al. JOURNAL OF CHROMATOGRAPHY A
- COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents
- (2013) Ramon Subirós-Funosas et al. JOURNAL OF PEPTIDE SCIENCE
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- Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes
- (2013) Denis Prat et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Total synthesis of α-conotoxin MII using a soluble-tag-assisted method
- (2013) Shingo Kitada et al. TETRAHEDRON
- Towards a carbon-negative sustainable bio-based economy
- (2013) Bartel Vanholme et al. Frontiers in Plant Science
- One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines
- (2012) Vjekoslav Štrukil et al. CHEMICAL COMMUNICATIONS
- Solvent-assisted mechanochemistry
- (2012) Graham A. Bowmaker CHEMICAL COMMUNICATIONS
- 2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry
- (2012) Vittorio Pace et al. ChemSusChem
- Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide
- (2012) Donna S. MacMillan et al. GREEN CHEMISTRY
- Tag-Assisted Liquid-Phase Peptide Synthesis Using Hydrophobic Benzyl Alcohols as Supports
- (2012) Yohei Okada et al. JOURNAL OF ORGANIC CHEMISTRY
- Soluble-support-assisted Electrochemical Reactions: Application to Anodic Disulfide Bond Formation
- (2012) Shingo Kitada et al. ORGANIC LETTERS
- Novel diphenylmethyl-Derived Amide Protecting Group for Efficient Liquid-Phase Peptide Synthesis: AJIPHASE
- (2012) Daisuke Takahashi et al. ORGANIC LETTERS
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- (2012) Pasquale Palladino et al. ORGANIC LETTERS
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- (2012) Daisuke Takahashi et al. TETRAHEDRON LETTERS
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- (2011) Shingo Kitada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2011) Ayman El-Faham et al. CHEMICAL REVIEWS
- Mechanochemistry: opportunities for new and cleaner synthesis
- (2011) Stuart L. James et al. CHEMICAL SOCIETY REVIEWS
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- (2011) Keiko Hojo et al. Chemistry Central Journal
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- (2011) Alessandra Tolomelli et al. ChemMedChem
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- (2011) Richard K. Henderson et al. GREEN CHEMISTRY
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- (2011) Joshua R. Dunetz et al. ORGANIC LETTERS
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- (2011) Concepción Jiménez-González et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
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- (2011) I. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) Gegen Tana et al. CHEMICAL COMMUNICATIONS
- Membrane enhanced peptide synthesis
- (2010) Sheung So et al. CHEMICAL COMMUNICATIONS
- Fundamental challenges and opportunities for preparative supercritical fluid chromatography
- (2010) Georges Guiochon et al. JOURNAL OF CHROMATOGRAPHY A
- Green Synthesis of α,β- and β,β-Dipeptides under Solvent-Free Conditions
- (2010) José G. Hernández et al. JOURNAL OF ORGANIC CHEMISTRY
- Aiming for the Ideal Synthesis
- (2010) Tanja Gaich et al. JOURNAL OF ORGANIC CHEMISTRY
- PyOxP and PyOxB: the Oxyma-based novel family of phosphonium salts
- (2010) Ramon Subirós-Funosas et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Organic Solvent Nanofiltration: A New Paradigm in Peptide Synthesis
- (2010) Sheung So et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Greening analytical chromatography
- (2010) Christopher J. Welch et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Solvent-Free Synthesis of Peptides
- (2009) Valérie Declerck et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- COMU: A Safer and More Effective Replacement for Benzotriazole-Based Uronium Coupling Reagents
- (2009) Ayman El-Faham et al. CHEMISTRY-A EUROPEAN JOURNAL
- Oxyma: An Efficient Additive for Peptide Synthesis to Replace the Benzotriazole-Based HOBt and HOAt with a Lower Risk of Explosion[1]
- (2009) Ramon Subirós-Funosas et al. CHEMISTRY-A EUROPEAN JOURNAL
- Synthesis and Application ofN-Hydroxylamine Derivatives as Potential Replacements for HOBt
- (2009) Ayman El-Faham et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Manufacturing peptides as active pharmaceutical ingredients
- (2009) Aikaterini A Zompra et al. Future Medicinal Chemistry
- Multigram-Scale Synthesis of Short Peptides via a Simplified Repetitive Solution-Phase Procedure
- (2009) Célia Meneses et al. JOURNAL OF ORGANIC CHEMISTRY
- Solid-phase peptide synthesis using acetonitrile as a solvent in combination with PEG-based resins
- (2009) Gerardo A. Acosta et al. JOURNAL OF PEPTIDE SCIENCE
- COMU: A third generation of uronium-type coupling reagents
- (2009) Ayman El-Faham et al. JOURNAL OF PEPTIDE SCIENCE
- Synthesis of hydrophobic phase-tagged prolyl peptides featuring rapid reaction/separation
- (2009) Kazuhiro Chiba et al. TETRAHEDRON
- Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)
- (2008) Thomas Müller-Späth et al. BIOTECHNOLOGY AND BIOENGINEERING
- Role of recycling in improving the performance of chromatographic solvent gradient purifications
- (2008) Abhijit Tarafder et al. JOURNAL OF CHROMATOGRAPHY A
- Function-Oriented Synthesis, Step Economy, and Drug Design
- (2007) Paul A. Wender et al. ACCOUNTS OF CHEMICAL RESEARCH
- Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation
- (2007) Kim Alfonsi et al. GREEN CHEMISTRY
- On choosing the right ether for peptide precipitation after acid cleavage
- (2007) Beatriz G. de La Torre et al. JOURNAL OF PEPTIDE SCIENCE
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