Continuous downstream processing for high value biological products: A Review

Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography

(2015) Amit K. Dutta et al.   JOURNAL OF BIOTECHNOLOGY

Twin-column CaptureSMB: A novel cyclic process for protein A affinity chromatography

(2015) Monica Angarita et al.   JOURNAL OF CHROMATOGRAPHY A

Continuous Processing for Production of Biopharmaceuticals

(2015) Anurag S. Rathore et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Preparative crystallization of a single chain antibody using an aqueous two-phase system

(2014) Hauke Huettmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

A membrane stirrer for product recovery and substrate feeding

(2014) T. Femmer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation

(2014) Nikolaus Hammerschmidt et al.   Biotechnology Journal

Avoiding antibody aggregation during processing: Establishing hold times

(2014) Varsha Joshi et al.   Biotechnology Journal

Internal virus polarization model for virus retention by the Ultipor®VF Grade DV20 membrane

(2014) Nigel B. Jackson et al.   BIOTECHNOLOGY PROGRESS

Understanding and modeling alternating tangential flow filtration for perfusion cell culture

(2014) William Kelly et al.   BIOTECHNOLOGY PROGRESS

Multi-Stage Aqueous Two-Phase Extraction for the Purification of Monoclonal Antibodies

(2014) Jan K. Eggersgluess et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Continuous purification of active pharmaceutical ingredients using multistage organic solvent nanofiltration membrane cascade

(2014) Ludmila Peeva et al.   CHEMICAL ENGINEERING SCIENCE

Design and Operation of Continuous Countercurrent Chromatography in Biotechnological Production

(2014) Steffen Zobel et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Unfolding of a model protein on ion exchange and mixed mode chromatography surfaces

(2014) Adrian M. Gospodarek et al.   JOURNAL OF CHROMATOGRAPHY A

Unfolding and aggregation of a glycosylated monoclonal antibody on a cation exchange column. Part II. Protein structure effects by hydrogen deuterium exchange mass spectrometry

(2014) Jing Guo et al.   JOURNAL OF CHROMATOGRAPHY A

Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process

(2013) Marie-Françoise Clincke et al.   BIOTECHNOLOGY PROGRESS

The potential impact of membrane cascading on downstream processing of oligosaccharides

(2013) Nirmal V. Patil et al.   CHEMICAL ENGINEERING SCIENCE

Modeling and control of crystal shape in continuous protein crystallization

(2013) Joseph Sang-Il Kwon et al.   CHEMICAL ENGINEERING SCIENCE

Continuous aqueous two-phase systems devices for the recovery of biological products

(2013) Edith Espitia-Saloma et al.   FOOD AND BIOPRODUCTS PROCESSING

Online control of the twin-column countercurrent solvent gradient process for biochromatography

(2013) M. Krättli et al.   JOURNAL OF CHROMATOGRAPHY A

Simulated Moving Bed Strategies and Designs: From Established Systems to the Latest Developments

(2013) José P. S. Aniceto et al.   SEPARATION AND PURIFICATION REVIEWS

Continuous Countercurrent Tangential Chromatography for Monoclonal Antibody Purification

(2013) Boris Napadensky et al.   SEPARATION SCIENCE AND TECHNOLOGY

Continuous downstream processing of biopharmaceuticals

(2013) Alois Jungbauer   TRENDS IN BIOTECHNOLOGY

Anion exchange membrane adsorbers for flow-through polishing steps: Part II. Virus, host cell protein, DNA clearance, and antibody recovery

(2012) Justin Weaver et al.   BIOTECHNOLOGY AND BIOENGINEERING

Zonal rate model for axial and radial flow membrane chromatography. Part I: Knowledge transfer across operating conditions and scales

(2012) Pranay Ghosh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated continuous production of recombinant therapeutic proteins

(2012) Veena Warikoo et al.   BIOTECHNOLOGY AND BIOENGINEERING

A new large-scale manufacturing platform for complex biopharmaceuticals

(2012) Jens H. Vogel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Periodic counter-current chromatography - design and operational considerations for integrated and continuous purification of proteins

(2012) Rahul Godawat et al.   Biotechnology Journal

A combined degradation of dyes and inactivation of viruses by UV and UV/H2O2

(2012) Elena Timchak et al.   CHEMICAL ENGINEERING JOURNAL

Quality by design: Impact of formulation variables and their interactions on quality attributes of a lyophilized monoclonal antibody

(2012) David Awotwe-Otoo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1)

(2012) Ron Gillespie et al.   JOURNAL OF CHROMATOGRAPHY A

Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production

(2011) Jemelle Dizon-Maspat et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform

(2011) Efren Pacis et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recent Advances in Membrane Bioreactors: Configuration Development, Pollutant Elimination, and Sludge Reduction

(2011) Fangang Meng et al.   ENVIRONMENTAL ENGINEERING SCIENCE

Protein concentration with single-pass tangential flow filtration (SPTFF)

(2011) Catherine Casey et al.   JOURNAL OF MEMBRANE SCIENCE

In situ product recovery: Submerged membranes vs. external loop membranes

(2011) Frederike Carstensen et al.   JOURNAL OF MEMBRANE SCIENCE

Towards Protein Crystallization as a Process Step in Downstream Processing of Therapeutic Antibodies: Screening and Optimization at Microbatch Scale

(2011) Yuguo Zang et al.   PLoS One

Countercurrent tangential chromatography for large-scale protein purification

(2010) Oleg Shinkazh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Purification of singly PEGylated α-lactalbumin using charged ultrafiltration membranes

(2010) Krisada Ruanjaikaen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Two step capture and purification of IgG2 using multicolumn countercurrent solvent gradient purification (MCSGP)

(2010) T. Müller-Späth et al.   BIOTECHNOLOGY AND BIOENGINEERING

Increasing the activity of monoclonal antibody therapeutics by continuous chromatography (MCSGP)

(2010) T. Müller-Späth et al.   BIOTECHNOLOGY AND BIOENGINEERING

Continuous Plug Flow Crystallization of Pharmaceutical Compounds

(2010) Alejandro J. Alvarez et al.   CRYSTAL GROWTH & DESIGN

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

CFD simulation of an internal spin-filter: evidence of lateral migration and exchange flow through the mesh

(2009) Alvio Figueredo-Cardero et al.   CYTOTECHNOLOGY

Application of high-performance tangential flow filtration (HPTFF) to the purification of a human pharmaceutical antibody fragment expressed inEscherichia coli

(2008) Bénédicte Lebreton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)

(2008) Thomas Müller-Späth et al.   BIOTECHNOLOGY AND BIOENGINEERING

Viral clearance using monoliths

(2008) Mark R. Etzel et al.   JOURNAL OF CHROMATOGRAPHY A

Simulated moving bed chromatography for the separation of enantiomers

(2008) Arvind Rajendran et al.   JOURNAL OF CHROMATOGRAPHY A