Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives
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Title
Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives
Authors
Keywords
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Journal
Frontiers in Molecular Biosciences
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-06-14
DOI
10.3389/fmolb.2021.697586
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- (2021) Declan M. Gorman et al. AMINO ACIDS
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- (2021) David S. Mathiesen et al. Frontiers in Endocrinology
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- (2021) John J. Nestor et al. Peptide Science
- Trends in peptide drug discovery
- (2021) Markus Muttenthaler et al. NATURE REVIEWS DRUG DISCOVERY
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- (2021) Ryan A. Lafferty et al. Frontiers in Endocrinology
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- (2020) Bronwen J. Mayo et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
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- (2020) Hong Cui et al. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Pharmacological Characterization of Apraglutide a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist for the Treatment of Short Bowel Syndrome
- (2020) Diane M Hargrove et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Site-specific and temporal effects of apraglutide, a novel long-acting glucagon-like peptide-2 receptor agonist, on intestinal growth in mice
- (2020) Sarah E Martchenko et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Pan-cancer mapping of differential protein-protein interactions
- (2020) Gizem Gulfidan et al. Scientific Reports
- Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases
- (2020) Hannah Louise Zakariassen et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Zonulin as a potential putative biomarker of risk for shared Type 1 Diabetes and Celiac disease Autoimmunity
- (2020) Lauren K. Wood Heickman et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial
- (2020) Bruno François et al. INTENSIVE CARE MEDICINE
- Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH)
- (2020) Kyeongjin Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Combination gut hormones: prospects and questions for the future of obesity and diabetes therapy
- (2020) Bernard Khoo et al. JOURNAL OF ENDOCRINOLOGY
- Glucagon-based therapy: Past, present and future
- (2020) Mohan Patil et al. PEPTIDES
- Emerging cytoprotective peptide therapies for stroke
- (2020) Bruno P. Meloni et al. Expert Review of Neurotherapeutics
- Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients
- (2020) Steven Fishbane et al. Kidney International Reports
- Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection
- (2020) Chung-Yang Yeh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Once-daily, subcutaneous vosoritide therapy in children with achondroplasia: a randomised, double-blind, phase 3, placebo-controlled, multicentre trial
- (2020) Ravi Savarirayan et al. LANCET
- Enhanced immunotherapy with LHRH-R targeted lytic peptide in ovarian cancer
- (2020) Mark Seungwook Kim et al. MOLECULAR CANCER THERAPEUTICS
- Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
- (2020) Christian B. Billesbølle et al. NATURE
- An evaluation of difelikefalin as a treatment option for moderate-to-severe pruritus in end stage renal disease
- (2020) Zoe M. Lipman et al. EXPERT OPINION ON PHARMACOTHERAPY
- The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials
- (2020) Thinzar Min et al. Diabetes Therapy
- Novel Long-Acting GLP-2 Analogue, FE 203799 (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Bowel Syndrome with Total Resection of the Ileum
- (2019) George M. Slim et al. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
- Peptidomimetics: A Synthetic Tool for Inhibiting Protein–Protein Interactions in Cancer
- (2019) Lloyd Mabonga et al. International Journal of Peptide Research and Therapeutics
- P120 BBT-401 IS A SELECTIVE PELLINO-1 PROTEIN-PROTEIN INTERACTION INHIBITOR IN CLINICAL DEVELOPMENT TARGETING A FIRST-IN-CLASS DRUG FOR UC TREATMENT.
- (2019) Gwanghee Lee et al. INFLAMMATORY BOWEL DISEASES
- FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4
- (2019) Lana McClements et al. BMC CANCER
- Therapeutic Opportunities for Hepcidin in Acute Care Medicine
- (2019) Lakhmir S. Chawla et al. CRITICAL CARE CLINICS
- The Discovery and Development of Liraglutide and Semaglutide
- (2019) Lotte Bjerre Knudsen et al. Frontiers in Endocrinology
- C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia
- (2019) Ravi Savarirayan et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2019) Lucia Ferrazzano et al. ACS Sustainable Chemistry & Engineering
- Glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, for patients with short bowel syndrome: a randomised phase 2 trial
- (2019) Rahim M Naimi et al. Lancet Gastroenterology & Hepatology
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- (2019) Saurav Roy Choudhury et al. CELL
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- (2019) Roger van Groenendael et al. SEMINARS IN NEPHROLOGY
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- (2019) Marie Bastin et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
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- (2018) Jolene L. Lau et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2018) D. McGuire et al. OSTEOARTHRITIS AND CARTILAGE
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- (2018) Jeffrey A. Rappaport et al. Frontiers in Oncology
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- (2018) T. Tiffany Wang et al. LEUKEMIA
- Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases
- (2018) Christoffer Clemmensen et al. Nature Reviews Endocrinology
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- (2018) Raymond Kaempfer Toxins
- LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
- (2018) Tamer Coskun et al. Molecular Metabolism
- GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis
- (2018) William R. Swindell et al. Translational Neurodegeneration
- The greening of peptide synthesis
- (2017) Stefan B. Lawrenson et al. GREEN CHEMISTRY
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- (2017) Joan Serrano et al. TRENDS IN FOOD SCIENCE & TECHNOLOGY
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- (2016) S. J. Henderson et al. DIABETES OBESITY & METABOLISM
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- (2016) Katarzyna Smietana et al. NATURE REVIEWS DRUG DISCOVERY
- Novel Targets of Drug Treatment for Pulmonary Hypertension
- (2015) Jian Hu et al. American Journal of Cardiovascular Drugs
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- (2015) R. L. Dods et al. BIOSCIENCE REPORTS
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- (2015) Gabriel Sosne et al. CORNEA
- Peptide therapeutics: current status and future directions
- (2015) Keld Fosgerau et al. DRUG DISCOVERY TODAY
- Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies
- (2015) Stefan D. Anker et al. EUROPEAN HEART JOURNAL
- Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis
- (2015) Raya Massoud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A multi-cytokine inhibitory peptide (BNZ 132-1) that is a potential therapeutic agent for HAMTSP and other necrotizing diseases.
- (2015) Toshie Nata et al. Retrovirology
- Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model
- (2015) Sinaya Vaisburd et al. Scientific Reports
- Novel LHRH-receptor-targeted cytolytic peptide, EP-100: first-in-human phase I study in patients with advanced LHRH-receptor-expressing solid tumors
- (2014) Kelly K. Curtis et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Davunetide: Peptide Therapeutic in Neurological Disorders
- (2014) Iddo Magen et al. CURRENT MEDICINAL CHEMISTRY
- Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss
- (2014) Markus Suckfuell et al. OTOLOGY & NEUROTOLOGY
- Ghrelin decreases motor deficits after traumatic brain injury
- (2013) Nicole E. Lopez et al. JOURNAL OF SURGICAL RESEARCH
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- (2012) Robert Zimmer et al. ANNALS OF THE RHEUMATIC DISEASES
- Selective Membrane Disruption: Mode of Action of C16G2, a Specifically Targeted Antimicrobial Peptide
- (2011) Christopher W. Kaplan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2011) Dan Donnelly BRITISH JOURNAL OF PHARMACOLOGY
- Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia
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- (2011) Gila Arad et al. PLOS BIOLOGY
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- (2010) Jan Willem van den Berg et al. CRITICAL CARE MEDICINE
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- (2010) Alexander Schneider et al. JOURNAL OF FLUORESCENCE
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- (2010) Claudio Festuccia et al. PROSTATE
- Liraglutide: A Once-Daily Incretin Mimetic for the Treatment of Type 2 Diabetes Mellitus
- (2009) Joshua J Neumiller et al. ANNALS OF PHARMACOTHERAPY
- Population Pharmacokinetics of Teduglutide Following Repeated Subcutanenous Administrations in Healthy Participants and in Patients With Short Bowel Syndrome and Crohn's Disease
- (2009) Jean-Francois Marier et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2008) A. Safholm et al. CLINICAL CANCER RESEARCH
- Inhalation of vasoactive intestinal peptide in pulmonary hypertension
- (2008) H. H. Leuchte et al. EUROPEAN RESPIRATORY JOURNAL
- Estimating the size of the human interactome
- (2008) M. P. H. Stumpf et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of tyroserleutide on gene expression of calmodulin and PI3K in hepatocellular carcinoma
- (2007) Lan Zhao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
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