Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification
Authors
Keywords
-
Journal
Biotechnology Journal
Volume -, Issue -, Pages 1900226
Publisher
Wiley
Online
2020-04-16
DOI
10.1002/biot.201900226
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Characterization of therapeutic oligonucleotides by liquid chromatography
- (2020) Alexandre Goyon et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Analysis of Antisense Oligonucleotides and Their Metabolites with the Use of Ion Pair Reversed-Phase Liquid Chromatography Coupled with Mass Spectrometry
- (2019) Anna Kaczmarkiewicz et al. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
- The role of fluoroalcohols as counter anions for ion-pairing reversed-phase liquid chromatography/high-resolution electrospray ionization mass spectrometry analysis of oligonucleotides
- (2019) Rong Liu et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Small alkyl amines as ion-pair reagents for the separation of positional isomers of impurities in phosphate diester oligonucleotides
- (2019) Stilianos G. Roussis et al. JOURNAL OF CHROMATOGRAPHY A
- Stable-bond polymeric reversed-phase/weak anion-exchange mixed-mode stationary phases obtained by simultaneous functionalization and crosslinking of a poly(3-mercaptopropyl)methylsiloxane-film on vinyl silica via thiol-ene double click reaction
- (2019) Stefanie Bäurer et al. JOURNAL OF CHROMATOGRAPHY A
- Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides
- (2019) Martin Enmark et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Determination of the Equilibrium Constant and Rate constant of Protein–Oligonucleotide Complex Dissociation under the Conditions of Ideal-Filter Capillary Electrophoresis
- (2019) An Le et al. ANALYTICAL CHEMISTRY
- Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP)
- (2019) Sebastian Vogg et al. Biotechnology Journal
- Ideal‐filter capillary electrophoresis: A highly efficient partitioning method for selection of protein binders from oligonucleotide libraries
- (2019) An T. H. Le et al. ELECTROPHORESIS
- A review on native and denaturing purification methods for non-coding RNA (ncRNA)
- (2019) Fariha Kanwal et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Bridged Nucleic Acids Reloaded
- (2019) Alfonso Soler-Bistué et al. MOLECULES
- Bioproduction of pure, kilobase-scale single-stranded DNA
- (2019) Tyson R. Shepherd et al. Scientific Reports
- Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease
- (2019) Jinkuk Kim et al. NEW ENGLAND JOURNAL OF MEDICINE
- Continuous integrated manufacturing of therapeutic proteins
- (2018) Daniel Johannes Karst et al. CURRENT OPINION IN BIOTECHNOLOGY
- Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy
- (2018) Pui Yan Ho et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Capillary electrophoresis, a method for the determination of nucleic acid ligands covalently attached to quantum dots representing a donor of Förster resonance energy transfer
- (2018) Vladimíra Datinská et al. JOURNAL OF SEPARATION SCIENCE
- Current understanding of the human microbiome
- (2018) Jack A Gilbert et al. NATURE MEDICINE
- Review on investigations of antisense oligonucleotides with the use of mass spectrometry
- (2018) Sylwia Studzińska TALANTA
- Inotersen: First Global Approval
- (2018) Susan J. Keam DRUGS
- Patisiran: First Global Approval
- (2018) Sheridan M. Hoy DRUGS
- Monolithic alkylsilane column: A promising separation medium for oligonucleotides by ion-pair reversed-phase liquid chromatography
- (2018) Jun-qin Qiao et al. JOURNAL OF CHROMATOGRAPHY A
- Ideal-Filter Capillary Electrophoresis (IFCE) to Facilitate One-Step Selection of Aptamers
- (2018) An T. H. Le et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Alkylamine ion-pairing reagents and the chromatographic separation of oligonucleotides
- (2018) Ning Li et al. JOURNAL OF CHROMATOGRAPHY A
- High resolution fingerprinting of single and double-stranded RNA using ion-pair reverse-phase chromatography
- (2018) Alison O. Nwokeoji et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- PIWI-interacting RNAs: small RNAs with big functions
- (2018) Deniz M. Ozata et al. NATURE REVIEWS GENETICS
- RNA therapy: Are we using the right molecules?
- (2018) Ai-Ming Yu et al. PHARMACOLOGY & THERAPEUTICS
- Analysis of the first and second generation of antisense oligonucleotides in serum samples with the use of ultra high performance liquid chromatography coupled with tandem mass spectrometry
- (2018) Anna Kaczmarkiewicz et al. TALANTA
- Market access of Spinraza (Nusinersen) for spinal muscular atrophy: intellectual property rights, pricing, value and coverage considerations
- (2017) S Simoens et al. GENE THERAPY
- Experimental design of a twin-column countercurrent gradient purification process
- (2017) Fabian Steinebach et al. JOURNAL OF CHROMATOGRAPHY A
- Separation of small interfering RNA stereoisomers using reversed-phase ion-pairing chromatography
- (2017) Li Li et al. JOURNAL OF CHROMATOGRAPHY A
- Application of hydrophilic interaction liquid chromatography coupled with mass spectrometry in the analysis of phosphorothioate oligonucleotides in serum
- (2017) Sylwia Studzińska et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Application of phenyl-based stationary phases for the study of retention and separation of oligonucleotides
- (2017) Sylwia Studzińska et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- The impact of ion-pairing reagents on the selectivity and sensitivity in the analysis of modified oligonucleotides in serum samples by liquid chromatography coupled with tandem mass spectrometry
- (2017) Sylwia Studzińska et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?
- (2017) Valentina D'Atri et al. JOURNAL OF SEPARATION SCIENCE
- FDA-Approved Oligonucleotide Therapies in 2017
- (2017) Cy A. Stein et al. MOLECULAR THERAPY
- The chemical evolution of oligonucleotide therapies of clinical utility
- (2017) Anastasia Khvorova et al. NATURE BIOTECHNOLOGY
- Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
- (2017) Naoki Iwamoto et al. NATURE BIOTECHNOLOGY
- Cellular uptake and trafficking of antisense oligonucleotides
- (2017) Stanley T Crooke et al. NATURE BIOTECHNOLOGY
- Analysis of oligonucleotides by ion-pairing hydrophilic interaction liquid chromatography/electrospray ionization mass spectrometry
- (2017) Lingzhi Gong RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Quantitative determination of a siRNA (AD00370) in rat plasma using peptide nucleic acid probe and HPLC with fluorescence detection
- (2017) Qingguo Tian et al. Bioanalysis
- Eteplirsen in the treatment of Duchenne muscular dystrophy
- (2017) Kenji Rowel Lim et al. Drug Design Development and Therapy
- Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model
- (2017) Karima Relizani et al. Molecular Therapy-Nucleic Acids
- Achieving Single-Nucleotide Specificity in Direct Quantitative Analysis of Multiple MicroRNAs (DQAMmiR)
- (2016) David W. Wegman et al. ANALYTICAL CHEMISTRY
- Advances in time course extracellular production of human pre-miR-29b from Rhodovulum sulfidophilum
- (2016) Patrícia Pereira et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Conversion of adenine to 5-amino-4-pyrimidinylimidazole caused by acetyl capping during solid phase oligonucleotide synthesis
- (2016) Andrew A. Rodriguez et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- High-density mammalian cell cultures in stirred-tank bioreactor without external pH control
- (2016) Sen Xu et al. JOURNAL OF BIOTECHNOLOGY
- The Role of Fluorinated Alcohols as Mobile Phase Modifiers for LC-MS Analysis of Oligonucleotides
- (2016) Babak Basiri et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Coming of age: ten years of next-generation sequencing technologies
- (2016) Sara Goodwin et al. NATURE REVIEWS GENETICS
- The delivery of therapeutic oligonucleotides
- (2016) Rudolph L. Juliano NUCLEIC ACIDS RESEARCH
- Fluorescence coupled in-capillary DNA hybridization assay and its application to identification of DNA point mutation
- (2016) Jianhao Wang et al. SENSORS AND ACTUATORS B-CHEMICAL
- Advances in quantitative bioanalysis of oligonucleotide biomarkers and therapeutics
- (2016) Laixin Wang et al. Bioanalysis
- Bioengineering of noncoding RNAs for research agents and therapeutics
- (2016) Pui Yan Ho et al. Wiley Interdisciplinary Reviews-RNA
- Gold-nanoparticle extraction and reversed-electrode-polarity stacking mode combined to enhance capillary electrophoresis sensitivity for conjugated nucleosides and oligonucleotides containing thioether linkers
- (2015) Valentina Bosi et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- OncoRep: an n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing
- (2015) Tobias Meißner et al. BMC Medical Genomics
- Separation Behavior of Short Oligonucleotides by Ion-Pair Reversed-Phase Capillary Liquid Chromatography Using a Silica-Based Monolithic Column Applied to Simple Detection of SNPs
- (2015) Kunio Kawamura et al. CHROMATOGRAPHIA
- Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics
- (2015) Axel Vater et al. DRUG DISCOVERY TODAY
- Polymeric drugs: Advances in the development of pharmacologically active polymers
- (2015) Jing Li et al. JOURNAL OF CONTROLLED RELEASE
- Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymes
- (2015) Lucia Greenough et al. NUCLEIC ACIDS RESEARCH
- Analysis of oligonucleotides by liquid chromatography with alkylamide stationary phase
- (2015) Bogusław Buszewski et al. Open Chemistry
- Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?
- (2015) Veronique G. LeBlanc et al. Cancers
- Formation of the N2-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping
- (2014) Andrew A. Rodriguez et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Orthogonal ion pairing reversed phase liquid chromatography purification of oligonucleotides with bulky fluorophores
- (2014) Concordio Anacleto et al. JOURNAL OF CHROMATOGRAPHY A
- Synthetic oligonucleotide separations by mixed-mode reversed-phase/weak anion-exchange liquid chromatography
- (2014) Aleksandra Zimmermann et al. JOURNAL OF CHROMATOGRAPHY A
- The therapeutic monoclonal antibody market
- (2014) Dawn M Ecker et al. mAbs
- Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
- (2014) W. Brad Wan et al. NUCLEIC ACIDS RESEARCH
- Phosphorothioates, Essential Components of Therapeutic Oligonucleotides
- (2014) Fritz Eckstein Nucleic Acid Therapeutics
- High-performance liquid chromatography purification of chemically modified RNA aptamers
- (2013) Chi-Yen Lin et al. ANALYTICAL BIOCHEMISTRY
- Separation and identification of phosphorothioate oligonucleotides by HILIC-ESIMS
- (2013) Renee Easter et al. Analytical Methods
- Factors influencing the separation of oligonucleotides using reversed-phase/ion-exchange mixed-mode high performance liquid chromatography columns
- (2013) Mirlinda Biba et al. JOURNAL OF CHROMATOGRAPHY A
- Gene therapy clinical trials worldwide to 2012 - an update
- (2013) Samantha L. Ginn et al. JOURNAL OF GENE MEDICINE
- Efficient and specific gene knockdown by small interfering RNAs produced in bacteria
- (2013) Linfeng Huang et al. NATURE BIOTECHNOLOGY
- Strong anion-exchange fast performance liquid chromatography as a versatile tool for preparation and purification of RNA produced by in vitro transcription
- (2013) J. Koubek et al. RNA
- Coupling activators for the oligonucleotide synthesis via phosphoramidite approach
- (2013) Xia Wei TETRAHEDRON
- Preparation of methacrylate-based anion-exchange monolithic microbore column for chromatographic separation of DNA fragments and oligonucleotides
- (2012) Akhmad Sabarudin et al. ANALYTICA CHIMICA ACTA
- Clinical pharmacokinetics of second generation antisense oligonucleotides
- (2012) Rosie Z Yu et al. Expert Opinion on Drug Metabolism & Toxicology
- Reversed-phase ion-pair liquid chromatography electrospray ionization tandem mass spectrometry for separation, sequencing and mapping of sites of base modification of isomeric oligonucleotide adducts using monolithic column
- (2012) Vaneet K. Sharma et al. JOURNAL OF CHROMATOGRAPHY A
- An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics
- (2011) Thazha P. Prakash CHEMISTRY & BIODIVERSITY
- Analysis of oligonucleotides by hydrophilic interaction liquid chromatography coupled to negative ion electrospray ionization mass spectrometry
- (2011) Lingzhi Gong et al. JOURNAL OF CHROMATOGRAPHY A
- Comprehensive hydrophilic interaction and ion-pair reversed-phase liquid chromatography for analysis of di- to deca-oligonucleotides
- (2011) Qin Li et al. JOURNAL OF CHROMATOGRAPHY A
- Chromatographic methods for the determination of therapeutic oligonucleotides
- (2011) A. Cary McGinnis et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Separation and identification of oligonucleotides by hydrophilic interaction liquid chromatography (HILIC)—inductively coupled plasma mass spectrometry (ICPMS)
- (2010) Renee N. Easter et al. ANALYST
- DNAzyme-mediated recovery of small recombinant RNAs from a 5S rRNA-derived chimera expressed in Escherichia coli
- (2010) Yamei Liu et al. BMC BIOTECHNOLOGY
- Oligonucleotide N3′→P5′ Phosphoramidates andThio-Phoshoramidates as Potential Therapeutic Agents
- (2010) Sergei M. Gryaznov CHEMISTRY & BIODIVERSITY
- Development trends for human monoclonal antibody therapeutics
- (2010) Aaron L. Nelson et al. NATURE REVIEWS DRUG DISCOVERY
- Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA
- (2010) Pradeep S. Pallan et al. NUCLEIC ACIDS RESEARCH
- Rapid, nondenaturing RNA purification using weak anion-exchange fast performance liquid chromatography
- (2010) L. E. Easton et al. RNA
- Therapeutic antibodies: successes, limitations and hopes for the future
- (2009) Patrick Chames et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cationic PMMA Nanoparticles Bind and Deliver Antisense Oligoribonucleotides Allowing Restoration of Dystrophin Expression in the mdx Mouse
- (2009) Paola Rimessi et al. MOLECULAR THERAPY
- A generic protocol for the expression and purification of recombinant RNA in Escherichia coli using a tRNA scaffold
- (2009) Luc Ponchon et al. Nature Protocols
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now