Human neural organoids: Models for developmental neurobiology and disease

Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons

(2021) Dong Won Kim et al.   Communications Biology

Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis

(2021) Lotta Hof et al.   BMC BIOLOGY

Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex

(2021) Yuanyuan Fu et al.   Cell Reports

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

(2021) Ugomma C. Eze et al.   NATURE NEUROSCIENCE

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis

(2020) Zhe Zhu et al.   Cell Stem Cell

An update on human astrocytes and their role in development and disease

(2020) Martina Majo et al.   GLIA

Use of 3D Organoids as a Model to Study Idiopathic Form of Parkinson’s Disease

(2020) Chlebanowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell stress in cortical organoids impairs molecular subtype specification

(2020) Aparna Bhaduri et al.   NATURE

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing

(2020) Benedetta Artegiani et al.   NATURE CELL BIOLOGY

Generation of homogeneous midbrain organoids with in vivo- like cellular composition facilitates neurotoxin-based Parkinson's disease modeling

(2020) Tae Hwan Kwak et al.   STEM CELLS

Modeling medulloblastoma in vivo and with human cerebellar organoids

(2020) Claudio Ballabio et al.   Nature Communications

Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain

(2020) Yoshiaki Tanaka et al.   Cell Reports

Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells

(2020) Takatoshi Kasai et al.   Cell Reports

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures

(2020) Akshayalakshmi Sridhar et al.   Cell Reports

Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa

(2020) Mei-Ling Gao et al.   Frontiers in Cell and Developmental Biology

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

(2020) Xuyu Qian et al.   Cell Stem Cell

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

(2020) Birgitta E. Michels et al.   Cell Stem Cell

Do not keep it simple: recent advances in the generation of complex organoids

(2020) Philipp Wörsdörfer et al.   JOURNAL OF NEURAL TRANSMISSION

Molecular design of hypothalamus development

(2020) Roman A. Romanov et al.   NATURE

Machine learning-assisted neurotoxicity prediction in human midbrain organoids

(2020) Anna S. Monzel et al.   PARKINSONISM & RELATED DISORDERS

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

Deconstructing cerebellar development cell by cell

(2020) Max J. van Essen et al.   PLoS Genetics

Modeling and Targeting Alzheimer’s Disease With Organoids

(2020) Angelos Papaspyropoulos et al.   Frontiers in Pharmacology

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids

(2020) Lisa M. Smits et al.   CELL AND TISSUE RESEARCH

Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus

(2020) Timothy Goodman et al.   DEVELOPMENT

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deconstructing and reconstructing the human brain with regionally specified brain organoids

(2020) Yangfei Xiang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cell Atlas of The Human Fovea and Peripheral Retina

(2020) Wenjun Yan et al.   Scientific Reports

Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation

(2020) Ashna Alladin et al.   eLife

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons

(2020) Anne Hedegaard et al.   Stem Cell Reports

iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation

(2020) Aarne Fleischer et al.   Molecular Therapy-Methods & Clinical Development

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

(2020) Cameron S. Cowan et al.   CELL

The Use of Induced Pluripotent Stem Cells as a Model for Developmental Eye Disorders

(2020) Jonathan Eintracht et al.   Frontiers in Cellular Neuroscience

The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development

(2020) Dong Won Kim et al.   Nature Communications

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

(2020) Jules Scholler et al.   Light-Science & Applications

Generation of Functional Human 3D Cortico-Motor Assembloids

(2020) Jimena Andersen et al.   CELL

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

(2019) Carla B. Mellough et al.   Stem Cells Translational Medicine

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

(2019) Jason Tchieu et al.   NATURE BIOTECHNOLOGY

Human colon organoids reveal distinct physiologic and oncogenic Wnt responses

(2019) Birgitta E. Michels et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation

(2019) Chia-Hsiang Chang et al.   DEVELOPMENTAL CELL

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

(2019) Yangfei Xiang et al.   Cell Stem Cell

Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina

(2019) Yi-Rong Peng et al.   CELL

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

Specification of positional identity in forebrain organoids

(2019) Gustav Y. Cederquist et al.   NATURE BIOTECHNOLOGY

High-resolution 3D imaging of fixed and cleared organoids

(2019) Johanna F. Dekkers et al.   Nature Protocols

Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification

(2019) Brian S. Clark et al.   NEURON

Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids

(2019) Sangbae Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

(2019) Hyosung Kim et al.   Stem Cell Reports

Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues

(2019) Liqing Song et al.   Scientific Reports

Human Organoids: Tools for Understanding Biology and Treating Diseases

(2019) Frans Schutgens et al.   Annual Review of Pathology-Mechanisms of Disease

Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours

(2019) P. Fusco et al.   BMC CANCER

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

(2019) Parthiv Haldipur et al.   SCIENCE

Brain Organoids: Human Neurodevelopment in a Dish

(2019) Silvia Benito-Kwiecinski et al.   Cold Spring Harbor Perspectives in Biology

Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo

(2019) Matthew J. Brooks et al.   Stem Cell Reports

Species-Specific miRNAs in Human Brain Development and Disease

(2019) Kanella Prodromidou et al.   Frontiers in Cellular Neuroscience

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

(2018) Thomas A. Forbes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate

(2018) M. Zeeshan Ozair et al.   Cell Stem Cell

The ethics of experimenting with human brain tissue

(2018) Nita A. Farahany et al.   NATURE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

(2018) Xufeng Xue et al.   NATURE MATERIALS

Imaging organoids: a bright future ahead

(2018) Anne C Rios et al.   NATURE METHODS

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

Development of the Thalamocortical Interactions: Past, Present and Future

(2018) Guillermina López-Bendito   NEUROSCIENCE

Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors

(2018) Koichiro Ogawa et al.   Scientific Reports

Use of bioreactors for culturing human retinal organoids improves photoreceptor yields

(2018) Patrick Ovando-Roche et al.   Stem Cell Research & Therapy

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

Single cell RNA sequencing of stem cell-derived retinal ganglion cells

(2018) Maciej Daniszewski et al.   Scientific Data

Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus

(2018) Elizabeth A. Newman et al.   DEVELOPMENTAL BIOLOGY

Applications of human brain organoids to clinical problems

(2018) H. Isaac Chen et al.   DEVELOPMENTAL DYNAMICS

Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells

(2018) Clarisse M. Fligor et al.   Scientific Reports

Stem Cells, Genome Editing, and the Path to Translational Medicine

(2018) Frank Soldner et al.   CELL

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

(2018) Kiara C. Eldred et al.   SCIENCE

Cerebral cortex development: an outside-in perspective

(2017) Gulistan Agirman et al.   FEBS LETTERS

In situ generation of human brain organoids on a micropillar array

(2017) Yujuan Zhu et al.   LAB ON A CHIP

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons

(2017) Jiro Kawada et al.   Stem Cell Reports

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells

(2017) Karl J. Wahlin et al.   Scientific Reports

The transcriptional and splicing landscape of intestinal organoids undergoing nutrient starvation or endoplasmic reticulum stress

(2016) Jessica Tsalikis et al.   BMC GENOMICS

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

(2016) Eirini P Papapetrou   NATURE MEDICINE

Thalamus plays a central role in ongoing cortical functioning

(2016) S Murray Sherman   NATURE NEUROSCIENCE

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells

(2016) Chikafumi Ozone et al.   Nature Communications

Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells

(2016) Bastian Zimmer et al.   Stem Cell Reports

The Types of Retinal Ganglion Cells: Current Status and Implications for Neuronal Classification

(2015) Joshua R. Sanes et al.   Annual Review of Neuroscience

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Consensus Paper: Cerebellar Development

(2015) Ketty Leto et al.   CEREBELLUM

Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling

(2015) Shufeng Zhou et al.   DEVELOPMENT

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells

(2015) F. T. Merkle et al.   DEVELOPMENT

Differentiation of hypothalamic-like neurons from human pluripotent stem cells

(2015) Liheng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors

(2015) Navid Nouri et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells

(2015) Julien Maruotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model

(2015) Luis Puelles et al.   Frontiers in Neuroanatomy

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors

(2014) Antoine Forget et al.   DEVELOPMENTAL CELL

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Intrinsically different retinal progenitor cells produce specific types of progeny

(2014) Connie Cepko   NATURE REVIEWS NEUROSCIENCE

Mesodiencephalic Dopaminergic Neuronal Differentiation Does Not Involve GLI2A-Mediated SHH-Signaling and Is under the Direct Influence of Canonical WNT Signaling

(2014) Simone Mesman et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Engineering of Midbrain Organoids Containing Long-Lived Dopaminergic Neurons

(2014) Vannary Tieng et al.   STEM CELLS AND DEVELOPMENT

Decision making during interneuron migration in the developing cerebral cortex

(2014) Jiami Guo et al.   TRENDS IN CELL BIOLOGY

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells

(2014) Jelle van den Ameele et al.   TRENDS IN NEUROSCIENCES

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

(2014) Xiufeng Zhong et al.   Nature Communications

Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish

(2014) Ilary Allodi et al.   Frontiers in Neuroscience

Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells

(2014) Katherine P. Gill et al.   Translational Vision Science & Technology

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Retinal neurogenesis

(2013) L. Centanin et al.   DEVELOPMENT

Tbr2 Expression in Cajal-Retzius Cells and Intermediate Neuronal Progenitors Is Required for Morphogenesis of the Dentate Gyrus

(2013) R. D. Hodge et al.   JOURNAL OF NEUROSCIENCE

LHX2 Is Necessary for the Maintenance of Optic Identity and for the Progression of Optic Morphogenesis

(2013) A. Roy et al.   JOURNAL OF NEUROSCIENCE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy

(2013) Yicong Wu et al.   NATURE BIOTECHNOLOGY

Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development

(2013) Leslie Ratié et al.   Neural Development

The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus

(2013) Guangnan Li et al.   NEURON

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

(2013) E. R. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specification of Functional Cranial Placode Derivatives from Human Pluripotent Stem Cells

(2013) Zehra Dincer et al.   Cell Reports

Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b

(2012) A. Bosco et al.   DEVELOPMENT

In vitro organogenesis in three dimensions: self-organising stem cells

(2012) Y. Sasai et al.   DEVELOPMENT

Wnt Signaling Regulates Postembryonic Hypothalamic Progenitor Differentiation

(2012) Xu Wang et al.   DEVELOPMENTAL CELL

Differential deployment of paralogous Wnt genes in the mouse and chick embryo during development

(2012) Audrey Martin et al.   EVOLUTION & DEVELOPMENT

Microphthalmia-associated Transcription Factor (MITF) Promotes Differentiation of Human Retinal Pigment Epithelium (RPE) by Regulating microRNAs-204/211 Expression

(2012) Jeffrey Adijanto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tbr2 Is Essential for Hippocampal Lineage Progression from Neural Stem Cells to Intermediate Progenitors and Neurons

(2012) R. D. Hodge et al.   JOURNAL OF NEUROSCIENCE

Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions

(2012) Jeanette Beers et al.   Nature Protocols

The Pulvinar Regulates Information Transmission Between Cortical Areas Based on Attention Demands

(2012) Y. B. Saalmann et al.   SCIENCE

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

The cerebellum and neuropsychological functioning: A critical review

(2011) Christopher J. O'Halloran et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Retinal Ganglion Cells with Distinct Directional Preferences Differ in Molecular Identity, Structure, and Central Projections

(2011) J. N. Kay et al.   JOURNAL OF NEUROSCIENCE

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

(2011) Sandra Blaess et al.   Neural Development

Self-organization of multiple spatial and context memories in the hippocampus

(2011) Federico Stella et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract

(2011) W. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment

(2011) Jason S. Meyer et al.   STEM CELLS

Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation

(2010) S. Blackshaw et al.   JOURNAL OF NEUROSCIENCE

A genomic atlas of mouse hypothalamic development

(2010) Tomomi Shimogori et al.   NATURE NEUROSCIENCE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina

(2010) Anand Swaroop et al.   NATURE REVIEWS NEUROSCIENCE

The Basics of Brain Development

(2010) Joan Stiles et al.   NEUROPSYCHOLOGY REVIEW

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

(2010) B.-Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus

(2010) Z. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Building a bridal chamber: development of the thalamus

(2010) Steffen Scholpp et al.   TRENDS IN NEUROSCIENCES

Cerebellum and Nonmotor Function

(2009) Peter L. Strick et al.   Annual Review of Neuroscience

SHH Pathway and Cerebellar Development

(2009) Catherine Vaillant et al.   CEREBELLUM

Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons

(2009) Dong-Youn Hwang et al.   JOURNAL OF NEUROCHEMISTRY

The Development of the Thalamic Motor Learning Area Is Regulated by Fgf8 Expression

(2009) A. Martinez-Ferre et al.   JOURNAL OF NEUROSCIENCE

Sonic Hedgehog Signaling Controls Thalamic Progenitor Identity and Nuclei Specification in Mice

(2009) T. Y. Vue et al.   JOURNAL OF NEUROSCIENCE

Shh dependent and independent maintenance of basal midbrain

(2009) Ariadna Perez-Balaguer et al.   MECHANISMS OF DEVELOPMENT

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis

(2009) Matthew B. Johnson et al.   NEURON

Generation of retinal cells from mouse and human induced pluripotent stem cells

(2009) Yasuhiko Hirami et al.   NEUROSCIENCE LETTERS

Spatiotemporally separableShhdomains in the midbrain define distinct dopaminergic progenitor pools

(2009) Milan Joksimovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling early retinal development with human embryonic and induced pluripotent stem cells

(2009) J. S. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genes and signaling events that establish regional patterning of the mammalian forebrain

(2009) Renée V. Hoch et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures

(2008) Christopher A Reid et al.   BMC NEUROSCIENCE

Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene

(2008) Kesi Chen et al.   BMC NEUROSCIENCE

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Fgf8 controls regional identity in the developing thalamus

(2008) A. Kataoka et al.   DEVELOPMENT

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

(2008) S. L. Lewis et al.   DEVELOPMENT

Neurogenin 2 has an essential role in development of the dentate gyrus

(2008) C. Galichet et al.   DEVELOPMENT

Three-dimensional neural constructs: a novel platform for neurophysiological investigation

(2008) Hillary R Irons et al.   Journal of Neural Engineering

Intermediate Progenitors in Adult Hippocampal Neurogenesis: Tbr2 Expression and Coordinate Regulation of Neuronal Output

(2008) R. D. Hodge et al.   JOURNAL OF NEUROSCIENCE

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

(2008) T. Wataya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA