Delivery strategies in treatments of leukemia

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Recent advances of redox-responsive nanoplatforms for tumor theranostics

(2021) Miaomiao Chen et al.   JOURNAL OF CONTROLLED RELEASE

Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy

(2021) Tzu-Chieh Ho et al.   Science Advances

Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects

(2021) Changlong Wang et al.   Nature Nanotechnology

Biomimetic, Hypoxia‐Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co‐Targeting of Therapy‐Induced Bone Marrow Niches

(2020) Xiao Dong et al.   ADVANCED FUNCTIONAL MATERIALS

Recent Advances in the Management of Acute Lymphoblastic Leukaemia

(2020) Katharine A. Hodby et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Recent advances in the combination delivery of drug for leukemia and other cancers

(2020) Thikrayat Al-Attar et al.   Expert Opinion on Drug Delivery

Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia

(2020) Kambere Amerigos Daddy J.C. et al.   Pharmaceutics

A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia

(2020) Nisarg J. Shah et al.   Nature Biomedical Engineering

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

Designing Stimuli-Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

(2020) Muhammad Ovais et al.   ADVANCED MATERIALS

Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring

(2020) Elias Jabbour et al.   AMERICAN JOURNAL OF HEMATOLOGY

Dual oligopeptides modification mediates arsenic trioxide containing nanoparticles to eliminate primitive chronic myeloid leukemia cells inside bone marrow niches

(2020) Luhui Fan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Delivery of a model lipophilic membrane cargo to bone marrow via cell-derived microparticles

(2020) Chunyan Yang et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen

(2020) Xiaoling Xie et al.   Nature Biomedical Engineering

Cryo-shocked cancer cells for targeted drug delivery and vaccination

(2020) Tianyuan Ci et al.   Science Advances

Light-Inducible Exosome-Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells

(2019) Lin Huang et al.   ADVANCED FUNCTIONAL MATERIALS

Combinatorial nanocarriers against drug resistance in hematological cancers: Opportunities and emerging strategies

(2019) Saikat Ghosh et al.   JOURNAL OF CONTROLLED RELEASE

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemia

(2019) Rishi S. Kotecha et al.   Oncotarget

Properties of FDA-approved small molecule protein kinase inhibitors

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20

(2019) Kenneth W. Locke et al.   DRUG DELIVERY

FDA Approval Summary: Glasdegib for newly-diagnosed acute myeloid leukemia

(2019) Kelly J. Norsworthy et al.   CLINICAL CANCER RESEARCH

Immunoliposomes in acute myeloid leukaemia therapy. An overview of possible targets and obstacles

(2019) Aditi Singh et al.   CURRENT MEDICINAL CHEMISTRY

Daunorubicin-containing CLL1-targeting nanomicelles have anti-leukemia stem cell activity in acute myeloid leukemia

(2019) Tzu-yin Lin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cancer treatment and survivorship statistics, 2019

(2019) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Side effects from acute myeloid leukemia treatment: results from a national survey

(2019) Norah L. Crossnohere et al.   CURRENT MEDICAL RESEARCH AND OPINION

Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia

(2019) Noureldien H. E. Darwish et al.   MOLECULES

In vitro and in vivo effect of hyaluronic acid modified, doxorubicin and gallic acid co-delivered lipid-polymeric hybrid nano-system for leukemia therapy

(2019) Yanping Shao et al.   Drug Design Development and Therapy

FDA Approval Summary: Calaspargase Pegol-mknl For Treatment of Acute Lymphoblastic Leukemia in Children and Young Adults

(2019) Ruo-Jing Li et al.   CLINICAL CANCER RESEARCH

CD123/CD33 dual-antibody modified liposomes effectively target acute myeloid leukemia cells and reduce antigen-negative escape

(2019) Shili Sun et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Expansion of primitive human hematopoietic stem cells by culture in a zwitterionic hydrogel

(2019) Tao Bai et al.   NATURE MEDICINE

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery

(2019) Jyotsna Kailashiya et al.   Oncotarget

CD64-targeted HO-1 RNA interference enhances chemosensitivity in orthotopic model of acute myeloid leukemia and patient-derived bone marrow cells

(2019) Seok-Beom Yong et al.   BIOMATERIALS

The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease

(2019) Motoko Koyama et al.   BLOOD

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

(2019) Yang Yang et al.   Nanoscale Research Letters

HDL-AuNPs-BMS Nanoparticle Conjugates as Molecularly Targeted Therapy for Leukemia

(2018) Na Shen et al.   ACS Applied Materials & Interfaces

Bone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration

(2018) Qingchang Chen et al.   ACS Applied Materials & Interfaces

Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy

(2018) Rong Deng et al.   BIOMATERIALS

Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy

(2018) Fan Niu et al.   BIOMATERIALS

Targeted drug delivery for tumor therapy inside the bone marrow

(2018) Chao-Feng Mu et al.   BIOMATERIALS

Chimeric antigen receptor–modified T cells: CD19 and the road beyond

(2018) Alexander I. Salter et al.   BLOOD

Exosomes in acute myeloid leukemia inhibit hematopoiesis

(2018) Michael Boyiadzis et al.   CURRENT OPINION IN HEMATOLOGY

Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives

(2018) Rajesh K. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Roles of the bone marrow niche in hematopoiesis, leukemogenesis, and chemotherapy resistance in acute myeloid leukemia

(2018) Andi Wang et al.   Hematology

Vincristine-Loaded and sgc8-Modified Liposome as a Potential Targeted Drug Delivery System for Treating Acute Lymphoblastic Leukemia

(2018) Siliang Duan et al.   Journal of Biomedical Nanotechnology

Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system

(2018) Gangliang Huang et al.   JOURNAL OF CONTROLLED RELEASE

Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why

(2018) Enrico Derenzini et al.   Journal of Hematology & Oncology

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy

(2018) Federico Rossari et al.   Journal of Hematology & Oncology

Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches

(2018) Wei Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the bone marrow microenvironment in acute leukemia

(2018) Christina Karantanou et al.   LEUKEMIA & LYMPHOMA

Evolution of CLL treatment — from chemoimmunotherapy to targeted and individualized therapy

(2018) Jan A. Burger et al.   Nature Reviews Clinical Oncology

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML

(2018) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bispecific antibodies for cancer therapy: A review

(2018) Anuradha Krishnamurthy et al.   PHARMACOLOGY & THERAPEUTICS

Design of peptide–dendrimer conjugates with tumor homing and antitumor effects

(2018) Chie Kojima et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

(2018) Christian Chabannon et al.   Science Translational Medicine

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

(2018) Raquel Díaz et al.   Small

Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles

(2018) Tamoghna Mandal et al.   Scientific Reports

Formulation, Development, and In Vitro Evaluation of a CD22 Targeted Liposomal System Containing a Non-Cardiotoxic Anthracycline for B Cell Malignancies

(2018) Nivesh Mittal et al.   Pharmaceutics

Harnessing albumin as a carrier for cancer therapies

(2018) Ella N. Hoogenboezem et al.   ADVANCED DRUG DELIVERY REVIEWS

The potential for clinical translation of antibody-targeted nanoparticles in the treatment of acute myeloid leukaemia

(2018) Jianfeng Guo et al.   JOURNAL OF CONTROLLED RELEASE

Nanomedicines for the treatment of hematological malignancies

(2018) Anil K. Deshantri et al.   JOURNAL OF CONTROLLED RELEASE

Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

(2018) Inna M. Yasinska et al.   Nanoscale

Immunotherapy in acute myeloid leukemia and myelodysplastic syndromes: The dawn of a new era?

(2018) Yuxin Liu et al.   BLOOD REVIEWS

FDA Approval Summary: (Daunorubicin and Cytarabine) Liposome for Injection for the Treatment of Adults with High-Risk Acute Myeloid Leukemia

(2018) Aviva C Krauss et al.   CLINICAL CANCER RESEARCH

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

(2018) Quanyin Hu et al.   Nature Biomedical Engineering

Platelet for drug delivery

(2018) Yifei Lu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Inotuzumab ozogamicin in relapsed B-cell acute lymphoblastic leukemia

(2017) Swapna Thota et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia

(2017) Hima V. Vangapandu et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Application of aptamers in treatment and diagnosis of leukemia

(2017) Rezvan Yazdian-Robati et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Durable Molecular Remissions in Chronic Lymphocytic Leukemia Treated With CD19-Specific Chimeric Antigen Receptor–Modified T Cells After Failure of Ibrutinib

(2017) Cameron J. Turtle et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy

(2017) Jing Liu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Leukemia-specific delivery of mutant NOTCH1 targeted therapy

(2017) Giovanni Roti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Checkpoint inhibitors in hematological malignancies

(2017) Chi Young Ok et al.   Journal of Hematology & Oncology

Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles

(2017) Nicolas Floc'h et al.   MOLECULAR CANCER THERAPEUTICS

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

(2017) Carlos Boto et al.   Nature Communications

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

(2017) T Terwilliger et al.   Blood Cancer Journal

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Remission of lymphoblastic leukaemia in an intravascular fluidic environment by pliable drug carrier with a sliding target ligand

(2017) Donghyun Jang et al.   Scientific Reports

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Liposomal cytarabine and daunorubicin (CPX-351) for treatment of acute myeloid leukemia

(2017) Aaron Ronson et al.   Expert Opinion on Orphan Drugs

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Human CD64-targeted non-viral siRNA delivery system for blood monocyte gene modulation

(2017) Seok-Beom Yong et al.   Scientific Reports

Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells

(2016) Paul N. Durfee et al.   ACS Nano

N-Heterocyclic Carbene-Gold(I) Complexes Conjugated to a Leukemia-Specific DNA Aptamer for Targeted Drug Delivery

(2016) Weijia Niu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features

(2016) Nina Rosa Neuendorff et al.   ANNALS OF HEMATOLOGY

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting

(2016) Francesca Chiarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Coinhibition of overexpressed genes in acute myeloid leukemia subtype M2 by gold nanoparticles functionalized with five antisense oligonucleotides and one anti-CD33(+)/CD34(+) aptamer

(2016) M A Zaimy et al.   CANCER GENE THERAPY

Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells

(2016) A. Kothari et al.   CANCER RESEARCH

Allogeneic Stem Cell Transplantation: A Historical and Scientific Overview

(2016) Anurag K. Singh et al.   CANCER RESEARCH

Driving gene-engineered T cell immunotherapy of cancer

(2016) Laura A Johnson et al.   CELL RESEARCH

MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies

(2016) Liqin Liu et al.   CLINICAL CANCER RESEARCH

Mechanism study of PEGylated polyester and β-cyclodextrin integrated micelles on drug resistance reversal in MRP1-overexpressed HL60/ADR cells

(2016) Qian Ji et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Immune-related adverse events with immune checkpoint blockade: a comprehensive review

(2016) J.M. Michot et al.   EUROPEAN JOURNAL OF CANCER

The development of agents targeting the BCR-ABL tyrosine kinase as Philadelphia chromosome-positive acute lymphoblastic leukemia treatment

(2016) Xavier Thomas et al.   Expert Opinion on Drug Discovery

Nanomedicine approaches in acute lymphoblastic leukemia

(2016) Andra-Sorina Tatar et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of bone loss with surface-modulated, drug-loaded nanoparticles in an intraosseous model of prostate cancer

(2016) Isaac M. Adjei et al.   JOURNAL OF CONTROLLED RELEASE

Using Gold Nanoparticles as Delivery Vehicles for Targeted Delivery of Chemotherapy Drug Fludarabine Phosphate to Treat Hematological Cancers

(2016) Steven Song et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Codelivery of Ponatinib and SAR302503 by Active Bone-Targeted Polymeric Micelles for the Treatment of Therapy-Resistant Chronic Myeloid Leukemia

(2016) Chao-Feng Mu et al.   MOLECULAR PHARMACEUTICS

Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery

(2016) Neda Habibi et al.   Nano Today

Materials and methods for delivery of biological drugs

(2016) Alexander N. Zelikin et al.   Nature Chemistry

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

(2016) Constanze Schneider et al.   NATURE MEDICINE

Immunological off-target effects of imatinib

(2016) Laurence Zitvogel et al.   Nature Reviews Clinical Oncology

Ipilimumab for Patients with Relapse after Allogeneic Transplantation

(2016) Matthew S. Davids et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia

(2016) Hagop M. Kantarjian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia

(2016) Joyce C de Mello et al.   PHARMACOLOGICAL RESEARCH

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

(2016) Susan Ashton et al.   Science Translational Medicine

Drug-loaded erythrocytes: on the road toward marketing approval

(2016) Vanessa Bourgeaux et al.   Drug Design Development and Therapy

Targeted delivery of vincristine to T-cell acute lymphoblastic leukemia cells using an aptamer-modified albumin conjugate

(2016) Seyed Mohammad Taghdisi et al.   RSC Advances

Long-Term Side Effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

(2016) Lauren Caldemeyer et al.   Current Hematologic Malignancy Reports

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

Aptamer–Drug Conjugates

(2015) Guizhi Zhu et al.   BIOCONJUGATE CHEMISTRY

Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters

(2015) William R. Strohl   BIODRUGS

Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia

(2015) Nianxi Zhao et al.   BIOMATERIALS

Polyaptamer DNA nanothread-anchored, reduced graphene oxide nanosheets for targeted delivery

(2015) Mi-Gyeong Kim et al.   BIOMATERIALS

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

(2015) F. McClanahan et al.   BLOOD

Emerging therapeutic drugs for AML

(2015) E. M. Stein et al.   BLOOD

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

Targeting of folate receptor   on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells

(2015) R. C. Lynn et al.   BLOOD

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Targeted and controlled release delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer-modified gold nanoparticles

(2015) Noor Mohammad Danesh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

In vivo targeting of leukemia stem cells by directing parthenolide-loaded nanoparticles to the bone marrow niche

(2015) H Zong et al.   LEUKEMIA

Management of adverse events associated with idelalisib treatment: expert panel opinion

(2015) Steven E. Coutré et al.   LEUKEMIA & LYMPHOMA

Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

(2015) Xiaojing Lin et al.   LEUKEMIA RESEARCH

Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies

(2015) Boris Shor et al.   MOLECULAR IMMUNOLOGY

CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia

(2015) Vinu Krishnan et al.   MOLECULAR PHARMACEUTICS

CD33-Targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia

(2015) Hong Li et al.   MOLECULAR PHARMACEUTICS

Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery

(2015) Lei Mei et al.   Nano Research

A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

(2015) Sara Capolla et al.   Nano Research

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia

(2015) Jan A. Burger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin

(2015) K D Marjon et al.   ONCOGENE

Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model

(2015) Patrick D. Halley et al.   Small

Stimuli-responsive terpolymer mPEG-b-PDMAPMA-b-PAH mediated co-delivery of adriamycin and siRNA to enhance anticancer efficacy

(2015) Minghui Xu et al.   RSC Advances

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia

(2014) J. R. Brown et al.   BLOOD

A phase 1 study of the PI3K  inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL)

(2014) B. S. Kahl et al.   BLOOD

Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia

(2014) Noriko Satake et al.   BRITISH JOURNAL OF HAEMATOLOGY

Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials

(2014) Robert K Hills et al.   LANCET ONCOLOGY

Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia

(2014) R Mani et al.   LEUKEMIA

Development of Synthetic Peptide-Modified Liposomes with LDL Receptor Targeting Capacity and Improved Anticancer Activity

(2014) Mei Liu et al.   MOLECULAR PHARMACEUTICS

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preserving Catalytic Activity and Enhancing Biochemical Stability of the Therapeutic Enzyme Asparaginase by Biocompatible Multilayered Polyelectrolyte Microcapsules

(2013) Christos S. Karamitros et al.   BIOMACROMOLECULES

Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells

(2013) Bo Yu et al.   BIOMATERIALS

Nuclear localization of P-glycoprotein is responsible for protection of the nucleus from doxorubicin in the resistant LoVo cell line

(2013) Witold Szaflarski et al.   BIOMEDICINE & PHARMACOTHERAPY

Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia

(2013) Hagop M. Kantarjian et al.   CANCER

Older and new purine nucleoside analogs for patients with acute leukemias

(2013) Pawel Robak et al.   CANCER TREATMENT REVIEWS

Nanoparticles Engineered with Rituximab and Loaded with Nutlin-3 Show Promising Therapeutic Activity in B-Leukemic Xenografts

(2013) R. Voltan et al.   CLINICAL CANCER RESEARCH

Acute lymphoblastic leukaemia

(2013) Hiroto Inaba et al.   LANCET

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Photosensitizer-Gold Nanorod Composite for Targeted Multimodal Therapy

(2013) Jian Wang et al.   Small

Transferrin as a drug carrier: Cytotoxicity, cellular uptake and transport kinetics of doxorubicin transferrin conjugate in the human leukemia cells

(2013) Marzena Szwed et al.   TOXICOLOGY IN VITRO

Enzyme-responsive nanoparticles for drug release and diagnostics

(2012) Roberto de la Rica et al.   ADVANCED DRUG DELIVERY REVIEWS

Milatuzumab-Conjugated Liposomes as Targeted Dexamethasone Carriers for Therapeutic Delivery in CD74+ B-cell Malignancies

(2012) Y. Mao et al.   CLINICAL CANCER RESEARCH

Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan

(2012) Ariane Galaup et al.   Expert Opinion on Drug Metabolism & Toxicology

Tyrosine kinase inhibitors in acute and chronic leukemias

(2012) Maro Ohanian et al.   EXPERT OPINION ON PHARMACOTHERAPY

Protein-based nanocarriers as promising drug and gene delivery systems

(2012) Ahmed O. Elzoghby et al.   JOURNAL OF CONTROLLED RELEASE

p53 protein expression in chronic lymphocytic leukemia

(2012) Ludger Sellmann et al.   LEUKEMIA & LYMPHOMA

Pharmacokinetics of CPX-351; a nano-scale liposomal fixed molar ratio formulation of cytarabine:daunorubicin, in patients with advanced leukemia

(2012) E.J. Feldman et al.   LEUKEMIA RESEARCH

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

Erythrocyte-Inspired Delivery Systems

(2012) Che-Ming J. Hu et al.   Advanced Healthcare Materials

E-Selectin-Targeted Porous Silicon Particle for Nanoparticle Delivery to the Bone Marrow

(2011) Aman P. Mann et al.   ADVANCED MATERIALS

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

(2011) S.-J. Chen et al.   BLOOD

Antibody-Drug Conjugates of Calicheamicin Derivative: Gemtuzumab Ozogamicin and Inotuzumab Ozogamicin

(2011) A. D. Ricart   CLINICAL CANCER RESEARCH

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

Bone metastasis targeting: A novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel

(2011) Kiran Ramanlal Chaudhari et al.   JOURNAL OF CONTROLLED RELEASE

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells

(2011) E K Allan et al.   LEUKEMIA

Characterization of high-affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells

(2011) Hongyong Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

The bone marrow microenvironment and leukemia: biology and therapeutic targeting

(2011) Edward Allan R Sison et al.   Expert Review of Hematology

P-Glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells

(2010) Ruibin Li et al.   ACS Nano

Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia

(2010) Pier Paolo Piccaluga et al.   LEUKEMIA & LYMPHOMA

BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: A review

(2010) Xin An et al.   LEUKEMIA RESEARCH

Metronomic chemotherapy: new rationale for new directions

(2010) Eddy Pasquier et al.   Nature Reviews Clinical Oncology

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Polymeric carriers: Preclinical safety and the regulatory implications for design and development of polymer therapeutics

(2009) Rogério Gaspar et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

(2009) Yu-Fen Huang et al.   CHEMBIOCHEM

Therapeutic targeting of microenvironmental interactions in leukemia: Mechanisms and approaches

(2009) Marina Konopleva et al.   DRUG RESISTANCE UPDATES

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

L-Asparaginase encapsulated intact erythrocytes for treatment of acute lymphoblastic leukemia (ALL)

(2009) Young Min Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Contribution of bone microenvironment to leukemogenesis and leukemia progression

(2009) F Ayala et al.   LEUKEMIA

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with Other Alkylating Agents

(2008) L. M. Leoni et al.   CLINICAL CANCER RESEARCH

The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance

(2008) M. B. Meads et al.   CLINICAL CANCER RESEARCH

Phase I Safety and Pharmacokinetic Study of CT-011, a Humanized Antibody Interacting with PD-1, in Patients with Advanced Hematologic Malignancies

(2008) R. Berger et al.   CLINICAL CANCER RESEARCH

Targeted drug delivery via folate receptors

(2008) Xiaobin Zhao et al.   Expert Opinion on Drug Delivery

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

(2008) J A Burger et al.   LEUKEMIA

In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy

(2008) Paul Tardi et al.   LEUKEMIA RESEARCH