Leukemia-specific delivery of mutant NOTCH1 targeted therapy

Targeting of folate receptor   on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells

(2015) R. C. Lynn et al.   BLOOD

IMGN853, a Folate Receptor-  (FR )-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR -Expressing Tumors

(2015) O. Ab et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Targeting thapsigargin towards tumors

(2015) Nhu Thi Quynh Doan et al.   STEROIDS

Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors

(2015) Ignace Vergote et al.   Therapeutic Advances in Medical Oncology

Notch Signaling Drives Stemness and Tumorigenicity of Esophageal Adenocarcinoma

(2014) Z. Wang et al.   CANCER RESEARCH

Folate Receptor-β in Activated Macrophages: Ligand Binding and Receptor Recycling Kinetics

(2014) Bindu Varghese et al.   MOLECULAR PHARMACEUTICS

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

(2013) Giovanni Roti et al.   CANCER CELL

Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer

(2013) Deborah K. Armstrong et al.   GYNECOLOGIC ONCOLOGY

Farletuzumab in lung cancer

(2013) Anish Thomas et al.   LUNG CANCER

A Trojan Horse in Drug Development: Targeting of Thapsigargins Towards Prostate Cancer Cells

(2012) S. Christensen et al.   Anti-Cancer Agents in Medicinal Chemistry

Notch signaling in human development and disease

(2012) Andrea L. Penton et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think: Table I.

(2011) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

(2010) M. Dail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new genetic lesion in B-CLL: aNOTCH1PEST domain mutation

(2009) Mauro Di Ianni et al.   BRITISH JOURNAL OF HAEMATOLOGY

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

Phase II evaluation of topotecan and navelbine in patients with recurrent ovarian, fallopian tube or primary peritoneal cancer

(2008) Thomas J. Herzog et al.   GYNECOLOGIC ONCOLOGY

Folate receptor alpha as a tumor target in epithelial ovarian cancer

(2008) Kimberly R. Kalli et al.   GYNECOLOGIC ONCOLOGY

Impact of High and Low Folate Diets on Tissue Folate Receptor Levels and Antitumor Responses Toward Folate-Drug Conjugates

(2008) C. P. Leamon et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Notch tumor suppressor function

(2008) G P Dotto   ONCOGENE