Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia

The Preparation, Determination of a Flexible Complex Liposome Co-Loaded with Cabazitaxel and β-Elemene, and Animal Pharmacodynamics on Paclitaxel-Resistant Lung Adenocarcinoma

(2019) Yi-Ying Zeng et al.   MOLECULES

In vitro and in vivo effect of hyaluronic acid modified, doxorubicin and gallic acid co-delivered lipid-polymeric hybrid nano-system for leukemia therapy

(2019) Yanping Shao et al.   Drug Design Development and Therapy

A Triple Co-Delivery Liposomal Carrier That Enhances Apoptosis via an Intrinsic Pathway in Melanoma Cells

(2019) Nina Filipczak et al.   Cancers

Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR

(2018) Imran Shair Mohammad et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of novel macropinocytosis inhibitors using a rational screen of FDA-approved drugs

(2018) Hui-Ping Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of β-elemene on the kinetics of intracellular transport of d -luciferin potassium salt (ABC substrate) in doxorubicin-resistant breast cancer cells and the associated molecular mechanism

(2018) Chao-yuan Tang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Chitosan hydrochloride/hyaluronic acid nanoparticles coated by mPEG as long-circulating nanocarriers for systemic delivery of mitoxantrone

(2018) Jiajia Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Preliminary evaluation of the potential role of β‑elemene in reversing erlotinib‑resistant human NSCLC A549/ER cells

(2018) Lan Lin et al.   Oncology Letters

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

(2018) Bingtao Zhai et al.   International Journal of Nanomedicine

Drug-delivering-drug approach-based codelivery of paclitaxel and disulfiram for treating multidrug-resistant cancer

(2018) Imran Shair Mohammad et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor

(2017) Yurui Xu et al.   International Journal of Nanomedicine

A Phase I/II trial of continuous hepatic intra-arterial infusion of 5-fluorouracil, mitoxantrone and cisplatin for advanced hepatocellular carcinoma

(2017) Masafumi Ikeda et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Mitoxantrone- and Folate-TPGS2k Conjugate Hybrid Micellar Aggregates To Circumvent Toxicity and Enhance Efficiency for Breast Cancer Therapy

(2017) Nida El Islem Guissi et al.   MOLECULAR PHARMACEUTICS

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer

(2017) Jinglu Wang et al.   Oncotarget

Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy

(2017) Xiaolian Sun et al.   Theranostics

Intracellular Trafficking Pathways of Edwardsiella tarda: From Clathrin- and Caveolin-Mediated Endocytosis to Endosome and Lysosome

(2017) Zhi-hai Sui et al.   Frontiers in Cellular and Infection Microbiology

β-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect

(2017) Ziyu Jiang et al.   Frontiers in Pharmacology

Co-encapsulation of paclitaxel and baicalein in nanoemulsions to overcome multidrug resistance via oxidative stress augmentation and P-glycoprotein inhibition

(2016) Luhua Meng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

(2016) Mirela Enache et al.   MOLECULES

Mitoxantrone and Etoposide for the Treatment of Acute Myeloid Leukemia Patients in First Relapse

(2016) Annie Im et al.   ONCOLOGY RESEARCH

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

(2016) Li Lv et al.   Oncotarget

β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1

(2016) Xiaoqiang Li et al.   Scientific Reports

pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(d,l-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-glycoprotein inhibitor

(2015) Yong Zhao et al.   Acta Biomaterialia

Nanoparticle-Based Combination Therapy for Cancer Treatment

(2015) Ji Yhee et al.   CURRENT PHARMACEUTICAL DESIGN

Selection of resistant acute myeloid leukemia SKM-1 and MOLM-13 cells by vincristine-, mitoxantrone- and lenalidomide-induced upregulation of P-glycoprotein activity and downregulation of CD33 cell surface exposure

(2015) D. Imrichova et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Co-delivery of docetaxel and chloroquine via PEO–PPO–PCL/TPGS micelles for overcoming multidrug resistance

(2015) Chunhuan Shi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

�-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression

(2014) Jun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Co-delivery of doxorubicin and P-gp inhibitor by a reduction-sensitive liposome to overcome multidrug resistance, enhance anti-tumor efficiency and reduce toxicity

(2014) Jie Tang et al.   DRUG DELIVERY

Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique

(2014) Rohan M. Shah et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Transport Pathways of Solid Lipid Nanoparticles Across Madin–Darby Canine Kidney Epithelial Cell Monolayer

(2014) Gui-Hong Chai et al.   MOLECULAR PHARMACEUTICS

β-elemene reverses the drug resistance of A549/DDP lung cancer cells by activating intracellular redox system, decreasing mitochondrial membrane potential and P-glycoprotein expression, and inducing apoptosis

(2014) Chengcai Yao et al.   Thoracic Cancer

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells

(2013) Zhi-Jun Dai et al.   Cancer Cell International

Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation

(2013) Andjelka B. Kovačević et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

The Role of E3 Ubiquitin Ligase Cbl Proteins in β-Elemene Reversing Multi-Drug Resistance of Human Gastric Adenocarcinoma Cells

(2013) Ye Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unexpected Performance of Physical Mixtures over Solid Dispersions on the Dissolution Behavior of Benznidazole from Tablets

(2013) Darío Leonardi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Multistep Targeted Nano Drug Delivery System Aiming at Leukemic Stem Cells and Minimal Residual Disease

(2013) Yongping Shi et al.   MOLECULAR PHARMACEUTICS

Integration of in Silico and in Vitro Tools for Scaffold Optimization during Drug Discovery: Predicting P-Glycoprotein Efflux

(2013) Prashant V. Desai et al.   MOLECULAR PHARMACEUTICS

β-elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter

(2013) HUI-QIN GUO et al.   ONCOLOGY REPORTS

Reversion of Multidrug Resistance in a Chemoresistant Human Breast Cancer Cell Line by ß-Elemene

(2012) Hong-Bin Xu et al.   PHARMACOLOGY

Preparation and characterization of β-elemene-loaded microemulsion

(2011) Chan-Juan Hu et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone

(2010) Alejandro F. Barrero et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines

(2009) Francesca Greco et al.   ADVANCED DRUG DELIVERY REVIEWS

The synergistic reversal effect of multidrug resistance by quercetin and hyperthermia in doxorubicin-resistant human myelogenous leukemia cells

(2008) Jing Shen et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA