From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

(2010) P. Isakson et al.   BLOOD

Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group

(2010) F. Lo-Coco et al.   BLOOD

Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710

(2010) B. L. Powell et al.   BLOOD

Favourable outcome of patients with childhood acute promyelocytic leukaemia after treatment with reduced cumulative anthracycline doses

(2010) Ursula Creutzig et al.   BRITISH JOURNAL OF HAEMATOLOGY

PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia

(2010) Kankan Wang et al.   CANCER CELL

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Effect of arsenic trioxide (Trisenox) on actin organization in K-562 erythroleukemia cells.

(2010) Magdalena Izdebska et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting

(2010) Rihab Nasr et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide

(2010) Dennis J. Goussetis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Agent Arsenic Trioxide in the Treatment of Newly Diagnosed Acute Promyelocytic Leukemia: Long-Term Follow-Up Data

(2010) Vikram Mathews et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia

(2010) Hiba El Hajj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia

(2010) J.-H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus

(2010) F. Wolfe-Simon et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Use of All-trans Retinoic Acid in Combination with Arsenic Trioxide for Remission Induction in Patients with Newly Diagnosed Acute Promyelocytic Leukemia and for Consolidation/Maintenance in CR Patients

(2009) Chong-Wen Dai et al.   ACTA HAEMATOLOGICA

Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience

(2009) L. Ades et al.   BLOOD

Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia

(2009) J. Zhou et al.   BLOOD

Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome

(2009) M. Luesink et al.   BLOOD

Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)

(2009) G. Kchour et al.   BLOOD

Arsenic trioxide-mediated Notch pathway inhibition depletes the cancer stem-like cell population in gliomas

(2009) Yunbo Zhen et al.   CANCER LETTERS

Therapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure

(2009) R. Nasr et al.   CLINICAL CANCER RESEARCH

Aquatic arsenic: Toxicity, speciation, transformations, and remediation

(2009) Virender K. Sharma et al.   ENVIRONMENT INTERNATIONAL

Darinaparsin: a novel organic arsenical with promising anticancer activity

(2009) Koren K Mann et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Induction of Metallothionein I by Arsenic via Metal-activated Transcription Factor 1

(2009) Xiaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells

(2009) John T. Butler et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2

(2009) X. He et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synergy between Proteasome Inhibitors and Imatinib Mesylate in Chronic Myeloid Leukemia

(2009) Zheng Hu et al.   PLoS One

A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia

(2009) Q.-Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

(2009) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic Activates EGFR Pathway Signaling in the Lung

(2009) Angeline S. Andrew et al.   TOXICOLOGICAL SCIENCES

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways

(2008) P. Lunghi et al.   BLOOD

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

Arsenite alters global histone H3 methylation

(2008) X. Zhou et al.   CARCINOGENESIS

Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study

(2008) JE Chang et al.   HEMATOLOGICAL ONCOLOGY

Arsenic Trioxide Augments Chk2/p53-mediated Apoptosis by Inhibiting Oncogenic Wip1 Phosphatase

(2008) Akinori Yoda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic trioxide, thalidomide and retinoid acid combination therapy in higher risk myelodysplastic syndrome patients

(2007) Wen-Li Zheng et al.   LEUKEMIA RESEARCH