The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease

ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells

(2019) Brad Griesenauer et al.   JOURNAL OF IMMUNOLOGY

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

(2019) Ya-Yuan Fu et al.   IMMUNITY

Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease

(2019) Wei Huang et al.   Frontiers in Immunology

Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance

(2019) Benson M. George et al.   Cell Stem Cell

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

(2018) Masao Hashimoto et al.   Annual Review of Medicine

New Insights into Graft-Versus-Host Disease and Graft Rejection

(2018) Eric Perkey et al.   Annual Review of Pathology-Mechanisms of Disease

Unexpected High Incidence of Human Herpesvirus-6 Encephalitis After Naive T Cell-Depleted Graft of Haploidentical Stem Cell Transplantation in Pediatric Patients

(2018) Sisinni L et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

High gastrointestinal microbial diversity and clinical outcome in graft-versus-host disease patients

(2018) Florent Malard et al.   BONE MARROW TRANSPLANTATION

Flt-3L Expansion of Recipient CD8α+Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD

(2018) Kate A. Markey et al.   CLINICAL CANCER RESEARCH

Myeloma-escape after stem cell transplantation is a consequence of T cell exhaustion and is prevented by TIGIT blockade

(2018) Simone A. Minnie et al.   BLOOD

Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts

(2018) Jonathan E. Wosen et al.   Frontiers in Immunology

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

(2018) Moshe Biton et al.   CELL

Microbiome: An Emerging New Frontier in Graft-Versus-Host Disease

(2018) Reena Kumari et al.   DIGESTIVE DISEASES AND SCIENCES

GM-CSF therapy inhibits chronic graft-versus-host disease via expansion of regulatory T cells

(2018) Masaaki Hotta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

(2018) Matthew J. Christopher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity

(2017) Catherine Matte-Martone et al.   JOURNAL OF CLINICAL INVESTIGATION

R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

(2017) Eiko Hayase et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

(2016) Lucie Leveque-El mouttie et al.   BLOOD

Alloantigen presentation and graft-versus-host disease: fuel for the fire

(2016) M. Koyama et al.   BLOOD

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy

(2016) Akanksha Chhabra et al.   Science Translational Medicine

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

(2016) Yusuke Shono et al.   Science Translational Medicine

Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans

(2015) H. Nakasone et al.   BLOOD

Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts

(2015) Marie Bleakley et al.   JOURNAL OF CLINICAL INVESTIGATION

Donor colonic CD103+dendritic cells determine the severity of acute graft-versus-host disease

(2015) Motoko Koyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey

(2015) R Zeiser et al.   LEUKEMIA

Endogenous antigen processing drives the primary CD4+ T cell response to influenza

(2015) Michael A Miller et al.   NATURE MEDICINE

Host-Derived CD8+ Dendritic Cells Protect Against Acute Graft-versus-Host Disease after Experimental Allogeneic Bone Marrow Transplantation

(2014) Michael Weber et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease

(2014) Kylie A. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon-γ Induces Expression of MHC Class II on Intestinal Epithelial Cells and Protects Mice from Colitis

(2014) Christoph Thelemann et al.   PLoS One

Complete Suppression of the Gut Microbiome Prevents Acute Graft-Versus-Host Disease following Allogeneic Bone Marrow Transplantation

(2014) Jaak M. Vossen et al.   PLoS One

The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo

(2013) A. Heine et al.   BLOOD

Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow

(2013) I. Milo et al.   BLOOD

HLA class II upregulation during viral infection leads to HLA-DP-directed graft-versus-host disease after CD4+ donor lymphocyte infusion

(2013) S. Stevanovi  et al.   BLOOD

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

The Early Activation Marker CD69 Regulates the Expression of Chemokines and CD4 T Cell Accumulation in Intestine

(2013) Katarina Radulovic et al.   PLoS One

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

Allospecific CD4+ Effector Memory T Cells Do Not Induce Graft-versus-Host Disease in Mice

(2012) Ping Zhang et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

(2012) K. A. Markey et al.   BLOOD

Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of  -defensins

(2012) Y. Eriguchi et al.   BLOOD

Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction

(2012) H. Li et al.   JOURNAL OF IMMUNOLOGY

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Durable donor engraftment after radioimmunotherapy using  -emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation

(2011) Y. Chen et al.   BLOOD

Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen

(2011) B. C. Betts et al.   BLOOD

Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells

(2011) T. Toubai et al.   BLOOD

Risk factors for acute GVHD and survival after hematopoietic cell transplantation

(2011) M. Jagasia et al.   BLOOD

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

(2011) M. Srinivasan et al.   BLOOD

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

(2011) Daigo Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Graft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL Resistant

(2011) C. Matte-Martone et al.   JOURNAL OF IMMUNOLOGY

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

(2011) Motoko Koyama et al.   NATURE MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells

(2010) M. Bleakley et al.   BLOOD

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma

(2010) G. R. Hill et al.   BLOOD

Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice

(2010) Shoji Asakura et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation

(2010) Ken-ichi Matsuoka et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: MHC Class II Expression by Pulmonary Nonhematopoietic Cells Plays a Critical Role in Controlling Local Inflammatory Responses

(2010) D. Kreisel et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells

(2010) H. Li et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells

(2009) M. Koyama et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

T Cell Allorecognition via Molecular Mimicry

(2009) Whitney A. Macdonald et al.   IMMUNITY

Central Memory CD8 + T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia

(2009) Hong Zheng et al.   JOURNAL OF IMMUNOLOGY

Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

(2009) Luca Vago et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alveolar Type II Epithelial Cells Present Antigen to CD4+T Cells and Induce Foxp3+Regulatory T Cells

(2008) Marcus Gereke et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

(2008) P. A. Taylor et al.   BLOOD

A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells

(2008) Kristin Hochweller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY