Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients

(2019) Denis Migliorini et al.   NEURO-ONCOLOGY

Phase 1 Immunotherapy Trial with Two Chimeric HER-2 B-Cell Peptide Vaccines emulsified in Montanide ISA 720VG and nor-MDP Adjuvant in Advanced Solid Tumors

(2019) Tanios Bekaii-Saab et al.   CLINICAL CANCER RESEARCH

Recent advance in polymer based microspheric systems for controlled protein and peptide delivery

(2019) Yuanyuan Yang et al.   CURRENT MEDICINAL CHEMISTRY

SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations

(2019) Ruchi Pandey et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined Vaccination with NY-ESO-1 Protein, Poly-ICLC, and Montanide Improves Humoral and Cellular Immune Responses in Patients with High-Risk Melanoma

(2019) Anna Pavlick et al.   Cancer Immunology Research

Vaccine therapy in hematologic malignancies

(2018) David Avigan et al.   BLOOD

Immune checkpoint molecules in acute myeloid leukaemia: managing the double-edged sword

(2018) Willemijn Hobo et al.   BRITISH JOURNAL OF HAEMATOLOGY

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

(2018) Tamara Maes et al.   CANCER CELL

Novel approaches to acute myeloid leukemia immunotherapy

(2018) Ofrat Beyar-Katz et al.   CLINICAL CANCER RESEARCH

A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia

(2018) Yiran Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel

(2018) David Porter et al.   Journal of Hematology & Oncology

A facile approach to enhance antigen response for personalized cancer vaccination

(2018) Aileen Weiwei Li et al.   NATURE MATERIALS

A dual-function epidermal growth factor receptor pathway substrate 8 (Eps8)-derived peptide exhibits a potent cytotoxic T lymphocyte-activating effect and a specific inhibitory activity

(2018) Xiaoling Xie et al.   Cell Death & Disease

Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs

(2018) Jianyu Li et al.   Advanced Healthcare Materials

Programming CAR-T cells to kill cancer

(2018) Louai Labanieh et al.   Nature Biomedical Engineering

Immunotherapy in acute myeloid leukemia and myelodysplastic syndromes: The dawn of a new era?

(2018) Yuxin Liu et al.   BLOOD REVIEWS

Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy

(2018) Shouheng Lin et al.   mAbs

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

(2018) Quanyin Hu et al.   Nature Biomedical Engineering

Checkpoint inhibition in the bone marrow

(2018) Martina Seiffert   Nature Biomedical Engineering

Checkpoint inhibitors in hematological malignancies

(2017) Chi Young Ok et al.   Journal of Hematology & Oncology

Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia

(2017) Mingxue Fan et al.   Journal of Hematology & Oncology

Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma

(2017) J Bae et al.   LEUKEMIA

Immunotherapy: Cancer vaccines on the move

(2017) Jacques Banchereau et al.   Nature Reviews Clinical Oncology

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

(2017) Henrik Jespersen et al.   Nature Communications

Polylactic acid (PLA) controlled delivery carriers for biomedical applications

(2016) Betty Tyler et al.   ADVANCED DRUG DELIVERY REVIEWS

Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery

(2016) Balaji Narasimhan et al.   Annual Review of Biomedical Engineering

Introduction to a review series on advances in cell-based immune therapeutics in hematology

(2016) Catherine M. Bollard et al.   BLOOD

Beyond antigens and adjuvants: formulating future vaccines

(2016) Tyson J. Moyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

(2016) Partow Kebriaei et al.   JOURNAL OF CLINICAL INVESTIGATION

PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies

(2016) M H Qazilbash et al.   LEUKEMIA

Rekindling cancer vaccines

(2016) Malorye Allison Branca   NATURE BIOTECHNOLOGY

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions

(2016) J. Rosenblatt et al.   Science Translational Medicine

Peptide-based synthetic vaccines

(2016) Mariusz Skwarczynski et al.   Chemical Science

How I treat refractory and early relapsed acute myeloid leukemia

(2015) F. Thol et al.   BLOOD

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients--Report of a Phase I/IIa Clinical Trial

(2015) A. Legat et al.   CLINICAL CANCER RESEARCH

Therapeutic cancer vaccines

(2015) Cornelis J.M. Melief et al.   JOURNAL OF CLINICAL INVESTIGATION

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Generation of cytotoxic T lymphocytes specific for native or modified peptides derived from the epidermal growth factor receptor pathway substrate 8 antigen

(2014) Yuhua Li et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptide-based vaccines for cancer therapy

(2014) Giorgio Parmiani et al.   Human Vaccines & Immunotherapeutics

Injectable, porous, and cell-responsive gelatin cryogels

(2013) Sandeep T. Koshy et al.   BIOMATERIALS

Leukemia-associated antigens and their relevance to the immunotherapy of acute myeloid leukemia

(2012) S Anguille et al.   LEUKEMIA

Next-generation leukemia immunotherapy

(2011) K. Vincent et al.   BLOOD

Peptide vaccine therapy for leukemia

(2011) K. Rezvani   INTERNATIONAL JOURNAL OF HEMATOLOGY

Acid-Sensing Ion Channels Contribute to the Effect of Acidosis on the Function of Dendritic Cells

(2011) J. Tong et al.   JOURNAL OF IMMUNOLOGY

Long-term WT1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease

(2011) A Tsuboi et al.   LEUKEMIA

Integrity of SOS1/EPS8/ABI1 Tri-Complex Determines Ovarian Cancer Metastasis

(2010) H. Chen et al.   CANCER RESEARCH

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML)

(2009) I. M. Borrello et al.   BLOOD

Acceptable Donor-Specific Antibody Levels Allowing for Successful Deceased and Living Donor Kidney Transplantation After Desensitization Therapy

(2008) Nancy L. Reinsmoen et al.   TRANSPLANTATION