Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Adaptive immunity to SARS-CoV-2 and COVID-19

(2021) Alessandro Sette et al.   CELL

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

(2021) Els Wauters et al.   CELL RESEARCH

Early induction of functional SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

(2021) Anthony T. Tan et al.   Cell Reports

Dysregulated host response in SARS-CoV-2 induced critical illness

(2021) Shilpa Tiwari-Heckler et al.   Open Forum Infectious Diseases

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

(2021) Nina Le Bert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Praktische Aspekte von COVID-19-Obduktionen

(2021) Peter Boor et al.   PATHOLOGE

T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19

(2021) Olatz Zenarruzabeitia et al.   Frontiers in Immunology

Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses

(2021) Stephan Schlickeiser et al.   Frontiers in Immunology

Cellsnp-lite: an efficient tool for genotyping single cells

(2021) Xianjie Huang et al.   BIOINFORMATICS

Activation of classical and alternative complement pathways in the pathogenesis of lung injury in COVID-19

(2021) Abhigyan Satyam et al.   CLINICAL IMMUNOLOGY

Complement cascade in severe forms of COVID‐19: Recent advances in therapy

(2021) Nassima Chouaki Benmansour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Endothelial cell, myeloid, and adaptive immune responses in SARS‐CoV‐2 infection

(2021) Nicolas Degauque et al.   FASEB JOURNAL

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.

(2021) Laura Bergamaschi et al.   IMMUNITY

Characterization of T lymphocytes in severe COVID‐19 patients

(2021) Daniela Fenoglio et al.   JOURNAL OF MEDICAL VIROLOGY

The spatial landscape of lung pathology during COVID-19 progression

(2021) André F. Rendeiro et al.   NATURE

Single-cell multi-omics analysis of the immune response in COVID-19

(2021) Emily Stephenson et al.   NATURE MEDICINE

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

(2021) Willianne Hoepel et al.   Science Translational Medicine

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

(2021) György Sinkovits et al.   Frontiers in Immunology

SARS‐CoV‐2 RNA screening in routine pathology specimens

(2021) Saskia Stillfried et al.   Microbial Biotechnology

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

(2021) Bingyu Yan et al.   Science Immunology

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

(2021) Lina Ma et al.   Science Immunology

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

(2021) Benjamin Krämer et al.   IMMUNITY

Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients

(2021) Jonathan Youngs et al.   PLoS Pathogens

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality

(2021) Federica Defendi et al.   Frontiers in Immunology

A time-resolved proteomic and prognostic map of COVID-19

(2021) Vadim Demichev et al.   Cell Systems

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients

(2021) Dickson W. L. Wong et al.   Cells

The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

(2020) Julia L. McKechnie et al.   Cell Host & Microbe

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure

(2020) Lola Jacquemont et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

(2020) Sara Mastaglio et al.   CLINICAL IMMUNOLOGY

Rationale for targeting complement in COVID‐19

(2020) Anastasia Polycarpou et al.   EMBO Molecular Medicine

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)

(2020) Florian Kurth et al.   INFECTION

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

Single-cell landscape of immunological responses in patients with COVID-19

(2020) Ji-Yuan Zhang et al.   NATURE IMMUNOLOGY

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

(2020) Christoph B. Messner et al.   Cell Systems

Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment

(2020) Uma Shanmugasundaram et al.   JCI Insight

Immunopathology of Hyperinflammation in COVID-19

(2020) Joshua N. Gustine et al.   AMERICAN JOURNAL OF PATHOLOGY

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

COVID-19-neutralizing antibodies predict disease severity and survival

(2020) Wilfredo F. Garcia-Beltran et al.   CELL

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput

(2019) Vadim Demichev et al.   NATURE METHODS

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Minimizing Batch Effects in Mass Cytometry Data

(2019) Ronald P. Schuyler et al.   Frontiers in Immunology

Complement and the Regulation of T Cell Responses

(2018) Erin E. West et al.   Annual Review of Immunology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Invariant Natural Killer T Cell Subsets—More Than Just Developmental Intermediates

(2018) S. Harsha Krovi et al.   Frontiers in Immunology

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism

(2018) Giuseppina Arbore et al.   Nature Communications

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

(2017) A E Oja et al.   Mucosal Immunology

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Syntaxin 4 mediates endosome recycling for lytic granule exocytosis in cytotoxic T-lymphocytes

(2017) Waldo A. Spessott et al.   TRAFFIC

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol

(2016) Anders H. Kverneland et al.   CYTOMETRY PART A

Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1

(2016) Mehul Sharma et al.   FEBS Journal

Complement-Mediated Regulation of Metabolism and Basic Cellular Processes

(2016) Christoph Hess et al.   IMMUNITY

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Elevated Numbers of Fc RIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

(2014) N. K. Bjorkstrom et al.   JOURNAL OF IMMUNOLOGY

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Malaria Inhibits Surface Expression of Complement Receptor 1 in Monocytes/Macrophages, Causing Decreased Immune Complex Internalization

(2013) C. Fernandez-Arias et al.   JOURNAL OF IMMUNOLOGY

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

FcγRIIIa (CD16) Induction on Human T Lymphocytes and CD16pos T-Lymphocyte Amplification

(2011) Béatrice Clémenceau et al.   JOURNAL OF IMMUNOTHERAPY

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

(2011) Peng Qiu et al.   NATURE BIOTECHNOLOGY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune complex clearance by complement receptor type 1 in SLE

(2008) Maria Kavai   AUTOIMMUNITY REVIEWS

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY