Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

(2020) Yajing Fu et al.   VIROLOGICA SINICA

Will Complement Inhibition Be the New Target in Treating COVID-19–Related Systemic Thrombosis?

(2020) Courtney M. Campbell et al.   CIRCULATION

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

(2020) Christopher M Petrilli et al.   BMJ-British Medical Journal

C3 and ACE1 polymorphisms are more important confounders in the spread and outcome of COVID-19 in comparison with ABO polymorphism

(2020) Joris R Delanghe et al.   European Journal of Preventive Cardiology

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

(2020) Sara Mastaglio et al.   CLINICAL IMMUNOLOGY

Endothelial Injury and Thrombotic Microangiopathy in COVID-19: Treatment with the Lectin-Pathway Inhibitor Narsoplimab

(2020) Alessandro Rambaldi et al.   IMMUNOBIOLOGY

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection

(2020) Vijendra Ramlall et al.   NATURE MEDICINE

A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial

(2020) Keisha Smith et al.   Trials

Combination of Ruxolitinib and Eculizumab for Treatment of Severe SARS-CoV-2-Related Acute Respiratory Distress Syndrome: A Controlled Study

(2020) Valentina Giudice et al.   Frontiers in Pharmacology

Az első két sikeres, convalescens friss fagyasztott plazmával történő terápia hazai alkalmazása intenzív osztályon kezelt, kritikus állapotú, COVID–19-fertőzésben szenvedő betegekben.

(2020) Ilona Bobek et al.   ORVOSI HETILAP

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

(2020) Jia Yu et al.   BLOOD

Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19

(2020) Jeffrey Laurence et al.   CLINICAL IMMUNOLOGY

Complement activation in the disease course of COVID-19 and its effects on clinical outcomes

(2020) Aline H de Nooijer et al.   JOURNAL OF INFECTIOUS DISEASES

Eculizumab treatment for renal failure in a pediatric patient with COVID-19

(2020) Ruchi Mahajan et al.   JOURNAL OF NEPHROLOGY

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

(2020) Luca Perico et al.   Nature Reviews Nephrology

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

(2020) Jan C. Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients

(2020) Michael Hultström et al.   THROMBOSIS AND HAEMOSTASIS

Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin System

(2020) Pascal Urwyler et al.   Frontiers in Immunology

Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: A retrospective cohort study

(2020) Shilin Fang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Complement analysis in the era of targeted therapeutics

(2018) Zoltán Prohászka et al.   MOLECULAR IMMUNOLOGY

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Complement analysis 2016: Clinical indications, laboratory diagnostics and quality control

(2016) Zoltán Prohászka et al.   IMMUNOBIOLOGY

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement activation in thrombotic thrombocytopenic purpura

(2012) M. RÉTI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

(2011) M. Heurich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traitors of the immune system—Enhancing antibodies in HIV infection: Their possible implication in HIV vaccine development

(2008) Zoltán Beck et al.   VACCINE