Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Authors
Keywords
-
Journal
Science Immunology
Volume 6, Issue 59, Pages eabh2259
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-05-14
DOI
10.1126/sciimmunol.abh2259
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial
- (2021) Eli Mansour et al. Trials
- Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)
- (2021) Jeroen J. A. van Kampen et al. Nature Communications
- Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19
- (2021) Davide Scozzi et al. JCI Insight
- Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19
- (2021) Luca Valenti et al. JOURNAL OF AUTOIMMUNITY
- The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System
- (2021) Miklós Lipcsey et al. Frontiers in Immunology
- A neutrophil activation signature predicts critical illness and mortality in COVID-19
- (2021) Matthew L. Meizlish et al. Blood Advances
- Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
- (2021) Andrea R. Daamen et al. Scientific Reports
- SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
- (2021) Bingyu Yan et al. Science Immunology
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells
- (2020) Martin Kolev et al. IMMUNITY
- Immunology of COVID-19: current state of the science
- (2020) Nicolas Vabret et al. IMMUNITY
- Complement activation in patients with COVID-19: A novel therapeutic target
- (2020) Massimo Cugno et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Impaired Cellular Immune Responses During the First Week of Severe Acute Influenza Infection
- (2020) Jackson S Turner et al. JOURNAL OF INFECTIOUS DISEASES
- Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
- (2020) Maximilian Ackermann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases
- (2020) Cynthia Magro et al. Translational Research
- Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans
- (2020) Sharon E Fox et al. Lancet Respiratory Medicine
- Diagnostic and Prognostic Significance of Complement in Patients with Alcohol‐associated Hepatitis
- (2020) Xiude Fan et al. HEPATOLOGY
- Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)
- (2020) W. Joost Wiersinga et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
- (2020) Benjamin T Bradley et al. LANCET
- Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study
- (2020) Luca Carsana et al. LANCET INFECTIOUS DISEASES
- Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis
- (2020) Julien Carvelli et al. NATURE
- Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
- (2020) Vijendra Ramlall et al. NATURE MEDICINE
- Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study
- (2020) George Goshua et al. Lancet Haematology
- Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
- (2020) Christoph B. Messner et al. Cell Systems
- Severe immunosuppression and not a cytokine storm characterize COVID-19 infections
- (2020) Kenneth E. Remy et al. JCI Insight
- Local complement activation is associated with primary graft dysfunction after lung transplantation
- (2020) Hrishikesh S. Kulkarni et al. JCI Insight
- The complement system in COVID-19: friend and foe?
- (2020) Anuja Java et al. JCI Insight
- Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
- (2020) Jia Yu et al. BLOOD
- Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
- (2020) Panagiotis Skendros et al. JOURNAL OF CLINICAL INVESTIGATION
- Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies
- (2020) Ting Zhou et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
- (2020) Luca Perico et al. Nature Reviews Nephrology
- Transcriptional and proteomic insights into the host response in fatal COVID-19 cases
- (2020) Meng Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
- (2020) Jan C. Holter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes
- (2020) Daniel E Leisman et al. Lancet Respiratory Medicine
- Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV): A structured summary of a study protocol for a randomised controlled trial
- (2020) Jozefien Declercq et al. Trials
- Comparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with covid-19 and seasonal influenza: cohort study
- (2020) Yan Xie et al. BMJ-British Medical Journal
- Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations
- (2020) Caroline Diorio et al. Blood Advances
- The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?
- (2018) Hrishikesh S. Kulkarni et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Kallikrein Cleaves C3 and Activates Complement
- (2017) Sarah Irmscher et al. Journal of Innate Immunity
- A novel “complement-metabolism-inflammasome axis” as a key regulator of immune cell effector function
- (2016) Giuseppina Arbore et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Effect of Blood Sampling, Processing, and Storage on the Measurement of Complement Activation Biomarkers
- (2015) Shangbin Yang et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- C3a modulates IL-1 secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
- (2013) E. Asgari et al. BLOOD
- Biospecimen Reporting for Improved Study Quality (BRISQ)
- (2011) Helen M. Moore et al. JOURNAL OF PROTEOME RESEARCH
- A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms
- (2010) Y. Zhou et al. JOURNAL OF VIROLOGY
- Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA
- (2009) J. Zhang et al. JOURNAL OF GENERAL VIROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started