Article
Chemistry, Multidisciplinary
Shuting Jiang, Yueqi Ni, Fanyu Zhang, Yiling Duan, Haoning Qi, Wenting Mo, Qinchao Tang, Richard J. Miron, Yufeng Zhang
Summary: Zirconium implants are favored by clinicians for their superior mechanical properties, although they have poorer early osseointegration compared to titanium implants. The mechanism for the higher inflammation caused by zirconia implants is currently unknown. This study demonstrates that zirconium oxide triggers complement activation, leading to differences in inflammation compared to titanium oxide. The results provide new insights for implant design and optimization.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, Research & Experimental
Megha Srinivas, Preeti Sharma, Siddharth Jhunjhunwala
Summary: Research findings suggest that immune cells can phagocytose particles under constant fluidic flow. Different cell types show similar or better uptake rates under flow conditions. Even in the presence of crowded red blood cells, neutrophils and monocytes are able to uptake particles while flowing.
MOLECULAR PHARMACEUTICS
(2021)
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Huayang Wang, Qianqian Shao, Jiaoyang Wang, Lei Zhao, Liyang Wang, Zhiqiang Cheng, Congbo Yue, Wendan Chen, Hongchun Wang, Yi Zhang
Summary: This study found that CXCR2 expression decreases in circulating monocytes of patients with colorectal cancer (CRC) and is negatively associated with systemic inflammatory markers and positively associated with intratumoural immunocyte infiltration. The pro-inflammatory cytokine IFN-gamma downregulates CXCR2 expression of monocytes/TAMs by promoting GRK-2 expression. The CXCR2 signaling pathway is important for the chemotaxis of monocytes and their responsiveness to LPS stimulation. Monocytes with decreased CXCR2 expression show distinct phenotypes and functions after differentiating into TAMs.
Article
Immunology
Emily Fraser, Laura Denney, Agne Antanaviciute, Karl Blirando, Chaitanya Vuppusetty, Yuejuan Zheng, Emmanouela Repapi, Valentina Iotchkova, Stephen Taylor, Neil Ashley, Victoria St Noble, Rachel Benamore, Rachel Hoyles, Colin Clelland, Joseph M. D. Rastrick, Clare S. Hardman, Nasullah K. Alham, Rachel E. Rigby, Alison Simmons, Jan Rehwinkel, Ling-Pei Ho
Summary: Monocytes in idiopathic pulmonary fibrosis (IPF) patients exhibit a distinct immunophenotype from age-matched controls, with an activated type I interferon pathway that may contribute to driving chronic inflammation and fibrosis. These findings strengthen the potential role of monocytes in the pathogenesis of IPF.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aida Dama, Chiara Baggio, Carlotta Boscaro, Mattia Albiero, Andrea Cignarella
Summary: Estrogen receptor activity plays a crucial role in mediating various physiological processes in the cardiovascular system. Gender and hormonal factors have significant impacts on endothelial biology, particularly in cardiometabolic risk post-menopause. Additionally, estrogen pathways regulate angiogenesis through complex mechanisms and influence other cell types like monocytes and macrophages, offering potential therapeutic solutions for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Sabrina Geisberger, Hendrik Bartolomaeus, Patrick Neubert, Ralf Willebrand, Christin Zasada, Thomas Bartolomaeus, Victoria McParland, Dries Swinnen, Anneleen Geuzens, Andras Maifeld, Luka Krampert, Marion Vogl, Anja Mahler, Nicola Wilck, Lajos Marko, Ekin Tilic, Sofia K. Forslund, Katrina J. Binger, Johannes Stegbauer, Ralf Dechend, Markus Kleinewietfeld, Jonathan Jantsch, Stefan Kempa, Dominik N. Mueller
Summary: Research shows that high salt intake leads to intracellular sodium accumulation, inhibiting mitochondrial respiration in macrophages and affecting immune cell function. While these changes may help resolve bacterial infections, they could also accelerate the development of inflammatory cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Yuling Chen, Timo Gaber
Summary: Oxygen availability varies in the human body, impacting immune cell function through transcriptional regulation by HIFs. Severe hypoxia under pathophysiological conditions can lead to dysfunctional immune response and tissue damage.
Article
Critical Care Medicine
Relber A. Goncales, Helder Novais Bastos, Claudio Duarte-Oliveira, Daniela Antunes, Oksana Sokhatska, Maria Jacob, Rui Rolo, Claudia F. Campos, Sergio D. Sasaki, Alessia Donato, Sarah N. Mapelli, Sandra Costa, Conceicao Souto Moura, Luis Delgado, Antonio Morais, Egidio Torrado, Frank L. van de Veerdonk, Thomas Weichhart, John D. Lambris, Ricardo Silvestre, Cecilia Garlanda, Alberto Mantovani, Cristina Cunha, Agostinho Carvalho
Summary: This study reveals the role of long pentraxin PTX3 in sarcoidosis, finding that its deficiency can lead to amplified complement activation and promote granuloma formation. The results suggest that PTX3 plays a pivotal role in macrophages to restrain granulomatous inflammation and this signaling axis holds therapeutic potential for targeting granuloma formation in sarcoidosis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Marc A. Fernandez-Yague, Lauren A. Hymel, Claire E. Olingy, Claire McClain, Molly E. Ogle, Jose R. Garcia, Dustin Minshew, Sofiya Vyshnya, Hong Seo Lim, Peng Qiu, Andres J. Garcia, Edward A. Botchwey
Summary: Understanding the immune response to hydrogel implantation is crucial for designing immunomodulatory biomaterials. Through the use of advanced techniques such as high-dimensional flow cytometry and intravital imaging, the study found that RGD-presenting hydrogels can promote cellular infiltration and revascularization, and can direct the immune response through controlling macrophage cytokine secretion.
Article
Pharmacology & Pharmacy
Yanqin Li, Xuan Li, Xu Chen, Xiaoqian Sun, Xiangning Liu, Gang Wang, Yizhou Liu, Lingwen Cui, Tianhua Liu, Wei Wang, Yong Wang, Chun Li
Summary: Qishen granule has been proven to be effective in treating heart failure in China by regulating splenic monocytes release and myocardial inflammatory response through the TLR4-MyD88-NF-κB pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
John P. Hussman
Summary: Infection by the novel SARS-CoV-2 coronavirus can lead to a range of outcomes, with severe cases possibly involving expanded viral tropism to inflammatory monocytes and macrophages, causing dysregulated immune responses. Severe clinical deterioration in COVID-19 patients may be influenced by various factors including hyperinflammatory monocyte response, release of neutrophil extracellular traps, thrombosis, and viral entry into immune cells expressing Fc gamma receptors.
FRONTIERS IN MEDICINE
(2021)
Article
Hematology
Yajing Zhao, Pengcheng Xu, Li Guo, Haoyi Wang, Yanan Min, Qi Feng, Yu Hou, Tao Sun, Guosheng Li, Xuebin Ji, Jihua Qiu, Jun Peng, Xinguang Liu, Ming Hou
Summary: The study found increased proinflammatory CD16(+) monocytes in peripheral blood of ITP patients and elevated TNF-alpha-expressing macrophages in the spleen. TNF-alpha blockade reduced the number and function of proinflammatory subsets of monocytes and macrophages, leading to remarkable attenuation of antibody-mediated platelet destruction.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Immunology
Inderjeet Kalia, Rajesh Anand, Afshana Quadiri, Shreya Bhattacharya, Bijayalaxmi Sahoo, Agam Prasad Singh
Summary: By manipulating macrophages, the Plasmodium parasite evades host immune responses, utilizing the PbTIP protein released in the host bloodstream to suppress inflammation and upregulate anti-inflammatory cytokines, ultimately leading to successful infection in the host.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Jinzhong Niu, Fenglei Wu, Yu Huang, Jufen Tang, Bei Wang, Yishan Lu, Jia Cai, Jichang Jian
Summary: The OnHMGB1 gene was identified and characterized in Nile tilapia, and plays a crucial role in immune response, especially against pathogen infection.
AQUACULTURE REPORTS
(2021)
Article
Chemistry, Medicinal
Swapna Varghese, Raphael Rahmani, Stephanie Russell, Girdhar Singh Deora, Lori Ferrins, Arthur Toynton, Amy Jones, Melissa Sykes, Albane Kessler, Amanda Eufrasio, Artur Torres Cordeiro, Julian Sherman, Ana Rodriguez, Vicky M. Avery, Matthew J. Piggott, Jonathan B. Baell
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Infectious Diseases
Juan Rivera-Correa, Isadora Cristina de Siqueira, Sabrina Mota, Mateus Santana do Rosario, Pedro Antonio Pereira de Jesus, Luiz Carlos Junior Alcantara, Joel D. Ernst, Ana Rodriguez
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Chemistry, Medicinal
Justin R. Harrison, Sandipan Sarkar, Shahienaz Hampton, Jennifer Riley, Laste Stojanovski, Christer Sahlberg, Pia Appelqvist, Jessey Erath, Vinodhini Mathan, Ana Rodriguez, Marcel Kaiser, Dolores Gonzalez Pacanowska, Kevin D. Read, Nils Gunnar Johansson, Ian H. Gilbert
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Parasitology
Juan Rivera-Correa, Ana Rodriguez
TRENDS IN PARASITOLOGY
(2020)
Article
Chemistry, Medicinal
Baljinder Singh, Jean A. Bernatchez, Laura-Isobel McCall, Claudia M. Calvet, Jasmin Ackermann, Julia M. Souza, Diane Thomas, Everton M. Silva, Kelly A. Bachovchin, Dana M. Klug, Hitesh B. Jalani, Seema Bag, Melissa J. Buskes, Susan E. Leed, Norma E. Roncal, Erica C. Penn, Jessey Erath, Ana Rodriguez, Richard J. Sciotti, Robert F. Campbell, James McKerrow, Jair L. Siqueira-Neto, Lori Ferrins, Michael P. Pollastri
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Infectious Diseases
Juan Rivera-Correa, Maria Fernanda Yasnot-Acosta, Nubia Catalina Tovar, Maria Camila Velasco-Pareja, Alice Easton, Ana Rodriguez
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Parasitology
Alba Martinez-Florez, Melina Galizzi, Luis Izquierdo, Juan M. Bustamante, Ana Rodriguez, Fernando Rodriguez, Alheli Rodriguez-Cortes, Jordi Alberola
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2020)
Article
Microbiology
Alice Easton, Mayra Raciny-Aleman, Victor Liu, Erica Ruan, Christian Marier, Adriana Heguy, Maria Fernanda Yasnot, Ana Rodriguez, P'ng Loke
Article
Chemistry, Medicinal
Soledad Natalia Gonzalez, Jonathan J. Mills, Dante Maugeri, Christopher Olaya, Breana L. Laguera, Jeffrey R. Enders, Julian Sherman, Ana Rodriguez, Joshua G. Pierce, Juan Jose Cazzulo, Edward L. D'Antonio
Summary: The study discovered a competitive inhibitor Compound B targeting ribose 5-phosphate isomerase type B (RPI-B), which exhibited significant trypanocidal activity against T. cruzi infective life-stages. By targeting the active site residue Cys-69, this inhibitor provided a proof-of-concept for the development of next generation inhibitors with potential prodrug groups to treat Chagas' disease in the future.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Nieves Martinez-Peinado, Clara Martori, Nuria Cortes-Serra, Julian Sherman, Ana Rodriguez, Joaquim Gascon, Jordi Alberola, Maria-Jesus Pinazo, Alheli Rodriguez-Cortes, Julio Alonso-Padilla
Summary: The study found that 17-DMAG has a strong inhibitory effect on T. cruzi, particularly during the intracellular replicative stage of the parasite. Molecular docking results suggest that 17-DMAG may bind T. cruzi Hsp90 homologue Hsp83 with good affinity. However, evaluation in a mouse model of chronic T. cruzi infection did not show parasite growth inhibition, highlighting challenges in transitioning from in vitro assays to preclinical drug development stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Nieves Martinez-Peinado, Nuria Cortes-Serra, Julian Sherman, Ana Rodriguez, Juan M. Bustamante, Joaquim Gascon, Maria-Jesus Pinazo, Julio Alonso-Padilla
Summary: Chagas disease, caused by the parasite Trypanosoma cruzi, has its greatest burden in Latin America. Existing treatments present toxicity and variable efficacy, highlighting the urgent need for new therapeutic strategies. Drug repositioning offers a fast and low-cost approach to identify safer and more effective chemotherapies for Chagas disease.
Article
Chemistry, Medicinal
Scott B. Green, Robert J. Lanier Jr, Shane M. Carey, David R. Morgan, Hanna Gracz, Julian Sherman, Ana Rodriguez, Edward L. D'Antonio
Summary: The screening of eighteen amino sugar analogues against Trypanosoma cruzi glucokinase revealed five on-target confirmed inhibitors, all from the D-GlcN series. Four of these compounds were identified as strong TcGlcK inhibitors, while three showed significant in vitro anti-T. cruzi activity. Compounds 5 and 6 were further evaluated biochemically, with formal Ki values determined and exhibiting competitive inhibition mode for TcGlcK.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Letter
Respiratory System
Marisol Zuniga, Claudia Gomes, Steven E. Carsons, Michael T. Bender, Paolo Cotzia, Qing Robert Miao, David C. Lee, Ana Rodriguez
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Infectious Diseases
Juan Rivera-Correa, Joseph Verdi, Julian Sherman, Jeremy M. Sternberg, Jayne Raper, Ana Rodriguez
Summary: The study found evidence of autoimmunity against phosphatidylserine in Trypanosoma brucei infected mice and Human African Trypanosomiasis patients, suggesting a potential link between autoimmunity and anemia.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Medicine, Research & Experimental
Claudia Gomes, Rosauro Varo, Miquel Duran-Frigola, Antonio Sitoe, Rubio Bila, Sonia Machevo, Alfredo Mayor, Quique Bassat, Ana Rodriguez
Summary: Malaria can progress from an uncomplicated infection to a life-threatening severe disease. Early symptoms are often nonspecific, making it difficult to identify patients at high risk. By analyzing the transcriptomic response of human brain microvascular endothelial cells to Plasmodium falciparum-infected erythrocytes, several biomarkers have been identified to distinguish uncomplicated from severe malaria, as well as to differentiate children with cerebral malaria within the severe malaria group.