Review
Pharmacology & Pharmacy
Yaqun Li, Wenjie Zhao, Jinhua Liu, Zichao Chen, Qingtao Lv, Zhen Zhang
Summary: COVID-19 pneumonia, caused by SARS-CoV-2, has disrupted the pro-inflammatory/anti-inflammatory response, leading to a need to neutralize cytokine storm. Current treatments focus on vaccines for prevention and immunomodulatory therapies to alleviate immune imbalance, with antiviral drugs and respiratory support as clinical options.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Zarrilli, Valentina Angerilli, Gianluca Businello, Marta Sbaraglia, Giulia Traverso, Francesco Fortarezza, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Fiorella Calabrese, Angelo Paolo Dei Tos, Matteo Fassan
Summary: The histopathologic alterations in COVID-19 patients primarily occur in the lungs and blood vessels, with the highest clinical impact. However, many of the collected morphological data so far are nonspecific, erratic, and possibly associated with other co-existing factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jiayu Zhang, Xuejing Ma, Fuwei Liu, Deju Zhang, Jitao Ling, Zicheng Zhu, Yixuan Chen, Pingping Yang, Yanlin Yang, Xiao Liu, Jing Zhang, Jianping Liu, Peng Yu
Summary: 2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Severe cases of COVID-19 are associated with a cytokine storm, characterized by elevated levels of pro-inflammatory cytokines in the bloodstream. Recent studies have shown a higher severity of necrobiosis infection in diabetic patients, as well as higher morbidity and mortality in people with chronic metabolic diseases such as diabetes. Additionally, COVID-19 may result in hyperglycemia in infected individuals. This review explores the potential relationship between NLRP3 inflammatory vesicles in diabetes and COVID-19, and discusses the cellular/molecular mechanisms by which SARS-CoV-2 infection activates NLRP3 inflammatory vesicles. Finally, several promising targeted NLRP3 inflammatory vesicle inhibitors are proposed as a basis for clinical management of patients with diabetes combined with noncoronary pneumonia.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Charles Ochieng' Olwal, Nora Nghuchuzie Nganyewo, Kesego Tapela, Alexandra Lindsey Djomkam Zune, Oloche Owoicho, Yaw Bediako, Samuel Duodu
Summary: Sepsis and COVID-19 share many pathophysiological and clinical features, both leading to consumptive thrombocytopenia, coagulopathy, multi-organ dysfunction syndrome, respiratory failure, among other complications. Therefore, lessons learned from sepsis care could potentially inform on COVID-19 management.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Biying Hu, Shaoying Huang, Lianghong Yin
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang-Na Zhao, Yue You, Xiao-Ming Cui, Hui-Xia Gao, Guo-Lin Wang, Sheng-Bo Zhang, Lin Yao, Li-Jun Duan, Ka-Li Zhu, Yu-Ling Wang, Li Li, Jian-Hua Lu, Hai-Bin Wang, Jing-Fang Fan, Huan-Wei Zheng, Er-Hei Dai, Lu-Yi Tian, Mai-Juan Ma
Summary: By comparing the immune responses of asymptomatic and moderate patients, it was found that asymptomatic patients have specific immune characteristics in NK cells and effector T cells, with stronger TCR clonal expansion compared to moderate patients. Moderate patients exhibit varied magnitude and temporal dynamics of ISG expression across multiple cell populations but lower compared to patients with severe disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Qian-Fang Meng, Rui Tian, Haiyi Long, Xianjia Wu, Jialin Lai, Olga Zharkova, Jiong-Wei Wang, Xiaoyuan Chen, Lang Rao
Summary: The COVID-19 pandemic, caused by SARS-CoV-2, has had a significant impact on the global economy and daily life. Some patients develop severe symptoms and complications due to a cytokine storm induced by the virus. While neutralizing antibodies targeting inflammatory cytokines show promise, challenges remain in their application, sparking interest in new biomaterials and nanotechnology for potential therapeutic advancements. Researchers are working towards developing novel treatments to effectively manage COVID-19 and other inflammatory diseases.
ADVANCED MATERIALS
(2021)
Article
Immunology
Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Roering, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Athanasios Ziogas
Summary: Dexamethasone has anti-inflammatory effects in COVID-19 patients by inhibiting cytokine responses and interferon signaling pathways, which is beneficial for patients with severe symptoms but may have adverse effects on those with mild symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Hayder M. Al-kuraishy, Ali Ismail Al-Gareeb, Gomaa Mostafa-Hedeab, Keneth Iceland Kasozi, Gerald Zirintunda, Akhmed Aslam, Mamdouh Allahyani, Susan Christina Welburn, Gaber El-Saber Batiha
Summary: SARS-CoV-2 infection can lead to respiratory issues and excessive immune response, potentially resulting in multi-organ failure. The use of anti-inflammatory and anti-adrenergic agents can alleviate symptoms and prevent the development of a neural-cytokine loop.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Claude Kwe Yinda, Julia R. Port, Trenton Bushmaker, Irene Offei Owusu, Jyothi N. Purushotham, Victoria A. Avanzato, Robert J. Fischer, Jonathan E. Schulz, Myndi G. Holbrook, Madison J. Hebner, Rebecca Rosenke, Tina Thomas, Andrea Marzi, Sonja M. Best, Emmie de Wit, Carl Shaia, Neeltje van Doremalen, Vincent J. Munster
Summary: The study demonstrates that humanized transgenic mice developed dose-dependent disease when inoculated with SARS-CoV-2, showing upper and lower respiratory tract infection with viral replication also in the brain. The pathological and immunological manifestations observed in these mice resemble human COVID-19, suggesting the model's usefulness in elucidating COVID-19 pathogenesis and testing countermeasures.
Review
Immunology
Jun Wang, Qian Li, YuanWang Qiu, Hongzhou Lu
Summary: This article reviews the mechanisms of immune system imbalance and subsequent lung injury following COVID-19 virus infection. It is critical for the development of therapeutic agents and optimization of treatment strategies.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Immunology
Aliakbar Hasankhani, Abolfazl Bahrami, Bahareh Tavakoli-Far, Setare Iranshahi, Farnaz Ghaemi, Majid Reza Akbarizadeh, Ali H. Amin, Bahman Abedi Kiasari, Alireza Mohammadzadeh Shabestari
Summary: COVID-19 is a severe respiratory disease caused by SARS-CoV-2 infection. The hyperinflammatory response, characterized by cytokine storm, plays a crucial role in disease severity and mortality. Targeting key inflammatory factors, particularly PPARs, can be a potential therapeutic approach for controlling the hyperinflammatory response in severe COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Gustavo C. Paris, Aline A. Azevedo, Adriana L. Ferreira, Yanca M. A. Azevedo, Mateus A. Rainho, Genilza P. Oliveira, Karina R. Silva, Erika A. C. Cortez, Ana C. Stumbo, Simone N. Carvalho, Lais de Carvalho, Alessandra A. Thole
Summary: This article discusses the impact of the novel coronavirus on the lungs, kidneys, heart, vasculature, and central nervous system, as well as the therapeutic mechanisms of MSC in each tissue. Additionally, it explores the therapeutic effects of MSC in high-risk groups for COVID-19, such as obese, diabetic, and hypertensive patients.
Review
Medicine, Research & Experimental
Ajaikumar B. Kunnumakkara, Varsha Rana, Dey Parama, Kishore Banik, Sosmitha Girisa, Sahu Henamayee, Krishan Kumar Thakur, Uma Dutta, Prachi Garodia, Subash C. Gupta, Bharat B. Aggarwal
Summary: Spices with potent antioxidant and anti-inflammatory properties may help reduce COVID-19-associated complications and suppress cytokine storm. By regulating key molecular targets in inflammation, spices show potential for anti-inflammatory effects.
Review
Biochemistry & Molecular Biology
Man Wang, Wenguang Chang, Lei Zhang, Yuan Zhang
Summary: The review summarizes the interplay between SARS-CoV-2 infection and pyroptosis, a form of programmed cell death, highlighting the role of pyroptosis in COVID-19 immunopathogenesis. The review also discusses recent research advances in understanding the mechanisms linking pyroptosis and SARS-CoV-2 pathogenesis, and suggests the potential value of targeting pyroptosis as a therapeutic approach for COVID-19.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Immunology
Hakim Medjouel Khlifi, Sophie Guia, Eric Vivier, Emilie Narni-Mancinelli
Summary: NK cells are innate lymphoid cells that can directly kill tumor cells. They identify tumor cells through activating receptors and secrete cytokines and chemokines to shape the immune response. Targeting the activating receptors of NK cells has become an important strategy in immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Laura Chiossone, Eric Vivier
Summary: This article discusses the approaches developed to harness the anti-tumor function of NK cells and suggests promising strategies to enhance cancer immunotherapies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Laurent Gauthier, Angela Virone-Oddos, Jochen Beninga, Benjamin Rossi, Celine Nicolazzi, Celine Amara, Audrey Blanchard-Alvarez, Nicolas Gourdin, Jacqueline Courta, Alexandra Basset, Magali Agnel, Franceline Guillot, Gwendoline Grondin, Helene Bonnevaux, Anne-Laure Bauchet, Ariane Morel, Yannis Morel, Marielle Chiron, Eric Vivier
Summary: Researchers have developed a novel natural killer cell engager (NKCE) that targets leukemia cells and has potent antitumor activity without toxicity, suggesting its potential for clinical development.
NATURE BIOTECHNOLOGY
(2023)
Article
Cell Biology
Noella Lopes, Justine Galluso, Bertrand Escaliere, Sabrina Carpentier, Yann M. Kerdiles, Eric Vivier
Summary: NK cells and ILC1 are distinct populations of lymphocytes in peripheral tissues. This study used single-cell RNA sequencing and CITE-seq to explore the heterogeneity of NK and ILC1 between tissues. The researchers identified gene expression patterns specific to different subsets and markers to distinguish ILC1 from NK cells. This data provides valuable insights into the origin, phenotype, and biology of NK and ILC1 cells.
CELL REPORTS MEDICINE
(2022)
Letter
Critical Care Medicine
Julien Carvelli, Eric Vivier
CRITICAL CARE MEDICINE
(2023)
Review
Immunology
Noella Lopes, Eric Vivier, Emilie Narni-Mancinelli
Summary: The article introduces the developmental trajectory and cytokine production profile of innate lymphoid cells (ILCs). It describes the subsets, effector functions, and development of NK cells and ILC1s, and discusses their role in cancer and the effects of the tumor microenvironment on their metabolism.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Biology
Hanif J. Khameneh, Nicolas Fonta, Alessandro Zenobi, Charlene Niogret, Pedro Ventura, Concetta Guerra, Ivo Kwee, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Andrea Cavalli, Francesco Bertoni, Eric Vivier, Andreas Trumpp, Greta Guarda
Summary: This study reveals the importance of MYC in NK cells and its role in regulating translation and expansion, as well as anticancer immunity. Deficiency of MYC in NK cells results in reduced numbers and impaired cytotoxic functions of mature NK cells.
LIFE SCIENCE ALLIANCE
(2023)
Review
Immunology
Eve Playoust, Romain Remark, Eric Vivier, Pierre Milpied
Summary: B cells are crucial for immunity and are involved in affinity maturation and differentiation through B-cell receptor signals and signals from the microenvironment. They have been discovered to play important roles in antitumor responses in human cancers, but their dynamics and interplay are not well understood. B-cell responses involve both GC-dependent and GC-independent pathways, with affinity maturation occurring in GC reactions. Reactivation of high-affinity Bmem cells leads to the production of large numbers of PCs without BCR rediversification. Multiple tools and techniques are needed to understand B-cell dynamics in immune responses. Studying TIL-B cells and TIL-PC in solid tumors can provide insights for antitumor therapies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Meeting Abstract
Oncology
Laurent Greillier, Florence Monville, Vanina Leca, Frederic Vely, Stephane Garcia, Joseph Ciccolini, Florence Sabatier, Gilbert Ferrani, Nawel Boudai, Lamia Ghezali, Marcellin Landri, Clemence Marin, Mourad Hamimed, Laurent Arnaud, Melanie Karlsen, Kevin Atsou, Sivan Bokobza, Pauline Fleury, Arnaud Boyer, Clarisse Audigier-Valette, Stephanie Martinez, Herve Pegliasco, Patrice Ray, Lionel Falchero, Antoine Serre, Nicolas Cloarec, Louisiane Lebas, Stephane Hominal, Patricia Barre, Sarah Zahi, Ahmed Frikha, Pierre Bory, Maryannick Le Ray, Lilian Laborde, Virginie Martin, Richard Malkoun, Marie Roumieux, Julien Mazieres, Maurice Perol, Eric Vivier, Sebastien Benzekry, Jacques Fieschi, Fabrice Barlesi
Meeting Abstract
Hematology
Alexandre Tang, Laurent Gauthier, Jochen Beninga, Benjamin Rossi, Nicolas Gourdin, Audrey Blanchard-Alvarez, Celine Amara, Jacqueline Courta, Alexandra Basset, Dorothee Bourges, Alexandre Desjonqueres, Emmanuelle Menoret, Catherine Pellat-Deceunynck, Philippe Moreau, Yannis Morel, Marielle Chiron, Angela Virone-Oddos, Eric Vivier
Meeting Abstract
Hematology
Olivier Demaria, Guillaume Habif, Francois Le Floch, Laura Chiossone, Romain Remark, Marie Vetizou, Nadia Maurel, Laurent Gauthier, Yannis Morel, Carine Paturel, Eric Vivier, Pascale Andre
Article
Cell Biology
Olivier Demaria, Laurent Gauthier, Marie Vetizou, Audrey Blanchard Alvarez, Constance Vagne, Guillaume Habif, Luciana Batista, William Baron, Nourhene Belaid, Mathilde Girard-Madoux, Cedric Cesari, Melody Caratini, Frederic Bosco, Olivier Benac, Julie Lopez, Aurore Fenis, Justine Galluso, Sylvia Trichard, Barbara Carrette, Florent Carrette, Aurelie Maguer, Solene Jaubert, Audrey Sansaloni, Robin Letay-Drouet, Camille Kosthowa, Naouel Lovera, Arnaud Dujardin, Fabien Chanuc, Melanie Le Van, Sivan Bokobza, Nicolas Jarmuzynski, Camille Fos, Nicolas Gourdin, Romain Remark, Eric Lechevallier, Nicolas Fakhry, Sebastien Salas, Jean-Laurent Deville, Roger Le Grand, Cecile Bonnafous, Lukas Vollmy, Agnes Represa, Sabrina Carpentier, Benjamin Rossi, Ariane Morel, Stephanie Cornen, Ivan Perrot, Yannis Morel, Eric Vivier
Summary: This study presents the design of tetraspecific molecules that can activate natural killer cells for cancer therapy. The tetraspecific molecules selectively activate and proliferate natural killer cells, and the binding to tumor-associated antigens triggers cell cytotoxicity and cytokine production. In animal experiments, the tetraspecific molecules control tumor growth and accumulate at the tumor site. Furthermore, they can deplete circulating B cells without causing toxicity in non-human primates.
CELL REPORTS MEDICINE
(2022)
Article
Critical Care Medicine
Julien Carvelli, Ferhat Meziani, Jean Dellamonica, Pierre-Yves Cordier, Jerome Allardet-Servent, Megan Fraisse, Lionel Velly, Saber Davide Barbar, Samuel Lehingue, Christophe Guervilly, Maxime Desgrouas, Fabrice Camou, Christelle Piperoglou, Frederic Vely, Olivier Demaria, Joyson Karakunnel, Joanna Fares, Luciana Batista, Federico Rotolo, Julien Viotti, Agnes Boyer-Chammard, Karine Lacombe, Erwan Le Dault, Michel Carles, Nicolas Schleinitz, Eric Vivier
Summary: This study assessed the efficacy and safety of avdoralimab, an anti-C5aR1 mAb, in patients with severe COVID-19. The results showed that avdoralimab did not significantly improve clinical status or other relevant outcomes in these patients.
CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
K. Coyle, M. Ratsep, K. Laverty, M. M. Vandenbroek, L. R. Hilton, M. Mitchell, Y. Deng, D. J. Stewart, E. Vivier, M. L. Ormiston
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Oncology
Pedro Ventura, Milica Gakovic, Berenice Fischer, Sarah Thomson, Hanif J. Khameneh, Alessandro Zenobi, Giorgia Rota, Eric Vivier, Walter Birchmeier, Doreen Cantrell, Greta Guarda
CANCER IMMUNOLOGY RESEARCH
(2022)
