Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Molecules Great and Small: The Complement System

(2015) D. R. Mathern et al.   Clinical Journal of the American Society of Nephrology

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

(2015) Allison L. Totura et al.   mBio

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

(2015) Lisa E. Gralinski et al.   PLoS Genetics

The role of C5a in acute lung injury induced by highly pathogenic viral infections

(2015) Renxi Wang et al.   Emerging Microbes & Infections

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

New Metrics for Evaluating Viral Respiratory Pathogenesis

(2015) Vineet D. Menachery et al.   PLoS One

Severe acute respiratory syndrome vs. the Middle East respiratory syndrome

(2014) David S. Hui et al.   CURRENT OPINION IN PULMONARY MEDICINE

The Pathology and Pathogenesis of Experimental Severe Acute Respiratory Syndrome and Influenza in Animal Models

(2014) J.M.A. van den Brand et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

(2013) Shihui Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

(2013) Alexander V. Misharin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology

(2013) A. K. Haick et al.   JOURNAL OF GENERAL VIROLOGY

Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

(2013) C. Fett et al.   JOURNAL OF VIROLOGY

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

(2013) L. E. Gralinski et al.   mBio

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Mast Cell-Induced Lung Injury in Mice Infected with H5N1 Influenza Virus

(2012) Y. Hu et al.   JOURNAL OF VIROLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mannose Binding Lectin Is Required for Alphavirus-Induced Arthritis/Myositis

(2012) Bronwyn M. Gunn et al.   PLoS Pathogens

Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection

(2011) Wei-Chuan Chang et al.   BMC IMMUNOLOGY

Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation

(2011) D. S. Abi Abdallah et al.   INTERNATIONAL IMMUNOLOGY

Th17 Cytokines Are Critical for Respiratory Syncytial Virus-Associated Airway Hyperreponsiveness through Regulation by Complement C3a and Tachykinins

(2011) Monali M. Bera et al.   JOURNAL OF IMMUNOLOGY

A Protective Role for Complement C3 Protein during Pandemic 2009 H1N1 and H5N1 Influenza A Virus Infection

(2011) Kevin B. O'Brien et al.   PLoS One

Complement and viral pathogenesis

(2011) Kristina A. Stoermer et al.   VIROLOGY

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin

(2011) P. Avirutnan et al.   mBio

Direct Complement Restriction of Flavivirus Infection Requires Glycan Recognition by Mannose-Binding Lectin

(2010) Anja Fuchs et al.   Cell Host & Microbe

Infections of People with Complement Deficiencies and Patients Who Have Undergone Splenectomy

(2010) S. Ram et al.   CLINICAL MICROBIOLOGY REVIEWS

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

(2010) J. Zhao et al.   JOURNAL OF VIROLOGY

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

(2010) Y. Zhou et al.   JOURNAL OF VIROLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Lack of association between polymorphisms of MASP2and susceptibility to SARS coronavirus infection

(2009) Yan Wang et al.   BMC INFECTIOUS DISEASES

The complement system in systemic autoimmune disease

(2009) Min Chen et al.   JOURNAL OF AUTOIMMUNITY

Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus

(2008) John B. Johnson et al.   VIROLOGY