Review
Immunology
Vincent J. Venditto, Dalia Haydar, Ahmed Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod Creameans, Timothy J. Kopper, Chi Peng, David J. Feola
Summary: The rapid spread of COVID-19 has led to an increased focus on finding effective treatments, with many immunomodulatory therapies currently under investigation. Azithromycin, as an immunomodulatory drug, has potential benefits in late-stage treatment but also carries risks of immunosuppression and off-target effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Akash Saggam, Kirti Limgaokar, Swapnil Borse, Preeti Chavan-Gautam, Santosh Dixit, Girish Tillu, Bhushan Patwardhan
Summary: This review highlights the potential of Ashwagandha in managing COVID-19, showcasing its immunomodulatory, anti-inflammatory, and organ protective properties. It proposes Ashwagandha as a therapeutic adjuvant for COVID-19 management and suggests the need for further systematic studies to fully realize its potential.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tomasz Jedrzejewski, Malgorzata Pawlikowska, Justyna Sobocinska, Sylwia Wrotek
Summary: This paper analyzes the research advances in the anti-cancer and anti-viral effects of Coriolus versicolor (CV), a common species used in traditional Chinese herbal medicine. The direct effects of CV on cancer cells and angiogenesis are discussed based on in vitro and in vivo studies, as well as clinical research trials. The potential use of CV compounds in anti-viral treatment, including COVID-19 therapy, is also analyzed. Additionally, the significance of fever in viral infection and cancer is debated, with evidence suggesting that CV affects this phenomenon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yaw-Syan Fu, Wan-Yi Ho, Ning Kang, May-Jywan Tsai, Jingyi Wu, Liyue Huang, Ching-Feng Weng
Summary: This article reviews the application of curcumin as a treatment and prevention method for SARS-CoV-2 infection. Curcumin has various properties, including anti-inflammatory, antioxidant, and antimicrobial effects, making it a potential therapeutic agent against COVID-19.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ashasmita S. Mishra, Bhuvaneswari Varadarajan, Srayaa Sathish, Sujata Roy
Summary: COVID-19 poses a global challenge with limited treatment options. This study explores the use of withaferin A as a system pharmacophore to combat COVID-19 complications. Molecular docking and bioinformatics tools were utilized to identify potential targets and mechanisms of withaferin A. The results suggest its anti-thrombotic effects, modulation of T cell activation, and potential in addressing the cytokine storm via STAT3.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Jae Hyun Bae, Hun Jee Choe, Michael F. Holick, Soo Lim
Summary: Vitamin D is associated with immune and inflammatory responses, and low levels have been linked to increased risk and severity of COVID-19. Supplementation of vitamin D can help reduce the risk and severity of COVID-19 outcomes.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Dragan Primorac, Martin Cemerin, Vid Matisic, Vilim Molnar, Marko Strbad, Lenart Girandon, Lucija Zenic, Miomir Knezevic, Stephen Minger, Denis Polancec
Summary: The COVID-19 pandemic has had a significant impact globally and the overaggressive immune reaction in response to the virus can lead to ARDS. Mesenchymal stromal cell therapy presents a potential treatment option for severe patients.
Review
Biotechnology & Applied Microbiology
Priya Singh, Deepika Singh, Pratikshya Sa, Priyanka Mohapatra, Auromira Khuntia, Sanjeeb K Sahoo
Summary: The outbreak of SARS-CoV-2 infection has created an urgent need for advanced diagnostics and therapeutics, and nanotechnology appears to be highly relevant due to the unique properties of nanomaterials. This review discusses various nanoformulations that can be utilized in the fight against COVID-19, including personal protective equipment, disinfectants, diagnostics, therapeutics, and vaccination approaches utilizing nanoparticles to modulate the host immune system.
Article
Immunology
Dinesh Joshi, Kamal Sharma, Senthilraj Thangasami, Rahul Patel, Iva Patel
Summary: The administration of pentaglobin in COVID-19 patients did not significantly reduce the risk of mechanical ventilation or death, disease worsening, or inflammation reduction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alice Albergamo, Giulia Apprato, Francesca Silvagno
Summary: The genomic activity of vitamin D has significant effects on metabolism and physiological functions, particularly in relation to viral infections such as COVID-19. This review examines the correlation between vitamin D deficiency and increased risks of severe COVID-19 and respiratory distress syndrome. Clinical trials have tested vitamin D supplementation with promising results. Additionally, a biochemical analysis explores the antioxidant and anti-inflammatory functions of vitamin D and its influence on different biochemical pathways in the body's defense against viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Claudio Ucciferri, Alessandro Di Gasbarro, Paola Borrelli, Marta Di Nicola, Jacopo Vecchiet, Katia Falasca
Summary: This study found that the use of pidotimod in patients with mild-moderate COVID-19 can reduce the need for hospitalization and shorten the duration of illness. Patients in the pidotimod group had higher SpO2 in the walking test and a lower need for steroid rescue therapy.
Review
Endocrinology & Metabolism
Hugo Rodrigues Alves, Guilherme Schittine Bezerra Lomba, Cassiano Felippe Goncalves-de-Albuquerque, Patricia Burth
Summary: Irisin produced during exercise plays a crucial role in improving metabolism, preventing inflammation-related diseases, and potentially combating conditions like COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Madeleine Ennis, Katerina Tiligada
Summary: Reports on the potential benefits of the over-the-counter histamine H-2 receptor antagonist famotidine in treating COVID-19 began to emerge in April 2020. However, clinical trials are still ongoing to confirm these findings. Studies suggest that famotidine may have an immunomodulatory effect on COVID-19 inflammation, rather than a direct antiviral action against SARS-CoV-2.
INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Roberta Bernini, Francesca Velotti
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to the worst health crisis of this century, with no sufficient evidence to recommend polyphenols as potential immunomodulatory agents against COVID-19.
Article
Chemistry, Medicinal
Aurelia Magdalena Pisoschi, Aneta Pop, Florin Iordache, Loredana Stanca, Ovidiu Ionut Geicu, Liviu Bilteanu, Andreea Iren Serban
Summary: Oxidative stress is caused by an abundant generation of reactive oxygen species and a diminished capacity of the organism's endogenous systems to counteract them. In viral infections, activation of pro-oxidative pathways and increased inflammatory cytokines are common. Vitamin intake has been shown to lower oxidative stress markers, alleviate cytokine storm, and potentially reduce disease severity. Antioxidants also play a role in directly combating the virus. Careful consideration of timing, dosage, and interactions of micronutrients is important.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Hematology
Sofiane Fodil, Marine Arnaud, Camille Vaganay, Alexandre Puissant, Etienne Lengline, Nuala Mooney, Raphael Itzykson, Lara Zafrani
Summary: The vascular microenvironment plays a crucial role in AML, with ECs and leukemic cells interacting to influence disease progression and complications.
Review
Medicine, General & Internal
A. Neel, N. Degauque, S. Bruneau, C. Braudeau, M. Bucchia, A. Caristan, D. De Mornac, V Genin, A. Glemain, C. Oriot, M. Rimbert, S. Brouard, R. Josien, M. Hamidou
Summary: AAV is a group of rare systemic immune-mediated diseases characterized by small vessel necrotizing vasculitis and respiratory tract inflammation. Research in animal models and in humans has identified the roles of ANCA, neutrophils, T helper cells, B cells, complement activation, and other factors in the pathogenesis of AAV. New investigation tools may lead to a better understanding of the disease mechanisms and potential therapeutic targets.
REVUE DE MEDECINE INTERNE
(2022)
Article
Immunology
Gaelle Tilly, Marion Cadoux, Alexandra Garcia, Jeremy Morille, Sandrine Wiertlewski, Claire Pecqueur, Sophie Brouard, David Laplaud, Nicolas Degauque
Summary: The study found that 12 months of treatment with teriflunomide in patients with RRMS did not affect B cell or CD4 T cell compartments, but had a specific impact on CD8 T cells, including decreased proliferation and reduced production of inflammatory factors. DHODH inhibition also affected the migratory velocity of memory CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Marine Arnaud, Maud Loiselle, Camille Vaganay, Stphanie Pons, Emmanuel Letavernier, Jordane Demonchy, Sofiane Fodil, Manal Nouacer, Sandrine Placier, Perrine Frere, Eden Arrii, Julien Lion, Nuala Mooney, Raphael Itzykson, Chakib Djediat, Alexandre Puissant, Lara Zafrani
Summary: This study provides new insights into the pathophysiology of TLS-induced AKI and suggests that extracellular histones may be a novel target for therapeutic intervention in TLS when endothelial dysfunction occurs.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Editorial Material
Medicine, General & Internal
Nuala Mooney
Article
Surgery
Jesper Hjortdal, Matthew D. Griffin, Marion Cadoux, W. John Armitage, Max Bylesjo, Peadar Mac Gabhann, Conor C. Murphy, Uwe Pleyer, Derek Tole, Bertrand Vabres, Malcolm D. Walkinshaw, Pierre-Antoine Gourraud, Matilde Karakachoff, Sophie Brouard, Nicolas Degauque
Summary: This study investigated the acute rejection of corneal transplants and found that there were no activation signatures within the B cell and T cell repertoire at the time of diagnosis. However, in recipients of full-thickness corneal transplants, acute rejection was associated with differences in B cell maturity and regulatory CD4(+) T cell frequency compared to stable allografts.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Guillaume Claisse, Magali Devriese, Julien Lion, Nicolas Maillard, Sophie Caillat-Zucman, Nuala Mooney, Jean Luc Taupin
Summary: This study experimentally validated that the assumption of underestimating the signal of anti-HLA antibodies in single antigen bead (SAB) assays when multiple beads share the targeted eplet is not true. Therefore, this phenomenon should no longer be considered as a significant risk factor during patient follow-up pre- or post-transplantation.
Article
Surgery
Julien Lion, Mathilde Le Maitre, Camille de Truchis, Jean-Luc Taupin, Karine Poussin, Alain Haziot, Edward Chong, Denis Glotz, Nuala Mooney
Summary: The microvascular endothelium of the renal transplant is the first site of graft interaction with the host immune system and is often injured in chronic Antibody Mediated Rejection (AMR). IL-6 plays a crucial role in EC immunogenicity, and blocking IL-6 can help improve related inflammatory responses.
CLINICAL TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Tra-My Doan Ngoc, Gaelle Tilly, Richard Danger, Orianne Bonizec, Christophe Masset, Pierrick Guerif, Sarah Bruneau, Alexandre Glemain, Jean Harb, Marion Cadoux, Anais Vivet, Hoa Le Mai, Alexandra Garcia, David Laplaud, Roland Liblau, Magali Giral, Stephanie Blandin, Magalie Feyeux, Laurence Dubreuil, Claire Pecqueur, Matthew Cyr, Weiming Ni, Sophie Brouard, Nicolas Degauque
Summary: Our study reveals that humoral rejection of kidney transplants is associated with the accumulation of TEMRA CD8(+) T cells in blood and kidney graft biopsies. TEMRA CD8(+) T cells from kidney transplant recipients show enhanced migratory properties compared to EM CD8(+) T cells, with increased adhesion to activated endothelium and transmigration in response to CXCL12 chemokine. Furthermore, IL-15 stimulation promotes the migration of TEMRA and EM CD8(+) T cells induced by CXCL12 and enhances the generation of functional PSGL1, which interacts with P-selectin and facilitates adhesion to activated endothelium. Notably, inhibiting the migration of TEMRA CD8(+) T cells from kidney transplant recipients by targeting VLA-4 or LFA-1 suggests the potential therapeutic benefit of targeting these cells in transplant recipients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Immunology
Fabrice Cognasse, Hind Hamzeh-Cognasse, Anne-Claire Duchez, Natalia Shurko, Marie-Ange Eyraud, Charles-Antoine Arthaud, Amelie Prier, Marco Heestermans, Olivier Hequet, Brigitte Bonneaudeau, Sandrine Rochette-Eribon, Francoise Teyssier, Valerie Barlet-Excoffier, Patricia Chavarin, Dominique Legrand, Pascale Richard, Pascal Morel, Nuala Mooney, Pierre Tiberghien
Summary: Blood products in therapeutic transfusion contain biologically active constituents. This study investigated the effect of photochemical Pathogen Reduction Treatment (PRT) on inflammatory factors and endothelial cells in convalescent plasma. The results showed that most inflammatory soluble factors did not significantly change before and after PRT, but IL-8 concentrations decreased significantly and IL-18 concentrations increased. In addition, the release of IL-6 from cFFP was similar regardless of PRT treatment. Further research is needed to explore the physiological effects of IL-18 and IL-8, as well as the clinical relevance of PRT-treated convalescent plasma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Surgery
Julien Lion, Mathilde Le Maitre, Camille de Truchis, Jean-Luc Taupin, Karine Poussin, Alain Haziot, Edward Chong, Denis Glotz, Nuala Mooney
Summary: The microvascular endothelium of the renal transplant is the first site of graft interaction with the host immune system and is often injured in chronic Antibody Mediated Rejection (AMR). IL-6 blockade is currently under investigation as a therapeutic target for AMR. This study examined the role of IL-6 in endothelial cell immunogenicity and found that IL-6 blockade reduced pro-inflammatory responses in EC.
CLINICAL TRANSPLANTATION
(2023)
Article
Immunology
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: This study found that kidney allograft rejection is associated with an imbalance between immune cells with effector/memory functions and those with regulatory properties, manifested as a decrease in the percentage of circulating B cells and an increase in the ratio of CD28-CD8+ T cells to Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tess Van Meerhaeghe, Antoine Neel, Sophie Brouard, Nicolas Degauque
Summary: The role of B cells in the regulation of CD8 T cell survival, proliferation, and memory formation has been a topic of debate. B cells can act as antigen-presenting cells for CD8 T cells due to their high expression of MHC class I molecules. In various conditions, such as viral infections, autoimmune diseases, cancer, and allograft rejection, B cells have been shown to modulate CD8 T cell function. However, B-cell depletion therapies can impair CD8 T cell responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Surgery
H. L. Mai, N. Degauque, S. Le Bot, M. Rimbert, K. Renaudin, R. Danger, F. Le Borgne, C. Kerleau, F. Delbos, M. Giral, S. Brouard
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
