Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor

Antagonistic effects of finerenone and spironolactone on the aldosterone‐regulated transcriptome of human kidney cells

(2021) Florian Le Billan et al.   FASEB JOURNAL

HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling

(2021) Joshua G. Travers et al.   CIRCULATION

Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models

(2021) Benjamin Bonnard et al.   Scientific Reports

Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites

(2021) Marina Kulik et al.   NUCLEIC ACIDS RESEARCH

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

(2021) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

(2021) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

(2021) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors

(2021) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

A transcriptional switch governs fibroblast activation in heart disease

(2021) Michael Alexanian et al.   NATURE

Noncoding RNA therapeutics — challenges and potential solutions

(2021) Melanie Winkle et al.   NATURE REVIEWS DRUG DISCOVERY

Management of Chronic Hyperkalemia in Patients With Chronic Kidney Disease: An Old Problem With News Options

(2021) Enrique Morales et al.   Frontiers in Medicine

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA

(2020) John R. Pooley et al.   PLoS One

Mineralocorticoid Receptor Antagonists, Blood Pressure, and Outcomes in Heart Failure With Reduced Ejection Fraction

(2020) Matteo Serenelli et al.   JACC-Heart Failure

Targeting Strategies for Tissue-Specific Drug Delivery

(2020) Zongmin Zhao et al.   CELL

MiRNA ‐181a is a novel regulator of aldosterone–mineralocorticoid receptor‐mediated cardiac remodelling

(2020) Ankita Garg et al.   EUROPEAN JOURNAL OF HEART FAILURE

Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation

(2020) Karolien De Bosscher et al.   Nature Reviews Endocrinology

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine

(2020) Rajiv Agarwal et al.   EUROPEAN HEART JOURNAL

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

(2020) George L. Bakris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?

(2020) Laura Van Moortel et al.   Frontiers in Endocrinology

Finerenone and Cardiovascular Outcomes in Patients with Chronic Kidney Disease and Type 2 Diabetes

(2020) Gerasimos Filippatos et al.   CIRCULATION

Management of hyperkalemia during treatment with mineralocorticoid receptor blockers: findings from esaxerenone

(2020) Hiromi Rakugi et al.   HYPERTENSION RESEARCH

A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction

(2020) Lisa K. Mullany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes changes gene expression but not DNA methylation in cardiac cells

(2020) Achim Lother et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection

(2019) Kenneth Granberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis

(2019) Jonatan Barrera-Chimal et al.   KIDNEY INTERNATIONAL

The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone

(2019) Krister Bamberg et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Esaxerenone: First Global Approval

(2019) Sean Duggan   DRUGS

Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of The Heart Failure Association of the European Society of Cardiology

(2019) Petar M. Seferovic et al.   EUROPEAN JOURNAL OF HEART FAILURE

Bromodomains: a new target class for drug development

(2019) Andrea G. Cochran et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

(2019) Chi-Hsien Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antibody–drug conjugates for cancer

(2019) Cindy H Chau et al.   LANCET

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

(2019) Nadia Bougarne et al.   Frontiers in Immunology

Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study

(2019) Andrew Whittaker et al.   CTS-Clinical and Translational Science

Development of Anti-CD74 Antibody–Drug Conjugates to Target Glucocorticoids to Immune Cells

(2018) Philip E. Brandish et al.   BIOCONJUGATE CHEMISTRY

Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator

(2018) Fredrik Erlandsson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics of the Novel, Selective, Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in Healthy Volunteers: Results from an Absolute Bioavailability Study and Drug–Drug Interaction Studies In Vitro and In Vivo

(2018) Roland Heinig et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Corticosteroid receptors adopt distinct cyclical transcriptional signatures

(2018) Florian Le Billan et al.   FASEB JOURNAL

Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone’s Antifibrotic ActivityNovelty and Significance

(2018) Jana Grune et al.   HYPERTENSION

Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation

(2018) Mathieu Buonafine et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling

(2018) Jonatan Barrera-Chimal et al.   KIDNEY INTERNATIONAL

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

(2018) Krister Bamberg et al.   PLoS One

Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel–Mediated Intestinal Sodium Absorption and Blood Pressure Regulation

(2018) Toshifumi Nakamura et al.   Journal of the American Heart Association

Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis

(2018) Achim Lother et al.   JOURNAL OF ENDOCRINOLOGY

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

Mineralocorticoid receptor function and cognition in health and disease

(2018) Katja Wingenfeld et al.   PSYCHONEUROENDOCRINOLOGY

The role of galectin-3 in heart failure and cardiovascular disease

(2018) Xiao Zhong et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing

(2018) Daniela Fraccarollo et al.   HYPERTENSION

SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma

(2018) Xianzhou Song et al.   CANCER LETTERS

Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice

(2017) Elizabeth K Fletcher et al.   ENDOCRINOLOGY

Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT-CHF

(2017) João Pedro Ferreira et al.   EUROPEAN JOURNAL OF HEART FAILURE

Aldosterone Target NGAL (Neutrophil Gelatinase–Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NFκB PathwayNovelty and Significance

(2017) Ernesto Martínez-Martínez et al.   HYPERTENSION

Essential role of ICAM-1 in aldosterone-induced atherosclerosis

(2017) Vincenzo Marzolla et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor null mice: informing cell-type-specific roles

(2017) Timothy J Cole et al.   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Coregulators as mediators of mineralocorticoid receptor signalling diversity

(2017) Peter J Fuller et al.   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Evolution of the mineralocorticoid receptor: sequence, structure and function

(2017) Michael E Baker et al.   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development

(2017) Peter Kolkhof et al.   JOURNAL OF ENDOCRINOLOGY

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

(2017) Emily R. Weikum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats

(2017) Elizabeth T. Nguyen et al.   PHYSIOLOGY & BEHAVIOR

Use of Mineralocorticoid Receptor Antagonists in Patients With Heart Failure and Comorbid Diabetes Mellitus or Chronic Kidney Disease

(2017) Lauren B. Cooper et al.   Journal of the American Heart Association

Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander?

(2016) Valérie Desmedt et al.   AMERICAN JOURNAL OF NEPHROLOGY

Physicians' adherence to guideline-recommended medications in heart failure with reduced ejection fraction: data from the QUALIFY global survey

(2016) Michel Komajda et al.   EUROPEAN JOURNAL OF HEART FAILURE

Vascular Mineralocorticoid Receptors

(2016) Achim Lother et al.   HYPERTENSION

A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet

(2016) C Mammi et al.   INTERNATIONAL JOURNAL OF OBESITY

Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors

(2016) Rubén Jiménez-Canino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Third-generation Mineralocorticoid Receptor Antagonists

(2016) Elise P. Gomez-Sanchez   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

(2016) Jeffrey C. Kern et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes

(2016) Hisham Mohammed et al.   Nature Protocols

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

(2016) Michael I. Love et al.   NUCLEIC ACIDS RESEARCH

Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

(2016) Xianzhou Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus

(2016) Karen R. Mifsud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meet the neighbors: Mapping local protein interactomes by proximity-dependent labeling with BioID

(2016) Renata Varnaitė et al.   PROTEOMICS

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

(2015) Lei Wang et al.   CANCER CELL

A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain

(2015) Erika Atucha et al.   ENDOCRINOLOGY

Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist

(2015) Kiyoshi Arai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells

(2015) Florian Le Billan et al.   FASEB JOURNAL

Galectin-3 Blockade Inhibits Cardiac Inflammation and Fibrosis in Experimental Hyperaldosteronism and HypertensionNovelty and Significance

(2015) Ernesto Martínez-Martínez et al.   HYPERTENSION

Neutrophil Gelatinase–Associated Lipocalin, a Novel Mineralocorticoid Biotarget, Mediates Vascular Profibrotic Effects of MineralocorticoidsNovelty and Significance

(2015) Antoine Tarjus et al.   HYPERTENSION

Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1

(2015) Larbi Amazit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between the trout mineralocorticoid and glucocorticoid receptorsin vitro

(2015) Pia Kiilerich et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Novel interactions of the mineralocorticoid receptor

(2015) Peter J. Fuller   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The selection and function of cell type-specific enhancers

(2015) Sven Heinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor

(2015) Hae-Ahm Lee et al.   PLoS One

Advances and Challenges of Liposome Assisted Drug Delivery

(2015) Lisa Sercombe et al.   Frontiers in Pharmacology

The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries

(2015) Laurent Calvier et al.   JACC-Heart Failure

Collecting Duct Principal Cell Transport Processes and Their Regulation

(2014) D. Pearce et al.   Clinical Journal of the American Society of Nephrology

Identification and characterization of a ligand-selective mineralocorticoid receptor coactivator

(2014) Fraser M. Rogerson et al.   FASEB JOURNAL

Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects From Rat Cardiorenal Injury

(2014) Peter Kolkhof et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Crystal Structure of the Mineralocorticoid Receptor DNA Binding Domain in Complex with DNA

(2014) William H. Hudson et al.   PLoS One

Histone Deacetylase Inhibition Attenuates Transcriptional Activity of Mineralocorticoid Receptor Through Its Acetylation and Prevents Development of Hypertension

(2013) Hae-Ahm Lee et al.   CIRCULATION RESEARCH

Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12 440 patients of the ESC Heart Failure Long-Term Registry

(2013) Aldo P. Maggioni et al.   EUROPEAN JOURNAL OF HEART FAILURE

Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis

(2012) Laurent Calvier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nuclear Shuttling Precedes Dimerization in Mineralocorticoid Receptor Signaling

(2012) Claudia Grossmann et al.   CHEMISTRY & BIOLOGY

Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases

(2012) Lars Bärfacker et al.   ChemMedChem

Neutrophil Gelatinase-Associated Lipocalin Is a Novel Mineralocorticoid Target in the Cardiovascular System

(2012) Celine Latouche et al.   HYPERTENSION

Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone

(2012) Jonas H Graversen et al.   MOLECULAR THERAPY

Transcriptome analysis of aldosterone-regulated genes in human vascular endothelial cell lines stably expressing mineralocorticoid receptor

(2011) Naoko Sekizawa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular Signature of Mineralocorticoid Receptor Signaling in Cardiomyocytes: From Cultured Cells to Mouse Heart

(2010) Celine Latouche et al.   ENDOCRINOLOGY

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

The hsp90-FKBP52 Complex Links the Mineralocorticoid Receptor to Motor Proteins and Persists Bound to the Receptor in Early Nuclear Events

(2009) M. D. Galigniana et al.   MOLECULAR AND CELLULAR BIOLOGY

PPAR  blocks glucocorticoid receptor  -mediated transactivation but cooperates with the activated glucocorticoid receptor   for transrepression on NF- B

(2009) N. Bougarne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectins: structure, function and therapeutic potential

(2008) Ri-Yao Yang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE