Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion
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Title
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion
Authors
Keywords
Aldosterone, Excretion, Electrolytes, Urine, Kidneys, Diabetes mellitus, Blood plasma, Diet
Journal
PLoS One
Volume 13, Issue 2, Pages e0193380
Publisher
Public Library of Science (PLoS)
Online
2018-02-24
DOI
10.1371/journal.pone.0193380
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Note: Only part of the references are listed.- Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner
- (2017) Emily R. Weikum et al. MOLECULAR PHARMACOLOGY
- Third-generation Mineralocorticoid Receptor Antagonists
- (2016) Elise P. Gomez-Sanchez JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop
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- CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist, prevents hypertension and cardiorenal injury in Dahl salt-sensitive hypertensive rats
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- (2014) Agustin Casimiro-Garcia et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prediction and Management of Hyperkalemia Across the Spectrum of Chronic Kidney Disease
- (2014) Ivana Lazich et al. SEMINARS IN NEPHROLOGY
- Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial
- (2013) Bertram Pitt et al. EUROPEAN HEART JOURNAL
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- SM-368229, a Novel Selective and Potent Non-steroidal Mineralocorticoid Receptor Antagonist With Strong Urinary Na+ Excretion Activity
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- The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism
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- Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease
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- Molecular pharmacology of the mineralocorticoid receptor: Prospects for novel therapeutics
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- Aldosterone in the Pathogenesis of Chronic Kidney Disease and Proteinuria
- (2010) Yee Lu et al. CURRENT HYPERTENSION REPORTS
- Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms
- (2010) Faiez Zannad et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart
- (2008) Peter Wilson et al. CLINICAL SCIENCE
- Corticosteroids and Redox Potential Modulate Spontaneous Contractions in Isolated Rat Ventricular Cardiomyocytes
- (2008) Michel F. Rossier et al. HYPERTENSION
- A PAI-1 Mutant, PAI-1R, Slows Progression of Diabetic Nephropathy
- (2008) Y. Huang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?
- (2008) Michael Gekle et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
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