Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice

Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease

(2017) Faisal J. Alibhai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Glucocorticoids entrain molecular clock components in human peripheral cells

(2015) Marc Cuesta et al.   FASEB JOURNAL

Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NF-κB pathway

(2015) Lei Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology

(2015) Tami A. Martino et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure

(2014) Amanda J. Rickard et al.   HYPERTENSION

Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium

(2013) Jitka A. I. Virag et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Glucocorticoid-mediated Period2 induction delays the phase of circadian rhythm

(2013) Solmi Cheon et al.   NUCLEIC ACIDS RESEARCH

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

(2013) K. D. Nguyen et al.   SCIENCE

Development of dilated cardiomyopathy in Bmal1-deficient mice

(2012) Mellani Lefta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The RelB subunit of NFκB acts as a negative regulator of circadian gene expression

(2012) Marina M. Bellet et al.   CELL CYCLE

Macrophage Mineralocorticoid Receptor Signaling Plays a Key Role in Aldosterone-Independent Cardiac Fibrosis

(2012) Laura A. Bienvenu et al.   ENDOCRINOLOGY

Deletion of clock gene Per2 exacerbates cholestatic liver injury and fibrosis in mice

(2012) Peng Chen et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac Fibrosis

(2012) Amanda J. Rickard et al.   HYPERTENSION

Aldosterone Inhibits Antifibrotic Factors in Mouse Hypertensive Heart

(2012) Feriel Azibani et al.   HYPERTENSION

The Circadian Protein Period 1 Contributes to Blood Pressure Control and Coordinately Regulates Renal Sodium Transport Genes

(2012) Lisa R. Stow et al.   HYPERTENSION

Shift work and vascular events: systematic review and meta-analysis

(2012) M. V. Vyas et al.   BMJ-British Medical Journal

A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein

(2011) Jae Wook Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis

(2011) Morag J. Young et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis

(2011) B. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of myocardial injury in mice with functional deletion of the circadian rhythm gene mPer2

(2010) Jitka A. I. Virag et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Matrix Metalloproteinase 2 and 9 Dysfunction Underlie Vascular Stiffness in Circadian Clock Mutant Mice

(2010) Ciprian B. Anea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Cardiomyocyte Circadian Clock

(2010) David J. Durgan et al.   CIRCULATION RESEARCH

Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF)

(2010) Faiez Zannad et al.   EUROPEAN JOURNAL OF HEART FAILURE

Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

(2010) O. Castanon-Cervantes et al.   JOURNAL OF IMMUNOLOGY

Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display

(2010) Jun Yang et al.   MOLECULAR ENDOCRINOLOGY

Mini Screening of Kinase Inhibitors Affecting Period-length of Mammalian Cellular Circadian Clock

(2009) Kazuhiro Yagita et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension

(2009) Elise P. Gomez-Sanchez et al.   EXPERIMENTAL PHYSIOLOGY

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure

(2009) Amanda J. Rickard et al.   HYPERTENSION

Clock Gene Modulation by TNF-α Depends on Calcium and p38 MAP Kinase Signaling

(2009) Saskia Petrzilka et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice

(2009) Michelle L. Gumz et al.   JOURNAL OF CLINICAL INVESTIGATION

Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal Hsd3b6

(2009) Masao Doi et al.   NATURE MEDICINE

Diurnal Amplitudes of Arterial Pressure and Heart Rate Are Dampened inClockMutant Mice and Adrenalectomized Mice

(2008) Hiroyoshi Sei et al.   ENDOCRINOLOGY