Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

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Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug

(2015) Xianzhou Song et al.   PLoS One

Simulated Biological Fluids with Possible Application in Dissolution Testing

(2015) Margareth R. C. Marques et al.   DISSOLUTION TECHNOLOGIES

Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

(2014) Y. Wang et al.   CANCER RESEARCH

Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor

(2014) Fei Yan et al.   PLoS One

Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

(2012) Satyanarayana R. Pondugula et al.   CANCER LETTERS

Steroid receptor coactivator-3 as a potential molecular target for cancer therapy

(2012) Jean Ching-Yi Tien et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Nuclear receptor coregulators: modulators of pathology and therapeutic targets

(2012) David M. Lonard et al.   Nature Reviews Endocrinology

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor  -Klotho

(2012) T. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

(2011) Ping-zheng Zhou et al.   ACTA PHARMACOLOGICA SINICA

Steroid receptor coactivators 1, 2, and 3: Critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy

(2011) Amber B. Johnson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1

(2011) Ying Wang et al.   MOLECULAR ENDOCRINOLOGY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment

(2011) Elizabeth A. Platz et al.   Cancer Discovery

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

(2010) Yong Zhang et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Cardiac glycosides are potent inhibitors of interferon-β gene expression

(2010) Junqiang Ye et al.   Nature Chemical Biology

Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain

(2009) H. Ogawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk

(2008) Mark Bowlby et al.   CURRENT DRUG METABOLISM

The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression

(2008) L. Qin et al.   MOLECULAR AND CELLULAR BIOLOGY

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SRC-3 Transcription-Coupled Activation, Degradation, and the Ubiquitin Clock: Is There Enough Coactivator to Go Around in Cells?

(2008) D. M. Lonard et al.   Science Signaling