Foresight regarding drug candidates acting on the succinate–GPR91 signalling pathway for non-alcoholic steatohepatitis (NASH) treatment

2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation

(2021) Hao Huang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

(2021) Guiliang Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Hypoxia-inducible factor-2 promotes liver fibrosis in non-alcoholic steatohepatitis liver disease via the NF-κB signalling pathway

(2021) Hao Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

THR‐ß agonism improves disease activity and metabolism independent of body weight in a mouse model of non‐alcoholic steatohepatitis and fibrosis

(2021) Aimo Kannt et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

(2021) Lulu Sun et al.   Nature Reviews Gastroenterology & Hepatology

G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment

(2021) Ming Yang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Isotschimgine alleviates nonalcoholic steatohepatitis and fibrosis via FXR agonism in mice

(2021) Junxiao Li et al.   PHYTOTHERAPY RESEARCH

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

(2021) Ines L. Paraiso et al.   Frontiers in Pharmacology

Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial

(2021) Stephen A. Harrison et al.   NATURE MEDICINE

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF ‐β1/Smad2, NF‐κB, and AMPK signaling pathways

(2021) Guancheng Liu et al.   PHYTOTHERAPY RESEARCH

Pegbelfermin (BMS-986036): an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitis

(2020) Cristy R.C. Verzijl et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

Therapeutic landscape for NAFLD in 2020

(2020) Brent A. Neuschwander-Tetri   GASTROENTEROLOGY

Targeting FGF21 for the Treatment of Nonalcoholic Steatohepatitis

(2020) Mohammad Zarei et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages

(2020) Beibei Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity

(2020) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

GPR91 antagonist and TGF-β inhibitor suppressed collagen production of high glucose and succinate induced HSC activation

(2020) Mutsuko Sakai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery

(2020) Brenno Astiarraga et al.   DIABETES CARE

Hepatic HuR modulates lipid homeostasis in response to high-fat diet

(2020) Zhuojun Zhang et al.   Nature Communications

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

(2020) Naeimeh Atabaki-Pasdar et al.   PLOS MEDICINE

The nonalcoholic steatohepatitis (NASH) drug development graveyard: established hurdles and planning for future success

(2020) Joost P.H. Drenth et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway

(2020) Zhengbin Zhao et al.   Oxidative Medicine and Cellular Longevity

Omega-3 Polyunsaturated Fatty Acids EPA and DHA as an Adjunct to Non-Surgical Treatment of Periodontitis: A Randomized Clinical Trial

(2020) Mirella Stańdo et al.   Nutrients

Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems

(2020) Zi-Sheng Huang et al.   Frontiers in Pharmacology

Comparative Effects of Pterostilbene and Its Parent Compound Resveratrol on Oxidative Stress and Inflammation in Steatohepatitis Induced by High-Fat High-Fructose Feeding

(2020) Saioa Gómez-Zorita et al.   Antioxidants

Protective effects of polydatin against sulfur mustard-induced hepatic injury

(2019) Hao Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice

(2019) Takahiro Ohkura et al.   Frontiers in Immunology

A network-centric approach to drugging TNF-induced NF-κB signaling

(2019) Nicolas A. Pabon et al.   Nature Communications

Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis

(2019) Ning-Ping Zhang et al.   LABORATORY INVESTIGATION

Pharmacological Treatment for Non-alcoholic Fatty Liver Disease

(2019) Sven Francque et al.   ADVANCES IN THERAPY

Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in vitro and in vivo

(2019) Yong-li Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux

(2019) Xiaoting Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

(2019) Noelia Keiran et al.   NATURE IMMUNOLOGY

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

(2019) Ning Liang et al.   Nature Communications

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

Effects of Piceatannol and Resveratrol on Sirtuins and Hepatic Inflammation in High-Fat Diet-Fed Mice

(2019) Hee Jae Lee et al.   JOURNAL OF MEDICINAL FOOD

Phase 3 drug pipelines in the treatment of NASH

(2019) Yoshio Sumida et al.   HEPATOLOGY RESEARCH

Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice

(2019) Beibei Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation

(2019) Jie Wu et al.   LABORATORY INVESTIGATION

Fibroblast growth factor 21 in non-alcoholic fatty liver disease

(2019) Bradley Tucker et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Anti-NASH Drug Development Hitches a Lift on PPAR Agonism

(2019) Joost Boeckmans et al.   Cells

Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

(2018) N. Chalasani et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

NASH Leading Cause of Liver Transplant in Women: Updated Analysis of Indications For Liver Transplant and Ethnic and Gender Variances

(2018) Mazen Noureddin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition

(2018) Giang Nguyen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate induces hepatic fibrogenesis by promoting activation, proliferation, and migration, and inhibiting apoptosis of hepatic stellate cells

(2018) So Young Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

(2018) Maria Apostolopoulou et al.   DIABETES CARE

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes

(2018) Christian Carpéné et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Honokiol attenuates diet-induced non-alcoholic steatohepatitis by regulating macrophage polarization through activating peroxisome proliferator-activated receptor γ

(2018) Xueqing Zhong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Interorgan Metabolic Crosstalk in Human Insulin Resistance

(2018) Sofiya Gancheva et al.   PHYSIOLOGICAL REVIEWS

LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice

(2018) Cong Thuc Le et al.   PLoS One

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver fibrosis

(2018) M. Merve Aydin et al.   Turkish Journal of Gastroenterology

Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth

(2018) Hosni Cherif et al.   PLOS BIOLOGY

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

(2018) Sangwon Lee et al.   NATURE

Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation

(2018) Mingming Zhao et al.   PLOS BIOLOGY

Succinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis

(2018) Eun-Hee Cho   Frontiers in Endocrinology

Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma

(2018) Cristina Trejo-Solís et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial

(2018) Arun Sanyal et al.   LANCET

Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study

(2018) Edgar D. Charles et al.   Obesity

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

(2017) Shanaka Stanislaus et al.   ENDOCRINOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease

(2017) Fernando Bril et al.   HEPATOLOGY

Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-κB Pathways

(2017) Seong-Ah Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition

(2017) Kun Cao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of various peroxisome proliferator-activated receptors and their ligands in clinical practice

(2017) Giuseppe Derosa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

(2017) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

Alternative treatment methods attenuate the development of NAFLD: A review of resveratrol molecular mechanisms and clinical trials

(2017) Tomasz Charytoniuk et al.   NUTRITION

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

(2017) S Sengupta et al.   ONCOGENE

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

(2017) Mette Trauelsen et al.   Molecular Metabolism

FAP finds FGF21 easy to digest

(2016) M. P. Gillum et al.   BIOCHEMICAL JOURNAL

Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration

(2016) Poh-Shiow Yeh et al.   CANCER LETTERS

Global epidemiology of nonalcoholic fatty liver disease: Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) A. Lonardo et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Molecular Pathogenesis of NASH

(2016) Alessandra Caligiuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells

(2016) Ying Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21

(2016) Diana Ronai Dunshee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidemiology and natural history of non-alcoholic fatty liver disease

(2016) Yousef Fazel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insight into SUCNR1 (GPR91) structure and function

(2016) Julie Gilissen et al.   PHARMACOLOGY & THERAPEUTICS

Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease

(2016) Sara Heebøll et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression

(2016) Enas A Abd El-Haleim et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions

(2016) Sandra Favret et al.   Aging-US

The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy

(2016) Lei Yang et al.   PLoS One

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

(2015) Ying Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pharmacology of resveratrol in animals and humans

(2015) Eun-Jung Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis

(2015) AKIKO KATSURA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy

(2015) Guiyuan Ji et al.   Lipids in Health and Disease

The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy

(2015) Jia Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease

(2015) Sandra Pisonero-Vaquero et al.   MOLECULAR NUTRITION & FOOD RESEARCH

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Succinate Receptors (SUCNR1) as a Potential Target for Pharmacotherapy

(2015) S. V. Okovityi et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

(2015) Bryn M. Owen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase

(2014) You-Jin Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis of glycosides of resveratrol, pterostilbene, and piceatannol, and their anti-oxidant, anti-allergic, and neuroprotective activities

(2014) Daisuke Sato et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

(2014) Carla J Aguiar et al.   Cell Communication and Signaling

Fatty acid sources and their fluxes as they contribute to plasma triglyceride concentrations and fatty liver in humans

(2014) M. Miriam Jacome-Sosa et al.   CURRENT OPINION IN LIPIDOLOGY

Akt and p53R2, partners that dictate the progression and invasiveness of cancer

(2014) Bahman Yousefi et al.   DNA REPAIR

Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets

(2014) Ffolliott M. Fisher et al.   GASTROENTEROLOGY

Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation

(2014) William Peverill et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

(2014) Da Young Oh et al.   NATURE MEDICINE

Effects and mechanisms of resveratrol on the amelioration of oxidative stress and hepatic steatosis in KKAy mice

(2014) Wei Zhu et al.   Nutrition & Metabolism

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease

(2014) Forouzan Faghihzadeh et al.   NUTRITION RESEARCH

A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival

(2014) Fang Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes

(2014) Darwin V. Lee et al.   PLoS One

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Urinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity

(2014) Aihua Zhang et al.   Scientific Reports

JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide

(2013) Min Ho Kim et al.   BIOCHEMICAL PHARMACOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy

(2013) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds

(2013) Senthilkumar Kalimuthu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Aryl Hydrocarbon Receptor Sensitizes Mice to Nonalcoholic Steatohepatitis by Deactivating Mitochondrial Sirtuin Deacetylase Sirt3

(2013) J. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K/AKT and ERK pathways

(2013) Feng Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Proteomics Analysis of Hepatoprotective Effects for Scoparone Using MALDI-TOF/TOF Mass Spectrometry with Bioinformatics

(2013) Aihua Zhang et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

(2013) Alexei Kharitonenkov et al.   PLoS One

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells

(2013) Satyakumar Vidyashankar et al.   TOXICOLOGY IN VITRO

Neuro-Modulating Effects of Honokiol: A Review

(2013) Anna Woodbury et al.   Frontiers in Neurology

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils

(2012) Hua-Zhong Ying et al.   FOOD AND CHEMICAL TOXICOLOGY

Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells

(2012) Xiaoqin Luo et al.   Nutrition & Metabolism

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

(2012) Randy Hecht et al.   PLoS One

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

(2012) Ana Carolina Ariza et al.   Frontiers in Endocrinology

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Discovery of a potent and selective small molecule hGPR91 antagonist

(2011) Debnath Bhuniya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

(2011) J. Mu et al.   DIABETES

Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice

(2011) Zhigang Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders

(2010) Jui-Lung Shen et al.   MOLECULES

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway

(2009) Carla J. Aguiar et al.   CELL CALCIUM

Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent

(2009) Walee Chamulitrat et al.   HEPATOLOGY

The role of the GPR91 ligand succinate in hematopoiesis

(2009) Yaron Hakak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release

(2009) S. L. Vargas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prevention and Reversal of Obesity and Glucose Intolerance in Mice by DHA Derivatives

(2009) Martin Rossmeisl et al.   Obesity

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Nuclear Factor-κB Activation: From Bench to Bedside

(2008) Gautam Sethi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The G protein-coupled receptor G2A: Involvement in hepatic lipid metabolism and gallstone formation in mice

(2008) Laura E. Johnson et al.   HEPATOLOGY

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY

Insulin resistance, inflammation, and non-alcoholic fatty liver disease

(2008) Herbert Tilg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Resveratrol and trimethylated resveratrol protect from acute liver damage induced by CCl4 in the rat

(2007) Horacio Rivera et al.   JOURNAL OF APPLIED TOXICOLOGY