The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity

Phenotypical and Functional Polymorphism of Liver Resident Macrophages

(2019) Andrey V. Elchaninov et al.   Cells

The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions

(2019) Michele Biagioli et al.   Nutrients

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

(2019) Daphne van der Heide et al.   Frontiers in Immunology

Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand

(2018) Adriana Carino et al.   PHARMACOLOGICAL RESEARCH

Bile Acids Activated Receptors Regulate Innate Immunity

(2018) Stefano Fiorucci et al.   Frontiers in Immunology

Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

(2017) William M. Lee   JOURNAL OF HEPATOLOGY

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury

(2016) Jana C. Mossanen et al.   HEPATOLOGY

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

(2016) Claudia Finamore et al.   Scientific Reports

Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1

(2015) Barbara Renga et al.   PLoS One

Exploitation of Cholane Scaffold for the Discovery of Potent and Selective Farnesoid X Receptor (FXR) and G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) Ligands

(2014) Carmen Festa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells

(2013) Taiki Kida et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FOXO1 Mediates the Autocrine Effect of Endothelin-1 on Endothelial Cell Survival

(2012) Vincenza Cifarelli et al.   MOLECULAR ENDOCRINOLOGY

Acute liver failure

(2010) William Bernal et al.   LANCET

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice

(2010) Clarence David Williams et al.   LIVER INTERNATIONAL

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

(2009) Avlin B. Imaeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβ in TNF-α-treated adipocytes

(2008) Yu Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY