PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Molecular control of δ-opioid receptor signalling

(2014) Gustavo Fenalti et al.   NATURE

The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

(2013) Mathias Rask-Andersen et al.   Annual Review of Pharmacology and Toxicology

The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts

(2013) Dane D. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist

(2013) S. Hennen et al.   Science Signaling

Biasing the Prostaglandin F2α Receptor Responses toward EGFR-Dependent Transactivation of MAPK

(2012) Eugénie Goupil et al.   MOLECULAR ENDOCRINOLOGY

Studies of a ubiquitous receptor family

(2012) Bryan L. Roth et al.   NATURE

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

(2011) John A. Allen et al.   Annual Review of Pharmacology and Toxicology

Too many roads not taken

(2011) Aled M. Edwards et al.   NATURE

Discovery of  -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

(2011) J. A. Allen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies

(2010) Stephen J Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

(2009) D. S. Auld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Specific Mechanism for Nonspecific Activation in Reporter-Gene Assays

(2008) Douglas S. Auld et al.   ACS Chemical Biology

Characterization of Chemical Libraries for Luciferase Inhibitory Activity

(2008) Douglas S. Auld et al.   JOURNAL OF MEDICINAL CHEMISTRY

Different Internalization Properties of the  1a- and  1b-Adrenergic Receptor Subtypes: The Potential Role of Receptor Interaction with  -Arrestins and AP50

(2008) L. Stanasila et al.   MOLECULAR PHARMACOLOGY

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and β-arrestin interaction

(2007) Kyeong-Man Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS