The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
Authors
Keywords
-
Journal
Nature Reviews Gastroenterology & Hepatology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-02-11
DOI
10.1038/s41575-020-00404-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
- (2020) John Y. L. Chiang et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Cilofexor, a Nonsteroidal FXR Agonist, in Non‐Cirrhotic Patients with Nonalcoholic Steatohepatitis: A Phase 2 Randomized Controlled Trial
- (2020) Keyur Patel et al. HEPATOLOGY
- SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
- (2020) Jiyu Zhou et al. Nature Communications
- The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids
- (2020) Sarah Ducastel et al. Scientific Reports
- Obeticholic acid—a new therapy in PBC and NASH
- (2020) Roger W Chapman et al. BRITISH MEDICAL BULLETIN
- FXR Agonists as Therapy for Liver Disease
- (2020) Jay H. Hoofnagle HEPATOLOGY
- Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells
- (2020) Clarissa Campbell et al. NATURE
- Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor
- (2020) Raffaella Maria Gadaleta et al. EBioMedicine
- Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis
- (2020) Junhui Yu et al. Cell Death & Disease
- The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma
- (2019) S. Di Matteo et al. PLoS One
- FXR Regulates Intestinal Cancer Stem Cell Proliferation
- (2019) Ting Fu et al. CELL
- A Novel Mouse Model of Sporadic Colon Cancer Induced by Combination of Conditional Apc Genes and Chemical Carcinogen in the Absence of Cre Recombinase
- (2019) Jeffrey S Souris et al. CARCINOGENESIS
- Farnesoid X receptor represses matrix metalloproteinase 7 expression, revealing this regulatory axis as a promising therapeutic target in colon cancer
- (2019) Zhongsheng Peng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
- (2019) Jakob Wirbel et al. NATURE MEDICINE
- Obeticholic acid may increase the risk of gallstone formation in susceptible patients
- (2019) Samer Al-Dury et al. JOURNAL OF HEPATOLOGY
- FGF19‐mediated upregulation of SOX18 promotes hepatocellular carcinoma metastasis by transactivating FGFR4 and FLT4
- (2019) Jie Chen et al. HEPATOLOGY
- Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study
- (2019) Tilman Kühn et al. JNCI-Journal of the National Cancer Institute
- Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
- (2019) NaNa Keum et al. Nature Reviews Gastroenterology & Hepatology
- First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant Fibroblast Growth Factor 19 Signaling as a Driver Event in Hepatocellular Carcinoma
- (2019) Richard D Kim et al. Cancer Discovery
- Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
- (2019) Fengjie Huang et al. Nature Communications
- Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
- (2019) Zobair M Younossi et al. LANCET
- Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
- (2018) O. Erice et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Primary biliary cholangitis: Old and novel therapy
- (2018) Annarosa Floreani et al. European Journal of Internal Medicine
- An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers
- (2018) Amani Al-Khaifi et al. GASTROENTEROLOGY
- Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer
- (2018) Ting Liu et al. GASTROENTEROLOGY
- A Novel Fibroblast Growth Factor 15 Dependent- and Bile Acid Independent-Promotion of Liver Regeneration in Mice
- (2018) Bo Kong et al. HEPATOLOGY
- Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism
- (2018) Preeti Pathak et al. HEPATOLOGY
- The ileal FGF15/19 to hepatic FGFR4 axis regulates liver regeneration after partial hepatectomy in mice
- (2018) Qiang Li et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells
- (2018) Chi Ma et al. SCIENCE
- Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice
- (2018) Shoji Yamada et al. Oncotarget
- Characterization of Hepatocellular Carcinoma Patients with FGF19 Amplification Assessed by Fluorescence in situ Hybridization: A Large Cohort Study
- (2018) Hyo Jeong Kang et al. Liver Cancer
- Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
- (2018) Lulu Sun et al. NATURE MEDICINE
- Suppression of Hepatic Bile Acid Synthesis by a non-tumorigenic FGF19 analogue Protects Mice from Fibrosis and Hepatocarcinogenesis
- (2018) Raffaella Maria Gadaleta et al. Scientific Reports
- Treatment options for nonalcoholic steatohepatitis - a safety evaluation
- (2017) Danny Issa et al. Expert Opinion On Drug Safety
- Hepatic bile acid uptake in humans and mice: Multiple pathways and expanding potential role for gut-liver signaling
- (2017) Paul A. Dawson HEPATOLOGY
- Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis
- (2017) Hailong Cao et al. INTERNATIONAL JOURNAL OF CANCER
- Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism
- (2017) Preeti Pathak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15
- (2017) Mei Zhou et al. JOURNAL OF HEPATOLOGY
- Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth
- (2017) Eun-Kyung Kim et al. PLoS One
- Editor’s Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
- (2017) Shogo Takahashi et al. TOXICOLOGICAL SCIENCES
- Long-term Administration of Nuclear Bile Acid Receptor FXR Agonist Prevents Spontaneous Hepatocarcinogenesis in Abcb4−/− Mice
- (2017) Marica Cariello et al. Scientific Reports
- Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage
- (2017) Zhibo Gai et al. Scientific Reports
- The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway
- (2017) Yasmeen M. Attia et al. Scientific Reports
- Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis
- (2016) Bo Kong et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults
- (2016) P. T. Campbell et al. CANCER RESEARCH
- Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
- (2016) Annika Wahlström et al. Cell Metabolism
- An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice
- (2016) Cen Xie et al. DIABETES
- Obeticholic Acid: First Global Approval
- (2016) A. Markham et al. DRUGS
- An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
- (2016) Frank J. Gonzalez et al. GASTROENTEROLOGY
- RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer
- (2016) Mingxin Zuo et al. Oncotarget
- FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression
- (2016) Wei Wang et al. Oncotarget
- Activation of FXR protects against renal fibrosis via suppressing Smad3 expression
- (2016) Kai Zhao et al. Scientific Reports
- Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches
- (2015) Seth Amidon et al. AAPS PHARMSCITECH
- Proteomic and metabonomic biomarkers for hepatocellular carcinoma: a comprehensive review
- (2015) T Kimhofer et al. BRITISH JOURNAL OF CANCER
- Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
- (2015) Marc van de Wetering et al. CELL
- Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid
- (2015) Gideon M. Hirschfield et al. GASTROENTEROLOGY
- Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells
- (2015) Ornella I Selmin et al. JOURNAL OF NUTRITION
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
- Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells
- (2015) Jialin He et al. Molecular Cancer
- Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
- (2015) Sungsoon Fang et al. NATURE MEDICINE
- Ceramides – Lipotoxic Inducers of Metabolic Disorders
- (2015) Bhagirath Chaurasia et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells
- (2015) Mohamed-Sami Trabelsi et al. Nature Communications
- Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
- (2015) Changtao Jiang et al. Nature Communications
- Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma
- (2015) Xijun Liu et al. Oncotarget
- FXR induces SOCS3 and suppresses hepatocellular carcinoma
- (2015) Fei Guo et al. Oncotarget
- FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation
- (2015) Huakan Zhao et al. Oncotarget
- FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach
- (2015) Weiqiang Lu et al. Scientific Reports
- Gallbladder Cancer in the 21st Century
- (2015) Rani Kanthan et al. Journal of Oncology
- FXR and liver carcinogenesis
- (2014) Xiong-fei Huang et al. ACTA PHARMACOLOGICA SINICA
- Genomic portrait of resectable hepatocellular carcinomas: Implications ofRB1andFGF19aberrations for patient stratification
- (2014) Sung-Min Ahn et al. HEPATOLOGY
- Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development
- (2014) Iker Uriarte et al. INTERNATIONAL JOURNAL OF CANCER
- Transcriptional Regulation of the Intestinal Nuclear Bile Acid Farnesoid X Receptor (FXR) by the caudal-related Homeobox 2 (CDX2)
- (2014) Salvatore Modica et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
- (2014) Changtao Jiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades
- (2014) Alan F. Hofmann et al. JOURNAL OF LIPID RESEARCH
- Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis
- (2014) Rian M. Nijmeijer et al. PLoS One
- Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity
- (2014) Sharon Manley et al. Redox Biology
- FXR silencing in human colon cancer by DNA methylation and KRAS signaling
- (2013) Ann M. Bailey et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease
- (2013) Weibin Wu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
- (2013) Sama I. Sayin et al. Cell Metabolism
- Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
- (2013) Sunder Mudaliar et al. GASTROENTEROLOGY
- Obesity and colorectal cancer
- (2013) Marc Bardou et al. GUT
- Cocarcinogenic Effects of Intrahepatic Bile Acid Accumulation in Cholangiocarcinoma Development
- (2013) Elisa Lozano et al. MOLECULAR CANCER RESEARCH
- Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
- (2013) Shin Yoshimoto et al. NATURE
- Bile Acids Activate YAP to Promote Liver Carcinogenesis
- (2013) Sayeepriyadarshini Anakk et al. Cell Reports
- Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma
- (2012) Hongying Su et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Excess body weight and the risk of primary liver cancer: An updated meta-analysis of prospective studies
- (2012) Yi Chen et al. EUROPEAN JOURNAL OF CANCER
- Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
- (2012) Bo Kong et al. HEPATOLOGY
- Primary biliary cirrhosis and cancer risk: A systematic review and meta-analysis
- (2012) Yan Liang et al. HEPATOLOGY
- STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver
- (2012) Bin Gao et al. JOURNAL OF HEPATOLOGY
- FXR signaling in the enterohepatic system
- (2012) Tsutomu Matsubara et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Src-Mediated Cross-Talk between Farnesoid X and Epidermal Growth Factor Receptors Inhibits Human Intestinal Cell Proliferation and Tumorigenesis
- (2012) Zhongsheng Peng et al. PLoS One
- FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model
- (2012) Ulrich Deuschle et al. PLoS One
- Carcinogenicity of deoxycholate, a secondary bile acid
- (2011) Carol Bernstein et al. ARCHIVES OF TOXICOLOGY
- Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening
- (2011) Eric T. Sawey et al. CANCER CELL
- Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
- (2011) J. Prawitt et al. DIABETES
- MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression
- (2011) Xiang-yu Zhong et al. GENE
- Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
- (2011) R. M. Gadaleta et al. GUT
- The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract
- (2011) Serge J.L.B. Zweers et al. HEPATOLOGY
- Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis
- (2011) Sigurd Lax et al. INTERNATIONAL JOURNAL OF CANCER
- Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
- (2011) Fang Yan et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased Activation of the Wnt/ -Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice
- (2011) A. Wolfe et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
- (2011) Mingmei Liao et al. Molecular Cancer
- Improvements of mean body mass index and body weight in preobese and overweight Japanese adults with black Chinese tea (Pu-Erh) water extract
- (2011) Kazumitsu Kubota et al. NUTRITION RESEARCH
- Nuclear bile acid receptor FXR in the hepatic regeneration
- (2010) Wei-Dong Chen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity
- (2010) Iuliana Ristea Popescu et al. FEBS LETTERS
- Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function
- (2010) Alexandra Milona et al. HEPATOLOGY
- Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease
- (2010) Zhao-Xia Yang et al. Hepatology International
- Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
- (2010) Klementina Fon Tacer et al. MOLECULAR ENDOCRINOLOGY
- The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors
- (2009) Salvatore Modica et al. GASTROENTEROLOGY
- Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
- (2009) Songwen Zhang et al. JOURNAL OF HEPATOLOGY
- The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity
- (2009) P. Vavassori et al. JOURNAL OF IMMUNOLOGY
- Nuclear Bile Acid Receptor FXR Protects against Intestinal Tumorigenesis
- (2008) S. Modica et al. CANCER RESEARCH
- High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
- (2008) Frank G. Schaap et al. HEPATOLOGY
- Fifty years of advances in bile acid synthesis and metabolism
- (2008) David W. Russell JOURNAL OF LIPID RESEARCH
- Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
- (2008) R. R.M. Maran et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Ursodeoxycholic Acid Suppresses Cox-2 Expression in Colon Cancer: Roles of Ras, p38, and CCAAT/Enhancer-Binding Protein
- (2008) Sharad Khare et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More