Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Sanguinarine as a new chemical entity of thioredoxin reductase inhibitor to elicit oxidative stress and promote tumor cell apoptosis

(2020) Juan Yao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition

(2020) Zihang Chen et al.   INTEGRATIVE CANCER THERAPIES

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

(2020) Haiyang Zhang et al.   Molecular Cancer

Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma

(2020) Win Sen Heng et al.   MOLECULES

Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species

(2020) Abdul Q. Khan et al.   MOLECULES

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biological Activities of Alkaloids: From Toxicology to Pharmacology

(2020) Zbigniew Adamski et al.   Toxins

Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin

(2020) Weiqi Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells

(2019) Kanae Echizen et al.   ONCOGENE

ROS-generating oxidase NOX1 promotes the self-renewal activity of CD133+ thyroid cancer cells through activation of the Akt signaling

(2019) Cong Wang et al.   CANCER LETTERS

Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage

(2019) Anees Rahman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytotoxicity of the crude extract and constituents of the bark of Fagara tessmannii towards multi-factorial drug resistant cancer cells

(2019) Armelle T. Mbaveng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protoberberine compounds extracted from Chelidonium majus L. as novel natural photosensitizers for cancer therapy

(2019) Warowicka Alicja et al.   PHYTOMEDICINE

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

(2019) Jiao Peng et al.   Frontiers in Pharmacology

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

(2019) Sabah Akhtar et al.   Frontiers in Oncology

MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells

(2019) Bikul Das et al.   CANCER RESEARCH

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

Sanguinarine inhibits the proliferation of BGC-823 gastric cancer cells via regulating miR-96-5p/miR-29c-3p and the MAPK/JNK signaling pathway

(2019) Xian-Zhe Dong et al.   Journal of Natural Medicines

Nicotine-induced oxidative stress contributes to EMT and stemness during neoplastic transformation through epigenetic modifications in human kidney epithelial cells

(2019) Yu-Wei Chang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

(2019) Hirokazu Ohata et al.   Cell Reports

p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma

(2019) Beilei Zhang et al.   CANCER LETTERS

MicroRNA Networks Modulate Oxidative Stress in Cancer

(2019) Yang-Hsiang Lin   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chelerythrine induces apoptosis via ROS‐mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma

(2019) Hongchao He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells

(2019) Ke Tang et al.   ONCOGENE

Sanguinarine exhibits potent efficacy against cervical cancer cells through inhibiting the STAT3 pathway in vitro and in vivo

(2019) Huijuan Zhang et al.   Cancer Management and Research

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer

(2019) Hengqiang Zhao et al.   Molecular Therapy-Oncolytics

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

(2019) Frank Weinberg et al.   Cancers

Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies

(2019) Khan et al.   Cells

MicroRNA and Oxidative Stress Interplay in the Context of Breast Cancer Pathogenesis

(2019) Giulia Cosentino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology

(2019) Thomas Efferth et al.   SEMINARS IN CANCER BIOLOGY

Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

(2018) Xianling Gong et al.   BMC CANCER

Nuclear EGFR-PKM2 axis induces cancer stem cell-like characteristics in irradiation-resistant cells

(2018) Ying Shi et al.   CANCER LETTERS

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review

(2018) Mohammad Mohajeri et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Pharmacological and Therapeutic potential of Nitidine, a plant alkaloid

(2018) Haroon Khan et al.   CURRENT DRUG METABOLISM

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

(2018) Rute Moreira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemopreventive effects of FITOPROT against 5-fluorouracil-induced toxicity in HaCaT cells

(2018) Edvande Xavier dos Santos Filho et al.   LIFE SCIENCES

Reactive oxygen species in cancer stem cells of head and neck squamous cancer

(2018) Xu Qian et al.   SEMINARS IN CANCER BIOLOGY

RAS-mediated oncogenic signaling pathways in human malignancies

(2018) Abdul Q. Khan et al.   SEMINARS IN CANCER BIOLOGY

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chelerythrine induced cell death through ROS-dependent ER stress in human prostate cancer cells

(2018) Songjiang Wu et al.   OncoTargets and Therapy

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

(2018) Hai Wang et al.   Nature Communications

GLOBOCAN 2018: counting the toll of cancer

(2018) The Lancet   LANCET

Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia

(2018) Shilpa Kuttikrishnan et al.   LEUKEMIA & LYMPHOMA

Benzophenanthridine alkaloids from the roots of Thalictrum microgynum Lecoy.ex Oliv

(2018) Jie Jiang et al.   NATURAL PRODUCT RESEARCH

A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells

(2018) Maiara de S. Oliveira et al.   Redox Biology

Anticancer potential of sanguinarine for various human malignancies

(2017) Iman W Achkar et al.   Future Medicinal Chemistry

Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype

(2017) Stefan Rodic et al.   INTERNATIONAL JOURNAL OF CANCER

Sanguinarine exhibits antitumor activity via up-regulation of Fas-associated factor 1 in non-small cell lung cancer

(2017) Guangxia Wei et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms

(2017) Zeina Habli et al.   MOLECULES

Oxidative Stress Modulation and ROS-Mediated Toxicity in Cancer: A Review on In Vitro Models for Plant-Derived Compounds

(2017) María José Vallejo et al.   Oxidative Medicine and Cellular Longevity

Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid

(2017) Sehamuddin Galadari et al.   PHYTOMEDICINE

Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells

(2017) Daniel Bauer et al.   Cell Death & Disease

Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets

(2017) Jingmei Lin et al.   Oncotarget

Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development

(2017) Federica Papaccio et al.   Stem Cells Translational Medicine

Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells

(2017) Zheng-Hai Tang et al.   Redox Biology

Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation

(2016) Elaine Lai-Han Leung et al.   ANTIOXIDANTS & REDOX SIGNALING

Sanguinarine Induces Apoptosis of Human Oral Squamous Cell Carcinoma KB Cells via Inactivation of the PI3K/Akt Signaling Pathway

(2016) Tae Kyung Lee et al.   DRUG DEVELOPMENT RESEARCH

Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine

(2016) Anees Rahman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species

(2016) Yan Wang et al.   Oncotarget

A Review of Bioinsecticidal Activity of Solanaceae Alkaloids

(2016) Szymon Chowański et al.   Toxins

Erlotinib induces the human non-small-cell lung cancer cells apoptosis via activating ROS-dependent JNK pathways

(2016) Fenglian Shan et al.   Cancer Medicine

Aldehyde Dehydrogenase Is Regulated by  -Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells

(2015) M. Cojoc et al.   CANCER RESEARCH

ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine

(2015) Siraj Pallichankandy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats

(2015) AK Al-Asmari et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

A new cytotoxic benzophenanthridine isoquinoline alkaloid from the fruits ofMacleaya cordata

(2015) Hui-Liang Zou et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Sanguinarine-induced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stress

(2015) SHUANG GU et al.   ONCOLOGY REPORTS

Redox Regulation in Cancer Stem Cells

(2015) Shijie Ding et al.   Oxidative Medicine and Cellular Longevity

Chelidonine, a principal isoquinoline alkaloid of Chelidonium majus, attenuates eosinophilic airway inflammation by suppressing IL-4 and eotaxin-2 expression in asthmatic mice

(2015) Seung-Hyung Kim et al.   Pharmacological Reports

Cancer stem cell related markers of radioresistance in head and neck squamous cell carcinoma

(2015) Ina Kurth et al.   Oncotarget

Mechanisms of Superoxide Signaling in Epigenetic Processes: Relation to Aging and Cancer

(2015) Igor Afanas’ev   Aging and Disease

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Promoting Effects of Sanguinarine on Apoptotic Gene Expression in Human Neuroblastoma Cells

(2015) Emre Cecen et al.   Asian Pacific Journal of Cancer Prevention

Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition

(2014) Cristina Kalogris et al.   BIOCHEMICAL PHARMACOLOGY

High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma

(2014) Maqbool Ahmed et al.   CARCINOGENESIS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

High-Throughput Drug Screen Identifies Chelerythrine as a Selective Inducer of Death in a TSC2-null Setting

(2014) Doug Medvetz et al.   MOLECULAR CANCER RESEARCH

Alkaloids from the Tribe Bocconieae (Papaveraceae): A Chemical and Biological Review

(2014) Xuelong Yu et al.   MOLECULES

Nuclear receptor-induced transcription is driven by spatially and timely restricted waves of ROS

(2014) Bruno Perillo et al.   Nucleus

Redox Circuitries Driving Src Regulation

(2013) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

ROS Links Glucose Metabolism to Breast Cancer Stem Cell and EMT Phenotype

(2013) Michael S. Schieber et al.   CANCER CELL

Rapid human melanoma cell death induced by sanguinarine through oxidative stress

(2013) Ana Burgeiro et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bidirectional regulation of NF-κB by reactive oxygen species: A role of unfolded protein response

(2013) Shotaro Nakajima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein

(2013) Rachel P. Wilkie-Grantham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma

(2013) Rong Bu et al.   LEUKEMIA & LYMPHOMA

A Reactive Oxygen Species-Mediated, Self-Perpetuating Loop Persistently Activates Platelet-Derived Growth Factor Receptor  

(2013) H. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells

(2013) Sudjit Luanpitpong et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Redox regulation in stem-like cancer cells by CD44 variant isoforms

(2013) O Nagano et al.   ONCOGENE

Apoptosis Induction of Human Bladder Cancer Cells by Sanguinarine through Reactive Oxygen Species-Mediated Up-Regulation of Early Growth Response Gene-1

(2013) Min Ho Han et al.   PLoS One

Norcantharidin Induced DU145 Cell Apoptosis through ROS-Mediated Mitochondrial Dysfunction and Energy Depletion

(2013) Bo Shen et al.   PLoS One

Molecular basis of MAP kinase regulation

(2013) Wolfgang Peti et al.   PROTEIN SCIENCE

Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction

(2013) Min Ho Han et al.   TOXICOLOGY LETTERS

Sanguinarine Inhibits Vascular Endothelial Growth Factor Release by Generation of Reactive Oxygen Species in MCF-7 Human Mammary Adenocarcinoma Cells

(2013) Xian-zhe Dong et al.   Biomed Research International

Reactive Oxygen Species in Cancer Stem Cells

(2012) Xiaoke Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Alkaloids Isolated from Natural Herbs as the Anticancer Agents

(2012) Jin-Jian Lu et al.   Evidence-based Complementary and Alternative Medicine

Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells

(2012) Wenying Quan et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sanguinarine Induces Apoptosis of HT-29 Human Colon Cancer Cells via the Regulation of Bax/Bcl-2 Ratio and Caspase-9-Dependent Pathway

(2012) Jun Sik Lee et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Photodynamic therapy for breast cancer in a BALB/c mouse model

(2012) Tae-Gyu Ahn et al.   Journal of Gynecologic Oncology

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo

(2011) Virginia Tirino et al.   FASEB JOURNAL

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways

(2011) Shimei Qi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of reactive oxygen species in stem cells and cancer stem cells

(2011) Chiharu I. Kobayashi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells

(2011) Shao-Ping Chang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Resveratrol Suppresses Constitutive Activation of AKT via Generation of ROS and Induces Apoptosis in Diffuse Large B Cell Lymphoma Cell Lines

(2011) Azhar R. Hussain et al.   PLoS One

Asymmetric cancer cell division regulated by AKT

(2011) I. Dey-Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion

(2011) Meng Sun et al.   PROSTATE

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy

(2010) Spencer B. Gibson   Autophagy

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer

(2010) B. H. Kang et al.   CLINICAL CANCER RESEARCH

Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer

(2010) P. W. Gout et al.   Current Oncology

The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB1 receptor in vitro

(2010) Amey S. Dhopeshwarkar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

ABCG2: A potential marker of stem cells and novel target in stem cell and cancer therapy

(2010) Xi-wei Ding et al.   LIFE SCIENCES

c-Src–Mediated Phosphorylation of NoxA1 and Tks4 Induces the Reactive Oxygen Species (ROS)–Dependent Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma

(2009) Ilaria De Stefano et al.   BIOCHEMICAL PHARMACOLOGY

Butein induces G2/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation

(2009) Dong-Oh Moon et al.   CANCER LETTERS

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis

(2009) C. Maenhaut et al.   CARCINOGENESIS

Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1

(2009) Yong Zuo et al.   CELL RESEARCH

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Growth Factors Outside of the Platelet-derived Growth Factor (PDGF) Family Employ Reactive Oxygen Species/Src Family Kinases to Activate PDGF Receptor α and Thereby Promote Proliferation and Survival of Cells

(2009) Hetian Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Tumor Suppressor PTEN in Antioxidant Responsive Element-mediated Transcription and Associated Histone Modifications

(2009) Kensuke Sakamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress and Oxidative Damage in Carcinogenesis

(2009) James E. Klaunig et al.   TOXICOLOGIC PATHOLOGY

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

(2008) Wen-Sheng Wu et al.   CANCER AND METASTASIS REVIEWS

NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance

(2008) D. M. Townsend et al.   CANCER RESEARCH

Sanguinarine-Induced Apoptosis in Human Leukemia U937 Cells via Bcl-2 Downregulation and Caspase-3 Activation

(2008) Min Ho Han et al.   CHEMOTHERAPY

Sanguinarine, a Benzophenanthridine Alkaloid, Induces Apoptosis in MDA-MB-231 Human Breast Carcinoma Cells through a Reactive Oxygen Species-Mediated Mitochondrial Pathway

(2008) Woo Young Choi et al.   CHEMOTHERAPY

The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function

(2008) Gunbjørg Svineng et al.   CONNECTIVE TISSUE RESEARCH

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Sanguinarine-induced apoptosis: Generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL

(2008) Shin Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Understanding PTEN regulation: PIP2, polarity and protein stability

(2008) N R Leslie et al.   ONCOGENE

A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids

(2008) Vitaliy Kaminskyy et al.   TOXICOLOGY LETTERS