Editorial Material
Neurosciences
Mohammad Rafi Khezri, Morteza Ghasemnejad-Berenji, Donya Moloodsouri
Summary: One of the main players in apoptosis during Alzheimer's disease progression are different members of caspase family of proteases, with caspase-3 being the most well-known. The PI3K/AKT signaling pathway is the most important intracellular factor involved in regulating caspase-3 activity. This commentary aims to highlight the possible relations between the PI3K/AKT signaling pathway and caspase-3 in Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Ahmed M. Fathi, Shaimaa Waz, Eman Alaaeldin, Nisreen D. M. Toni, Azza A. K. El-Sheikh, Ahmed M. Sayed, Usama Ramadan Abdelmohsen, Maiiada H. Nazmy
Summary: Blackberry leaves have anti-inflammatory and antioxidant activities. In this study, site-specific delivery of blackberry leaves extract loaded AgNPs to hepatocytes in ischemia-reperfusion injury (IRI) was achieved, and the possible molecular mechanisms were verified. The results showed that pre-treatment with BBE protected against liver damage caused by I/R by reducing oxidative stress and promoting the activation of the anti-apoptotic signaling pathway.
Article
Environmental Sciences
Xiaomin Liu, Jinsheng Liu, Bing Yan, Zhuo Quan, Xiaolong Wang, Yujing Ma, Abdullah A. Alarfaj, Lei Yan
Summary: Breast cancer is a significant health issue for women, and its treatment has been a research focus. This study discovered that periplocin has anticancer properties against breast cancer by inhibiting the PI3K/Akt/mTOR pathway, leading to apoptosis and cell cycle arrest in breast cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Neurosciences
Dongmei Tang, Xue Wang, Jingfang Wu, Yimeng Li, Cai Li, Xiangyun Qiao, Li Fan, Yutao Chen, Huanhuan Zhu, Zhiyuan Zhang, Yingzi He
Summary: Cinchonine (CN) and cinchonidine (CD) can reduce ototoxicity caused by cisplatin and may help treat cisplatin-associated hearing loss.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Luqian Liu, Meijuan Yan, Rui Yang, Xuqing Qin, Ling Chen, Li Li, Junqiang Si, Xinzhi Li, Ketao Ma
Summary: This study confirmed the protective effect of adiponectin (APN) against lipopolysaccharide (LPS)-induced cardiomyocyte apoptosis, potentially through regulating the connexin43 (Cx43) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yueyue Zhu, Fan Wu, Jianing Hu, Yichi Xu, Jinwen Zhang, Yan Li, Yi Lin, Xiaorui Liu
Summary: Dysregulated trophoblast function, specifically related to lactate dehydrogenase A (LDHA) and the PI3K/AKT/FOXO1/CyclinD1 signaling pathway, may be involved in the development of pregnancy-associated complications such as unexplained recurrent spontaneous abortion (URSA). In this study, the authors found that reduced LDHA levels in the placental villus of URSA patients contributed to G0/G1 phase arrest and increased apoptosis in trophoblast cells. Furthermore, LDHA knockdown affected the phosphorylation levels of PI3K, AKT, and FOXO1, resulting in downregulation of CyclinD1. The findings highlight a novel regulatory pathway for trophoblast cell cycle and proliferation.
Article
Plant Sciences
Ziyan Chen, Bangjie He, Jungang Zhao, Jiacheng Li, Yifeng Zhu, Leilei Li, Wenming Bao, Jiuyi Zheng, Haitao Yu, Gang Chen
Summary: This study found that brusatol has inhibitory effects on the proliferation and epithelial-mesenchymal transition process of intrahepatic cholangiocarcinoma cells, and promotes apoptosis in these cells through activating the PI3K/Akt pathway. The findings were further validated in animal models, demonstrating the potential therapeutic effect of brusatol on intrahepatic cholangiocarcinoma.
Article
Pharmacology & Pharmacy
Kai-Di Wang, Miao-Lin Zhu, Cheng-Jiao Qin, Rui-Fang Dong, Cheng-Mei Xiao, Qing Lin, Rong-Yuan Wei, Xiao-Yu He, Xin Zang, Ling-Yi Kong, Yuan-Zheng Xia
Summary: This study revealed the anticancer mechanism of SNG in osteosarcoma, uncovering the potential apoptotic role of SSBP1 in osteosarcoma cells. This finding holds significant promise in advancing the development of novel anticancer drugs and identification of therapeutic targets.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Yan Sun, Huan Zhang, Junpeng Meng, Feng Guo, Dianyun Ren, Heshui Wu, Xin Jin
Summary: This study demonstrates that aberrant PCSK9 upregulation promotes cell proliferation and sorafenib resistance in HCC by inducing AKT activation. Additionally, competitive inhibition of PCSK9 palmitoylation enhances the antitumor effects of sorafenib in HCC.
Article
Biochemistry & Molecular Biology
Li-Li Zhu, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Zhao-Qing Meng, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: This study investigated the cardioprotective effect of Muscone on AMI rats and found that Muscone significantly reduced myocardial injury, improved cardiac function, and exerted protective effects by inhibiting oxidative stress and apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Immunology
Qihong Zhang, Tingting Xie, Guodong Mo, Zihao Zhang, Ling Lin, Xiquan Zhang
Summary: ACSL1, as an interferon-stimulated gene, plays a crucial role in restricting the replication of ALV-J and inducing apoptosis in primary monocyte-derived macrophages through the PI3K/Akt signaling pathway, leading to pro-inflammatory phenotypic changes. These results provide evidence that ACSL1 contributes to the antiviral response against ALV-J.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wenwen Dong, Bei Luo, Chang Qiu, Xu Jiang, Bo Shen, Li Zhang, Weiguo Liu, Wenbin Zhang
Summary: The study demonstrates that TRIM3 may attenuate cell apoptosis in Parkinson's disease by activating the PI3K/AKT signaling pathway, thereby improving cell viability in PD.
Article
Oncology
Yi Cheng, Guiying Wang, Lianmei Zhao, Suli Dai, Jing Han, Xuhua Hu, Chaoxi Zhou, Feifei Wang, Hongqing Ma, Baokun Li, Zesong Meng
Summary: The study found that PPM can inhibit CRC cell proliferation, induce cell apoptosis, and promote G0/G1 cell cycle arrest. Additionally, PPM's effect may be related to the PI3K/AKT signaling pathway, with minimal impact on mouse functions and enhanced anticancer effects when combined with 5-FU.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Mingyan Yao, Jing Zhang, Zhihong Li, Xiaoliang Bai, Jinhui Ma, Yukun Li
Summary: The study demonstrates that liraglutide can protect nucleus pulposus cells from high glucose-induced apoptosis by activating the PI3K/AKT/mTOR/caspase-3 and PI3K/AKT/GSK3 beta/caspase-3 signaling pathways.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Lingyu Li, Jing Li, Hui Chen, Yajun Shen, Yunping Lu, Min Zhang, Xiaofei Tang
Summary: This study investigated the roles and mechanisms of AZOX in oral leukoplakia (OLK) using network pharmacology and experimental validation. The results showed that AZOX may induce apoptosis in OLK through the PI3K/AKT and MAPK pathways. This study reveals the potential therapeutic targets of AZOX in OLK.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Ok Jo, Yun-Jeong Kang, Mee Sun Ock, Kyoung Seob Song, Moon-Jin Jeong, Soon-Jeong Jeong, Yung Hyun Choi, Eun-Ji Ko, Sun-Hee Leem, Suhkmann Kim, Heui-Soo Kim, Hee-Jae Cha
Article
Chemistry, Multidisciplinary
Soon-Jeong Jeong, Baik-Dong Choi, Hye-Yon Lee, Young-Hyoun Hwang, Byung-Hoon Kim, Yong-Ick Cho, Je-Jung Yun, Byung-Ho Lee, Moon-Jin Jeong
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2015)
Article
Cell Biology
Seung-Yeon Lee, Tae-Hee Nho, Baik-Dong Choi, Soon-Jeong Jeong, Do-Seon Lim, Moon-Jin Jeong
ANIMAL CELLS AND SYSTEMS
(2016)
Article
Chemistry, Multidisciplinary
Soon-Jeong Jeong, Moon-Jin Jeong
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2016)
Article
Oncology
Baik-Dong Choi, Seung-Yeon Lee, Soon-Jeong Jeong, Do-Seon Lim, Hee-Jae Cha, Won-Gyun Chung, Moon-Jin Jeong
MOLECULAR MEDICINE REPORTS
(2016)
Article
Medicine, Research & Experimental
Moon Hee Lee, Hee-Jae Cha, Eun Ok Choi, Min Ho Han, Sung Ok Kim, Gi-Young Kim, Su Hyun Hong, Cheol Park, Sung-Kwon Moon, Soon-Jeong Jeong, Moon-Jin Jeong, Wun-Jae Kim, Yung Hyun Choi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2017)
Article
Chemistry, Multidisciplinary
Baik-Dong Choi, Do-Seon Lim, Seung-Yeon Lee, Tae-Hee Nho, Soon-Jeong Jeong, Yeong-Mu Ko, Sung-Nam Gang, Young-Joon Kim, Xing-Hui Piao, Moon-Jin Jeong
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2018)
Article
Medicine, Research & Experimental
Baik-Dong Choi, Hee-Jung Lim, Seung-Yeon Lee, Myoung-Hwa Lee, Ki-Sung Kil, Do-Seon Lim, Soon-Jeong Jeong, Moon-Jin Jeong
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Biology
Sung Ok Kim, Hee-Jae Cha, Cheol Park, Hyesook Lee, Su Hyun Hong, Soon-Jeong Jeong, Shin-Hyung Park, Gi-Young Kim, Sun-Hee Leem, Cheng-Yun Jin, Eun-Joo Hwang, Yung Hyun Choi
Article
Pharmacology & Pharmacy
Cheol Park, Hyesook Lee, Chan-Young Kwon, Gi-Young Kim, Jin-Woo Jeong, Sung Ok Kim, Sung Hyun Choi, Soon-Jeong Jeong, Jeong Sook Noh, Yung Hyun Choi
Summary: Loganin has been shown to have anti-inflammatory and antioxidant effects by inhibiting the secretion of inflammatory mediators and oxidative stress reactions. Upregulation of the Nrf2/HO-1 signaling pathway is involved in the protective effect of loganin against inflammation and oxidative stress.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biotechnology & Applied Microbiology
Moon-Jin Jeong, Do-Seon Lim, Sung Ok Kim, Cheol Park, Sun-Hee Leem, Hyesook Lee, Gi-Yung Kim, Soon-Jeong Jeong, Yung Hyun Choi
Summary: The study demonstrates that rosmarinic acid (RA) can protect C2C12 myoblasts from H2O2-induced damage by inhibiting apoptosis, reducing ROS production, preserving DNA integrity, maintaining mitochondrial function, and activating the Nrf2/HO-1 antioxidant pathway.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Hyun Hwangbo, Seon Yeong Ji, Da Hye Kim, Min Yeong Kim, EunJin Bang, Su Hyun Hong, Sung Ok Kim, Soon-Jeong Jeong, Hyesook Lee, Sung-Kwon Moon, Jung-Hyun Shim, Gi-Young Kim, Suengmok Cho, Yung Hyun Choi
Summary: Phloroglucinol, a polyphenolic compound, has potent antioxidant activity in mouse myoblasts and may have therapeutic benefits for oxidative-stress-mediated muscle disease by activating Nrf2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Moon-Jin Jeong, Do-Seon Lim, Sung Ok Kim, Cheol Park, Yung Hyun Choi, Soon-Jeong Jeong
Summary: This study shows that rosmarinic acid can enhance osteoblast differentiation, cell viability, and mineralization on the titanium surface, upregulating Runx-2 and OPG, while downregulating RANKL through the RANKL/RANK/OPG pathway to promote bone formation.
ANIMAL CELLS AND SYSTEMS
(2021)
Article
Biology
Cheol Park, Hyesook Lee, Min Ho Han, Jin-Woo Jeong, Sung Ok Kim, Soon-Jeong Jeong, Bae-Jin Lee, Gi-Young Kim, Eui Kyun Park, You-Jin Jeon, Yung Hyun Choi