Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms

Clausenidin induces caspase-dependent apoptosis in colon cancer

(2016) Peter M. Waziri et al.   BMC Complementary and Alternative Medicine

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

(2016) Peng Zou et al.   CANCER LETTERS

Historical Spice as a Future Drug: Therapeutic Potential of Piperlongumine

(2016) Sahdeo Prasad et al.   CURRENT PHARMACEUTICAL DESIGN

Vinflunine for the treatment of breast cancer

(2016) Carole Gourmelon et al.   EXPERT OPINION ON PHARMACOTHERAPY

Recent advances in design, synthesis and bioactivity of paclitaxel-mimics

(2016) Guan Wen et al.   FITOTERAPIA

Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

(2016) Roberta Visconti et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quadruplex Nucleic Acids as Novel Therapeutic Targets

(2016) Stephen Neidle   JOURNAL OF MEDICINAL CHEMISTRY

Oxymatrine inhibits the proliferation of CaSki cells via downregulating HPV16E7 expression

(2016) ZHIJUN PEI et al.   ONCOLOGY REPORTS

Oxymatrine inhibits epithelial-mesenchymal transition through regulation of NF-κB signaling in colorectal cancer cells

(2016) Li Liang et al.   ONCOLOGY REPORTS

A Series of β-Carboline Alkaloids from the Seeds of Peganum harmala Show G-Quadruplex Interactions

(2016) Kai-Bo Wang et al.   ORGANIC LETTERS

Induction of apoptosis in human leukemia cells through an intrinsic pathway by cathachunine, a unique alkaloid isolated from Catharanthus roseus

(2016) Xiao-Dong Wang et al.   PHYTOMEDICINE

Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids fromTriclisia subcordata

(2016) Fidelia I. Uche et al.   PHYTOTHERAPY RESEARCH

Bioactive natural products in cancer prevention and therapy: Progress and promise

(2016) Anupam Bishayee et al.   SEMINARS IN CANCER BIOLOGY

Piperlongumine induces gastric cancer cell apoptosis and G2/M cell cycle arrest both in vitro and in vivo

(2016) Chaoqin Duan et al.   TUMOR BIOLOGY

Novel therapeutic strategies for patients with triple-negative breast cancer

(2016) Jun-Fei Zhang et al.   OncoTargets and Therapy

Vinflunine treatment in patients with metastatic urothelial cancer: A Nordic retrospective multicenter analysis

(2016) Karin Holmsten et al.   Oncology Letters

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

(2015) Hala Gali-Muhtasib et al.   APOPTOSIS

Piperlongumine selectively suppresses ABC-DLBCL through inhibition of NF-κB p65 subunit nuclear import

(2015) Mingshan Niu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function

(2015) Lot A. Devriese et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma

(2015) Konstantin Golovine et al.   CANCER BIOLOGY & THERAPY

Piperine inhibits the growth and motility of triple-negative breast cancer cells

(2015) Anna L. Greenshields et al.   CANCER LETTERS

Role of the nucleus in apoptosis: signaling and execution

(2015) Evgeniia A. Prokhorova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Piperine inhibits proliferation of human osteosarcoma cells via G2/M phase arrest and metastasis by suppressing MMP-2/-9 expression

(2015) Jian Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oxymatrine suppresses proliferation and induces apoptosis of hemangioma cells through inhibition of HIF-1a signaling

(2015) Z-W Fei et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents

(2015) Aaron DeBono et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxymatrine suppresses proliferation and facilitates apoptosis of human ovarian cancer cells through upregulating microRNA-29b and downregulating matrix metalloproteinase-2 expression

(2015) JINGWEI LI et al.   Molecular Medicine Reports

Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo

(2015) CUNZAO WU et al.   Molecular Medicine Reports

Selective anticancer activity of hirsutine against HER2-positive breast cancer cells by inducing DNA damage

(2015) CHENGHUA LOU et al.   ONCOLOGY REPORTS

RETRACTED: Effects of Oxymatrine on the Proliferation and Apoptosis of Human Hepatoma Carcinoma Cells

(2015) Yan Liu et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells

(2015) Saharolsadat Sajadian et al.   TOXICOLOGY MECHANISMS AND METHODS

Cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells

(2015) Saharolsadat Sajadian et al.   TOXICOLOGY MECHANISMS AND METHODS

Oxymatrine DownregulatesHPV16E7Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep-2 Cells In Vitro

(2015) Xin-Jiang Ying et al.   Biomed Research International

Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer

(2015) Nirmala Chandralega Kampan et al.   Biomed Research International

The Chromone Alkaloid, Rohitukine, Affords Anti-Cancer Activity via Modulating Apoptosis Pathways in A549 Cell Line and Yeast Mitogen Activated Protein Kinase (MAPK) Pathway

(2015) Safia et al.   PLoS One

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

(2015) Jong-Lyel Roh et al.   Oncotarget

Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells

(2014) Bingyu Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

(2014) F. M. Millimouno et al.   Cancer Prevention Research

Oxymatrine Extracted from Sophora flavescens Inhibited Cell Growth and Induced Apoptosis in Human Osteosarcoma MG-63 Cells In Vitro

(2014) Jianghua Wei et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Pharmacokinetic evaluation of vincristine for the treatment of lymphoid malignancies

(2014) Rabih Said et al.   Expert Opinion on Drug Metabolism & Toxicology

Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation

(2014) CHENGHUA LOU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

From arrow poison to herbal medicine – The ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae)

(2014) Deepak Kumar Semwal et al.   JOURNAL OF ETHNOPHARMACOLOGY

How Taxol/paclitaxel kills cancer cells

(2014) Beth A. Weaver   MOLECULAR BIOLOGY OF THE CELL

Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress

(2014) Paul B. Yaffe et al.   MOLECULAR CARCINOGENESIS

In Vitro and in Vivo Antitumor Activity of Scutebarbatine A on Human Lung Carcinoma A549 Cell Lines

(2014) Xiao-Kun Yang et al.   MOLECULES

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

(2014) Tae Hyong Kim et al.   NEURO-ONCOLOGY

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

(2014) U Bharadwaj et al.   ONCOGENE

Subditine, a New Monoterpenoid Indole Alkaloid from Bark of Nauclea subdita (Korth.) Steud. Induces Apoptosis in Human Prostate Cancer Cells

(2014) Sook Yee Liew et al.   PLoS One

Liriodenine induces the apoptosis of human laryngocarcinoma cells via the upregulation of p53 expression

(2014) LIANG LI et al.   Oncology Letters

Oxymatrine induces apoptosis in human cervical cancer cells through guanine nucleotide depletion

(2013) Mu Li et al.   ANTI-CANCER DRUGS

A pharmacokinetic evaluation of topotecan as a cervical cancer therapy

(2013) Fernanda Musa et al.   Expert Opinion on Drug Metabolism & Toxicology

Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells

(2013) Lei Zheng et al.   FOOD AND CHEMICAL TOXICOLOGY

Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy

(2013) Dong-yun Ouyang et al.   FOOD AND CHEMICAL TOXICOLOGY

Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells

(2013) Minh Truong Do et al.   FOOD CHEMISTRY

Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells

(2013) Tayyab A. Mansoor et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-κB-mediated VEGF signaling pathway

(2013) HUI CHEN et al.   ONCOLOGY REPORTS

Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells

(2013) Serge Ginzburg et al.   PROSTATE

Activation of ERK signaling and induction of colon cancer cell death by piperlongumine

(2013) H. Randhawa et al.   TOXICOLOGY IN VITRO

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway

(2013) Guangwen Shu et al.   TOXICOLOGY LETTERS

Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway

(2013) Yi Lin et al.   TUMOR BIOLOGY

Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway

(2013) Yong Zhang et al.   TUMOR BIOLOGY

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Plant Defense Against Herbivores: Chemical Aspects

(2012) Axel Mithöfer et al.   Annual Review of Plant Biology

Alkaloids Isolated from Natural Herbs as the Anticancer Agents

(2012) Jin-Jian Lu et al.   Evidence-based Complementary and Alternative Medicine

Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells

(2012) Paul B. Yaffe et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of Salt Bridge Dynamics in Inter Domain Recognition of Human IMPDH Isoforms: An Insight to Inhibitor Topology for Isoform-II

(2012) Hridoy R. Bairagya et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents

(2012) Michael Wink et al.   Frontiers in Microbiology

2011: the immune hallmarks of cancer

(2011) Federica Cavallo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Alpha-Tomatine Induces Apoptosis and Inhibits Nuclear Factor-Kappa B Activation on Human Prostatic Adenocarcinoma PC-3 Cells

(2011) Sui-Ting Lee et al.   PLoS One

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

Oxymatrine diminishes the side population and inhibits the expression of β-catenin in MCF-7 breast cancer cells

(2010) Ying Zhang et al.   MEDICAL ONCOLOGY

α-Tomatine inactivates PI3K/Akt and ERK signaling pathways in human lung adenocarcinoma A549 cells: Effect on metastasis

(2009) Yuan-Wei Shih et al.   FOOD AND CHEMICAL TOXICOLOGY

Apoptosis and cancer: mutations within caspase genes

(2009) S Ghavami et al.   JOURNAL OF MEDICAL GENETICS

Involvement of the HER2 pathway in repair of DNA damage produced by chemotherapeutic agents

(2009) J. J.M. Boone et al.   MOLECULAR CANCER THERAPEUTICS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

(2008) Daniel Laryea et al.   INVESTIGATIONAL NEW DRUGS

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

(2008) Avi Ashkenazi   NATURE REVIEWS DRUG DISCOVERY