Redox regulation in stem-like cancer cells by CD44 variant isoforms

Reactive Oxygen Species in Cancer Stem Cells

(2012) Xiaoke Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer-Initiating Cells

(2012) H. Ohata et al.   CANCER RESEARCH

CD44s Regulates the TGF- -Mediated Mesenchymal Phenotype and Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma

(2012) K. Mima et al.   CANCER RESEARCH

Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC- Transporter Using Positron Emission Tomography in Patients with Non-Small Cell Lung or Breast Cancer

(2012) S. Baek et al.   CLINICAL CANCER RESEARCH

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

(2012) Balaji Krishnamachary et al.   PLoS One

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

The convergence of radiation and immunogenic cell death signaling pathways

(2012) Encouse B. Golden et al.   Frontiers in Oncology

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

(2011) J Lewerenz et al.   CELL DEATH AND DIFFERENTIATION

Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases

(2011) Sebastian M. Dieter et al.   Cell Stem Cell

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

(2011) Rhonda L. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy

(2011) Phuc V Pham et al.   Journal of Translational Medicine

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells

(2011) L Y W Bourguignon et al.   ONCOGENE

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

An ESRP-regulated splicing programme is abrogated during the epithelial–mesenchymal transition

(2010) Claude C Warzecha et al.   EMBO JOURNAL

Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling

(2010) Ying Qu et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

(2010) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells

(2009) Mark G. Slomiany et al.   CANCER RESEARCH

Altered expression of glycan genes in cancers induced by epigenetic silencing and tumor hypoxia: Clues in the ongoing search for new tumor markers

(2009) Reiji Kannagi et al.   CANCER SCIENCE

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Tumor Necrosis Factor-α Regulates Transforming Growth Factor-β-dependent Epithelial-Mesenchymal Transition by Promoting Hyaluronan-CD44-Moesin Interaction

(2009) Eri Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

(2009) Shiren Sun et al.   KIDNEY INTERNATIONAL

ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing

(2009) Claude C. Warzecha et al.   MOLECULAR CELL

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer Stem Cells, Hypoxia and Metastasis

(2009) Richard P. Hill et al.   SEMINARS IN RADIATION ONCOLOGY

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis

(2008) J. Zeilstra et al.   CANCER RESEARCH

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

(2008) L. Du et al.   CLINICAL CANCER RESEARCH

Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance

(2008) Bryan P. Toole et al.   DRUG RESISTANCE UPDATES

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

(2008) Qihong Huang et al.   NATURE CELL BIOLOGY

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Involvement of CD44, a molecule with a thousand faces, in cancer dissemination

(2008) David Naor et al.   SEMINARS IN CANCER BIOLOGY