Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing

Could new COVID variants undermine vaccines? Labs scramble to find out

(2021) Ewen Callaway   NATURE

Evolution of antibody immunity to SARS-CoV-2

(2021) Christian Gaebler et al.   NATURE

Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

(A Little) Clarity on Convalescent Plasma for Covid-19

(2021) Louis M. Katz   NEW ENGLAND JOURNAL OF MEDICINE

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

(2021) Tyler N. Starr et al.   SCIENCE

Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial

(2021) Serge Bureau et al.   Lancet Respiratory Medicine

The right place for IL-1 inhibition in COVID-19

(2021) Giulio Cavalli et al.   Lancet Respiratory Medicine

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells

(2021) Anthony Kusnadi et al.   Science Immunology

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19

(2021) Perrine Janiaud et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Outpatient metformin use is associated with reduced severity of COVID‐19 disease in adults with overweight or obesity.

(2021) Carolyn T. Bramante et al.   JOURNAL OF MEDICAL VIROLOGY

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

(2021) Denis Y Logunov et al.   LANCET

Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients

(2021) Sharon Amit et al.   LANCET

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

(2021) Noa Dagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

(2021) Ivan O. Rosas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus

(2021) Sarah Al-Beltagi et al.   Viruses-Basel

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

(2021) Adam K. Wheatley et al.   Nature Communications

Vitamin D and covid-19

(2021) Karani S Vimaleswaran et al.   BMJ-British Medical Journal

Covid-19: Highest death rates seen in countries with most overweight populations

(2021) Jacqui Wise   BMJ-British Medical Journal

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

(2021) Jing Wu et al.   Cell Reports

The effect of vitamin D supplementation on acute respiratory tract infection in older Australian adults: an analysis of data from the D-Health Trial

(2021) Hai Pham et al.   Lancet Diabetes & Endocrinology

Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly

(2021) Weikan Wang et al.   Cells

The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis

(2021) Amare Teshome et al.   Frontiers in Public Health

Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration

(2021) Gregory J. Gillispie et al.   Life-Basel

Testosterone's Role in COVID-19

(2021) Jeremy M. Auerbach et al.   Journal of Sexual Medicine

Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study

(2021) Eleftheria Vasileiou et al.   LANCET

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

(2021) Obbina Abani et al.   LANCET

Targeting IL-6 in patients at high cardiovascular risk

(2021) Mette Christoffersen et al.   LANCET

IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

(2021) Paul M Ridker et al.   LANCET

Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study

(2021) Christian Holm Hansen et al.   LANCET

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

(2021) Nicole Doria-Rose et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effect of age on the clinical and immune characteristics of critically ill patients with COVID-19: A preliminary report

(2021) Chunling Hu et al.   PLoS One

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

(2021) Zhongfang Wang et al.   Nature Communications

Discipline in Stages: Regulating CD8+ Resident Memory T Cells

(2021) Rut Mora-Buch et al.   Frontiers in Immunology

Spike-antibody waning after second dose of BNT162b2 or ChAdOx1

(2021) Madhumita Shrotri et al.   LANCET

Covid-19 Breakthrough Infections in Vaccinated Health Care Workers

(2021) Moriah Bergwerk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Questioning the sex-specific differences in the association of smoking on the survival rate of hospitalized COVID-19 patients

(2021) Athar Khalil et al.   PLoS One

Peripheral and lung resident memory T cell responses against SARS-CoV-2

(2021) Judith Grau-Expósito et al.   Nature Communications

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

(2020) Luca Liberale et al.   EUROPEAN HEART JOURNAL

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity

(2020) Jonathan M. Rhodes et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Is global BCG vaccination‐induced trained immunity relevant to the progression of SARS‐CoV‐2 pandemic?

(2020) Mayda Gursel et al.   ALLERGY

Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series

(2020) Achille Aouba et al.   ANNALS OF THE RHEUMATIC DISEASES

The NLRP3 inflammasome regulates adipose tissue metabolism

(2020) Nicole G. Barra et al.   BIOCHEMICAL JOURNAL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

(2020) Jean-Laurent Casanova et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

At the Heart of the Matter: Unmasking and Addressing COVID-19's Toll on Diverse Populations

(2020) Norrisa Haynes et al.   CIRCULATION

Obesity a Risk Factor for Severe COVID-19 Infection: Multiple Potential Mechanisms

(2020) Naveed Sattar et al.   CIRCULATION

COVID-19 and Cardiovascular Disease

(2020) Kevin J. Clerkin et al.   CIRCULATION

Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells

(2020) Yueping Liu et al.   CLINICAL INFECTIOUS DISEASES

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

(2020) Bo Li et al.   Clinical Research in Cardiology

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes

(2020) Massimiliano Bonafè et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

(2020) Iziah E Sama et al.   EUROPEAN HEART JOURNAL

The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic

(2020)   EUROPEAN JOURNAL OF HUMAN GENETICS

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

(2020) Rong-Hui Du et al.   EUROPEAN RESPIRATORY JOURNAL

Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review

(2020) Nicholas E. Ingraham et al.   EUROPEAN RESPIRATORY JOURNAL

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

(2020) Jing Yang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

(2020) Donato Gemmati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults

(2020) Uri Hamiel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Coronavirus Occurrence and Transmission Over 8 Years in the HIVE Cohort of Households in Michigan

(2020) Arnold S Monto et al.   JOURNAL OF INFECTIOUS DISEASES

BCG scarring and improved child survival: a combined analysis of studies of BCG scarring

(2020) C. S. Benn et al.   JOURNAL OF INTERNAL MEDICINE

COVID-19 exacerbating inequalities in the US

(2020) Aaron van Dorn et al.   LANCET

Variations between women and men in risk factors, treatments, cardiovascular disease incidence, and death in 27 high-income, middle-income, and low-income countries (PURE): a prospective cohort study

(2020) Marjan Walli-Attaei et al.   LANCET

COVID-19 and Italy: what next?

(2020) Andrea Remuzzi et al.   LANCET

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Inhibitors of the Renin–Angiotensin–Aldosterone System and Covid-19

(2020) John A. Jarcho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of adipocytes and adipocyte‐like cells in the severity of COVID‐19 infections

(2020) Ilja L. Kruglikov et al.   Obesity

Prevalence, Severity and Mortality associated with COPD and Smoking in patients with COVID-19: A Rapid Systematic Review and Meta-Analysis

(2020) Jaber S. Alqahtani et al.   PLoS One

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin D’s Effect on Immune Function

(2020) Pieter-Jan Martens et al.   Nutrients

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

(2020) Christopher M Petrilli et al.   BMJ-British Medical Journal

Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study

(2020) Rui Huang et al.   PLoS Neglected Tropical Diseases

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

(2020) Marisa Stebegg et al.   eLife

The immune response to influenza in older humans: beyond immune senescence

(2020) Janet E. McElhaney et al.   Immunity & Ageing

Impact of sex and gender on COVID-19 outcomes in Europe

(2020) Catherine Gebhard et al.   Biology of Sex Differences

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population—Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures

(2020) Elisa Cisneros et al.   Frontiers in Immunology

Interferon-α2b Treatment for COVID-19

(2020) Qiong Zhou et al.   Frontiers in Immunology

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Tao Guo et al.   JAMA Cardiology

Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality

(2020) Robert O. Bonow et al.   JAMA Cardiology

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

(2020) Shaobo Shi et al.   JAMA Cardiology

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

(2020) Jiawei Chen et al.   AGING CELL

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

(2020) Rosanna Asselta et al.   Aging-US

COVID-19 fatalities, latitude, sunlight, and vitamin D

(2020) Paul B. Whittemore   AMERICAN JOURNAL OF INFECTION CONTROL

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

(2020) Yuan Hou et al.   BMC Medicine

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Immune monitoring of interleukin-7 compassionate use in a critically ill COVID-19 patient

(2020) Guillaume Monneret et al.   Cellular & Molecular Immunology

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?

(2020) Giuseppe Lippi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Metformin in COVID-19: A possible role beyond diabetes

(2020) Swati Sharma et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people

(2020) Julia Hippisley-Cox et al.   HEART

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool

(2020) Lianne Kok et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

(2020) Pedro M Folegatti et al.   LANCET

Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment

(2020) Sebastiano Cicco et al.   MEDIATORS OF INFLAMMATION

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

New-Onset Diabetes in Covid-19

(2020) Francesco Rubino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy

(2020) Corrado Lodigiani et al.   THROMBOSIS RESEARCH

The effect of Bacillus Calmette–Guérin (BCG) vaccination in preventing sever infectious respiratory diseases other than TB: Implications for the COVID-19 pandemic

(2020) Kiddus Yitbarek et al.   VACCINE

Immunological and inflammatory profiles in mild and severe cases of COVID-19

(2020) Jin-Wen Song et al.   Nature Communications

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

(2020) Sara De Biasi et al.   Nature Communications

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Obesity and covid-19: the role of the food industry

(2020) Monique Tan et al.   BMJ-British Medical Journal

Interplay between SARS-CoV-2 and the type I interferon response

(2020) Margarida Sa Ribero et al.   PLoS Pathogens

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

COVID-19 in people with diabetes: understanding the reasons for worse outcomes

(2020) Matteo Apicella et al.   Lancet Diabetes & Endocrinology

Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study

(2020) Naomi Holman et al.   Lancet Diabetes & Endocrinology

Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

(2020) Lucas Leite Cunha et al.   Frontiers in Immunology

Role of vitamin D in preventing of COVID-19 infection, progression and severity

(2020) Nurshad Ali   Journal of Infection and Public Health

COVID-19 and Diabetes: The Importance of Controlling RAGE

(2020) Ernestina M. De Francesco et al.   Frontiers in Endocrinology

Comprehensive mapping of immune perturbations associated with severe COVID-19

(2020) Leticia Kuri-Cervantes et al.   Science Immunology

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

(2020) Daniela Weiskopf et al.   Science Immunology

Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

(2020) Pierre Francois Laterre et al.   JAMA Network Open

Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis

(2020) Ian Huang et al.   Journal of Intensive Care

Subcutaneous injection of IFN alpha-2b for COVID-19: an observational study

(2020) Bo Wang et al.   BMC INFECTIOUS DISEASES

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

(2020) Evangelos J. Giamarellos-Bourboulis et al.   CELL

Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans

(2020) John Xie et al.   DIABETES CARE

SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype

(2020) Naoki Yamamoto et al.   GENE

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population

(2020) Sabra L. Klein et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia

(2020) Denis Y Logunov et al.   LANCET

Sex and gender: modifiers of health, disease, and medicine

(2020) Franck Mauvais-Jarvis et al.   LANCET

Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis

(2020) Sukrit Narula et al.   LANCET

Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

(2020) Hugo Zeberg et al.   NATURE

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

(2020) Evan J. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

(2020) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships

(2020) Barry M. Popkin et al.   Obesity Reviews

Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations

(2020) Anshika Srivastava et al.   PLoS One

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

(2020) Alina Baum et al.   SCIENCE

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

(2020) SangJoon Lee et al.   TRENDS IN IMMUNOLOGY

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia

(2020) Carlo Salvarani et al.   JAMA Internal Medicine

The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19

(2020) Mira Bosso et al.   Molecular Therapy-Methods & Clinical Development

Natural killer cell immunotypes related to COVID-19 disease severity

(2020) Christopher Maucourant et al.   Science Immunology

Considering Interim Interventions to Control COVID-19 Associated Morbidity and Mortality—Perspectives

(2020) Mark Christopher Arokiaraj   Frontiers in Public Health

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

(2020) Lauren B. Rodda et al.   CELL

Oxford–AstraZeneca COVID-19 vaccine efficacy

(2020) Maria Deloria Knoll et al.   LANCET

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Age and frailty in COVID-19 vaccine development

(2020) Melissa K Andrew et al.   LANCET

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

(2020) Maheshi N Ramasamy et al.   LANCET

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

(2020) Alicia T. Widge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

(2020) David M. Weinreich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

(2020) Sheila F. Lumley et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

(2020) Peter Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Covid-19: Critically ill patients treated with arthritis drug tocilizumab show improved outcomes, researchers report

(2020) Jacqui Wise   BMJ-British Medical Journal

Sex differences in COVID-19 case fatality: do we know enough?

(2020) Nabamallika Dehingia et al.   Lancet Global Health

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Phillip D Monk et al.   Lancet Respiratory Medicine

Accelerated lung aging and chronic obstructive pulmonary disease

(2019) Young Soon Yoon et al.   Expert Review of Respiratory Medicine

Testosterone Therapy in Men With Hypogonadism Prevents Progression From Prediabetes to Type 2 Diabetes: Eight-Year Data From a Registry Study

(2019) Aksam Yassin et al.   DIABETES CARE

Non-specific effects of BCG vaccine on viral infections

(2019) S.J.C.F.M. Moorlag et al.   CLINICAL MICROBIOLOGY AND INFECTION

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells

(2019) Emeka B. Okeke et al.   Frontiers in Immunology

Distribution of Killer-Cell Immunoglobulin-Like Receptor Genes and Combinations of Their Human Leucocyte Antigen Ligands in 11 Ethnic Populations in China

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CD4:8 Ratio >5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results From the BELFRAIL Study

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(2013) Stephanie Jost et al.   Annual Review of Immunology

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Killer Immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)

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Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

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Human NK cells display major phenotypic and functional changes over the life span

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The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20–100 years of age

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