Agephagy – Adapting Autophagy for Health During Aging

Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells

(2019) Alexander Agrotis et al.   Autophagy

Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster

(2019) Nga N. Nguyen et al.   Scientific Reports

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

(2019) Benjamin J. Ravenhill et al.   MOLECULAR CELL

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

The Genetics of Aging: A Vertebrate Perspective

(2019) Param Priya Singh et al.   CELL

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

(2019) Vikramjit Lahiri et al.   Cell Metabolism

History of The Selective Autophagy Research: How Did It Begin and Where Does It Stand Today?

(2019) Vladimir Kirkin   JOURNAL OF MOLECULAR BIOLOGY

Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline

(2019) Erin Munkácsy et al.   AGING CELL

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform

(2019) Maria Zachari et al.   DEVELOPMENTAL CELL

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

On the Fly: Recent Progress on Autophagy and Aging in Drosophila

(2019) Tamás Maruzs et al.   Frontiers in Cell and Developmental Biology

The Michael J. Fox Foundation for Parkinson’s Research Strategy to Advance Therapeutic Development of PINK1 and Parkin

(2019) Shalini Padmanabhan et al.   Biomolecules

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

(2019) Rosina Pryor et al.   CELL

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

(2019) Jorge Iván Castillo-Quan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The FoxO–Autophagy Axis in Health and Disease

(2019) Zhiyong Cheng   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

(2019) Oliver H. Tam et al.   Cell Reports

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases

(2018) Karlina J. Kauffman et al.   Autophagy

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

(2018) Brent E. Fitzwalter et al.   DEVELOPMENTAL CELL

Autophagy during ageing - from Dr Jekyll to Mr Hyde

(2018) Thomas Wilhelm et al.   FEBS Journal

Transcriptional and post-transcriptional regulation of autophagy in the yeastSaccharomyces cerevisiae

(2018) Elizabeth Delorme-Axford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomere Length and Bipolar Disorder

(2018) Timothy R Powell et al.   NEUROPSYCHOPHARMACOLOGY

Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster

(2018) Janet S. Mason et al.   PLoS One

Metabolic shift from glycogen to trehalose promotes lifespan and healthspan inCaenorhabditis elegans

(2018) Yonghak Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

(2018) Marina Ezcurra et al.   CURRENT BIOLOGY

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models

(2018) Fiona Kerr et al.   Frontiers in Molecular Neuroscience

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Linking Lipid Metabolism to Chromatin Regulation in Aging

(2018) Katharina Papsdorf et al.   TRENDS IN CELL BIOLOGY

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

(2017) Thomas Wilhelm et al.   GENES & DEVELOPMENT

New insights into autophagosome–lysosome fusion

(2017) Shuhei Nakamura et al.   JOURNAL OF CELL SCIENCE

Proteostasis and ageing: insights from long-lived mutant mice

(2017) William A. Sands et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epigenetic Control of Autophagy: Nuclear Events Gain More Attention

(2017) Sung Hee Baek et al.   MOLECULAR CELL

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

(2017) Shuo Han et al.   NATURE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

A pathway of targeted autophagy is induced by DNA damage in budding yeast

(2017) Vinay V. Eapen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Good Ol’ Fat: Links between Lipid Signaling and Longevity

(2017) Victor Bustos et al.   TRENDS IN BIOCHEMICAL SCIENCES

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

(2017) Graeme Hewitt et al.   TRENDS IN CELL BIOLOGY

Rethinking HSF1 in Stress, Development, and Organismal Health

(2017) Jian Li et al.   TRENDS IN CELL BIOLOGY

A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

(2017) N. Pengo et al.   Nature Communications

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

(2017) Silvan R. Urfer et al.   GeroScience

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

(2016) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Gerosuppression by pan-mTOR inhibitors

(2016) Olga V. Leontieva et al.   Aging-US

Fine-tuning autophagy: from transcriptional to posttranslational regulation

(2016) Joëlle Botti-Millet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options

(2016) Wilbert P. Vermeij et al.   Annual Review of Pharmacology and Toxicology

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

(2016) Graeme Hewitt et al.   Autophagy

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

A Ribosomal Perspective on Proteostasis and Aging

(2016) Kristan K. Steffen et al.   Cell Metabolism

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Systemic Analysis of Atg5 -Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons

(2016) Saori R. Yoshii et al.   DEVELOPMENTAL CELL

Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells

(2016) Dido Carrero et al.   Disease Models & Mechanisms

Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients

(2016) Alessio Squassina et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

Insulin signalling in Alzheimer′s disease and diabetes: from epidemiology to molecular links

(2016) E. M. Ribe et al.   JOURNAL OF INTERNAL MEDICINE

Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62

(2016) Yanan Wang et al.   MOLECULAR CELL

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth

(2016) Kuo-Hui Su et al.   NATURE CELL BIOLOGY

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

(2016) Jorge Iván Castillo-Quan et al.   Cell Reports

Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction

(2016) Sara Gelino et al.   PLoS Genetics

DNA Damage Response and Autophagy: A Meaningful Partnership

(2016) Aristides G. Eliopoulos et al.   Frontiers in Genetics

Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants

(2016) Robert J. Shmookler Reis et al.   Aging-US

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

(2015) Fu-Zheng Wei et al.   Autophagy

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Repurposing metformin: an old drug with new tricks in its binding pockets

(2015) R. Pryor et al.   BIOCHEMICAL JOURNAL

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

(2015) Cathy Slack et al.   CELL

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Membrane dynamics in autophagosome biogenesis

(2015) S. R. Carlsson et al.   JOURNAL OF CELL SCIENCE

Error-Prone Repair of DNA Double-Strand Breaks

(2015) Kasey Rodgers et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(2015) Emma Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury

(2015) Weiwei Lin et al.   Scientific Reports

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes

(2015) Mikhail Shaposhnikov et al.   Scientific Reports

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Dynamics of autophagosome formation: a pulse and a sequence of waves

(2014) Nicholas T. Ktistakis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

DAF-16 target identification in C. elegans: past, present and future

(2014) Jennifer M. A. Tullet   BIOGERONTOLOGY

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

(2014) M. Schiebler et al.   EMBO Molecular Medicine

The paradox of mitochondrial dysfunction and extended longevity

(2014) Erin Munkácsy et al.   EXPERIMENTAL GERONTOLOGY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

RAD6 Promotes Homologous Recombination Repair by Activating the Autophagy-Mediated Degradation of Heterochromatin Protein HP1

(2014) Su Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease

(2014) Oyinkan Sofola-Adesakin et al.   Frontiers in Aging Neuroscience

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast

(2013) John P. Aris et al.   EXPERIMENTAL GERONTOLOGY

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

 -6 Polyunsaturated fatty acids extend life span through the activation of autophagy

(2013) E. J. O'Rourke et al.   GENES & DEVELOPMENT

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial

(2013)   LANCET NEUROLOGY

Epigenetic Regulation of Autophagy by the Methyltransferase G9a

(2013) A. Artal-Martinez de Narvajas et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

The return of the nucleus: transcriptional and epigenetic control of autophagy

(2013) Jens Füllgrabe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

(2013) Tanima SenGupta et al.   Nature Communications

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Plasma long-chain free fatty acids predict mammalian longevity

(2013) Mariona Jové et al.   Scientific Reports

Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans

(2013) Bree N. Heestand et al.   PLoS Genetics

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

(2011) Travis J. Maures et al.   AGING CELL

A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

(2011) Ivana Bjedov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

(2011) Chunyu Jin et al.   Cell Metabolism

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

Low-dose lithium uptake promotes longevity in humans and metazoans

(2011) Kim Zarse et al.   EUROPEAN JOURNAL OF NUTRITION

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Trehalose extends longevity in the nematode Caenorhabditis elegans

(2010) Yoko Honda et al.   AGING CELL

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

(2010) Brigit E. Riley et al.   JOURNAL OF CELL BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mammalian models of extended healthy lifespan

(2010) C. Selman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

(2010) C. Kenyon   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

The Demographic and Biomedical Case for Late-Life Interventions in Aging

(2010) M. J. Rae et al.   Science Translational Medicine

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

PUMA- and Bax-induced autophagy contributes to apoptosis

(2009) K S Yee et al.   CELL DEATH AND DIFFERENTIATION

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

The new biology of ageing

(2009) L. Partridge   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

(2009) A. P. Siebold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Valproic acid extends Caenorhabditis elegans lifespan

(2008) Kimberley Evason et al.   AGING CELL

Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

(2008) David Gems et al.   Cell Metabolism

Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model

(2008) H.-L. Feng et al.   NEUROSCIENCE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

(2008) M. C. Wang et al.   SCIENCE