COVID-19 and Diabetes: The Importance of Controlling RAGE

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

Outcomes in Patients With Hyperglycemia Affected by Covid-19: Can We Do More on Glycemic Control?

(2020) Celestino Sardu et al.   DIABETES CARE

SARS-CoV-2-mediated inflammatory response in lungs: should we look at RAGE?

(2020) Armando Rojas et al.   INFLAMMATION RESEARCH

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

(2020) Chi Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Efficacy and safety of recombinant human soluble thrombomodulin in patients with sepsis‐associated coagulopathy: A systematic review and meta‐analysis

(2020) Emanuele Valeriani et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

(2020) Ulf Andersson et al.   MOLECULAR MEDICINE

CD147 is a Novel Interaction Partner of Integrin αMβ2 Mediating Leukocyte and Platelet Adhesion

(2020) David Heinzmann et al.   Biomolecules

Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome

(2020) Loris Roncon et al.   JOURNAL OF CLINICAL VIROLOGY

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

(2019) Matae Ahn et al.   Nature Microbiology

Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target?

(2019) Yanan Xie et al.   Journal of Neuroinflammation

HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury

(2019) Lei Mi et al.   BIOMEDICINE & PHARMACOTHERAPY

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

(2019) Dequina A. Nicholas et al.   Cell Metabolism

Soluble RAGE attenuates AngII-induced endothelial hyperpermeability by disrupting HMGB1-mediated crosstalk between AT1R and RAGE

(2019) Jisu Jeong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Association of IFNG gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases

(2019) Hidemi Hashimoto et al.   CYTOKINE

Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation

(2019) Esther Hoste et al.   Cell Reports

Targeting RAGE Signaling in Inflammatory Disease

(2018) Barry I. Hudson et al.   Annual Review of Medicine

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

(2018) Han Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells

(2018) Ulf Andersson et al.   SEMINARS IN IMMUNOLOGY

HMGB1 Increases IL-1β Production in Vascular Smooth Muscle Cells via NLRP3 Inflammasome

(2018) Eun Jung Kim et al.   Frontiers in Physiology

Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease)

(2018) Jesus Bermejo-Martin et al.   Journal of Clinical Medicine

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE

(2017) Travis B. Nielsen et al.   mBio

Emerging role of HMGB1 in lung diseases: friend or foe

(2016) Junying Ding et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Therapeutic potential of recombinant thrombomodulin for lung injury after pneumonectomy via inhibition of high-mobility group box 1 in mice

(2016) Yusuke Takahashi et al.   Journal of Trauma and Acute Care Surgery

Contraction of the type I IFN locus and unusual constitutive expression ofIFN-αin bats

(2016) Peng Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of recombinant thrombomodulin for lung injury after pneumonectomy via inhibition of high-mobility group box 1 in mice

(2016) Yusuke Takahashi et al.   Journal of Trauma and Acute Care Surgery

Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome

(2015) Matthieu Jabaudon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

High-mobility group box 1 enhances the inflammatory process in diabetic lung

(2015) Raluca Maria Boteanu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia

(2015) Yan Fei Qi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Soluble RAGE and the RAGE Ligands HMGB1 and S100A12 in Critical Illness

(2015) Catherine Ingels et al.   SHOCK

Pattern recognition receptors in innate immunity, host defense, and immunopathology

(2013) Rahul Suresh et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products

(2013) Laure Yatime et al.   FEBS Journal

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

(2013) Cherilyn M. Sirois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase

(2013) H Fang et al.   Cell Death & Disease

Diabetes Alters Activation and Repression of Pro- and Anti-Inflammatory Signaling Pathways in the Vasculature

(2013) Elyse Di Marco et al.   Frontiers in Endocrinology

Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications

(2010) W. Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands

(2010) Narayanam V. Rao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA