COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

Estrogen downregulates gp130 expression in HUVECs by regulating ADAM10 and ADAM17 via the estrogen receptor

(2020) Man Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

(2020) Donato Gemmati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

SeXY chromosomes and the immune system: reflections after a comparative study

(2020) Irene Meester et al.   Biology of Sex Differences

Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2

(2020) Guoshuai Cai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease

(2020) Wei Liu et al.   CHINESE MEDICAL JOURNAL

Smoking habit and hospitalization for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related pneumonia: The unsolved paradox behind the evidence.

(2020) Giovanna Garufi et al.   European Journal of Internal Medicine

COVID-19 and Smoking. Is Nicotine the Hidden Link?

(2020) Patrizia Russo et al.   EUROPEAN RESPIRATORY JOURNAL

Updated rapid risk assessment from ECDC on coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK

(2020)   Eurosurveillance

Shelter hospital mode: How do we prevent COVID-19 hospital-acquired infection?

(2020) Yong Yang et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis

(2020) Zhaohai Zheng et al.   JOURNAL OF INFECTION

Clinical Implications of SARS-Cov2 Interaction with Renin Angiotensin System

(2020) Agnieszka Brojakowska et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

(2020) Behnood Bikdeli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The versatile heparin in COVID‐19

(2020) Jecko Thachil   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2

(2020) Shiyu Yin et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Sex and Gender Disparities in the COVID-19 Pandemic

(2020) Jewel Gausman et al.   JOURNAL OF WOMENS HEALTH

Inhibitors of the Renin–Angiotensin–Aldosterone System and Covid-19

(2020) John A. Jarcho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tobacco industry in the time of COVID-19: time to shut it down?

(2020) Marita Hefler et al.   TOBACCO CONTROL

Sex difference and smoking predisposition in patients with COVID-19

(2020) Hua Cai   Lancet Respiratory Medicine

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

(2020) Shaobo Shi et al.   JAMA Cardiology

Global Spread of Coronavirus Disease 2019 and Malaria: An Epidemiological Paradox in the Early Stage of A Pandemic

(2020) Pietro Emanuele Napoli et al.   Journal of Clinical Medicine

Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)

(2020) Samuel James Brake et al.   Journal of Clinical Medicine

Epidemiological and clinical characteristics analysis of COVID-19 in the surrounding areas of Wuhan, Hubei Province in 2020

(2020) Yi Zheng et al.   PHARMACOLOGICAL RESEARCH

Factors determining the diffusion of COVID-19 and suggested strategy to prevent future accelerated viral infectivity similar to COVID

(2020) Mario Coccia   SCIENCE OF THE TOTAL ENVIRONMENT

The international imperative to rapidly and inexpensively monitor community-wide Covid-19 infection status and trends

(2020) Christian Daughton   SCIENCE OF THE TOTAL ENVIRONMENT

When the balance is broken: X‐linked gene dosage from two X chromosomes and female‐biased autoimmunity

(2019) Camille M. Syrett et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis

(2019) Laura Jane Smyth et al.   BMJ Open

New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways

(2019) Brianna Atto et al.   CLINICAL SCIENCE

Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses

(2019) Steve Oghumu et al.   JOURNAL OF IMMUNOLOGY

The Number of X Chromosomes Influences Inflammatory Cytokine Production Following Toll-Like Receptor Stimulation

(2019) Nicolas Lefèvre et al.   Frontiers in Immunology

The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

(2019) Denise S. Pinheiro et al.   PLoS One

Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS)

(2019) Veronica Tisato et al.   Genes

Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age

(2019) Antonino Zito et al.   Nature Communications

Hemostasis and Thrombosis in the Oldest Old

(2018) Ron Hoffman et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The Acid–Base Balance and Gender in Inflammation: A Mini-Review

(2018) Georges Jacques Casimir et al.   Frontiers in Immunology

Inherited genetic predispositions in F13A1 and F13B genes predict abdominal adhesion formation: identification of gender prognostic indicators

(2018) Donato Gemmati et al.   Scientific Reports

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

(2017) Rudragouda Channappanavar et al.   JOURNAL OF IMMUNOLOGY

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer

(2017) Ken J Kron et al.   NATURE GENETICS

Mechanistic insights in X-chromosome inactivation

(2017) Zhipeng Lu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Inherent X-Linked Genetic Variability and Cellular Mosaicism Unique to Females Contribute to Sex-Related Differences in the Innate Immune Response

(2017) Zoltan Spolarics et al.   Frontiers in Immunology

Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors

(2016) Jackye Peretz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis

(2016) Alaa Badawi et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

TheACE2G8790A Polymorphism: Involvement in Type 2 Diabetes Mellitus Combined with Cerebral Stroke

(2016) Yan-Hui Wu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

(2016) Jianle Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolution of sex-specific virulence in infectious diseases

(2016) Francisco Úbeda et al.   Nature Communications

Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study

(2015) Lillian Jespersen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mechanical Stress and the Induction of Lung Fibrosis via the Midkine Signaling Pathway

(2015) Rong Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Estrogen receptors regulate innate immune cells and signaling pathways

(2015) Susan Kovats   CELLULAR IMMUNOLOGY

Identification ofTMPRSS2as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

(2015) Zhongshan Cheng et al.   JOURNAL OF INFECTIOUS DISEASES

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Perspectives for angiotensin profiling with liquid chromatography/mass spectrometry to evaluate ACE/ACE2 balance in endothelial dysfunction and vascular pathologies

(2015) Mariola Olkowicz et al.   Pharmacological Reports

Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters

(2015) Fabiano C. Araujo et al.   PHYSIOLOGICAL GENOMICS

Factor XIII-A dynamics in acute myocardial infarction: a novel prognostic biomarker?

(2015) Giulia Zeri et al.   THROMBOSIS AND HAEMOSTASIS

Sex-based differences in immune function and responses to vaccination

(2015) S. L. Klein et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients

(2014) Mei Yang et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

17 -Estradiol Protects Females against Influenza by Recruiting Neutrophils and Increasing Virus-Specific CD8 T Cell Responses in the Lungs

(2014) D. P. Robinson et al.   JOURNAL OF VIROLOGY

Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension

(2014) Jian-Quan Luo et al.   Pharmacogenetics and Genomics

Pleiotropic Effect of Common Variants at ABO Glycosyltranferase Locus in 9q32 on Plasma Levels of Pancreatic Lipase and Angiotensin Converting Enzyme

(2014)   PLoS One

Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

(2014) A. N. Alagaili et al.   mBio

Malaria and hypertension. Another co-evolutionary adaptation?

(2014) Julio Gallego-Delgado et al.   Frontiers in Cellular and Infection Microbiology

From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

(2014) Sheila K. Patel et al.   Frontiers in Physiology

Quantitative Variation in Plasma Angiotensin-I Converting Enzyme Activity Shows Allelic Heterogeneity in theABOBlood Group Locus

(2013) Chikashi Terao et al.   ANNALS OF HUMAN GENETICS

Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects

(2013) Manuel Haschke et al.   CLINICAL PHARMACOKINETICS

ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients

(2013) E. Baena et al.   GENES & DEVELOPMENT

Gender difference of serum angiotensin-converting enzyme (ACE) activity in DD genotype of ACE insertion/deletion polymorphism in elderly Chinese

(2013) Ya-Feng Zhang et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Gender differences in sepsis

(2013) Martin K Angele et al.   Virulence

Sex and inflammation in respiratory diseases: a clinical viewpoint

(2013) Georges J Casimir et al.   Biology of Sex Differences

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

(2012) Sabra L. Klein   BIOESSAYS

Sex Differences and Sex Steroids in Lung Health and Disease

(2012) Elizabeth A. Townsend et al.   ENDOCRINE REVIEWS

Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women

(2012) W.G. Zhong et al.   GENETICS AND MOLECULAR RESEARCH

Cigarette smoking as a risk factor for influenza-associated mortality: evidence from an elderly cohort

(2012) Chit M. Wong et al.   Influenza and Other Respiratory Viruses

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

Genetic polymorphism of angiotensin I-converting enzyme (ACE), but not angiotensin II type I receptor (ATr1), has a gender-specific role in panic disorder

(2012) Burcu Bayoglu et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects

(2012) Yan-yan Li   Frontiers in Physiology

Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung

(2011) Wenxin Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genes that escape from X inactivation

(2011) Joel B. Berletch et al.   HUMAN GENETICS

Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist

(2011) Roelie M Wösten-van Asperen et al.   JOURNAL OF PATHOLOGY

Genetic polymorphisms linked to susceptibility to malaria

(2011) Adel Driss et al.   MALARIA JOURNAL

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Sex chromosome complement contributes to sex differences in coxsackievirus B3 but not influenza A virus pathogenesis

(2011) Dionne P Robinson et al.   Biology of Sex Differences

Angiotensin I-Converting Enzyme Insertion/Deletion Polymorphism and Increased Risk of Gall Bladder Cancer in Women

(2010) Kshitij Srivastava et al.   DNA AND CELL BIOLOGY

Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2

(2010) JiuChang Zhong et al.   HYPERTENSION

Gender differences and inflammation: an in vitro model of blood cells stimulation in prepubescent children

(2010) Georges JA Casimir et al.   Journal of Inflammation-London

The Xs and Y of immune responses to viral vaccines

(2010) Sabra L Klein et al.   LANCET INFECTIOUS DISEASES

Unknown

(2010) Rodrigo Fraga-Silva et al.   MOLECULAR MEDICINE

GENDER DIFFERENCES IN INFLAMMATORY MARKERS IN CHILDREN

(2010) Georges J. A. Casimir et al.   SHOCK

CHRONIC INFLAMMATORY DISEASES IN CHILDREN ARE MORE SEVERE IN GIRLS

(2010) Georges J. A. Casimir et al.   SHOCK

Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent

(2010) Jun Liu et al.   Biology of Sex Differences

Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension

(2009) Jian-Bo Zhou et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies

(2008) Patrice Guillon et al.   GLYCOBIOLOGY

Candesartan Ameliorates Cardiac Dysfunction Observed in Angiotensin-Converting Enzyme 2-Deficient Mice

(2008) Kazuto Nakamura et al.   HYPERTENSION RESEARCH

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION

Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats

(2007) Michele F. Hannah et al.   BRAIN BEHAVIOR AND IMMUNITY