Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

Mammalian Autophagy: How Does It Work?

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Mammalian autophagy and the plasma membrane

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CCT complex restricts neuropathogenic protein aggregation via autophagy

(2016) Mariana Pavel et al.   Nature Communications

The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

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Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

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Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy

(2015) Deepti S. Wilkinson et al.   MOLECULAR CELL

CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane

(2015) Na Mi et al.   NATURE CELL BIOLOGY

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons

(2014) J. Pan et al.   BLOOD

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

(2014) Q. Chen et al.   GENES & DEVELOPMENT

The Hippo-YAP signaling pathway and contact inhibition of growth

(2014) Barry M. Gumbiner et al.   JOURNAL OF CELL SCIENCE

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

(2014) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis

(2013) Xiaoming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Complex Stiffness Gradient Substrates for Studying Mechanotactic Cell Migration

(2012) Cheng-Hwa R. Kuo et al.   ADVANCED MATERIALS

The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy

(2012) Milton Osmar Aguilera et al.   Autophagy

Contact inhibition (of proliferation) redux

(2012) Andrea I McClatchey et al.   CURRENT OPINION IN CELL BIOLOGY

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

(2012) Karen Tumaneng et al.   NATURE CELL BIOLOGY

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

(2012) A Avivar-Valderas et al.   ONCOGENE

Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture

(2012) N Chen et al.   ONCOGENE

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization

(2011) Stacy Visser-Grieve et al.   CELL RESEARCH

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties

(2010) Angela M. Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Keeping in touch with contact inhibition of locomotion

(2010) Roberto Mayor et al.   TRENDS IN CELL BIOLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

(2008) M. Ota et al.   DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL