Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers

The Cytoskeleton as Regulator of Cell Signaling Pathways

(2019) Ossama Moujaber et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor

(2018) Jianyun Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors

(2018) Lee Roth et al.   Science Signaling

KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation

(2018) Rosemary Pike et al.   Science Signaling

EGFR-induced cytoskeletal changes drive complex cell behaviors: The tip of the iceberg

(2018) Christine Chiasson-MacKenzie et al.   Science Signaling

SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors

(2018) Lee Roth et al.   Science Signaling

KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation

(2018) Rosemary Pike et al.   Science Signaling

EGFR-induced cytoskeletal changes drive complex cell behaviors: The tip of the iceberg

(2018) Christine Chiasson-MacKenzie et al.   Science Signaling

Biology and evolution of poorly differentiated neuroendocrine tumors

(2017) David S Rickman et al.   NATURE MEDICINE

Emerging Variants of Castration-Resistant Prostate Cancer

(2017) Panagiotis J. Vlachostergios et al.   Current Oncology Reports

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

(2016) Asier Jayo et al.   DEVELOPMENTAL CELL

Improving fascin inhibitors to block tumor cell migration and metastasis

(2016) Shaoqin Han et al.   Molecular Oncology

Triple-negative breast cancer: is there a treatment on the horizon?

(2016) Hui Yao et al.   Oncotarget

Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture

(2015) Christopher M. Groen et al.   MOLECULAR BIOLOGY OF THE CELL

Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDγ mouse (Mus musculus) anterior prostate

(2015) FEDERICO F. CIFUENTES et al.   Oncology Letters

Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization

(2015) Fang-Ke Huang et al.   Nature Communications

The Proteomic Landscape of Triple-Negative Breast Cancer

(2015) Robert T. Lawrence et al.   Cell Reports

The Novel IKK2 Inhibitor LY2409881 Potently Synergizes with Histone Deacetylase Inhibitors in Preclinical Models of Lymphoma through the Downregulation of NF- B

(2014) C. Deng et al.   CLINICAL CANCER RESEARCH

Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer

(2014) Marie Schoumacher et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

(2014) Ang Li et al.   GASTROENTEROLOGY

DLC1-dependent parathyroid hormone–like hormone inhibition suppresses breast cancer bone metastasis

(2014) Yufeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis

(2013) Vanessa Y Tan et al.   BMC Medicine

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Fascin Is a Key Regulator of Breast Cancer Invasion That Acts via the Modification of Metastasis-Associated Molecules

(2011) Monther Al-Alwan et al.   PLoS One

Migrastatin analogues target fascin to block tumour metastasis

(2010) Lin Chen et al.   NATURE

Critical role of PI3K signaling for NF- B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells

(2010) B. Kloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Fascin Regulates Prostate Cancer Cell Invasion and Is Associated with Metastasis and Biochemical Failure in Prostate Cancer

(2009) A. D. Darnel et al.   CLINICAL CANCER RESEARCH

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Fascin1 is dispensable for mouse development but is favorable for neonatal survival

(2009) Yoshihiko Yamakita et al.   CELL MOTILITY AND THE CYTOSKELETON

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY