Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?

Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study

(2021) Stephen J. Nicholls et al.   Cardiovascular Diabetology

Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure

(2021) Edrous Alamer et al.   Retrovirology

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage

(2021) Amina Ait-Ammar et al.   Scientific Reports

LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

(2021) Delphine Planas et al.   EBioMedicine

Flower power: Locking HIV in the gut with French lilac

(2021) Olivier Rohr   EBioMedicine

Epigenetic crosstalk in chronic infection with HIV-1

(2020) Ulrike C Lange et al.   Seminars in Immunopathology

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals

(2020) Sam Kint et al.   Clinical Epigenetics

Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs

(2020) Amina Ait-Ammar et al.   Frontiers in Microbiology

Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

(2020) Daniel M. Muema et al.   BMC Medicine

Selective BET-bromodomain inhibition by JQ1 suppresses dendritic cell maturation and antigen-specific T-cell responses

(2020) Niklas Remke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

BRD4 inhibition suppresses PD-L1 expression in triple-negative breast cancer

(2020) Xin Jing et al.   EXPERIMENTAL CELL RESEARCH

Evolution of a concept: From accessory protein to key virulence factor, the case of HIV-1 Vpr

(2020) Clémentine Wallet et al.   BIOCHEMICAL PHARMACOLOGY

First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours

(2020) Malaka Ameratunga et al.   BRITISH JOURNAL OF CANCER

Clinical characteristics of HIV-1-infected patients with high levels of plasma interferon-γ: a multicenter observational study

(2019) Dai Watanabe et al.   BMC INFECTIOUS DISEASES

Helper T cell differentiation

(2019) Jordy Saravia et al.   Cellular & Molecular Immunology

Specific Activation In Vivo of HIV-1 by a Bromodomain Inhibitor from Monocytic Cells in Humanized Mice under Antiretroviral Therapy

(2019) Guangming Li et al.   JOURNAL OF VIROLOGY

HIV “shock and kill” therapy: In need of revision

(2019) Erik Abner et al.   ANTIVIRAL RESEARCH

A novel bromodomain inhibitor, CPI-203, serves as an HIV-1 latency-reversing agent by activating positive transcription elongation factor b

(2019) Taizhen Liang et al.   BIOCHEMICAL PHARMACOLOGY

Bromodomain inhibitor I-BET151 suppresses immune responses during fungal-immune interaction

(2019) Jorge Domínguez-Andrés et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury

(2019) Judith Sánchez-Ventura et al.   Journal of Neuroinflammation

Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription

(2019) Guillaume Mousseau et al.   mBio

Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine

(2019) Chang-Qing Tian et al.   Cell Death & Disease

Increased Plasma Levels of the TH2 chemokine CCL18 associated with low CD4+ T cell counts in HIV-1-infected Patients with a Suppressed Viral Load

(2019) Prashant Malhotra et al.   Scientific Reports

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production

(2019) Hunter R. Gibbons et al.   Scientific Reports

BET Bromodomain Inhibitors Suppress Inflammatory Activation of Gingival Fibroblasts and Epithelial Cells From Periodontitis Patients

(2019) Anna Maksylewicz et al.   Frontiers in Immunology

Deep latency: A new insight into a functional HIV cure

(2019) Maher M. Elsheikh et al.   EBioMedicine

T‐cell exhaustion in HIV infection

(2019) Craig Fenwick et al.   IMMUNOLOGICAL REVIEWS

The BET bromodomain inhibitor apabetalone induces apoptosis of latent HIV-1 reservoir cells following viral reactivation

(2018) Xuan-xuan Zhang et al.   ACTA PHARMACOLOGICA SINICA

A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other “Shock” Drugs

(2018) Erik Abner et al.   JOURNAL OF VIROLOGY

Peering into the HIV reservoir

(2018) Marcial García et al.   REVIEWS IN MEDICAL VIROLOGY

BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer

(2018) Xiangyi Li et al.   Cell Reports

Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation

(2018) Anne Gegonne et al.   Cell Reports

Computational study on the selective inhibition mechanism of MS402 to the first and second bromodomains of BRD4

(2018) Qianqian Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response inKras-Mutant Non–Small Cell Lung Cancer

(2018) Dennis O. Adeegbe et al.   Cancer Immunology Research

Enhancement of BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins

(2018) GC Sartor et al.   JOURNAL OF NEUROSCIENCE

T cell toxicity of HIV latency reversing agents

(2018) Manzhi Zhao et al.   PHARMACOLOGICAL RESEARCH

New Th17-specific therapeutic strategies for HIV remission

(2018) Delphine Planas et al.   Current Opinion in HIV and AIDS

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses

(2018) Alireza Saeidi et al.   Frontiers in Immunology

B-cell responses to HIV infection

(2017) Susan Moir et al.   IMMUNOLOGICAL REVIEWS

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

(2017) Ryan J. Conrad et al.   MOLECULAR CELL

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries

(2017) Sarah C. Hsu et al.   MOLECULAR CELL

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

(2017) Ka Lung Cheung et al.   MOLECULAR CELL

BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

(2017) Kalung Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

BET proteins are a key component of immunoglobulin gene expression

(2017) Jung Min Shim et al.   Epigenomics

Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography

(2017) Marco V. Wainstein et al.   Diabetology & Metabolic Syndrome

Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages

(2017) Wenhui Ren et al.   Scientific Reports

BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency

(2017) Panpan Lu et al.   Scientific Reports

A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association

(2017) Huachao Huang et al.   Frontiers in Microbiology

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

(2017) Rebecca P. Sumner et al.   Frontiers in Immunology

The IDO–AhR Axis Controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection

(2017) Eliseu Frank de Araújo et al.   Frontiers in Immunology

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

(2017) Thomas C. Roberts et al.   Scientific Reports

Cyclin-dependent kinases as therapeutic targets for HIV-1 infection

(2016) Andrew P. Rice   EXPERT OPINION ON THERAPEUTIC TARGETS

Improving combination antiretroviral therapy by targeting HIV-1 gene transcription

(2016) Valentin Le Douce et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

(2016) Yasushi Taniguchi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases

(2016) Balasundaram Padmanabhan et al.   JOURNAL OF BIOSCIENCES

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

(2016) Yuki Kagoya et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms of HIV latency

(2016) Daniele C. Cary et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokines and T-Cell Homeostasis in HIV Infection

(2016) Michael L. Freeman et al.   JOURNAL OF INFECTIOUS DISEASES

BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells

(2016) Ronald Schilderink et al.   MOLECULAR IMMUNOLOGY

Design and characterization of bivalent BET inhibitors

(2016) Minoru Tanaka et al.   Nature Chemical Biology

International AIDS Society global scientific strategy: towards an HIV cure 2016

(2016) Steven G Deeks et al.   NATURE MEDICINE

Nuclear landscape of HIV-1 infection and integration

(2016) Marina Lusic et al.   NATURE REVIEWS MICROBIOLOGY

Bromodomain and Extra Terminal (BET) Inhibitor Suppresses Macrophage-Driven Steroid-Resistant Exacerbations of Airway Hyper-Responsiveness and Inflammation

(2016) Thi Hiep Nguyen et al.   PLoS One

Residual inflammation and viral reservoirs

(2016) Marta Massanella et al.   Current Opinion in HIV and AIDS

Preclinical shock strategies to reactivate latent HIV-1

(2016) Gilles Darcis et al.   Current Opinion in HIV and AIDS

HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1

(2016) Valentin Le Douce et al.   Scientific Reports

BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression

(2016) Hengrui Zhu et al.   Cell Reports

Targeting the Brain Reservoirs: Toward an HIV Cure

(2016) Céline Marban et al.   Frontiers in Immunology

Targeting NF-κB Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency

(2015) Guochun Jiang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency

(2015) Cory H. White et al.   ANTIVIRAL RESEARCH

Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers

(2015) Anne Yuqing Yang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1

(2015) S. Bouchat et al.   EMBO Molecular Medicine

Factors Associated With Plasma IL-6 Levels During HIV Infection

(2015) Álvaro H. Borges et al.   JOURNAL OF INFECTIOUS DISEASES

Fate determination in mesenchymal stem cells: a perspective from histone-modifying enzymes

(2015) Biao Huang et al.   Stem Cell Research & Therapy

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice

(2014) Ravi Jahagirdar et al.   ATHEROSCLEROSIS

I-BET151 selectively regulates IL-6 production

(2014) Elyse Barrett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Viral Particles Drive Rapid Differentiation of Memory B Cells into Secondary Plasma Cells Producing Increased Levels of Antibodies

(2014) F. Zabel et al.   JOURNAL OF IMMUNOLOGY

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining

(2014) Andre Stanlie et al.   MOLECULAR CELL

HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters

(2014) Sebastian Eilebrecht et al.   NUCLEIC ACIDS RESEARCH

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151

(2014) Stuart J. Gallagher et al.   Pigment Cell & Melanoma Research

Uracil-DNA glycosylases-Structural and functional perspectives on an essential family of DNA repair enzymes

(2014) N. Schormann et al.   PROTEIN SCIENCE

Antibody B cell responses in HIV-1 infection

(2014) Hugo Mouquet   TRENDS IN IMMUNOLOGY

Reactivation of latent HIV-1 by new semi-synthetic ingenol esters

(2014) Diego Pandeló José et al.   VIROLOGY

The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis

(2014) Shannon R. Roff et al.   Frontiers in Immunology

A new BET on the control of HIV latency

(2013) Jonathan Karn   CELL CYCLE

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

Loss and Dysregulation of Th17 Cells during HIV Infection

(2013) Sandra L. Bixler et al.   Clinical & Developmental Immunology

Epigenetic Modification of FOXP3 in Patients With Chronic HIV Infection

(2013) Enass A. Abdel-Hameed et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The Many Lives of CTIP2: From AIDS to Cancer and Cardiac Hypertrophy

(2013) Valentin Le Douce et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BET bromodomain inhibition suppresses TH17-mediated pathology

(2013) Deanna A. Mele et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

(2013) S. Picaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTIP2 is a negative regulator of P-TEFb

(2013) T. Cherrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 transcription and latency: an update

(2013) Carine Van Lint et al.   Retrovirology

Bromodomain Proteins in HIV Infection

(2013) Daniela Boehm et al.   Viruses-Basel

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Innate Immune Recognition of HIV-1

(2012) Akiko Iwasaki   IMMUNITY

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Achieving a cure for HIV infection: do we have reasons to be optimistic?

(2012) V. Le Douce et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PKC phosphorylates HEXIM1 and regulates P-TEFb activity

(2012) Koh Fujinaga et al.   NUCLEIC ACIDS RESEARCH

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

(2012) Zichong Li et al.   NUCLEIC ACIDS RESEARCH

HIV-Induced T-Cell Activation/Exhaustion in Rectal Mucosa Is Controlled Only Partially by Antiretroviral Treatment

(2012) Cesar Mauricio Rueda et al.   PLoS One

Reactivation of Latent HIV-1 by Inhibition of BRD4

(2012) Jian Zhu et al.   Cell Reports

The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women

(2011) Sheila M. Keating et al.   AIDS

Analysis of the Human Endogenous Coregulator Complexome

(2011) Anna Malovannaya et al.   CELL

Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

(2011) Sebastian Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3

(2011) R. Gamsjaeger et al.   MOLECULAR AND CELLULAR BIOLOGY

LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing

(2011) V. Le Douce et al.   NUCLEIC ACIDS RESEARCH

HIV-1 Vif promotes the G1- to S-phase cell-cycle transition

(2010) J. Wang et al.   BLOOD

Innate Immune Activation in Primary HIV‐1 Infection

(2010) J. Judy Chang et al.   JOURNAL OF INFECTIOUS DISEASES

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Th17 cytokines in mucosal immunity and inflammation

(2010) Lokesh Guglani et al.   Current Opinion in HIV and AIDS

p21WAF1 gene promoter is epigenetically silenced by CTIP2 and SUV39H1

(2009) T Cherrier et al.   ONCOGENE

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

Initiation and maintenance of Th2 cell identity

(2008) Toshinori Nakayama et al.   CURRENT OPINION IN IMMUNOLOGY

The critical role of human transcriptional repressor CTCF mRNA up-regulation in the induction of anti-HIV-1 responses in CD4+ T cells

(2008) Yuchang Li et al.   IMMUNOLOGY LETTERS

Bromodomain Protein Brd4 Regulates Human Immunodeficiency Virus Transcription through Phosphorylation of CDK9 at Threonine 29

(2008) M. Zhou et al.   JOURNAL OF VIROLOGY

Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA

(2008) B. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription

(2008) Gary LeRoy et al.   MOLECULAR CELL

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE

T-cell exhaustion in HIV infection

(2008) Mohamed El-Far et al.   Current HIV/AIDS Reports