BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury

Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia

(2018) Kelly M. DeMars et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetic Modifications Associated to Neuroinflammation and Neuropathic Pain After Neural Trauma

(2018) Clara Penas et al.   Frontiers in Cellular Neuroscience

Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury

(2018) Michelle D. Rudman et al.   EXPERIMENTAL NEUROLOGY

Enhancement of adenovirus infection and adenoviral vector-mediated gene delivery by bromodomain inhibitor JQ1

(2018) Baojie Lv et al.   Scientific Reports

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

(2017) Ryan J. Conrad et al.   MOLECULAR CELL

RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease

(2017) Ravi Jahagirdar et al.   MOLECULAR PHARMACOLOGY

The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

(2017) E Benito et al.   Translational Psychiatry

Epigenetic Regulation of Monocyte and Macrophage Function

(2016) Marten A. Hoeksema et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of BET bromodomains alleviates inflammation in human RPE cells

(2016) M. Hytti et al.   BIOCHEMICAL PHARMACOLOGY

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease

(2016) Marco Magistri et al.   Current Alzheimer Research

IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury

(2016) Isaac Francos-Quijorna et al.   GLIA

Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

(2016) Caroline Guglielmetti et al.   GLIA

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

(2016) Yasushi Taniguchi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice

(2016) Dong U. Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

(2016) Dearbhaile Dooley et al.   Stem Cell Reports

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

(2015) Chen Shen et al.   MOLECULAR CELL

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

(2015) Erica Korb et al.   NATURE NEUROSCIENCE

The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

(2015) Chiara Pastori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

(2015) Lei-lei Fu et al.   Oncotarget

BET bromodomain proteins are required for glioblastoma cell proliferation

(2014) Chiara Pastori et al.   Epigenetics

Pain prevalence and its determinants after spinal cord injury: A systematic review

(2014) S. van Gorp et al.   EUROPEAN JOURNAL OF PAIN

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Function of microglia and macrophages in secondary damage after spinal cord injury

(2014) Yi Ren et al.   Neural Regeneration Research

The Therapeutic Role of Interleukin-10 after Spinal Cord Injury

(2013) Colton D. Thompson et al.   JOURNAL OF NEUROTRAUMA

From basics to clinical: A comprehensive review on spinal cord injury

(2013) Nuno A. Silva et al.   PROGRESS IN NEUROBIOLOGY

Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function

(2013) Yi Ren et al.   NEURAL PLASTICITY

The role of “anti-inflammatory” cytokines in axon regeneration

(2012) Pía M. Vidal et al.   CYTOKINE & GROWTH FACTOR REVIEWS

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis

(2012) Edgar T. Walters   Frontiers in Physiology

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

(2011) S. Rahman et al.   MOLECULAR AND CELLULAR BIOLOGY

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

A combined scoring method to assess behavioral recovery after mouse spinal cord injury

(2010) Ahdeah Pajoohesh-Ganji et al.   NEUROSCIENCE RESEARCH

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

(2007) Dustin J. Donnelly et al.   EXPERIMENTAL NEUROLOGY