T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

(2018) Masao Hashimoto et al.   Annual Review of Medicine

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

T cell senescence and CAR-T cell exhaustion in hematological malignancies

(2018) Dimitri Kasakovski et al.   Journal of Hematology & Oncology

A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation

(2018) Ewoud B. Compeer et al.   Nature Communications

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

(2018) Yean K. Yong et al.   Frontiers in Immunology

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

(2018) Muttiah Barathan et al.   Cells

Transcription Factor IRF4 Promotes CD8 + T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

(2017) Kevin Man et al.   IMMUNITY

CAR T-cell therapy of solid tumors

(2017) Carmen S M Yong et al.   IMMUNOLOGY AND CELL BIOLOGY

Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy

(2017) Cynthia L. Gay et al.   JOURNAL OF INFECTIOUS DISEASES

IRF9 Prevents CD8 + T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection

(2017) Magdalena Huber et al.   JOURNAL OF VIROLOGY

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

(2017) Paola Fisicaro et al.   NATURE MEDICINE

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways

(2017) Shengwei Liu et al.   Oncotarget

PD1 signal transduction pathways in T cells

(2017) Hugo Arasanz et al.   Oncotarget

Persistent infection due to a small-colony variant of Burkholderia pseudomallei leads to PD-1 upregulation on circulating immune cells and mononuclear infiltration in viscera of experimental BALB/c mice

(2017) Jia-Xiang See et al.   PLoS Neglected Tropical Diseases

Mitochondrial Control and Guidance of Cellular Activities of T Cells

(2017) Tung Chao et al.   Frontiers in Immunology

Negative Checkpoint Regulatory Molecule 2B4 (CD244) Upregulation Is Associated with Invariant Natural Killer T Cell Alterations and Human Immunodeficiency Virus Disease Progression

(2017) Fareed Ahmad et al.   Frontiers in Immunology

Unlocking the epigenetic code of T cell exhaustion

(2017) Jiazhu Wu et al.   Translational Cancer Research

Genetic footprints of T cell exhaustion

(2017) Marcus Buggert et al.   Translational Cancer Research

The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

(2016) Tamara Suprunenko et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Peripheral loss of CD8+CD161++TCRVα7·2+mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients

(2016) Muttiah Barathan et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Hepatitis C virus (HCV) RNA profiles among chronic HIV/HCV-coinfected individuals in ESPRIT; spontaneous HCV RNA clearance observed in nine individuals

(2016) D Grint et al.   HIV MEDICINE

Dynamic Changes in Chromatin Accessibility Occur in CD8 + T Cells Responding to Viral Infection

(2016) James P. Scott-Browne et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

(2016) Leonid Cherkassky et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic regulation of immune responses: therapeutic opportunities

(2016) Nadine Assmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting type I interferon–mediated activation restores immune function in chronic HIV infection

(2016) Anjie Zhen et al.   JOURNAL OF CLINICAL INVESTIGATION

Blimp-1–mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis

(2016) SuJin Hwang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion

(2016) Eunseon Ahn et al.   JOURNAL OF VIROLOGY

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

(2016) Madison Black et al.   Oncotarget

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes

(2015) Muttiah Barathan et al.   APOPTOSIS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Manipulating IL-10 signalling blockade for better immunotherapy

(2015) Guoying Ni et al.   CELLULAR IMMUNOLOGY

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Interleukin-17 and innate immunity in infections and chronic inflammation

(2015) Natasa Isailovic et al.   JOURNAL OF AUTOIMMUNITY

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation and microbiome in ARV-treated, SIV-infected macaques

(2015) A M Ortiz et al.   Mucosal Immunology

Attrition of TCR Vα7.2+ CD161++ MAIT Cells in HIV-Tuberculosis Co-Infection Is Associated with Elevated Levels of PD-1 Expression

(2015) Alireza Saeidi et al.   PLoS One

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

(2015) Kathrin Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration

(2015) I. Okoye et al.   SCIENCE

Adoptive Cell Therapy—Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors

(2015) Steven A. Feldman et al.   SEMINARS IN ONCOLOGY

T cell exhaustion during persistent viral infections

(2015) Shannon M. Kahan et al.   VIROLOGY

Immune Response in Hepatitis B Virus Infection

(2015) Anthony Tan et al.   Cold Spring Harbor Perspectives in Medicine

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

(2014) Matthew M. Staron et al.   IMMUNITY

Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression

(2014) Tom L. Stephen et al.   IMMUNITY

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

(2014) Pablo Penaloza-MacMaster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection

(2014) Fuqin Zhang et al.   MOLECULAR THERAPY

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection

(2014) Anna Schurich et al.   Frontiers in Immunology

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections

(2013) Cherie T. Ng et al.   Cell Host & Microbe

T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

(2013) Karin Krebs et al.   GASTROENTEROLOGY

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

(2013) Juanjuan Zhao et al.   HEPATOLOGY

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Role of regulatory T cells during virus infection

(2013) Tamara Veiga-Parga et al.   IMMUNOLOGICAL REVIEWS

Myeloid-derived suppressor cells: the dark knight or the joker in viral infections?

(2013) Celeste Goh et al.   IMMUNOLOGICAL REVIEWS

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

(2013) Bernd H. Zinselmeyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells

(2013) B. Youngblood et al.   JOURNAL OF IMMUNOLOGY

Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans

(2013) Douglas V. Dolfi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential Impact of PD-1 and/or Interleukin-10 Blockade on HIV-1-Specific CD4 T Cell and Antigen-Presenting Cell Functions

(2013) F. Porichis et al.   JOURNAL OF VIROLOGY

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection

(2013) David Gardiner et al.   PLoS One

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

(2013) M. J. Fuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection

(2013) T. A. W. Holderried et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular signatures of T-cell inhibition in HIV-1 infection

(2013) Marie Larsson et al.   Retrovirology

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

(2013) Iwana Schmitz et al.   PLoS Pathogens

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

(2013) Anna Schurich et al.   PLoS Pathogens

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

(2013) Liza B John et al.   OncoImmunology

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

(2012) Ravi Dyavar Shetty et al.   JOURNAL OF CLINICAL INVESTIGATION

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vivo Blockade of the PD-1 Receptor Suppresses HIV-1 Viral Loads and Improves CD4+ T Cell Levels in Humanized Mice

(2012) B. E. Palmer et al.   JOURNAL OF IMMUNOLOGY

Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes

(2012) M. A. Paley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-10 Mediated Regulation of Liver Inflammation during Acute Murine Cytomegalovirus Infection

(2012) Pamela J. Gaddi et al.   PLoS One

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

(2012) N. Patsoukis et al.   Science Signaling

Evolving role of 2B4/CD244 in T and NK cell responses during virus infection

(2012) Stephen N. Waggoner et al.   Frontiers in Immunology

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+T cells

(2011) Katarzyna Karwacz et al.   EMBO Molecular Medicine

Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells

(2011) Ben Youngblood et al.   IMMUNITY

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

(2011) Erin E. West et al.   IMMUNITY

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation

(2010) Thomas C. Wirth et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Pronounced Virus-Dependent Activation Drives Exhaustion but Sustains IFN-  Transcript Levels

(2010) K. J. Mackerness et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

(2010) Michael Quigley et al.   NATURE MEDICINE

Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

(2009) M. A. Brockman et al.   BLOOD

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention

(2009) Daniel E. Kaufmann et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

The role of secondary lymphatic tissue in immune deficiency of HIV infection

(2008) Timothy Schacker   AIDS

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

(2008) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

(2008) D. G. Brooks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA