Achieving a cure for HIV infection: do we have reasons to be optimistic?

HIV cure and eradication: how will we get from the laboratory to effective clinical trials?

(2011) Sharon R Lewin et al.   AIDS

Profaning the Ultimate Sanctuary: HIV Latency in Hematopoietic Stem Cells

(2011) Didier Trono et al.   Cell Host & Microbe

The Control of HIV Transcription: Keeping RNA Polymerase II on Track

(2011) Melanie Ott et al.   Cell Host & Microbe

Inhibitors of Histone Deacetylases

(2011) Kelly Huber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

(2011) Huabiao Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

The Emerging Race to Cure HIV Infections

(2011) J. Cohen   SCIENCE

Proviral HIV-genome-wide and pol-gene specific Zinc Finger Nucleases: Usability for targeted HIV gene therapy

(2011) Misaki Wayengera   Theoretical Biology and Medical Modelling

MicroRNAs and their potential involvement in HIV infection

(2011) Guihua Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication

(2011) Thomas Cherrier et al.   Virology Journal

Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)

(2011) Naoki Sakane et al.   PLoS Pathogens

Immunodeficiency and the risk of serious clinical endpoints in a well studied cohort of treated HIV-infected patients

(2010) Amit C Achhra et al.   AIDS

Allogeneic transplantation of CCR5-deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search for patient no. 2

(2010) Gero Hütter et al.   AIDS

HIV-1 Vaccine Development After STEP

(2010) Dan H. Barouch et al.   Annual Review of Medicine

Antiretroviral drugs

(2010) Erik De Clercq   CURRENT OPINION IN PHARMACOLOGY

Novel Antiretroviral Combinations in Treatment-Experienced Patients with HIV Infection

(2010) Babafemi Taiwo et al.   DRUGS

Histone H3 Lysine 4 di-methylation: A novel mark for transcriptional fidelity?

(2010) Marina Pinskaya et al.   Epigenetics

The future of antiretroviral therapy: challenges and needs

(2010) S. Moreno et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

DNA Cytosine Methylation in the Bovine Leukemia Virus Promoter Is Associated with Latency in a Lymphoma-derived B-cell Line

(2010) Valérie Pierard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both CD31+and CD31−Naive CD4+T Cells Are Persistent HIV Type 1–Infected Reservoirs in Individuals Receiving Antiretroviral Therapy

(2010) Fiona Wightman et al.   JOURNAL OF INFECTIOUS DISEASES

Markers of Inflammation, Coagulation, and Renal Function Are Elevated in Adults with HIV Infection

(2010) Jacqueline Neuhaus et al.   JOURNAL OF INFECTIOUS DISEASES

Financing of HIV/AIDS programme scale-up in low-income and middle-income countries, 2009–31

(2010) Robert Hecht et al.   LANCET

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

(2010) Tewodros Mamo et al.   Nanomedicine

Can HIV be cured with stem cell therapy?

(2010) Steven G Deeks et al.   NATURE BIOTECHNOLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

(2010) Valentin Le Douce et al.   Retrovirology

Host hindrance to HIV-1 replication in monocytes and macrophages

(2010) Anna Bergamaschi et al.   Retrovirology

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

Nanotechnology and HIV: potential applications for treatment and prevention

(2010) Peter S. Kim et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Stem cell-based approaches to treating HIV infection

(2010) Scott G Kitchen et al.   Current Opinion in HIV and AIDS

Epigenetic regulation of HIV latency

(2010) Shweta Hakre et al.   Current Opinion in HIV and AIDS

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV

(2010) Nicolas Chomont et al.   Current Opinion in HIV and AIDS

Histone deacetylase inhibitors and HIV latency

(2010) David M Margolis   Current Opinion in HIV and AIDS

Hematopoietic stem/precursor cells as HIV reservoirs

(2010) Lucy A McNamara et al.   Current Opinion in HIV and AIDS

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

(2010) Jonathan Karn   Current Opinion in HIV and AIDS

Mechanisms of HIV Latency: an Emerging Picture of Complexity

(2010) David M. Margolis   Current HIV/AIDS Reports

Nanotechnology-based systems for the treatment and prevention of HIV/AIDS

(2009) José das Neves et al.   ADVANCED DRUG DELIVERY REVIEWS

Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs

(2009) Puneet Sharma et al.   ADVANCED DRUG DELIVERY REVIEWS

Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir

(2009) Nathalie Sagot-Lerolle et al.   AIDS

The transport of anti-HIV drugs across blood–CNS interfaces: Summary of current knowledge and recommendations for further research

(2009) Lavanya Varatharajan et al.   ANTIVIRAL RESEARCH

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity

(2009) Adam Lesner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

Drug-resistant human immunodefiency virus

(2009) M.J. Kozal   CLINICAL MICROBIOLOGY AND INFECTION

H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activation

(2009) Marina Pinskaya et al.   EMBO JOURNAL

Uncontrolled Viral Replication as a Risk Factor for Non-AIDS Severe Clinical Events in HIV-Infected Patients on Long-Term Antiretroviral Therapy: APROCO/COPILOTE (ANRS CO8) Cohort Study

(2009) Tristan Ferry et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

A perspective on antiviral resistance

(2009) Paul D. Griffiths   JOURNAL OF CLINICAL VIROLOGY

Persistent Low‐Level Viremia in HIV‐1 Elite Controllers and Relationship to Immunologic Parameters

(2009) Florencia Pereyra et al.   JOURNAL OF INFECTIOUS DISEASES

Human Immunodeficiency Virus Integrates Directly into Naive Resting CD4+ T Cells but Enters Naive Cells Less Efficiently than Memory Cells

(2009) J. Dai et al.   JOURNAL OF VIROLOGY

A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression

(2009) K. S. Keedy et al.   JOURNAL OF VIROLOGY

The CDK Inhibitor p21Cip1/WAF1 Is Induced by Fc R Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages

(2009) A. Bergamaschi et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

(2009) Mayte Coiras et al.   NATURE REVIEWS MICROBIOLOGY

Not an HIV Cure, but Encouraging New Directions

(2009) Jay A. Levy   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival

(2009) Mari M. Kitahata et al.   NEW ENGLAND JOURNAL OF MEDICINE

p21WAF1 gene promoter is epigenetically silenced by CTIP2 and SUV39H1

(2009) T Cherrier et al.   ONCOGENE

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

(2009) Laurence Colin et al.   Retrovirology

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

(2009) Andrea Savarino et al.   Retrovirology

HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

(2009) Christopher M Coleman et al.   Retrovirology

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE

CpG Methylation Controls Reactivation of HIV from Latency

(2009) Jana Blazkova et al.   PLoS Pathogens

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Cellular Reservoirs of HIV-1 and their Role in Viral Persistence

(2008) Aikaterini Alexaki et al.   CURRENT HIV RESEARCH

Anticancer Drug Discovery Targeting DNA Hypermethylation

(2008) Niefang Yu et al.   CURRENT MEDICINAL CHEMISTRY

Reversal of HIV-1 latency with anti-microRNA inhibitors

(2008) Hui Zhang   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection

(2008) Lin Shen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy

(2008) Florencia Pereyra et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence for Persistent Low-Level Viremia in Individuals Who Control Human Immunodeficiency Virus in the Absence of Antiretroviral Therapy

(2008) H. Hatano et al.   JOURNAL OF VIROLOGY

Characterization of the Follicular Dendritic Cell Reservoir of Human Immunodeficiency Virus Type 1

(2008) B. F. Keele et al.   JOURNAL OF VIROLOGY

HIV immunology needs a new direction

(2008) Ruslan Medzhitov et al.   NATURE

Challenges in the development of an HIV-1 vaccine

(2008) Dan H. Barouch   NATURE

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Reflecting on a quarter century of HIV research

(2008) Andrew E Armitage et al.   NATURE IMMUNOLOGY

Transcription factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection

(2008) Julien van Grevenynghe et al.   NATURE MEDICINE

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

(2008) S. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Vaccine Research: The Way Forward

(2008) A. S. Fauci et al.   SCIENCE

HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination

(2008) Aikaterini Alexaki et al.   PLoS Pathogens

Hide-and-Seek: The Challenge of Viral Persistence in HIV-1 Infection

(2007) Luc Geeraert et al.   Annual Review of Medicine

Relationship between T Cell Activation and CD4+T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

(2007) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES