RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
Published 2013 View Full Article
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Title
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 49, Pages 19754-19759
Publisher
Proceedings of the National Academy of Sciences
Online
2013-11-19
DOI
10.1073/pnas.1310658110
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- (2012) Paul V. Fish et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2012) Tisha R. Joy PHARMACOLOGY & THERAPEUTICS
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- (2011) Susanne Muller et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
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- (2009) Fangnian Wang et al. BIOCHEMICAL JOURNAL
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