Improving combination antiretroviral therapy by targeting HIV-1 gene transcription

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID “Meet the Experts” 2015 Workshop Summary

(2016) Ramesh Akkina et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Deciphering structure-activity relationships in a series of Tat/TAR inhibitors

(2016) Lise Pascale et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

HIV-1 Eradication: Early Trials (and Tribulations)

(2016) Adam M. Spivak et al.   TRENDS IN MOLECULAR MEDICINE

Advances in computationally modeling human oral bioavailability

(2015) Junmei Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice

(2015) Sonia Mediouni et al.   CURRENT HIV RESEARCH

Didehydro-Cortistatin A: a new player in HIV-therapy?

(2015) Guillaume Mousseau et al.   Expert Review of Anti-Infective Therapy

Human X-DING-CD4 mediates resistance to HIV-1 infection through novel paracrine-like signaling

(2015) Rakhee Sachdeva et al.   FEBS Journal

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis

(2015) Noëlie Campos et al.   Retrovirology

ABX464: a good drug candidate instead of a magic bullet

(2015) Ben Berkhout et al.   Retrovirology

Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells

(2015) Sergey Iordanskiy et al.   VIROLOGY

Studies of retroviral infection in humanized mice

(2015) Matthew D. Marsden et al.   VIROLOGY

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

(2015) Guillaume Mousseau et al.   mBio

BLT humanized mice as a small animal model of HIV infection

(2015) Marshall E Karpel et al.   Current Opinion in Virology

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Epigenetic control of HIV-1 post integration latency: implications for therapy

(2015) Amit Kumar et al.   Clinical Epigenetics

HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

(2015) Jonathan E Reeder et al.   eLife

Cell-Penetrating, Dimeric α-Helical Peptides: Nanomolar Inhibitors of HIV-1 Transcription

(2014) Sangmok Jang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Involvement of miR-196a in HIV-associated neurocognitive disorders

(2014) Asen Bagashev et al.   APOPTOSIS

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands

(2014) Luca Sancineto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1E7-03, a Small Molecule Targeting Host Protein Phosphatase-1, Inhibits HIV-1 Transcription

(2014) Tatyana Ammosova et al.   BRITISH JOURNAL OF PHARMACOLOGY

NF-κB signaling at the crossroads of inflammation and atherogenesis: searching for new therapeutic links

(2014) Ioannis Pateras et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Potential mechanisms for cell-based gene therapy to treat HIV/AIDS

(2014) Elena Herrera-Carrillo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Towards improved shRNA and miRNA reagents as inhibitors of HIV1 replication

(2014) Ben Berkhout et al.   Future Microbiology

Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system

(2014) Bruno Sarmento et al.   International Journal of Nanomedicine

Development of pharmacophore similarity-based quantitative activity hypothesis and its applicability domain: applied on a diverse data-set of HIV-1 integrase inhibitors

(2014) Sivakumar Prasanth Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Tanshinone II A Inhibits Tat-Induced HIV-1 Transactivation Through Redox-Regulated AMPK/Nampt Pathway

(2014) Hong-Sheng Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Generation of improved humanized mouse models for human infectious diseases

(2014) Michael A. Brehm et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The search for a T cell line for testing novel antiviral strategies against HIV-1 isolates of diverse receptor tropism and subtype origin

(2014) Elena Herrera-Carrillo et al.   JOURNAL OF VIROLOGICAL METHODS

COMMD1/Murr1 Reinforces HIV-1 Latent Infection through IκB-α Stabilization

(2014) Manabu Taura et al.   JOURNAL OF VIROLOGY

Tumor Suppressor Cylindromatosis (CYLD) Controls HIV Transcription in an NF- B-Dependent Manner

(2014) L. Manganaro et al.   JOURNAL OF VIROLOGY

Design, Synthesis and Biological Evaluation of Substituted Guanidine Indole Derivatives as Potential Inhibitors of HIV-1 Tat-TAR Interaction

(2014) Jun Wang et al.   Medicinal Chemistry

Optimized Lentiviral Vectors for HIV Gene Therapy: Multiplexed Expression of Small RNAs and Inclusion of MGMTP140K Drug Resistance Gene

(2014) Janet Chung et al.   MOLECULAR THERAPY

A mechanistic theory to explain the efficacy of antiretroviral therapy

(2014) Sarah B. Laskey et al.   NATURE REVIEWS MICROBIOLOGY

HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters

(2014) Sebastian Eilebrecht et al.   NUCLEIC ACIDS RESEARCH

Towards novel therapeutics for HIV through fragment-based screening and drug design

(2014) Theresa Tiefenbrunn et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells

(2014) Sami Kukkonen et al.   Retrovirology

Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein

(2014) Zhitao Wan et al.   Retrovirology

Towards nanomedicines for neuroAIDS

(2014) Vidya Sagar et al.   REVIEWS IN MEDICAL VIROLOGY

Computer-aided design and discovery of protein–protein interaction inhibitors as agents for anti-HIV therapy

(2014) A.V. Veselovsky et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

New hope for eradication of HIV from the body: the role of polymeric nanomedicines in HIV/AIDS pharmacotherapy

(2014) Jimma Lenjisa et al.   JOURNAL OF NANOBIOTECHNOLOGY

Crystallization and preliminary X-ray diffraction analysis of a DING protein fromPseudomonas aeruginosaPA14

(2013) Ahmed Djeghader et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells

(2013) N. Kim et al.   BLOOD

DING proteins: numerous functions, elusive genes, a potential for health

(2013) François Bernier   CELLULAR AND MOLECULAR LIFE SCIENCES

Viral–Host Interactions That Control HIV-1 Transcriptional Elongation

(2013) Huasong Lu et al.   CHEMICAL REVIEWS

Computer-Aided Design, Synthesis and Validation of 2-Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity

(2013) Luca Sancineto et al.   ChemMedChem

The interplay between the X-DING-CD4, IFN-α and IL-8 gene activity in quiescent and mitogen- or HIV-1-exposed PBMCs from HIV-1 elite controllers, AIDS progressors and HIV-negative controls

(2013) Rakhee Sachdeva et al.   Innate Immunity

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides

(2013) G. M. Laird et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Many Lives of CTIP2: From AIDS to Cancer and Cardiac Hypertrophy

(2013) Valentin Le Douce et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Novel Neuroprotective GSK-3  Inhibitor Restricts Tat-Mediated HIV-1 Replication

(2013) I. Guendel et al.   JOURNAL OF VIROLOGY

HIPdb: A Database of Experimentally Validated HIV Inhibiting Peptides

(2013) Abid Qureshi et al.   PLoS One

Mice Transgenic for CD4-Specific Human CD4, CCR5 and Cyclin T1 Expression: A New Model for Investigating HIV-1 Transmission and Treatment Efficacy

(2013) Kieran Seay et al.   PLoS One

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation

(2013) H. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTIP2 is a negative regulator of P-TEFb

(2013) T. Cherrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 transcription and latency: an update

(2013) Carine Van Lint et al.   Retrovirology

Pseudomonas DING proteins as human transcriptional regulators and HIV-1 antagonists

(2013) Andrew Suh et al.   Virology Journal

Roles and functions of HIV-1 Tat protein in the CNS: an overview

(2013) Asen Bagashev et al.   Virology Journal

ZASC1 Stimulates HIV-1 Transcription Elongation by Recruiting P-TEFb and TAT to the LTR Promoter

(2013) James W. Bruce et al.   PLoS Pathogens

Identification of Novel Inhibitors of Human Immunodeficiency Virus Type 1 Replication byIn SilicoScreening Targeting Cyclin T1/Tat Interaction

(2012) Takayuki Hamasaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription

(2012) Alex A. Osorio et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Humanized mice: Current states and perspectives

(2012) Sylvie Garcia et al.   IMMUNOLOGY LETTERS

Anti-HIV-1 nanotherapeutics: promises and challenges for the future

(2012) Supriya Mahajan et al.   International Journal of Nanomedicine

Achieving a cure for HIV infection: do we have reasons to be optimistic?

(2012) V. Le Douce et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development

(2012) S. Dahiya et al.   JOURNAL OF GENERAL VIROLOGY

Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription

(2012) Rachel Van Duyne et al.   JOURNAL OF MOLECULAR BIOLOGY

Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?

(2012) Santhi Gorantla et al.   Journal of Neuroimmune Pharmacology

NF-κB as a potential therapeutic target in microbial diseases

(2012) Mariateresa Vitiello et al.   Molecular BioSystems

Animal models for HIV/AIDS research

(2012) Theodora Hatziioannou et al.   NATURE REVIEWS MICROBIOLOGY

Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells

(2012) Victoria A Green et al.   Virology Journal

Are subtype differences important in HIV drug resistance?

(2012) RJ Lessells et al.   Current Opinion in Virology

HIV cure and eradication: how will we get from the laboratory to effective clinical trials?

(2011) Sharon R Lewin et al.   AIDS

Tits and bits of HIV Tat protein

(2011) Manish K Johri et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Celastrol Inhibits Tat-Mediated Human Immunodeficiency Virus (HIV) Transcription and Replication

(2011) Vivek Narayan et al.   JOURNAL OF MOLECULAR BIOLOGY

A Small-Molecule Probe Induces a Conformation in HIV TAR RNA Capable of Binding Drug-Like Fragments

(2011) Amy Davidson et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

(2011) P.-H. Lin et al.   JOURNAL OF VIROLOGY

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

Genome-Wide Binding Map of the HIV-1 Tat Protein to the Human Genome

(2011) Céline Marban et al.   PLoS One

Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication

(2011) Thomas Cherrier et al.   Virology Journal

Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat-Transactivating Response Element (TAR) RNA

(2011) Matthew S. Lalonde et al.   PLoS Pathogens

Treating HIV-1 infection: what might the future hold?

(2011) Mathias Lichterfeld et al.   Therapeutic Advances in Chronic Disease

Role of HIV-1 Tat in AIDS pathogenesis: its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection

(2010) James Chun-bong Li et al.   AIDS

Eradication of HIV from the brain: reasons for pause

(2010) Avindra Nath et al.   AIDS

Impact of HIV Type 1 Subtype on Drug Resistance Mutations in Nigerian Patients Failing First-Line Therapy

(2010) B. Chaplin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Quinoline-based compounds as modulators of HIV transcription through NF-κB and Sp1 inhibition

(2010) Luis Miguel Bedoya et al.   ANTIVIRAL RESEARCH

A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

(2010) Akihiko Yokoyama et al.   CANCER CELL

The Drug Discovery Portal: a resource to enhance drug discovery from academia

(2010) Rachel L. Clark et al.   DRUG DISCOVERY TODAY

Unmet therapeutic needs in the new era of combination antiretroviral therapy for HIV-1

(2010) B. Taiwo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The future of antiretroviral therapy: challenges and needs

(2010) S. Moreno et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Suppression of HIV-1 transcriptional elongation by a DING phosphatase

(2010) Nune Darbinian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antiretroviral therapy and management of HIV infection

(2010) Paul A Volberding et al.   LANCET

Inhibition of active HIV-1 replication by NF-κB inhibitor DHMEQ

(2010) Ariko Miyake et al.   MICROBES AND INFECTION

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

(2010) Tewodros Mamo et al.   Nanomedicine

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation

(2010) Iván D'Orso et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

(2010) Evelyn M Kilareski et al.   Retrovirology

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

(2010) Valentin Le Douce et al.   Retrovirology

7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor

(2010) Gaelle Diribarne et al.   RNA Biology

Nanotechnology and HIV: potential applications for treatment and prevention

(2010) Peter S. Kim et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

(2010) Iván D’Orso et al.   Viruses-Basel

Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication

(2010) Frank Maldarelli   Current Opinion in HIV and AIDS

Nanotechnology-based systems for the treatment and prevention of HIV/AIDS

(2009) José das Neves et al.   ADVANCED DRUG DELIVERY REVIEWS

Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs

(2009) Puneet Sharma et al.   ADVANCED DRUG DELIVERY REVIEWS

The transport of anti-HIV drugs across blood–CNS interfaces: Summary of current knowledge and recommendations for further research

(2009) Lavanya Varatharajan et al.   ANTIVIRAL RESEARCH

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity

(2009) Adam Lesner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Denbinobin inhibits nuclear factor-κB and induces apoptosis via reactive oxygen species generation in human leukemic cells

(2009) Gonzalo Sánchez-Duffhues et al.   BIOCHEMICAL PHARMACOLOGY

The DING family of proteins: ubiquitous in eukaryotes, but where are the genes?

(2009) Anne Berna et al.   BIOESSAYS

For whom the bell tolls? DING proteins in health and disease

(2009) Anne Berna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Drug-resistant human immunodefiency virus

(2009) M.J. Kozal   CLINICAL MICROBIOLOGY AND INFECTION

15-Deoxy-Δ12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification

(2009) Parisa Kalantari et al.   FASEB JOURNAL

Evidence for phosphatase activity of p27SJ and its impact on the cell cycle

(2009) Nune Darbinian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A perspective on antiviral resistance

(2009) Paul D. Griffiths   JOURNAL OF CLINICAL VIROLOGY

Functions of Tat: the versatile protein of human immunodeficiency virus type 1

(2009) B. Romani et al.   JOURNAL OF GENERAL VIROLOGY

HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes

(2009) Laetitia Redel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors

(2009) Yu Mingyan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein

(2009) A. Davidson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Identification of the RelA domain responsible for action of a new NF-κB inhibitor DHMEQ

(2008) Mariko Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-κB-dependent pathway

(2008) Gonzalo Sánchez-Duffhues et al.   BIOCHEMICAL PHARMACOLOGY

The multi-tasking P-TEFb complex

(2008) Vanessa Brès et al.   CURRENT OPINION IN CELL BIOLOGY

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY

Exploring the use of novel drug delivery systems for antiretroviral drugs

(2008) Elizabeth Ojewole et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection

(2008) Lin Shen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inactivation of NF-κB Components by Covalent Binding of (−)-Dehydroxymethylepoxyquinomicin to Specific Cysteine Residues

(2008) Mizuki Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationship Study on Anti-HIV 6-Desfluoroquinolones

(2008) Oriana Tabarrini et al.   JOURNAL OF MEDICINAL CHEMISTRY

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH

Low molecular weight lignin suppresses activation of NF-κB and HIV-1 promoter

(2007) Shinya Mitsuhashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DING proteins; novel members of a prokaryotic phosphate-binding protein superfamily which extends into the eukaryotic kingdom

(2007) Anne Berna et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations

(2007) Tushar K. Vyas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS