International AIDS Society global scientific strategy: towards an HIV cure 2016

Treatment intensification followed by interleukin-7 reactivates HIV without reducing total HIV DNA

(2016) Christine Katlama et al.   AIDS

Macrophages sustain HIV replication in vivo independently of T cells

(2016) Jenna B. Honeycutt et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Clonally expanded CD4+T cells can produce infectious HIV-1 in vivo

(2016) Francesco R. Simonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

(2016) S. G. Hansen et al.   SCIENCE

HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report

(2016) Pierre Frange et al.   Lancet HIV

Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma

(2015) Fiona Wightman et al.   AIDS

A low HIV-DNA level in peripheral blood mononuclear cells at antiretroviral treatment interruption predicts a higher probability of maintaining viral control

(2015) Lambert Assoumou et al.   AIDS

Dendritic cell type-specific HIV-1 activation in effector T cells

(2015) Renée M. van der Sluis et al.   AIDS

Stakeholder Engagement in HIV Cure Research: Lessons Learned from Other HIV Interventions and the Way Forward

(2015) Ying-Ru Lo et al.   AIDS PATIENT CARE AND STDS

The Ethics of HIV “Cure” Research: What Can We Learn from Consent Forms?

(2015) Gail E. Henderson   AIDS RESEARCH AND HUMAN RETROVIRUSES

Exploring the Social Meaning of Curing HIV: A Qualitative Study of People Who Inject Drugs in Guangzhou, China

(2015) Carissa E. Chu et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Exploring the Potential of Monoclonal Antibody Therapeutics for HIV-1 Eradication

(2015) Zelda Euler et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

(2015) Gregory Q. Del Prete et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants

(2015) Priyanka Uprety et al.   CLINICAL INFECTIOUS DISEASES

Dual-Affinity Re-Targeting proteins direct T cell–mediated cytolysis of latently HIV-infected cells

(2015) Julia A.M. Sung et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

(2015) Luca Micci et al.   JOURNAL OF CLINICAL INVESTIGATION

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads

(2015) Kelly A. Metcalf Pate et al.   JOURNAL OF INFECTIOUS DISEASES

Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies

(2015) Amanda M. Crooks et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 Virion Production from Single Inducible Proviruses following T-Cell ActivationEx Vivo

(2015) John K. Bui et al.   JOURNAL OF VIROLOGY

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

(2015) Matthew R. Gardner et al.   NATURE

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques

(2015) Philip J Santangelo et al.   NATURE METHODS

Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells

(2015) Drake J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

(2015) Rebecca M. Lynch et al.   Science Translational Medicine

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

(2015) Guillaume Mousseau et al.   mBio

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption

(2015) Jacob Hurst et al.   Nature Communications

Activation and lysis of human CD4 cells latently infected with HIV-1

(2015) Amarendra Pegu et al.   Nature Communications

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

(2015) Julian H Elliott et al.   Lancet HIV

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

(2015) Francesco Andrea Procopio et al.   EBioMedicine

Social and ethical implications of HIV cure research

(2014) Joseph D. Tucker et al.   AIDS

Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children

(2014) Jintanat Ananworanich et al.   AIDS

Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling

(2014) Guochun Jiang et al.   AIDS

Lifespan of effector memory CD4+ T cells determined by replication-incompetent integrated HIV-1 provirus

(2014) Hiromi Imamichi et al.   AIDS

Reduction of HIV Persistence Following Transplantation in HIV-Infected Kidney Transplant Recipients

(2014) P. G. Stock et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation

(2014) Timothy J. Henrich et al.   ANNALS OF INTERNAL MEDICINE

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

Advancing community stakeholder engagement in biomedical HIV prevention trials: principles, practices and evidence

(2014) Peter A Newman et al.   Expert Review of Vaccines

Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells

(2014) Nina Calantone et al.   IMMUNITY

Words Matter

(2014) Joseph D. Tucker et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

An HIV Cure

(2014) Anthony S. Fauci et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research

(2014) Melissa J. Churchill et al.   JOURNAL OF NEUROVIROLOGY

HIV DNA Subspecies Persist in both Activated and Resting Memory CD4+ T Cells during Antiretroviral Therapy

(2014) J. M. Murray et al.   JOURNAL OF VIROLOGY

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

(2014) James B. Whitney et al.   NATURE

Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission

(2014) Alejandro B Balazs et al.   NATURE MEDICINE

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Absence of HIV-1 after Treatment Cessation in an Infant

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?

(2014) Paul E. Sax et al.   PLoS One

Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir

(2014) T.-W. Chun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

(2014) T. A. Wagner et al.   SCIENCE

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

(2014) F. Maldarelli et al.   SCIENCE

Immunologic strategies for HIV-1 remission and eradication

(2014) D. H. Barouch et al.   SCIENCE

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

(2014) Julian H. Elliott et al.   PLoS Pathogens

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

(2014) Paul W. Denton et al.   PLoS Pathogens

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

(2014) Richard Brad Jones et al.   PLoS Pathogens

Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy

(2014) Mary F. Kearney et al.   PLoS Pathogens

Influence of Age at Virologic Control on Peripheral Blood Human Immunodeficiency Virus Reservoir Size and Serostatus in Perinatally Infected Adolescents

(2014) Deborah Persaud et al.   JAMA Pediatrics

Immunity to HIV in Early Life

(2014) Maximilian Muenchhoff et al.   Frontiers in Immunology

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

(2013) Fiona Wightman et al.   AIDS

Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model

(2013) P. M. Younan et al.   BLOOD

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

Increase in 2–Long Terminal Repeat Circles and Decrease in D-dimer After Raltegravir Intensification in Patients With Treated HIV Infection: A Randomized, Placebo-Controlled Trial

(2013) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

HIV Antibody Characterization as a Method to Quantify Reservoir Size During Curative Interventions

(2013) P. D. Burbelo et al.   JOURNAL OF INFECTIOUS DISEASES

The Distribution of HIV DNA and RNA in Cell Subsets Differs in Gut and Blood of HIV-Positive Patients on ART: Implications for Viral Persistence

(2013) Steven A. Yukl et al.   JOURNAL OF INFECTIOUS DISEASES

Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire

(2013) Joseph P. Casazza et al.   JOURNAL OF INFECTIOUS DISEASES

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Past, present and future: 30 years of HIV research

(2013) Françoise Barré-Sinoussi et al.   NATURE REVIEWS MICROBIOLOGY

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

(2013) Deborah Persaud et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time

(2013) L. Josefsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

(2013) S. G. Hansen et al.   SCIENCE

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

(2013) Susanne Eriksson et al.   PLoS Pathogens

Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient

(2013) Steven A. Yukl et al.   PLoS Pathogens

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4+ T Cells

(2013) Vanessa A. Evans et al.   PLoS Pathogens

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

(2013) Gregory M. Laird et al.   PLoS Pathogens

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Cell-Based Measures of Viral Persistence Are Associated With Immune Activation and Programmed Cell Death Protein 1 (PD-1)–Expressing CD4+ T cells

(2012) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection

(2012) N. M. Archin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells

(2012) Scott G. Kitchen et al.   PLoS Pathogens

HIV Latency in the Humanized BLT Mouse

(2011) M. D. Marsden et al.   JOURNAL OF VIROLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates

(2010) Brian C. Beard et al.   JOURNAL OF CLINICAL INVESTIGATION

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

(2010) M. Tyagi et al.   JOURNAL OF VIROLOGY

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

(2010)   SCIENCE

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

Chemokine receptor 5 knockout strategies

(2010) Paula Cannon et al.   Current Opinion in HIV and AIDS

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough

(2008) Yefei Han et al.   Cell Host & Microbe

Dangerous medicines: Unproven AIDS cures and counterfeit antiretroviral drugs

(2008) Joseph J Amon   Globalization and Health