Thrombin: A Pivotal Player in Hemostasis and Beyond

Thrombin Generation in Patients with Coronavirus Disease 2019

(2021) Marco Benati et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Disseminated intravascular coagulation: epidemiology, biomarkers, and management

(2021) Kasper Adelborg et al.   BRITISH JOURNAL OF HAEMATOLOGY

Impact of minimally invasive extracorporeal circulation on coagulation—a randomized trial

(2020) Ivy Susanne Modrau et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

An anti‐factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A

(2020) Masahiro Takeyama et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

(2020) Julie Helms et al.   INTENSIVE CARE MEDICINE

Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19

(2020) Antonio Chistolini et al.   BRITISH JOURNAL OF HAEMATOLOGY

A modified thrombin generation assay to evaluate the plasma coagulation potential in the presence of emicizumab, the bispecific antibody to factors IXa/X

(2020) Kenichi Ogiwara et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation

(2020) Annabel Blasi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hypofibrinolytic state and high thrombin generation may play a major role in SARS‐COV2 associated thrombosis

(2020) Christophe Nougier et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombin generation’s role in predicting coronary disease severity

(2020) Boaz Elad et al.   PLoS One

The thrombin–inflammation axis in cancer progression

(2020) Rachel Cantrell et al.   THROMBOSIS RESEARCH

Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease

(2020) Jaclyn Iannucci et al.   Frontiers in Neuroscience

Evaluation of COVID‐19 coagulopathy; laboratory characterization using thrombin generation and nonconventional haemostasis assays

(2020) Danielle White et al.   International Journal of Laboratory Hematology

Thrombin Generation and Cirrhosis: State of the Art and Perspectives

(2020) Aurélien Lebreton et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Comparison of bypassing agents in patients on emicizumab using global hemostasis assays

(2020) Hande Kizilocak et al.   HAEMOPHILIA

Thrombin generation profile in non-thrombotic factor V Leiden carriers

(2019) Paul Billoir et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Thrombin signaling promotes pancreatic adenocarcinoma through PAR-1-dependent immune evasion

(2019) Yi Yang et al.   CANCER RESEARCH

Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding

(2019) M Schreuder et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy

(2019) Ana Luisa Palacios-Acedo et al.   Frontiers in Immunology

Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study

(2019) Pauline C.S. van Paridon et al.   HAEMATOLOGICA

Thrombin generation, thrombin-antithrombin complex, and prothrombin fragment F1+2 as biomarkers for hypercoagulability in cancer patients

(2019) Mikkel Lundbech et al.   THROMBOSIS RESEARCH

Stimulation of KLF14/PLK1 pathway by thrombin signaling potentiates endothelial dysfunction in Type 2 diabetes mellitus

(2018) Jun-sheng Hao et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

(2018) Xiaohong Ruby Xu et al.   BLOOD

Role of thrombin in the pathogenesis of atherosclerosis

(2018) Najmeh Jaberi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice

(2018) G. N. Adams et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders—A Systematic Review

(2018) Kerstin Göbel et al.   Frontiers in Immunology

Proinflammatory signaling functions of thrombin in cancer

(2017) Safieh Ebrahimi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

(2017) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH

(2017) Y. Dargaud et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S

(2017) B. Dahlbäck   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

D-Dimer and prothrombin fragment 1 + 2 in urine and plasma in patients with clinically suspected venous thromboembolism

(2016) Fredrik Wexels et al.   BLOOD COAGULATION & FIBRINOLYSIS

Thrombin—unique coagulation system protein with multifaceted impacts on cancer and metastasis

(2016) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

Thrombin Generation Assay and Its Application in the Clinical Laboratory

(2016) A. Tripodi   CLINICAL CHEMISTRY

The epidemiology of venous thromboembolism

(2016) John A. Heit et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

(2016) Guomin Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Platelet Physiology

(2016) Andrew Frelinger et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

(2016) Guomin Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen

(2015) G. N. Adams et al.   CANCER RESEARCH

The risk of a first and a recurrent venous thrombosis associated with an elevated D-dimer level and an elevated thrombin potential: results of the THE-VTE study

(2015) A. van Hylckama Vlieg et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PH motifs in PAR1&2 endow breast cancer growth

(2015) A. Kancharla et al.   Nature Communications

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

(2015) Michael R. Preusch et al.   Drug Design Development and Therapy

MASP-1 Induced Clotting – The First Model of Prothrombin Activation by MASP-1

(2015) Lorenz Jenny et al.   PLoS One

Experimental research Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice

(2014) Simon Pingel et al.   Archives of Medical Science

Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance

(2014) Karla C.S. Queiroz et al.   INTERNATIONAL JOURNAL OF CANCER

Inverse association of the endogenous thrombin potential (ETP) with cardiovascular death: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

(2014) Jochen G. Schneider et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

An Updated Concept of Coagulation With Clinical Implications

(2014) Gregory Romney et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study

(2014) Rinske Loeffen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Risk Assessment for Thrombosis in Cancer

(2014) Marcelo Gomes et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Increased thrombin generation in splanchnic vein thrombosis is related to the presence of liver cirrhosis and not to the thrombotic event

(2014) Roza Chaireti et al.   THROMBOSIS RESEARCH

Proteinase activated-receptors-associated signaling in the control of gastric cancer

(2014) Silvia Sedda   WORLD JOURNAL OF GASTROENTEROLOGY

Systematic Review: d-Dimer to Predict Recurrent Disease after Stopping Anticoagulant Therapy for Unprovoked Venous Thromboembolism

(2013) Madeleine Verhovsek et al.   ANNALS OF INTERNAL MEDICINE

Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability ofd-Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism

(2013) James Douketis et al.   ANNALS OF INTERNAL MEDICINE

Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article

(2013) Yvonne Bosch et al.   Journal of Cardiothoracic Surgery

The transition of prothrombin to thrombin

(2013) S. Krishnaswamy   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

(2013) Julian I. Borissoff et al.   PLoS One

Thrombin Generation in the Glasgow Myocardial Infarction Study

(2013) Machiel Smid et al.   PLoS One

General mechanisms of coagulation and targets of anticoagulants (Section I)

(2013) Steen Husted et al.   THROMBOSIS AND HAEMOSTASIS

Investigation of the phenotype heterogeneity in severe hemophilia A using thromboelastography, thrombin generation, and thrombodynamics

(2013) Ivan D. Tarandovskiy et al.   THROMBOSIS RESEARCH

Determining the impact of instrument variation and automated software algorithms on the TGT in hemophilia and normalized plasma

(2013) S.A. Woodle et al.   THROMBOSIS RESEARCH

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery

(2013) Yvonne P.J. Bosch et al.   THROMBOSIS RESEARCH

Unifying the mechanism of recombinant FVIIa action: dose dependence is regulated differently by tissue factor and phospholipids

(2012) A. M. Shibeko et al.   BLOOD

Whole-Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay

(2012) M. Ninivaggi et al.   CLINICAL CHEMISTRY

Prothrombin Activation by Platelet-associated Prothrombinase Proceeds through the Prethrombin-2 Pathway via a Concerted Mechanism

(2012) Laura M. Haynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the mechanisms of venous thrombosis

(2012) Nigel Mackman   JOURNAL OF CLINICAL INVESTIGATION

Enhanced Effector Function of CD8+ T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1

(2012) Amanda Hurley et al.   JOURNAL OF INFECTIOUS DISEASES

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation

(2012) Katharina Hess et al.   PLoS One

Fibrinogen as a Hemostatic Agent

(2012) Benny Sørensen et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Thrombin inhibition profiles in healthy individuals and thrombophilic patients

(2012) Ursula Harbrecht et al.   THROMBOSIS AND HAEMOSTASIS

Data management in Thrombin Generation

(2012) H. Coenraad Hemker et al.   THROMBOSIS RESEARCH

Accelerated In Vivo Thrombin Formation Independently Predicts the Presence and Severity of CT Angiographic Coronary Atherosclerosis

(2012) Julian I. Borissoff et al.   JACC-Cardiovascular Imaging

Venous Valvular Stasis–Associated Hypoxia and Thrombosis: What Is the Link?

(2011) Edwin G. Bovill et al.   Annual Review of Physiology

Increased Thrombin Generation Is Associated With Acute Ischemic Stroke but Not With Coronary Heart Disease in the Elderly

(2011) Laure Carcaillon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PAR-1 and Thrombin: The Ties That Bind the Microenvironment to Melanoma Metastasis

(2011) M. Zigler et al.   CANCER RESEARCH

Prediction of Venous Thromboembolism in Patients With Cancer by Measuring Thrombin Generation: Results From the Vienna Cancer and Thrombosis Study

(2011) Cihan Ay et al.   JOURNAL OF CLINICAL ONCOLOGY

Arterial thrombus formation in cardiovascular disease

(2011) Giuseppe Lippi et al.   Nature Reviews Cardiology

Mechanisms of platelet activation by thrombin: A short history

(2011) Erica De Candia   THROMBOSIS RESEARCH

Extrahepatic Synthesis of FVII in Human Atheroma and Smooth Muscle Cells in Vitro

(2010) JOSIAH N. WILCOX et al.   Annals of the New York Academy of Sciences

Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell

(2010) Sung-Woon Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery

(2010) Y. Dargaud et al.   BLOOD

Colitis-Associated Cancer Is Dependent on the Interplay between the Hemostatic and Inflammatory Systems and Supported by Integrin αMβ2Engagement of Fibrinogen

(2010) Kris A. Steinbrecher et al.   CANCER RESEARCH

Risk Assessment of Recurrence in Patients With Unprovoked Deep Vein Thrombosis or Pulmonary Embolism

(2010) Sabine Eichinger et al.   CIRCULATION

Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix

(2010) A. Klepfish et al.   INTERNATIONAL JOURNAL OF CANCER

Protease-Activated Receptor-1 Antagonist F 16618 Reduces Arterial Restenosis by Down-Regulation of Tumor Necrosis Factor   and Matrix Metalloproteinase 7 Expression, Migration, and Proliferation of Vascular Smooth Muscle Cells

(2010) P. Chieng-Yane et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A 2-Step Mechanism of Arterial Thrombus Formation Induced by Human Atherosclerotic Plaques

(2010) Armin J. Reininger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile

(2010) E. SANTAGOSTINO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding

(2010) M. COAKLEY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombin generation in patients with a first acute myocardial infarction

(2010) M. SMID et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Etk/Bmx Regulates Proteinase-Activated-Receptor1 (PAR1) in Breast Cancer Invasion: Signaling Partners, Hierarchy and Physiological Significance

(2010) Irit Cohen et al.   PLoS One

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

D-Dimer and Prothrombin Fragment 1 + 2 Predict Venous Thromboembolism in Patients With Cancer: Results From the Vienna Cancer and Thrombosis Study

(2009) Cihan Ay et al.   JOURNAL OF CLINICAL ONCOLOGY

Elevated d-dimer levels predict recurrence in patients with idiopathic venous thromboembolism: a meta-analysis

(2009) E. BRUINSTROOP et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Peak thrombin generation and subsequent venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE) study

(2009) P. L. LUTSEY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen

(2008) Anders Krarup et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Aortic Atherosclerosis, Hypercoagulability, and Stroke

(2008) Marco R. Di Tullio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High thrombin generation measured in the presence of thrombomodulin is associated with an increased risk of recurrent venous thromboembolism

(2008) A. TRIPODI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study

(2008) M. BESSER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombin enhances the production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 in cultured rat glomerular epithelial cells

(2008) T. Fujita et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Thrombin up-regulates vascular endothelial growth factor in experimental gliomas

(2008) Ying Xu et al.   NEUROLOGICAL RESEARCH

Mechanisms of Thrombus Formation

(2008) Bruce Furie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduction of blood coagulation and monocyte-platelet interaction following the use of a minimal extracorporeal circulation system (Synergy®) in coronary artery bypass grafting (CABG)

(2008) PA Farneti et al.   PERFUSION-UK

Standardization and Clinical Utility of Thrombin-Generation Assays

(2008) Erik Berntorp et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Thrombin generation, fibrin clot formation and hemostasis

(2008) Alisa S. Wolberg et al.   TRANSFUSION AND APHERESIS SCIENCE